Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1778803563', 'doi': 'https://doi.org/10.1039/b314146b', 'title': 'Lipid protrusions, membrane softness, and enzymatic activity', 'display_name': 'Lipid protrusions, membrane softness, and enzymatic activity', 'publication_year': 2004, 'publication_date': '2004-01-01', 'ids': {'openalex': 'https://openalex.org/W1778803563', 'doi': 'https://doi.org/10.1039/b314146b', 'mag': '1778803563'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1039/b314146b', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S181332294', 'display_name': 'Physical Chemistry Chemical Physics', 'issn_l': '1463-9076', 'issn': ['1463-9076', '1463-9084'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320556', 'host_organization_name': 'Royal Society of Chemistry', 'host_organization_lineage': ['https://openalex.org/P4310320556'], 'host_organization_lineage_names': ['Royal Society of Chemistry'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5033764113', 'display_name': 'Pernille Høyrup', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Pernille Høyrup', 'raw_affiliation_strings': ['Department of Chemistry, Technical University of Denmark, Building 207, DK-2800 Lyngby, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Technical University of Denmark, Building 207, DK-2800 Lyngby, Denmark', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032903330', 'display_name': 'Thomas H. Callisen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Thomas H. Callisen', 'raw_affiliation_strings': ['Department of Chemistry, Technical University of Denmark, Building 207, DK-2800 Lyngby, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Technical University of Denmark, Building 207, DK-2800 Lyngby, Denmark', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110071915', 'display_name': 'Morten Ø. Jensen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Morten Ø. Jensen', 'raw_affiliation_strings': ['Quantum Protein Centre, Department of Physics, Technical University of Denmark, Building 309, DK-2800 Lyngby, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Quantum Protein Centre, Department of Physics, Technical University of Denmark, Building 309, DK-2800 Lyngby, Denmark', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112546951', 'display_name': 'A. Halperin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3020098449', 'display_name': 'CEA Grenoble', 'ror': 'https://ror.org/02mg6n827', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I2738703131', 'https://openalex.org/I3020098449']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Avi Halperin', 'raw_affiliation_strings': ['UMR 5819, DRFMC/SI3M, CEA-CENG, 17 Rue des Martyrs,F-38054 Grenoble Cedex 9,France'], 'affiliations': [{'raw_affiliation_string': 'UMR 5819, DRFMC/SI3M, CEA-CENG, 17 Rue des Martyrs,F-38054 Grenoble Cedex 9,France', 'institution_ids': ['https://openalex.org/I3020098449']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5017893762', 'display_name': 'Ole G. Mouritsen', 'orcid': 'https://orcid.org/0000-0002-4258-8960'}, 'institutions': [{'id': 'https://openalex.org/I177969490', 'display_name': 'University of Southern Denmark', 'ror': 'https://ror.org/03yrrjy16', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I177969490']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Ole G. Mouritsen', 'raw_affiliation_strings': ['MEMPHYS-Center for Biomembrane Physics, Department of Physics, University of Southern Denmark, Campusvej 55,DK-5230 Odense M,Denmark'], 'affiliations': [{'raw_affiliation_string': 'MEMPHYS-Center for Biomembrane Physics, Department of Physics, University of Southern Denmark, Campusvej 55,DK-5230 Odense M,Denmark', 'institution_ids': ['https://openalex.org/I177969490']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.95, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 35, 'citation_normalized_percentile': {'value': 0.746102, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '6', 'issue': '7', 'first_page': '1608', 'last_page': '1615'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10407', 'display_name': 'Lipid Membrane Structure and Behavior', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10407', 