Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1799794593', 'doi': 'https://doi.org/10.1111/j.1742-4658.2012.08586.x', 'title': 'Structural role of the active‐site metal in the conformation of <i>Trypanosoma brucei</i> phosphoglycerate mutase', 'display_name': 'Structural role of the active‐site metal in the conformation of <i>Trypanosoma brucei</i> phosphoglycerate mutase', 'publication_year': 2012, 'publication_date': '2012-04-03', 'ids': {'openalex': 'https://openalex.org/W1799794593', 'doi': 'https://doi.org/10.1111/j.1742-4658.2012.08586.x', 'mag': '1799794593', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22458781'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1742-4658.2012.08586.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S37672443', 'display_name': 'FEBS Journal', 'issn_l': '1742-464X', 'issn': ['1742-464X', '1742-4658'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5076256994', 'display_name': 'Gustavo Fernando Mercaldi', 'orcid': 'https://orcid.org/0000-0003-1445-6060'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}, {'id': 'https://openalex.org/I4210099967', 'display_name': 'Laboratório Nacional de Ciência e Tecnologia do Bioetanol', 'ror': 'https://ror.org/00w1v8g84', 'country_code': 'BR', 'type': 'other', 'lineage': ['https://openalex.org/I4210099967']}, {'id': 'https://openalex.org/I4210158387', 'display_name': 'Brazilian Biosciences National Laboratory', 'ror': 'https://ror.org/04kjcjc51', 'country_code': 'BR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210151455', 'https://openalex.org/I4210152696', 'https://openalex.org/I4210158387']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Gustavo F. Mercaldi', 'raw_affiliation_strings': ['Instituto de Física de São Carlos, Grupo de Cristalografia, Universidade de São Paulo, São Carlos, São Paulo, Brazil', 'Present address\n Laboratório Nacional de Biociências, Centro Nacional de Pesquisas em Energia e Materiais, Campinas, São Paulo 13083-100, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Física de São Carlos, Grupo de Cristalografia, Universidade de São Paulo, São Carlos, São Paulo, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}, {'raw_affiliation_string': 'Present address\n Laboratório Nacional de Biociências, Centro Nacional de Pesquisas em Energia e Materiais, Campinas, São Paulo 13083-100, Brazil', 'institution_ids': ['https://openalex.org/I4210099967', 'https://openalex.org/I4210158387']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026042540', 'display_name': 'H.M. Pereira', 'orcid': 'https://orcid.org/0000-0002-8652-6729'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Humberto M. Pereira', 'raw_affiliation_strings': ['Instituto de Física de São Carlos, Grupo de Cristalografia, Universidade de São Paulo, São Carlos, São Paulo, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Física de São Carlos, Grupo de Cristalografia, Universidade de São Paulo, São Carlos, São Paulo, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024057798', 'display_name': 'Artur T. Cordeiro', 'orcid': 'https://orcid.org/0000-0002-5676-2456'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}, {'id': 'https://openalex.org/I4210099967', 'display_name': 'Laboratório Nacional de Ciência e Tecnologia do Bioetanol', 'ror': 'https://ror.org/00w1v8g84', 'country_code': 'BR', 'type': 'other', 'lineage': ['https://openalex.org/I4210099967']}, {'id': 'https://openalex.org/I4210158387', 'display_name': 'Brazilian Biosciences National Laboratory', 'ror': 'https://ror.org/04kjcjc51', 'country_code': 'BR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210151455', 'https://openalex.org/I4210152696', 'https://openalex.org/I4210158387']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Artur T. Cordeiro', 'raw_affiliation_strings': ['Instituto de Física de São Carlos, Grupo de Cristalografia, Universidade de São Paulo, São Carlos, São Paulo, Brazil', 'Present address\n Laboratório Nacional de Biociências, Centro Nacional de Pesquisas em Energia e Materiais, Campinas, São Paulo 13083-100, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Física de São Carlos, Grupo de Cristalografia, Universidade de São Paulo, São Carlos, São Paulo, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}, {'raw_affiliation_string': 