Title: ROLE OF THE NUCLEUS LOCUS COERULEUS IN SYMPATHETHIC AND CENTRAL NORADRENERGIC ACTIVATION AS REFLECTED BY CHANGES IN THE NOREPINEPHRINE METABOLITE 3-METHOXY-4-HYDROXYPHENETHYLENEGLYCOL (MHPG) IN RATS
Abstract: Stimulation of the brain nucleus locus coeruleus (LC) produces a large increase in plasma levels of MHPG. Blockade of the sympathetic nervous system (SNS) significantly attenuates the plasma MHPG increase after LC stimulation, suggesting a possible influence of the LC on the SNS. Unilateral lesioning of the anatomical region containing the LC blocks the plasma MHPG increase when the lesioned site is stimulated. Spinal cord MHPG increased after LC stimulation, and a significant correlation was found between spinal cord MHPG and plasma MHPG, suggesting that the descending projections of the LC to the spinal cord may be involved in the plasma MHPG increase.
Publication Year: 1979
Publication Date: 1979-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
Access and Citation
Cited By Count: 4
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