'display_name': 'Lipid Membrane Structure and Behavior', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10044', 'display_name': 'Protein Structure and Dynamics', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10923', 'display_name': 'Force Microscopy Techniques and Applications', 'score': 0.9892, 'subfield': {'id': 'https://openalex.org/subfields/3107', 'display_name': 'Atomic and Molecular Physics, and Optics'}, 'field': {'id': 'https://openalex.org/fields/31', 'display_name': 'Physics and Astronomy'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lipid-bilayer-mechanics', 'display_name': 'Lipid bilayer mechanics', 'score': 0.778234}, {'id': 'https://openalex.org/keywords/flexural-rigidity', 'display_name': 'Flexural rigidity', 'score': 0.44278097}], 'concepts': [{'id': 'https://openalex.org/C39944091', 'wikidata': 'https://www.wikidata.org/wiki/Q423279', 'display_name': 'Lipid bilayer', 'level': 3, 'score': 0.82450086}, {'id': 'https://openalex.org/C85145957', 'wikidata': 'https://www.wikidata.org/wiki/Q12246850', 'display_name': 'Lipid bilayer mechanics', 'level': 5, 'score': 0.778234}, {'id': 'https://openalex.org/C76564549', 'wikidata': 'https://www.wikidata.org/wiki/Q17154515', 'display_name': 'Lipid bilayer phase behavior', 'level': 4, 'score': 0.66191137}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6426629}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.64142895}, {'id': 'https://openalex.org/C192157962', 'wikidata': 'https://www.wikidata.org/wiki/Q4087243', 'display_name': 'Bilayer', 'level': 3, 'score': 0.62318027}, {'id': 'https://openalex.org/C2778918659', 'wikidata': 'https://www.wikidata.org/wiki/Q186915', 'display_name': 'Phospholipid', 'level': 3, 'score': 0.6075511}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.58879906}, {'id': 'https://openalex.org/C59593255', 'wikidata': 'https://www.wikidata.org/wiki/Q901663', 'display_name': 'Molecular dynamics', 'level': 2, 'score': 0.5184319}, {'id': 'https://openalex.org/C86183883', 'wikidata': 'https://www.wikidata.org/wiki/Q507505', 'display_name': 'Arrhenius equation', 'level': 3, 'score': 0.5049451}, {'id': 'https://openalex.org/C159467904', 'wikidata': 'https://www.wikidata.org/wiki/Q2001702', 'display_name': 'Chemical physics', 'level': 1, 'score': 0.48715207}, {'id': 'https://openalex.org/C125501631', 'wikidata': 'https://www.wikidata.org/wiki/Q1587185', 'display_name': 'Biological membrane', 'level': 3, 'score': 0.48676562}, {'id': 'https://openalex.org/C73099012', 'wikidata': 'https://www.wikidata.org/wiki/Q5459050', 'display_name': 'Flexural rigidity', 'level': 2, 'score': 0.44278097}, {'id': 'https://openalex.org/C95121573', 'wikidata': 'https://www.wikidata.org/wiki/Q190474', 'display_name': 'Activation energy', 'level': 2, 'score': 0.3089085}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.21443713}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.19877875}, {'id': 'https://openalex.org/C147597530', 'wikidata': 'https://www.wikidata.org/wiki/Q369472', 'display_name': 'Computational chemistry', 'level': 1, 'score': 0.16195628}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0948489}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.074747235}, {'id': 'https://openalex.org/C159985019', 'wikidata': 'https://www.wikidata.org/wiki/Q181790', 'display_name': 'Composite material', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1039/b314146b', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S181332294', 'display_name': 'Physical Chemistry Chemical Physics', 'issn_l': '1463-9076', 'issn': ['1463-9076', '1463-9084'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320556', 'host_organization_name': 'Royal Society of Chemistry', 'host_organization_lineage': ['https://openalex.org/P4310320556'], 'host_organization_lineage_names': ['Royal Society of Chemistry'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.76, 'display_name': 'Affordable and clean energy', 'id': 'https://metadata.un.org/sdg/7'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 53, 'referenced_works': ['https://openalex.org/W1482031494', 'https://openalex.org/W1501888177', 'https://openalex.org/W1544412212', 'https://openalex.org/W1573783211', 