Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1800290569', 'doi': None, 'title': 'Microbiology and Industrial Biotechnology of Food-Grade Proteases: A Perspective', 'display_name': 'Microbiology and Industrial Biotechnology of Food-Grade Proteases: A Perspective', 'publication_year': 2006, 'publication_date': '2006-01-01', 'ids': {'openalex': 'https://openalex.org/W1800290569', 'mag': '1800290569'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/0d29304b2a314faca055ffebc43e1873', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['doaj'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5039791172', 'display_name': 'Alagarsamy Sumantha', 'orcid': 'https://orcid.org/0000-0003-3237-937X'}, 'institutions': [{'id': 'https://openalex.org/I66760702', 'display_name': 'Council of Scientific and Industrial Research', 'ror': 'https://ror.org/021wm7p51', 'country_code': 'IN', 'type': 'government', 'lineage': ['https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}, {'id': 'https://openalex.org/I4210107015', 'display_name': 'Institute of Minerals and Materials Technology', 'ror': 'https://ror.org/01g7qth32', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I2799351866', 'https://openalex.org/I4210107015', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}, {'id': 'https://openalex.org/I146682468', 'display_name': 'National Institute for Interdisciplinary Science and Technology', 'ror': 'https://ror.org/05bkc5375', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I146682468', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Alagarsamy Sumantha', 'raw_affiliation_strings': ['Biotechnology Division, Regional Research Laboratory (CSIR), Trivandrum—695 019, India'], 'affiliations': [{'raw_affiliation_string': 'Biotechnology Division, Regional Research Laboratory (CSIR), Trivandrum—695 019, India', 'institution_ids': ['https://openalex.org/I66760702', 'https://openalex.org/I4210107015', 'https://openalex.org/I146682468']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079047069', 'display_name': 'Christian Larroche', 'orcid': 'https://orcid.org/0000-0001-7348-9191'}, 'institutions': [{'id': 'https://openalex.org/I169645620', 'display_name': 'Institut Pascal', 'ror': 'https://ror.org/03vgfxd91', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I169645620', 'https://openalex.org/I198244214', 'https://openalex.org/I4210095849']}, {'id': 'https://openalex.org/I4210087602', 'display_name': 'Laboratoire de Génie Chimique', 'ror': 'https://ror.org/003jnac13', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I134560555', 'https://openalex.org/I205747304', 'https://openalex.org/I4210087602', 'https://openalex.org/I4210095849']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Christian Larroche', 'raw_affiliation_strings': ['Laboratoire de Génie Chimique et Biochimique, CUST-Université Blaise Pascal, 24 Avenue des Landais, B.P. 206, F-63174, Aubière Cedex, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de Génie Chimique et Biochimique, CUST-Université Blaise Pascal, 24 Avenue des Landais, B.P. 206, F-63174, Aubière Cedex, France', 'institution_ids': ['https://openalex.org/I169645620', 'https://openalex.org/I4210087602']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5028114748', 'display_name': 'Ashok Pandey', 'orcid': 'https://orcid.org/0000-0003-1626-3529'}, 'institutions': [{'id': 'https://openalex.org/I66760702', 'display_name': 'Council of Scientific and Industrial Research', 'ror': 'https://ror.org/021wm7p51', 'country_code': 'IN', 'type': 'government', 'lineage': ['https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}, {'id': 'https://openalex.org/I4210107015', 'display_name': 'Institute of Minerals and Materials Technology', 'ror': 'https://ror.org/01g7qth32', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I2799351866', 