Title: SPECT attenuation correction comparison of CT with Gadolinium-153 transmission sources
Abstract:2213 Objectives: SPECT images contain soft tissue attenuation artifacts that may be perceived as perfusion defects in myocardial perfusion imaging (MPI). Gadolinium-153 (Gd) transmission sources are c...2213 Objectives: SPECT images contain soft tissue attenuation artifacts that may be perceived as perfusion defects in myocardial perfusion imaging (MPI). Gadolinium-153 (Gd) transmission sources are commonly used for attenuation correction (AC); however, due to the low radiation flux of Gd, CT-AC has been found to be more accurate and effective in minimizing attenuation artifacts. The purpose of this study is to compare CT-AC with Gd-AC in MPI. Methods: Using a SPECT phantom with a cardiac insert (Data Spectrum Corp, Chapel Hill, NC) containing two defects and varying amounts of background, three separate studies were acquired on each of the following SPECT camera systems: Hybrid SPECT/CT (Philips Precedence, Milpitas, CA) and a gamma camera equipped with Gd-AC (Philips Forte, Milpitas, CA). The amount of radioactivity in the wall of the cardiac phantom was determined by calculating the percentage of sestamibi that is normally taken up by the myocardium (~1.2 %) following injection of a dose (40 mCi). The first study on each system contained no phantom background activity. The second and third studies had increasing background activities of 4.2 mCi and 6.1 mCi of TcO4, respectively, to simulate chest background activity found in patients of varying sizes. Each study was processed using iterative reconstruction with scatter correction and compared for myocardial edge detection, chamber volume, and myocardial wall volume. Results: When visually comparing the processed data from the two systems, the SPECT/CT displayed less image noise, better edge detection, and defect definition than Gd-AC. As background activity increased, the SPECT/CT images showed little variation in defect detection and myocardial edge definition, whereas Gd-AC edge detection appeared less distinct. The SPECT/CT calculated phantom chamber and wall volumes were 83 mL and 114 mL, respectively, while the Gd-AC calculated volumes were 82 mL and 130 mL. The actual phantom volumes were 63 mL for the chamber and 112 mL for the wall. Conclusions: CT-AC demonstrated better edge detection and more accurate wall volume measurements than Gd-AC.Read More
Publication Year: 2007
Publication Date: 2007-05-01
Language: en
Type: article
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