'https://openalex.org/W1583480464', 'https://openalex.org/W1596283653', 'https://openalex.org/W1597272615', 'https://openalex.org/W1964146632', 'https://openalex.org/W1964809614', 'https://openalex.org/W1968967184', 'https://openalex.org/W1975915604', 'https://openalex.org/W1979691568', 'https://openalex.org/W1980065528', 'https://openalex.org/W1989297681', 'https://openalex.org/W1992315080', 'https://openalex.org/W1993935098', 'https://openalex.org/W1998534538', 'https://openalex.org/W2000253964', 'https://openalex.org/W2006881882', 'https://openalex.org/W2015443939', 'https://openalex.org/W2016179892', 'https://openalex.org/W2020835297', 'https://openalex.org/W2021492290', 'https://openalex.org/W2026885029', 'https://openalex.org/W2030762880', 'https://openalex.org/W2035786823', 'https://openalex.org/W2037243669', 'https://openalex.org/W2038225831', 'https://openalex.org/W2042701227', 'https://openalex.org/W2043544498', 'https://openalex.org/W2046903347', 'https://openalex.org/W2047148211', 'https://openalex.org/W2049709847', 'https://openalex.org/W2051222727', 'https://openalex.org/W2059571424', 'https://openalex.org/W2067236876', 'https://openalex.org/W2080550444', 'https://openalex.org/W2080868953', 'https://openalex.org/W2082944347', 'https://openalex.org/W2085215859', 'https://openalex.org/W2086373505', 'https://openalex.org/W2094730996', 'https://openalex.org/W2095511857', 'https://openalex.org/W2103815459', 'https://openalex.org/W2114524505', 'https://openalex.org/W2126662679', 'https://openalex.org/W2132305492', 'https://openalex.org/W2136851236', 'https://openalex.org/W2148341297', 'https://openalex.org/W2528603494', 'https://openalex.org/W2949246524', 'https://openalex.org/W3021319952', 'https://openalex.org/W4206542356'], 'related_works': ['https://openalex.org/W594362905', 'https://openalex.org/W2791164453', 'https://openalex.org/W2743948424', 'https://openalex.org/W2515835312', 'https://openalex.org/W2032791805', 'https://openalex.org/W2017978840', 'https://openalex.org/W1972569972', 'https://openalex.org/W1966181270', 'https://openalex.org/W1881124823', 'https://openalex.org/W1512344551'], 'abstract_inverted_index': {'The': [0, 58], 'activity': [1, 103], 'of': [2, 23, 44, 49, 65, 94, 104, 111], 'phospholipase': [3], 'A2': [4], 'on': [5, 84, 98, 107], 'lipid': [6, 46, 88, 108], 'bilayers': [7, 96, 109], 'displays': [8], 'a': [9, 56, 63, 119], 'characteristic': [10], 'lag–burst': [11], 'behavior': [12], 'that': [13, 42, 73], 'has': [14, 27], 'previously': [15], 'been': [16, 75], 'shown': [17], 'to': [18, 79], 'reflect': [19], 'the': [20, 24, 50, 81, 85, 99, 102, 122, 127], 'physical': [21], 'properties': [22], 'substrate.': [25], 'It': [26], 'remained': [28], 'unclear': [29], 'which': [30], 'underlying': [31], 'molecular': [32, 67], 'mechanism': [33], 'is': [34, 60], 'responsible': [35], 'for': [36], 'this': [37], 'phenomenon.': [38], 'We': [39], 'propose': [40], 'here': [41], 'protrusions': [43], 'single': [45], 'molecules': [47], 'out': [48], 'bilayer': [51, 123], 'plane': [52], 'could': [53], 'provide': [54], 'such': [55], 'mechanism.': [57], 'proposal': [59], 'supported': [61], 'by': [62], 'combination': [64], 'atomic-scale': [66], 'dynamics': [68], 'simulations,': [69], 'theory,': [70], 'and': [71, 91, 97, 126], 'experiments': [72, 117], 'have': [74], 'performed': [76], 'in': [77], 'order': [78], 'investigate': [80], 'relationship': [82], 'between': [83, 121], 'one': [86], 'side': [87, 101], 'protrusion': [89], 'modes': [90], 'mechanical': [92], 'softness': [93], 'phospholipid': [95], 'other': [100], 'enzymes': [105], 'acting': [106], 'composed': [110], 'different': [112], 'unsaturated': [113], 'lipids.': [114], 'Specifically,': [115], 'our': [116], 'show': [118], 'correlation': [120], 'bending': [124], 'rigidity': [125], 'apparent': [128], 'Arrhenius': [129], 'activation': [130], 'energy': [131], 'extracted': [132], 'from': [133], 'systematic': [134], 'lag-time': [135], 'versus': [136], 'temperature': [137], 'analyses.': [138]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1778803563', 'counts_by_year': [{'year': 2019, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-09T22:52:55.661478', 'created_date': '2016-06-24'}