Publication Information

{'id': 'https://openalex.org/W1797160017', 'doi': 'https://doi.org/10.1002/jcph.169', 'title': 'Evaluation of the relationship between polymorphisms in<i>CYP2C8</i>and<i>CYP2C9</i>and the pharmacokinetics of celecoxib', 'display_name': 'Evaluation of the relationship between polymorphisms in<i>CYP2C8</i>and<i>CYP2C9</i>and the pharmacokinetics of celecoxib', 'publication_year': 2013, 'publication_date': '2013-08-28', 'ids': {'openalex': 'https://openalex.org/W1797160017', 'doi': 'https://doi.org/10.1002/jcph.169', 'mag': '1797160017', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23996211'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jcph.169', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S146237847', 'display_name': 'The Journal of Clinical Pharmacology', 'issn_l': '0091-2700', 'issn': ['0091-2700', '1552-4604'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5027243725', 'display_name': 'Rocío Prieto‐Pérez', 'orcid': 'https://orcid.org/0000-0002-5055-8817'}, 'institutions': [{'id': 'https://openalex.org/I4210130498', 'display_name': 'Hospital Universitario de La Princesa', 'ror': 'https://ror.org/03cg5md32', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210130498', 'https://openalex.org/I4210139293']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Rocío Prieto-Pérez', 'raw_affiliation_strings': ['Service of Clinical Pharmacology; Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP); Madrid Spain'], 'affiliations': [{'raw_affiliation_string': 'Service of Clinical Pharmacology; Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP); Madrid Spain', 'institution_ids': ['https://openalex.org/I4210130498']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111421362', 'display_name': 'Dolores Ochoa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210130498', 'display_name': 'Hospital Universitario de La Princesa', 'ror': 'https://ror.org/03cg5md32', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210130498', 'https://openalex.org/I4210139293']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Dolores Ochoa', 'raw_affiliation_strings': ['Service of Clinical Pharmacology; Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP); Madrid Spain'], 'affiliations': [{'raw_affiliation_string': 'Service of Clinical Pharmacology; Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP); Madrid Spain', 'institution_ids': ['https://openalex.org/I4210130498']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042898621', 'display_name': 'Teresa Cabaleiro', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210130498', 'display_name': 'Hospital Universitario de La Princesa', 'ror': 'https://ror.org/03cg5md32', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210130498', 'https://openalex.org/I4210139293']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Teresa Cabaleiro', 'raw_affiliation_strings': ['Service of Clinical Pharmacology; Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP); Madrid Spain'], 'affiliations': [{'raw_affiliation_string': 'Service of Clinical Pharmacology; Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP); Madrid Spain', 'institution_ids': ['https://openalex.org/I4210130498']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107990871', 'display_name': 'Manuel Román', 'orcid': 'https://orcid.org/0000-0002-7562-9845'}, 'institutions': [{'id': 'https://openalex.org/I4210130498', 'display_name': 'Hospital Universitario de La Princesa', 'ror': 'https://ror.org/03cg5md32', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210130498', 'https://openalex.org/I4210139293']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Manuel Román', 'raw_affiliation_strings': ['Service of Clinical Pharmacology; Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP); Madrid Spain'], 'affiliations': [{'raw_affiliation_string': 'Service of Clinical Pharmacology; Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP); Madrid Spain', 'institution_ids': ['https://openalex.org/I4210130498']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020970234', 'display_name': 'Sergio Daniel Sánchez-Rojas', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210130498', 'display_name': 'Hospital Universitario de La Princesa', 'ror': 'https://ror.org/03cg5md32', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210130498', 'https://openalex.org/I4210139293']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Sergio Daniel Sánchez-Rojas', 'raw_affiliation_strings': ['Service of Clinical Pharmacology; Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP); Madrid Spain'], 'affiliations': [{'raw_affiliation_string': 'Service of Clinical Pharmacology; Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP); Madrid Spain', 'institution_ids': ['https://openalex.org/I4210130498']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014911897', 'display_name': 'María Talegón', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210130498', 'display_name': 'Hospital Universitario de La Princesa', 'ror': 'https://ror.org/03cg5md32', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210130498', 'https://openalex.org/I4210139293']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'María Talegón', 'raw_affiliation_strings': ['Service of Clinical Pharmacology; Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP); Madrid Spain'], 'affiliations': [{'raw_affiliation_string': 'Service of Clinical Pharmacology; Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP); Madrid Spain', 'institution_ids': ['https://openalex.org/I4210130498']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5010358276', 'display_name': 'Francisco Abad‐Santos', 'orcid': 'https://orcid.org/0000-0002-6519-8885'}, 'institutions': [{'id': 'https://openalex.org/I4210130498', 'display_name': 'Hospital Universitario de La Princesa', 'ror': 'https://ror.org/03cg5md32', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210130498', 'https://openalex.org/I4210139293']}, {'id': 'https://openalex.org/I4210132431', 'display_name': 'Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas', 'ror': 'https://ror.org/03cn6tr16', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210132431']}, {'id': 'https://openalex.org/I2801357902', 'display_name': 'Instituto de Salud Carlos III', 'ror': 'https://ror.org/00ca2c886', 'country_code': 'ES', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801357902', 'https://openalex.org/I4387152914']}], 'countries': ['ES'], 'is_corresponding': True, 'raw_author_name': 'Francisco Abad-Santos', 'raw_affiliation_strings': ['Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd); Instituto de Salud Carlos III; Madrid Spain', 'Service of Clinical Pharmacology; Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP); Madrid Spain'], 'affiliations': [{'raw_affiliation_string': 'Service of Clinical Pharmacology; Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP); Madrid Spain', 'institution_ids': ['https://openalex.org/I4210130498']}, {'raw_affiliation_string': 'Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd); Instituto de Salud Carlos III; Madrid Spain', 'institution_ids': ['https://openalex.org/I4210132431', 'https://openalex.org/I2801357902']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5010358276'], 'corresponding_institution_ids': ['https://openalex.org/I4210130498', 'https://openalex.org/I4210132431', 'https://openalex.org/I2801357902'], 'apc_list': {'value': 3760, 'currency': 'USD', 'value_usd': 3760, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.646, 'has_fulltext': False, 'cited_by_count': 29, 'citation_normalized_percentile': {'value': 0.95529, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '53', 'issue': '12', 'first_page': '1261', 'last_page': '1267'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12910', 'display_name': 'Eicosanoids and Hypertension Pharmacology', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cyp2c8', 'display_name': 'CYP2C8', 'score': 0.88529617}, {'id': 'https://openalex.org/keywords/celecoxib', 'display_name': 'Celecoxib', 'score': 0.7434897}, {'id': 'https://openalex.org/keywords/crossover-study', 'display_name': 'Crossover study', 'score': 0.56581163}], 'concepts': [{'id': 'https://openalex.org/C3946865', 'wikidata': 'https://www.wikidata.org/wiki/Q5014962', 'display_name': 'CYP2C9', 'level': 4, 'score': 0.92413354}, {'id': 'https://openalex.org/C115368759', 'wikidata': 'https://www.wikidata.org/wiki/Q14916190', 'display_name': 'CYP2C8', 'level': 5, 'score': 0.88529617}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.8105113}, {'id': 'https://openalex.org/C2776467144', 'wikidata': 'https://www.wikidata.org/wiki/Q408801', 'display_name': 'Celecoxib', 'level': 2, 'score': 0.7434897}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.7014902}, {'id': 'https://openalex.org/C22979827', 'wikidata': 'https://www.wikidata.org/wiki/Q5137311', 'display_name': 'Cmax', 'level': 3, 'score': 0.64483577}, {'id': 'https://openalex.org/C87813604', 'wikidata': 'https://www.wikidata.org/wiki/Q1242899', 'display_name': 'Crossover study', 'level': 4, 'score': 0.56581163}, {'id': 'https://openalex.org/C33664856', 'wikidata': 'https://www.wikidata.org/wiki/Q3271142', 'display_name': 'CYP2D6', 'level': 4, 'score': 0.487336}, {'id': 'https://openalex.org/C526171541', 'wikidata': 'https://www.wikidata.org/wiki/Q407693', 'display_name': 'Cytochrome P450', 'level': 3, 'score': 0.4825141}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.47727698}, {'id': 'https://openalex.org/C109650736', 'wikidata': 'https://www.wikidata.org/wiki/Q424440', 'display_name': 'CYP3A4', 'level': 4, 'score': 0.43500713}, {'id': 'https://openalex.org/C55775858', 'wikidata': 'https://www.wikidata.org/wiki/Q1152227', 'display_name': 'Pharmacogenetics', 'level': 4, 'score': 0.4272273}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.32401437}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.31896394}, {'id': 'https://openalex.org/C135763542', 'wikidata': 'https://www.wikidata.org/wiki/Q106016', 'display_name': 'Genotype', 'level': 3, 'score': 0.22219145}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.14110044}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.12837085}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.10997492}, {'id': 'https://openalex.org/C27081682', 'wikidata': 'https://www.wikidata.org/wiki/Q269829', 'display_name': 'Placebo', 'level': 3, 'score': 0.10128951}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001189', 'descriptor_name': 'Aryl Hydrocarbon Hydroxylases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D052246', 'descriptor_name': 