Title: A role for kappa-, but not mu-opioid, receptor activation in acute food deprivation-induced reinstatement of heroin seeking in rats
Abstract: Addiction BiologyVolume 20, Issue 3 p. 423-432 PRECLINICAL STUDY A role for kappa-, but not mu-opioid, receptor activation in acute food deprivation-induced reinstatement of heroin seeking in rats Firas Sedki, Firas Sedki Department of Psychology, Center for Studies in Behavioral Neurobiology/Groupe de Recherche en Neurobiologie Comportementale, Concordia University, Montreal, Quebec, CanadaSearch for more papers by this authorKarine Eigenmann, Karine Eigenmann Department of Psychology, Center for Studies in Behavioral Neurobiology/Groupe de Recherche en Neurobiologie Comportementale, Concordia University, Montreal, Quebec, CanadaSearch for more papers by this authorJessica Gelinas, Jessica Gelinas Department of Psychology, Center for Studies in Behavioral Neurobiology/Groupe de Recherche en Neurobiologie Comportementale, Concordia University, Montreal, Quebec, CanadaSearch for more papers by this authorNicholas Schouela, Nicholas Schouela Department of Psychology, Center for Studies in Behavioral Neurobiology/Groupe de Recherche en Neurobiologie Comportementale, Concordia University, Montreal, Quebec, CanadaSearch for more papers by this authorShannon Courchesne, Shannon Courchesne Department of Psychology, Center for Studies in Behavioral Neurobiology/Groupe de Recherche en Neurobiologie Comportementale, Concordia University, Montreal, Quebec, CanadaSearch for more papers by this authorUri Shalev, Corresponding Author Uri Shalev Department of Psychology, Center for Studies in Behavioral Neurobiology/Groupe de Recherche en Neurobiologie Comportementale, Concordia University, Montreal, Quebec, CanadaCorrespondence to: Uri Shalev, Concordia University, Department of Psychology, CSBN/GRNC, 7141 Sherbrooke St. W., Montreal H4B 1R6, Canada. E-mail: [email protected]Search for more papers by this author Firas Sedki, Firas Sedki Department of Psychology, Center for Studies in Behavioral Neurobiology/Groupe de Recherche en Neurobiologie Comportementale, Concordia University, Montreal, Quebec, CanadaSearch for more papers by this authorKarine Eigenmann, Karine Eigenmann Department of Psychology, Center for Studies in Behavioral Neurobiology/Groupe de Recherche en Neurobiologie Comportementale, Concordia University, Montreal, Quebec, CanadaSearch for more papers by this authorJessica Gelinas, Jessica Gelinas Department of Psychology, Center for Studies in Behavioral Neurobiology/Groupe de Recherche en Neurobiologie Comportementale, Concordia University, Montreal, Quebec, CanadaSearch for more papers by this authorNicholas Schouela, Nicholas Schouela Department of Psychology, Center for Studies in Behavioral Neurobiology/Groupe de Recherche en Neurobiologie Comportementale, Concordia University, Montreal, Quebec, CanadaSearch for more papers by this authorShannon Courchesne, Shannon Courchesne Department of Psychology, Center for Studies in Behavioral Neurobiology/Groupe de Recherche en Neurobiologie Comportementale, Concordia University, Montreal, Quebec, CanadaSearch for more papers by this authorUri Shalev, Corresponding Author Uri Shalev Department of Psychology, Center for Studies in Behavioral Neurobiology/Groupe de Recherche en Neurobiologie Comportementale, Concordia University, Montreal, Quebec, CanadaCorrespondence to: Uri Shalev, Concordia University, Department of Psychology, CSBN/GRNC, 7141 Sherbrooke St. W., Montreal H4B 1R6, Canada. E-mail: [email protected]Search for more papers by this author First published: 13 April 2014 https://doi.org/10.1111/adb.12133Citations: 20Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Stress is considered to be one of the major triggers to drug relapse, even after prolonged periods of abstinence. In rats, the activation of stress-related brain systems, including corticotropin-releasing factor and norepinephrine, is critical for stress-induced reinstatement of extinguished drug seeking, an animal model for drug relapse. In addition, there are strong indications that activation of the endogenous opioid system is important for the effects of stress on drug seeking. More specifically, activation of the dynorphin/kappa opioid receptor (KOR) system is critically involved in the reinstatement of cocaine seeking following exposure to stressors, such as footshock, forced swimming or social stress. However, studies on the role of the dynorphin/KOR system in stress-induced reinstatement of heroin seeking are scarce. Here, rats were trained to self-administer heroin (0.1 mg/kg/infusion) for 10 days. Drug seeking was then extinguished and the rats were tested for acute (21 hours) food deprivation-induced reinstatement of heroin seeking. In two separate experiments, rats were injected with the mu-opioid receptor (MOR) antagonist, naltrexone (0.0, 1.0, 10.0 mg/kg; s.c.) or the KOR antagonist, norBNI (0.0, 1.0, 10.0 mg/kg; i.p.) before the reinstatement test. 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Publication Year: 2014
Publication Date: 2014-04-13
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 25
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