'Present address\n Laboratório Nacional de Biociências, Centro Nacional de Pesquisas em Energia e Materiais, Campinas, São Paulo 13083-100, Brazil', 'institution_ids': ['https://openalex.org/I4210099967', 'https://openalex.org/I4210158387']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010885639', 'display_name': 'Paul A.M. Michels', 'orcid': 'https://orcid.org/0000-0003-3726-6104'}, 'institutions': [{'id': 'https://openalex.org/I4210114657', 'display_name': 'de Duve Institute', 'ror': 'https://ror.org/022em3k58', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114657']}, {'id': 'https://openalex.org/I95674353', 'display_name': 'UCLouvain', 'ror': 'https://ror.org/02495e989', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I95674353']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Paul A. M. Michels', 'raw_affiliation_strings': ['Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université Catholique de Louvain, Brussels, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université Catholique de Louvain, Brussels, Belgium', 'institution_ids': ['https://openalex.org/I4210114657', 'https://openalex.org/I95674353']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5059638044', 'display_name': 'Otávio Henrique Thiemann', 'orcid': 'https://orcid.org/0000-0001-9971-5863'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Otavio H. Thiemann', 'raw_affiliation_strings': ['Instituto de Física de São Carlos, Grupo de Cristalografia, Universidade de São Paulo, São Carlos, São Paulo, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Física de São Carlos, Grupo de Cristalografia, Universidade de São Paulo, São Carlos, São Paulo, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4580, 'currency': 'USD', 'value_usd': 4580, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.686, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 18, 'citation_normalized_percentile': {'value': 0.773074, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '279', 'issue': '11', 'first_page': '2012', 'last_page': '2021'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11162', 'display_name': 'Enzyme Structure and Function', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11162', 'display_name': 'Enzyme Structure and Function', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12827', 'display_name': 'Biochemical and Molecular Research', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10044', 'display_name': 'Protein Structure and Dynamics', 'score': 0.9941, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/phosphoglycerate-mutase', 'display_name': 'Phosphoglycerate mutase', 'score': 0.9753866}, {'id': 'https://openalex.org/keywords/phosphoglycerate-kinase', 'display_name': 'Phosphoglycerate kinase', 'score': 0.8639822}, {'id': 'https://openalex.org/keywords/protein-data-bank', 'display_name': 'Protein Data Bank', 'score': 0.6552246}], 'concepts': [{'id': 'https://openalex.org/C91754966', 'wikidata': 'https://www.wikidata.org/wiki/Q415490', 'display_name': 'Phosphoglycerate mutase', 'level': 4, 'score': 0.9753866}, {'id': 'https://openalex.org/C2779502636', 'wikidata': 'https://www.wikidata.org/wiki/Q33244', 'display_name': 'Trypanosoma brucei', 'level': 3, 'score': 0.87476844}, {'id': 'https://openalex.org/C155911427', 'wikidata': 'https://www.wikidata.org/wiki/Q24772193', 'display_name': 'Phosphoglycerate kinase', 'level': 3, 'score': 0.8639822}, {'id': 'https://openalex.org/C65556437', 'wikidata': 'https://www.wikidata.org/wiki/Q766195', 'display_name': 'Protein Data Bank (RCSB PDB)', 'level': 2, 'score': 0.83489466}, {'id': 'https://openalex.org/C119145174', 'wikidata': 'https://www.wikidata.org/wiki/Q7251429', 'display_name': 'Protein Data Bank', 'level': 3, 'score': 0.6552246}, {'id': 'https://openalex.org/C41183919', 'wikidata': 'https://www.wikidata.org/wiki/Q423026', 'display_name': 'Active site', 'level': 3, 'score': 0.65514773}, {'id': 'https://openalex.org/C47701112', 'wikidata': 'https://www.wikidata.org/wiki/Q735188', 'display_name': 'Protein structure', 'level': 2, 'score': 0.5271306}, {'id': 'https://openalex.org/C166342909', 'wikidata': 'https://www.wikidata.org/wiki/Q845326', 'display_name': 'Allosteric regulation', 'level': 3, 'score': 0.4950563}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.47456673}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.46668917}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.38364697}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.28417718}, {'id': 'https://openalex.org/C20251656', 'wikidata': 'https://www.wikidata.org/wiki/Q162643', 'display_name': 'Glycolysis', 'level': 3, 'score': 0.24690962}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003035', 'descriptor_name': 'Cobalt', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D010736', 'descriptor_name': 'Phosphoglycerate Mutase', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D015800', 'descriptor_name': 'Protozoan Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D014346', 'descriptor_name': 'Trypanosoma brucei brucei', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D000409', 'descriptor_name': 'Alanine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000409', 'descriptor_name': 'Alanine', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000409', 'descriptor_name': 'Alanine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001051', 'descriptor_name': 'Apoenzymes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D001051', 'descriptor_name': 'Apoenzymes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001051', 'descriptor_name': 'Apoenzymes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001224', 'descriptor_name': 'Aspartic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001224', 'descriptor_name': 'Aspartic Acid', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D001224', 'descriptor_name': 'Aspartic Acid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020134', 'descriptor_name': 'Catalytic Domain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002413', 'descriptor_name': 'Cations, Divalent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003035', 'descriptor_name': 'Cobalt', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003035', 'descriptor_name': 'Cobalt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018360', 'descriptor_name': 'Crystallography, X-Ray', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007894', 'descriptor_name': 'Leishmania mexicana', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D007894', 'descriptor_name': 'Leishmania mexicana', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D007894', 'descriptor_name': 'Leishmania mexicana', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010736', 'descriptor_name': 'Phosphoglycerate Mutase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010736', 'descriptor_name': 'Phosphoglycerate Mutase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017433', 'descriptor_name': 'Protein Structure, Secondary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015800', 'descriptor_name': 'Protozoan Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015800', 'descriptor_name': 'Protozoan Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053838', 'descriptor_name': 'Scattering, Small Angle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D040681', 'descriptor_name': 'Structural Homology, Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014346', 'descriptor_name': 'Trypanosoma brucei brucei', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D014346', 'descriptor_name': 'Trypanosoma brucei brucei', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014961', 'descriptor_name': 'X-Ray Diffraction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1742-4658.2012.08586.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S37672443', 'display_name': 'FEBS Journal', 'issn_l': '1742-464X', 'issn': ['1742-464X', '1742-4658'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22458781', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.46, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1512001995', 'https://openalex.org/W1965270719', 'https://openalex.org/W1966748041', 'https://openalex.org/W1982126789', 'https://openalex.org/W1988051581', 'https://openalex.org/W1992191979', 'https://openalex.org/W1993991270', 'https://openalex.org/W1996920787', 'https://openalex.org/W1999918339', 'https://openalex.org/W2001641653', 'https://openalex.org/W2010917504', 