'Cyclooxygenase 2 Inhibitors', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001189', 'descriptor_name': 'Aryl Hydrocarbon Hydroxylases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001189', 'descriptor_name': 'Aryl Hydrocarbon Hydroxylases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000068579', 'descriptor_name': 'Celecoxib', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018592', 'descriptor_name': 'Cross-Over Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052246', 'descriptor_name': 'Cyclooxygenase 2 Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052246', 'descriptor_name': 'Cyclooxygenase 2 Inhibitors', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D065727', 'descriptor_name': 'Cytochrome P-450 CYP2C8', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065729', 'descriptor_name': 'Cytochrome P-450 CYP2C9', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005838', 'descriptor_name': 'Genotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011110', 'descriptor_name': 'Polymorphism, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D055815', 'descriptor_name': 'Young Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jcph.169', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S146237847', 'display_name': 'The Journal of Clinical Pharmacology', 'issn_l': '0091-2700', 'issn': ['0091-2700', '1552-4604'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23996211', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.73}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 26, 'referenced_works': ['https://openalex.org/W1531212948', 'https://openalex.org/W1843853776', 'https://openalex.org/W1979716218', 'https://openalex.org/W1987941468', 'https://openalex.org/W1989810877', 'https://openalex.org/W1993182297', 'https://openalex.org/W1999419099', 'https://openalex.org/W2000135012', 'https://openalex.org/W2012583441', 'https://openalex.org/W2047398257', 'https://openalex.org/W2050620617', 'https://openalex.org/W2051165003', 'https://openalex.org/W2070921940', 'https://openalex.org/W2071866045', 'https://openalex.org/W2084256772', 'https://openalex.org/W2102694890', 'https://openalex.org/W2109453128', 'https://openalex.org/W2112032502', 'https://openalex.org/W2120216632', 'https://openalex.org/W2128680329', 'https://openalex.org/W2138467859', 'https://openalex.org/W2144767160', 'https://openalex.org/W2149319043', 'https://openalex.org/W2150667466', 'https://openalex.org/W2151327895', 'https://openalex.org/W2160859576'], 'related_works': ['https://openalex.org/W3147210480', 'https://openalex.org/W2952185350', 'https://openalex.org/W2567759360', 'https://openalex.org/W2554856411', 'https://openalex.org/W2380178840', 'https://openalex.org/W2373331165', 'https://openalex.org/W2070921940', 'https://openalex.org/W1999419099', 'https://openalex.org/W1988021903', 'https://openalex.org/W1797160017'], 'abstract_inverted_index': {'Celecoxib': [0], 'is': [1], 'metabolized': [2], 'by': [3], 'enzymes': [4], 'of': [5, 29, 77, 84, 144, 152, 159], 'the': [6, 17, 60, 66, 81, 128, 150, 156], 'cytochrome': [7], 'P450': [8], '(CYP450)': [9], 'superfamily,': [10], 'mainly': [11], 'CYP2C9': [12, 18, 69], 'and': [13, 27, 38, 68, 75, 80, 89, 96, 99, 102, 105, 109], 'CYP3A4.': [14], 'Polymorphisms': [15], 'in': [16, 48, 65, 120, 125, 133, 164, 168], 'gene': [19], 'have': [20], 'been': [21], 'associated': [22], 'with': [23, 54, 122, 127, 135], 'decreased': [24, 163], 'enzyme': [25], 'activity': [26], 'alteration': [28], 'celecoxib': [30, 55, 160], 'pharmacokinetic': [31, 82], 'parameters.': [32], 'However,': [33], 'literature': [34], 'reports': [35], 'are': [36, 41], 'limited,': [37], 'some': [39], 'results': [40], 'contradictory.': [42], 'We': [43, 58, 137], 'enrolled': [44], '24': [45], 'healthy': [46], 'volunteers': [47], 'a': [49, 92], 'single-dose': [50], 'replicated': [51], 'crossover': [52], 'trial': [53], '200': [56], 'mg.': [57], 'evaluated': [59], 'association': [61], 'between': [62], 'single-nucleotide': [63], 'polymorphisms': [64, 148], 'CYP2C8': [67, 147], 'genes': [70], '(CYP2C8*2,': [71], 'CYP2C8*3,': [72], 'CYP2C8*4,': [73], 'CYP2C9*2,': [74], 'CYP2C9*3)': [76], 'these': [78], 'individuals': [79], 'parameters': [83], 'celecoxib.': [85, 153], 'Subjects': [86], 'carrying': [87, 114], 'CYP2C9*1/*3': [88], 'CYP2C9*3/*3': [90, 123], 'had': [91], 'higher': [93, 119], 'AUC': [94], '(2-': [95], '7.7-fold,': [97], 'respectively)': [98, 104, 111], 'Cmax': [100], '(1.5-': [101], '1.8-fold,': [103], 'lower': [106], 'clearance': [107], '(2.3-': [108], '10-fold,': [110], 'than': [112, 124], 'those': [113, 126, 134], 'CYP2C9*1/*1.': [115], 'Half-life': [116], 'was': [117], '2.7-fold': [118], 'subjects': [121], 'wild': [129], 'type': [130], 'but': [131], 'not': [132, 139], 'CYP2C9*1/*3.': [136], 'did': [138], 'find': [140], 'any': [141], 'significant': [142], 'effect': [143], 'gender': [145], 'or': [146], 'on': [149], 'pharmacokinetics': [151], 'In': [154], 'conclusion,': [155], 'recommended': [157], 'dose': [158], 'should': [161], 'be': [162], 'CYP2C9*3': [165], 'carriers,': [166], 'especially': [167], 'homozygous': [169], 'subjects.': [170]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1797160017', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-14T09:22:06.571065', 'created_date': '2016-06-24'}