Title: Reversal of chronic to resolved infection by <scp>IL</scp>‐10 blockade is <scp>LCMV</scp> strain dependent
Abstract: Chronic viral infections lead to CD 8 + T ‐cell exhaustion, characterized by impaired cytokine secretion. The immune‐regulatory cytokine IL ‐10 promotes chronicity of infection with lymphocytic choriomeningitis virus ( LCMV) C lone 13, as absence of IL ‐10 or blocking of IL ‐10 R during early LCMV C lone 13 infection results in viral clearance. Thus, treatment of humans suffering from chronic viral infections with IL ‐10 neutralizing or IL ‐10 R blocking antibodies was proposed to boost virus‐specific T ‐cell responses to enhance control or even clear the viral infection. Here we demonstrate that although CD 4 + and CD 8 + T cells can produce elevated levels of cytokines in IL ‐10 −/− mice early after infection compared with WT mice, IL ‐10 −/− mice cannot clear an infection with the quicker replicating LCMV strain D ocile, eventually resulting in T ‐cell exhaustion. These data suggest that the success of IL ‐10 blockade to control chronic viral infections may critically depend on the virulence of the infecting strain.
Publication Year: 2012
Publication Date: 2012-12-26
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 21
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot