Publication Information

{'id': 'https://openalex.org/W1821997135', 'doi': 'https://doi.org/10.1093/clinchem/27.11.1838', 'title': 'Method for testing antiserum titer and avidity in nephelometric systems.', 'display_name': 'Method for testing antiserum titer and avidity in nephelometric systems.', 'publication_year': 1981, 'publication_date': '1981-11-01', 'ids': {'openalex': 'https://openalex.org/W1821997135', 'doi': 'https://doi.org/10.1093/clinchem/27.11.1838', 'mag': '1821997135', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6975190'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/clinchem/27.11.1838', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S139212996', 'display_name': 'Clinical Chemistry', 'issn_l': '0009-9147', 'issn': ['0009-9147', '1530-8561'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320272', 'host_organization_name': 'American Association for Clinical Chemistry', 'host_organization_lineage': ['https://openalex.org/P4310320272'], 'host_organization_lineage_names': ['American Association for Clinical Chemistry'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5058532404', 'display_name': 'Gail A. Hudson', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'G A Hudson', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032719999', 'display_name': 'Robert F. Ritchie', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'R F Ritchie', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5112384421', 'display_name': 'J E Haddow', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J E Haddow', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4088, 'currency': 'USD', 'value_usd': 4088, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.098, 'has_fulltext': False, 'cited_by_count': 16, 'citation_normalized_percentile': {'value': 0.865036, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 85}, 'biblio': {'volume': '27', 'issue': '11', 'first_page': '1838', 'last_page': '1844'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11949', 'display_name': 'Nuclear Physics and Applications', 'score': 0.0762, 'subfield': {'id': 'https://openalex.org/subfields/3108', 'display_name': 'Radiation'}, 'field': {'id': 'https://openalex.org/fields/31', 'display_name': 'Physics and Astronomy'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11949', 'display_name': 'Nuclear Physics and Applications', 'score': 0.0762, 'subfield': {'id': 'https://openalex.org/subfields/3108', 'display_name': 'Radiation'}, 'field': {'id': 'https://openalex.org/fields/31', 'display_name': 'Physics and Astronomy'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/avidity', 'display_name': 'Avidity', 'score': 0.86658025}], 'concepts': [{'id': 'https://openalex.org/C32611913', 'wikidata': 'https://www.wikidata.org/wiki/Q2166189', 'display_name': 'Titer', 'level': 3, 'score': 0.880181}, {'id': 'https://openalex.org/C179223381', 'wikidata': 'https://www.wikidata.org/wiki/Q419425', 'display_name': 'Avidity', 'level': 3, 'score': 0.86658025}, {'id': 'https://openalex.org/C91523082', 'wikidata': 'https://www.wikidata.org/wiki/Q420496', 'display_name': 'Antiserum', 'level': 3, 'score': 0.8352784}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.40191153}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.35545978}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.2382913}], 'mesh': [{'descriptor_ui': 'D000941', 'descriptor_name': 'Antigens', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D007106', 'descriptor_name': 'Immune Sera', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D000936', 'descriptor_name': 'Antigen-Antibody Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000941', 'descriptor_name': 'Antigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007106', 'descriptor_name': 'Immune Sera', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007074', 'descriptor_name': 'Immunoglobulin G', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D007074', 'descriptor_name': 'Immunoglobulin G', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009391', 'descriptor_name': 'Nephelometry and Turbidimetry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009391', 'descriptor_name': 'Nephelometry and Turbidimetry', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D009961', 'descriptor_name': 'Orosomucoid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009961', 'descriptor_name': 'Orosomucoid', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D000515', 'descriptor_name': 'alpha 1-Antitrypsin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000515', 'descriptor_name': 'alpha 1-Antitrypsin', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/clinchem/27.11.1838', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S139212996', 'display_name': 'Clinical Chemistry', 'issn_l': '0009-9147', 'issn': ['0009-9147', '1530-8561'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320272', 'host_organization_name': 'American Association for Clinical Chemistry', 'host_organization_lineage': ['https://openalex.org/P4310320272'], 'host_organization_lineage_names': ['American Association for Clinical Chemistry'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6975190', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4313366611', 'https://openalex.org/W2466764880', 'https://openalex.org/W2413356637', 'https://openalex.org/W2368890815', 'https://openalex.org/W2356060231', 'https://openalex.org/W2178718402', 'https://openalex.org/W1830270182', 'https://openalex.org/W1821997135', 'https://openalex.org/W1536816732', 'https://openalex.org/W1494372634'], 'abstract_inverted_index': {'Antiserum': [0, 42, 71], 'performance': [1], 'in': [2, 180], 'a': [3, 22, 96], 'nephelometric': [4, 28, 58], 'system': [5], 'can': [6, 44, 73, 147], 'be': [7, 46, 74, 148], 'characterized': [8], 'by': [9, 48, 76, 127, 165], 'parameters': [10, 130], 'derived': [11, 20], 'from': [12, 21, 34, 142], 'measuring': [13], 'reaction': [14], 'rates.': [15], 'The': [16], 'characterization': [17], 'process': [18], 'is': [19, 112], 'series': [23], 'of': [24, 37, 61, 117, 123, 139, 168], 'dose-response': [25, 63, 98], 'curves': [26], '(elicited': [27], 'response': [29, 59], 'vs': [30, 66, 93], 'antigen': [31, 51], 'concentration)': [32], 'generated': [33], 'various': [35], 'dilutions': [36], 'the': [38, 50, 56, 67, 115, 137, 158, 174], 'antiserum': [39, 69, 82, 94, 132, 155, 176], 'being': [40], 'tested.': [41], 'titer': [43, 107, 124], 'then': [45], 'calculated': [47, 75], 'plotting': [49, 77], 'concentration': [52], 'found': [53], 'at': [54], 'one-half': [55], 'maximum': [57], '(Hmax)': [60], 'each': [62], 'curve': [64, 99], '(C50)': [65], 'corresponding': [68, 81], 'dilution.': [70], 'avidity': [72, 126], 'Hmax': [78, 92, 120], 'against': [79], 'its': [80], 'concentration.': [83], 'After': [84], 'general': [85], 'expressions': [86], 'are': [87], 'determined': [88], 'for': [89, 101, 114], 'C50': [90, 118], 'and': [91, 108, 119, 125, 135, 152, 171], 'concentration,': [95], 'single': [97], 'suffices': [100], 'characterizing': [102], 'antisera': [103, 167], 'with': [104, 131, 136], 'respect': [105], 'to': [106, 150, 161, 172, 178], 'avidity.': [109], 'Direct': [110], 'evidence': [111], 'provided': [113], 'validity': [116], 'as': [121], 'measures': [122], 'correlating': [128], 'these': [129], 'binding': [133], 'strength': [134], 'number': [138], 'antibodies': [140], 'eluted': [141], 'immobilized': [143], 'antigen.': [144], 'This': [145], 'method': [146], 'applied': [149], 'evaluate': [151], 'compare': [153], 'different': [154, 169], 'lots': [156], 'having': [157], 'same': [159], 'specificity,': [160, 170], 'identify': [162], 'reagent': [163], 'inadequacies': [164], 'comparing': [166], 'predict': [173], 'optimal': [175], 'dilution': [177], 'use': [179], 'performing': [181], 'an': [182], 'assay.': [183]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1821997135', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-14T09:16:07.869425', 'created_date': '2016-06-24'}