Title: Local infusion of ghrelin enhanced hippocampal synaptic plasticity and spatial memory through activation of phosphoinositide 3-kinase in the dentate gyrus of adult rats
Abstract: European Journal of NeuroscienceVolume 33, Issue 2 p. 266-275 Local infusion of ghrelin enhanced hippocampal synaptic plasticity and spatial memory through activation of phosphoinositide 3-kinase in the dentate gyrus of adult rats Liang Chen, Liang Chen School of Life Science, University of Science and Technology of China, Hefei, Anhui, ChinaSearch for more papers by this authorTairan Xing, Tairan Xing School of Life Science, University of Science and Technology of China, Hefei, Anhui, ChinaSearch for more papers by this authorMing Wang, Ming Wang School of Life Science, University of Science and Technology of China, Hefei, Anhui, ChinaSearch for more papers by this authorYanyan Miao, Yanyan Miao School of Life Science, University of Science and Technology of China, Hefei, Anhui, ChinaSearch for more papers by this authorMingliang Tang, Mingliang Tang School of Life Science, University of Science and Technology of China, Hefei, Anhui, ChinaSearch for more papers by this authorJutao Chen, Jutao Chen School of Life Science, University of Science and Technology of China, Hefei, Anhui, ChinaSearch for more papers by this authorGuangwu Li, Guangwu Li The Neurobiology Institute of Anhui Medical University, Hefei, Anhui, ChinaSearch for more papers by this authorDi-Yun Ruan, Di-Yun Ruan School of Life Science, University of Science and Technology of China, Hefei, Anhui, ChinaSearch for more papers by this author Liang Chen, Liang Chen School of Life Science, University of Science and Technology of China, Hefei, Anhui, ChinaSearch for more papers by this authorTairan Xing, Tairan Xing School of Life Science, University of Science and Technology of China, Hefei, Anhui, ChinaSearch for more papers by this authorMing Wang, Ming Wang School of Life Science, University of Science and Technology of China, Hefei, Anhui, ChinaSearch for more papers by this authorYanyan Miao, Yanyan Miao School of Life Science, University of Science and Technology of China, Hefei, Anhui, ChinaSearch for more papers by this authorMingliang Tang, Mingliang Tang School of Life Science, University of Science and Technology of China, Hefei, Anhui, ChinaSearch for more papers by this authorJutao Chen, Jutao Chen School of Life Science, University of Science and Technology of China, Hefei, Anhui, ChinaSearch for more papers by this authorGuangwu Li, Guangwu Li The Neurobiology Institute of Anhui Medical University, Hefei, Anhui, ChinaSearch for more papers by this authorDi-Yun Ruan, Di-Yun Ruan School of Life Science, University of Science and Technology of China, Hefei, Anhui, ChinaSearch for more papers by this author First published: 11 January 2011 https://doi.org/10.1111/j.1460-9568.2010.07491.xCitations: 83 Di-Yun Ruan, as above.E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Ghrelin, an orexigenic hormone, is mainly produced by the stomach and released into the circulation. Ghrelin receptors (growth hormone secretagogue receptors) are expressed throughout the brain, including the hippocampus. The activation of ghrelin receptors facilitates high-frequency stimulation (HFS)-induced long-term potentiation (LTP) in vitro, and also improves learning and memory. Herein, we report that a single infusion of ghrelin into the hippocampus led to long-lasting potentiation of excitatory postsynaptic potentials (EPSPs) and population spikes (PSs) in the dentate gyrus of anesthetized rats. This potentiation was accompanied by a reduction in paired-pulse depression of the EPSP slope, an increase in paired-pulse facilitation of the PS amplitude, and an enhancement of EPSP–spike coupling, suggesting the involvement of both presynaptic and postsynaptic mechanisms. Meanwhile, ghrelin infusion time-dependently increased the phosphorylation of Akt-Ser473, a downstream molecule of phosphoinositide 3-kinase (PI3K). Interestingly, PI3K inhibitors, but not NMDA receptor antagonist, inhibited ghrelin-induced potentiation. Although ghrelin had no effect on the induction of HFS-induced LTP, it prolonged the expression of HFS-induced LTP through extracellular signal-regulated kinase (ERK)1/2. The Morris water maze test showed that ghrelin enhanced spatial memory, and that this was prevented by pretreatment with PI3K inhibitor. Taken together, the findings show that: (i) a single infusion of ghrelin induced a new form of synaptic plasticity by activating the PI3K signaling pathway, without HFS and NMDA receptor activation; (ii) a single infusion of ghrelin also enhanced the maintenance of HFS-induced LTP through ERK activation; and (iii) repetitive infusion of ghrelin enhanced spatial memory by activating the PI3K signaling pathway. Thus, we propose that the ghrelin signaling pathway could have therapeutic value in cognitive deficits. Citing Literature Volume33, Issue2January 2011Pages 266-275 RelatedInformation
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 105
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