'https://openalex.org/I4210107015', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}, {'id': 'https://openalex.org/I146682468', 'display_name': 'National Institute for Interdisciplinary Science and Technology', 'ror': 'https://ror.org/05bkc5375', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I146682468', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Ashok Pandey', 'raw_affiliation_strings': ['Biotechnology Division, Regional Research Laboratory (CSIR), Trivandrum—695 019, India'], 'affiliations': [{'raw_affiliation_string': 'Biotechnology Division, Regional Research Laboratory (CSIR), Trivandrum—695 019, India', 'institution_ids': ['https://openalex.org/I66760702', 'https://openalex.org/I4210107015', 'https://openalex.org/I146682468']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.144, 'has_fulltext': False, 'cited_by_count': 238, 'citation_normalized_percentile': {'value': 0.945711, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11617', 'display_name': 'Enzyme Production and Characterization', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11617', 'display_name': 'Enzyme Production and Characterization', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12991', 'display_name': 'Phytase and its Applications', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11561', 'display_name': 'Protein Hydrolysis and Bioactive Peptides', 'score': 0.9956, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/industrial-microbiology', 'display_name': 'Industrial microbiology', 'score': 0.5553733}, {'id': 'https://openalex.org/keywords/industrial-biotechnology', 'display_name': 'Industrial biotechnology', 'score': 0.51344}, {'id': 'https://openalex.org/keywords/food-microbiology', 'display_name': 'Food microbiology', 'score': 0.4927056}], 'concepts': [{'id': 'https://openalex.org/C182220744', 'wikidata': 'https://www.wikidata.org/wiki/Q7251226', 'display_name': 'Proteases', 'level': 3, 'score': 0.74463767}, {'id': 'https://openalex.org/C12713177', 'wikidata': 'https://www.wikidata.org/wiki/Q1900281', 'display_name': 'Perspective (graphical)', 'level': 2, 'score': 0.56299204}, {'id': 'https://openalex.org/C2779039970', 'wikidata': 'https://www.wikidata.org/wiki/Q3610387', 'display_name': 'Industrial microbiology', 'level': 3, 'score': 0.5553733}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.53387785}, {'id': 'https://openalex.org/C2991947430', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Industrial biotechnology', 'level': 2, 'score': 0.51344}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.4939099}, {'id': 'https://openalex.org/C58684123', 'wikidata': 'https://www.wikidata.org/wiki/Q1810993', 'display_name': 'Food microbiology', 'level': 3, 'score': 0.4927056}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.47276288}, {'id': 'https://openalex.org/C31903555', 'wikidata': 'https://www.wikidata.org/wiki/Q1637030', 'display_name': 'Food science', 'level': 1, 'score': 0.2837686}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.20491111}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.10777813}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.09449807}, {'id': 'https://openalex.org/C100544194', 'wikidata': 'https://www.wikidata.org/wiki/Q41760', 'display_name': 'Fermentation', 'level': 2, 'score': 0.08477816}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.08057371}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.064290226}, {'id': 'https://openalex.org/C154945302', 'wikidata': 'https://www.wikidata.org/wiki/Q11660', 'display_name': 'Artificial intelligence', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doaj.org/article/0d29304b2a314faca055ffebc43e1873', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/12', 'display_name': 'Responsible consumption and