'https://openalex.org/W2011751998', 'https://openalex.org/W2017519450', 'https://openalex.org/W2021123893', 'https://openalex.org/W2035503835', 'https://openalex.org/W2038840577', 'https://openalex.org/W2063319931', 'https://openalex.org/W2066088601', 'https://openalex.org/W2074127990', 'https://openalex.org/W2077027393', 'https://openalex.org/W2096064309', 'https://openalex.org/W2097677595', 'https://openalex.org/W2109184569', 'https://openalex.org/W2113800550', 'https://openalex.org/W2127078413', 'https://openalex.org/W2133193289', 'https://openalex.org/W2134201060', 'https://openalex.org/W2134302370', 'https://openalex.org/W2144081223', 'https://openalex.org/W2146332813', 'https://openalex.org/W2160754382', 'https://openalex.org/W2170408275', 'https://openalex.org/W4210675630'], 'related_works': ['https://openalex.org/W305539055', 'https://openalex.org/W2518314460', 'https://openalex.org/W2401430279', 'https://openalex.org/W2106612397', 'https://openalex.org/W2090630809', 'https://openalex.org/W2088162897', 'https://openalex.org/W2041065534', 'https://openalex.org/W2020669016', 'https://openalex.org/W2017519450', 'https://openalex.org/W2016904861'], 'abstract_inverted_index': {'Phosphoglycerate': [0], 'mutases': [1], '(PGAMs)': [2], 'participate': [3], 'in': [4, 12, 53, 132, 147, 172], 'both': [5], 'the': [6, 9, 35, 40, 44, 68, 73, 87, 91, 104, 109, 113, 120, 125, 142, 148, 162, 181, 192], 'glycolytic': [7], 'and': [8, 17, 57, 108, 116, 139, 210], 'gluconeogenic': [10], 'pathways': [11], 'reversible': [13], 'isomerization': [14], 'of': [15, 22, 34, 43, 124, 135], '3‐phosphoglycerate': [16], '2‐phosphoglycerate.': [18], 'PGAMs': [19], 'are': [20, 29], 'members': [21], 'two': [23], 'distinct': [24], 'protein': [25], 'families:': [26], 'enzymes': [27], 'that': [28], 'dependent': [30], 'on': [31], 'or': [32], 'independent': [33, 48, 76, 136], '2,3‐bisphosphoglycerate': [36], 'cofactor.': [37], 'We': [38], 'determined': [39], 'X‐ray': [41, 64], 'structure': [42, 71, 100], 'monomeric': [45], 'Trypanosoma': [46, 182], 'brucei': [47, 183], 'PGAM': [49, 77, 137], '(': [50, 215], 'Tb': [51, 69, 152], 'iPGAM)': [52], 'its': [54, 117, 145, 170], 'apoenzyme': [55, 163], 'form,': [56], 'confirmed': [58], 'this': [59], 'observation': [60], 'by': [61, 129, 213], 'small': [62], 'angle': [63], 'scattering': [65], 'data.': [66], 'Comparing': [67], 'iPGAM': [70, 153], 'with': [72, 81, 191], 'Leishmania': [74], 'mexicana': [75], 'structure,': [78], 'previously': [79], 'reported': [80, 101], 'a': [82], 'phosphoglycerate': [83, 185], 'molecule': [84], 'bound': [85, 111], 'to': [86, 112, 119], 'active': [88, 96, 114], 'site,': [89, 115], 'revealed': [90], 'domain': [92, 121], 'movement': [93], 'resulting': [94], 'from': [95], 'site': [97], 'occupation.': [98], 'The': [99], 'here': [102, 166], 'shows': [103], 'interaction': [105, 217], 'between': [106], 'Asp319': [107, 128], 'metal': [110], 'contribution': [118], 'movement.': [122], 'Substitution': [123], 'metal‐binding': [126], 'residue': [127], 'Ala': [130], 'resulted': [131], 'complete': [133], 'loss': [134], 'activity,': [138], 'showed': [140], 'for': [141, 159, 169, 180, 195], 'first': [143], 'time': [144], 'involvement': [146], 'enzyme’s': [149], 'function.': [150], 'As': [151], 'is': [154], 'an': [155], 'attractive': [156], 'molecular': [157], 'target': [158], 'drug': [160, 174], 'development,': [161], 'conformation': [164], 'described': [165], 'provides': [167], 'opportunities': [168], 'use': [171], 'structure‐based': [173], 'design': [175], 'approaches.': [176], 'Database': [177], 'Structural': [178, 196], 'data': [179], '2,3‐bisphosphoglycerate‐independent': [184], 'mutase': [186], '(iPGAM)': [187], 'has': [188], 'been': [189], 'deposited': [190], 'Research': [193], 'Collaboratory': [194], 'Bioinformatics': [197], '(RCSB)': [198], 'Protein': [199], 'Data': [200], 'Bank': [201], 'under': [202], 'code': [203], '3NVL': [204], '.': [205], 'Structured': [206], 'digital': [207], 'abstract': [208], 'TbiPGAM': [209, 211], 'bind': [212], 'x‐raycrystallography': [214], 'View': [216], ')': [218]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1799794593', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-11T05:39:01.447507', 'created_date': '2016-06-24'}