Publication Information

{'id': 'https://openalex.org/W1825871834', 'doi': 'https://doi.org/10.18632/oncotarget.4895', 'title': 'miR-146b-5p functions as a tumor suppressor by targeting TRAF6 and predicts the prognosis of human gliomas', 'display_name': 'miR-146b-5p functions as a tumor suppressor by targeting TRAF6 and predicts the prognosis of human gliomas', 'publication_year': 2015, 'publication_date': '2015-08-06', 'ids': {'openalex': 'https://openalex.org/W1825871834', 'doi': 'https://doi.org/10.18632/oncotarget.4895', 'mag': '1825871834', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26320176', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4745716'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.4895', 'pdf_url': 'https://www.oncotarget.com/article/4895/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 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'is_corresponding': False, 'raw_author_name': 'Huining Li', 'raw_affiliation_strings': ['Department of Neuropathology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.', 'Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin 300052, China', 'Tianjin Key Laboratory of Injuries, Variations and Regeneration of the Nervous System, Tianjin 300052, China'], 'affiliations': [{'raw_affiliation_string': 'Tianjin Key Laboratory of Injuries, Variations and Regeneration of the Nervous System, Tianjin 300052, China', 'institution_ids': []}, {'raw_affiliation_string': 'Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin 300052, China', 'institution_ids': ['https://openalex.org/I1327237609']}, {'raw_affiliation_string': 'Department of Neuropathology, Tianjin Neurological Institute, Tianjin Medical University General 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'https://orcid.org/0000-0002-9972-3799'}, 'institutions': [{'id': 'https://openalex.org/I5740404', 'display_name': 'Tianjin Medical University', 'ror': 'https://ror.org/02mh8wx89', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I5740404']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lin Yu', 'raw_affiliation_strings': ['Department of Biochemistry, Basic Medical College of Tianjin Medical University, Tianjin 300070, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Basic Medical College of Tianjin Medical University, Tianjin 300070, China.', 'institution_ids': ['https://openalex.org/I5740404']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100324150', 'display_name': 'Yanyan Li', 'orcid': 'https://orcid.org/0009-0005-7231-9293'}, 'institutions': [{'id': 'https://openalex.org/I2802534033', 'display_name': 'Tianjin Medical University General Hospital', 'ror': 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'Accepted:': [227], 'July': [228], '24,': [229], 'Published:': [231], 'August': [232], '06,': [233], '2015': [234], 'ABSTRACT': [235], 'Down-regulation': [236], 'miR-146b-5p': [238, 250, 267, 305, 314, 324, 343, 347, 377, 403, 416], 'contributes': [239], 'tumorigenesis': [241], 'several': [243], 'human': [244, 279], 'cancers.': [245], 'However,': [246], 'relevance': [248], 'prognosis,': [252], 'proliferation': [253, 329], 'apoptosis': [255], 'gliomas': [257, 297], 'remains': [258], 'unknown.': [259], 'In': [260, 386], 'present': [262], 'study,': [263], 'we': [264, 334], 'demonstrated': [265], 'that': [266, 313, 346], 'expression': [268, 306, 363, 378], 'was': [269, 315, 364], 'inversely': [270, 374], 'correlated': [271, 284, 366, 375], 'with': [272, 285, 294, 298, 367, 376], 'grades': [273, 369], 'Ki-67': [275, 371], 'index': [276, 372], '147': [278], 'glioma': [280, 327, 368, 384], 'specimens,': [281], 'but': [282, 373], 'positively': [283, 365], 'patients’': [286, 320], 'survival.': [287, 321], 'Furthermore,': [288], 'two': [289], 'distinct': [290], 'subgroups': [291], 'patients': [293], 'grade': [295], 'I-IV': [296], 'different': [299], 'prognoses': [300], 'were': [301], 'identified': [302], 'according': [303], 'our': [308], 'specimens.': [309], 'Cox': [310], 'regression': [311], 'showed': [312], 'an': [316], 'independent': [317], 'predictor': [318], 'for': [319, 423], 'Overexpression': [322], 'dramatically': [325], 'suppressed': [326], 'cell': [328, 388], 'induced': [331], 'apoptosis.': [332], 'Mechanistically,': [333], 'validated': [335], 'TRAF6': [336, 362, 392, 418], 'as': [337, 404, 419], 'a': [338, 405], 'direct': [339], 'functional': [340], 'target': [341], 'found': [345], 'overexpression': [348], 'significantly': [349], 'decreased': [350], 'phosphorylated': [351], 'TAK1': [352], 'IκBα,': [354], 'pivotal': [356], 'downstream': [357], 'effectors': [358], 'TRAF6.': [360], 'Moreover,': [361], 'predicted': [380], 'poor': [381], 'patients.': [385], 'glioblastoma': [387], 'lines,': [389], 'silencing': [390], 'could': [393], 'mimic': [394], 'anti-tumor': [396], 'effect': [397], 'miR-146b-5p.': [399], 'Our': [400], 'findings': [401], 'identify': [402], 'tumor': [406], 'suppressor': [407], 'novel': [409], 'prognostic': [410], 'biomarker': [411], 'suggest': [415], 'potential': [420], 'therapeutic': [421], 'candidates': [422], 'malignant': [424], 'gliomas.': [425]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1825871834', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 16}, {'year': 2017, 'cited_by_count': 20}, {'year': 2016, 'cited_by_count': 5}], 'updated_date': '2024-12-13T04:58:19.678165', 'created_date': '2016-06-24'}