production', 'score': 0.45}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 102, 'referenced_works': ['https://openalex.org/W118686142', 'https://openalex.org/W1482190881', 'https://openalex.org/W1482493857', 'https://openalex.org/W1485474307', 'https://openalex.org/W1498144012', 'https://openalex.org/W1501717569', 'https://openalex.org/W1503386432', 'https://openalex.org/W1607505629', 'https://openalex.org/W1712467530', 'https://openalex.org/W1775749144', 'https://openalex.org/W1902712333', 'https://openalex.org/W1917266910', 'https://openalex.org/W1943114487', 'https://openalex.org/W1970664435', 'https://openalex.org/W1972283313', 'https://openalex.org/W1976843839', 'https://openalex.org/W1979491775', 'https://openalex.org/W1980211123', 'https://openalex.org/W1984733193', 'https://openalex.org/W1985391255', 'https://openalex.org/W1985917720', 'https://openalex.org/W1986808796', 'https://openalex.org/W1988105057', 'https://openalex.org/W1988576955', 'https://openalex.org/W1989828088', 'https://openalex.org/W1991927584', 'https://openalex.org/W1994548699', 'https://openalex.org/W1996234003', 'https://openalex.org/W1996390850', 'https://openalex.org/W1997084429', 'https://openalex.org/W2001049522', 'https://openalex.org/W2001490951', 'https://openalex.org/W2006972232', 'https://openalex.org/W2008419295', 'https://openalex.org/W2008939974', 'https://openalex.org/W2010784949', 'https://openalex.org/W2011559320', 'https://openalex.org/W2015587006', 'https://openalex.org/W2018069051', 'https://openalex.org/W2018870958', 'https://openalex.org/W2019919839', 'https://openalex.org/W2024845297', 'https://openalex.org/W2025944423', 'https://openalex.org/W2026482320', 'https://openalex.org/W2027342101', 'https://openalex.org/W2027428584', 'https://openalex.org/W2027814524', 'https://openalex.org/W2031163411', 'https://openalex.org/W2034766013', 'https://openalex.org/W2035536980', 'https://openalex.org/W2038441393', 'https://openalex.org/W2041665965', 'https://openalex.org/W2044288991', 'https://openalex.org/W2049338420', 'https://openalex.org/W2049789982', 'https://openalex.org/W2050396114', 'https://openalex.org/W2051889716', 'https://openalex.org/W2054229854', 'https://openalex.org/W2066947471', 'https://openalex.org/W2069260732', 'https://openalex.org/W2073714920', 'https://openalex.org/W2073815568', 'https://openalex.org/W2074018288', 'https://openalex.org/W2077610870', 'https://openalex.org/W2078793536', 'https://openalex.org/W2079444794', 'https://openalex.org/W2082314988', 'https://openalex.org/W2084661556', 'https://openalex.org/W2094097613', 'https://openalex.org/W2102628698', 'https://openalex.org/W2104520651', 'https://openalex.org/W2106242480', 'https://openalex.org/W2106318286', 'https://openalex.org/W2109668833', 'https://openalex.org/W2111254012', 'https://openalex.org/W2113652248', 'https://openalex.org/W2114329602', 'https://openalex.org/W2126758610', 'https://openalex.org/W2139481502', 'https://openalex.org/W2141957171', 'https://openalex.org/W2143948627', 'https://openalex.org/W2145089135', 'https://openalex.org/W2145127182', 'https://openalex.org/W2145898720', 'https://openalex.org/W2148493393', 'https://openalex.org/W2252155753', 'https://openalex.org/W2261471960', 'https://openalex.org/W2321944123', 'https://openalex.org/W2408486203', 'https://openalex.org/W2409839515', 'https://openalex.org/W2414763383', 'https://openalex.org/W2415842304', 'https://openalex.org/W2419238814', 'https://openalex.org/W2424529955', 'https://openalex.org/W2466838604', 'https://openalex.org/W2495189501', 'https://openalex.org/W286524430', 'https://openalex.org/W29039502', 'https://openalex.org/W603517135', 'https://openalex.org/W79376890', 'https://openalex.org/W84693886', 'https://openalex.org/W955104134'], 'related_works': ['https://openalex.org/W4381112750', 'https://openalex.org/W4211195137', 'https://openalex.org/W2921569970', 'https://openalex.org/W2767821978', 'https://openalex.org/W2182214819', 'https://openalex.org/W2079754263', 'https://openalex.org/W2067370452', 'https://openalex.org/W2056435571', 'https://openalex.org/W2049361230', 'https://openalex.org/W1982197198'], 'abstract_inverted_index': {'Summary': [0], 'Recent': [1], 'developments': [2, 43], 'in': [3, 8, 44, 96, 103, 121, 142, 188], 'industrial': [4], 'biotechnology': [5], 'have': [6, 25, 94], 'resulted': [7], 'the': [9, 16, 31, 42, 45, 55, 62, 85, 165, 168, 182], 'exploitation': [10], 'ofnew': [11], 'and': [12, 15, 64, 128, 135, 153, 171, 192, 198], 'undiscovered': [13], 'microorganisms': [14], 'devising': [17], 'of': [18, 30, 47, 58, 84, 112, 138, 160, 167], 'improved': [19], 'methods': [20, 57], 'for': [21, 98, 110], 'en-zyme': [22], 'production,': [23], 'which': [24, 122, 140], 'led': [26], 'to': [27, 54, 126, 181], 'increased': [28], 'yields': [29], 'enzyme,': [32], 'thus': [33], 'making': [34], 'a': [35], 'viableindustrial': [36], 'process': [37], 'feasible.': [38], 'This': [39], 'review': [40], 'tracks': [41], 'field': [46], 'acidic': [48, 72], 'andneutral': [49], 'protease': [50], 'production': [51, 59], 'with': [52], 'regard': [53], 'producers,': [56], 'andtheir': [60], 'improvement,': [61], 'product': [63], 'its': [65], 'applications.': [66], 'Key': [67], 'words': [68], ':': [69], 'neutral': [70], 'protease,': [71, 73], 'fermentation,': [74], 'genetic': [75], 'engineering,': [76], 'purifica-tion,': [77], 'enzyme': [78], 'assay': [79], 'Introduction': [80], 'Proteases': [81, 114, 186], 'are': [82, 115], 'one': [83], 'industrially': [86], 'most': [87], 'importantenzymes.': [88], 'These': [89, 131], 'proteolytic': [90, 161], '(protein': [91], 'digesting)': [92], 'biocata-lysts': [93], 'been': [95], 'use': [97], 'many': [99], 'centuries,': [100], 'at': [101], 'first': [102], 'thedairy': [104], 'industry': [105], 'as': [106, 145], 'milk-clotting': [107], 'agents': [108], '(rennet)': [109], 'themanufacture': [111], 'cheese.': [113], 'enzymes': [116, 162], 'that': [117], 'cata-lyse': [118], 'hydrolytic': [119], 'reactions': [120, 205], 'protein': [123], 'molecules': [124], 'aredegraded': [125], 'peptides': [127], 'amino': [129, 169], 'acids.': [130], 'constitutea': [132], 'very': [133], 'large': [134], 'complex': [136], 'group': [137], 'enzymes,': [139], 'dif-fer': [141], 'properties': [143], 'such': [144], 'substrate': [146], 'specificity,': [147], 'active': [148], 'siteand': [149], 'catalytic': [150], 'mechanism,': [151], 'pH': [152], 'temperature': [154], 'optima': [155], 'andstability': [156], 'profile.': [157], 'The': [158], 'specificity': [159], 'isgoverned': [163], 'by': [164], 'nature': [166], 'acid': [170], 'other': [172], 'func-tional': [173], 'groups': [174], '(aromatic': [175], 'or': [176, 178], 'aliphatic': [177], 'sulphur-contain-ing)': [179], 'close': [180], 'bond': [183], 'being': [184], 'hydrolysed.': [185], 'arepresent': [187], 'all': [189], 'living': [190], 'beings': [191], 'play': [193], 'an': [194], 'important': [195], 'rolein': [196], 'normal': [197], 'abnormal': [199], 'physiological': [200], 'conditions,': [201], 'cata-lysing': [202], 'various': [203], 'metabolic': [204], '(': [206]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1800290569', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 17}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 18}, {'year': 2018, 'cited_by_count': 21}, {'year': 2017, 'cited_by_count': 17}, {'year': 2016, 'cited_by_count': 16}, {'year': 2015, 'cited_by_count': 16}, {'year': 2014, 'cited_by_count': 17}, {'year': 2013, 'cited_by_count': 25}, {'year': 2012, 'cited_by_count': 13}], 'updated_date': '2024-12-16T07:30:09.308669', 'created_date': '2016-06-24'}