Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1778267513', 'doi': 'https://doi.org/10.1158/1538-7445.am2014-5544', 'title': 'Abstract 5544: Patient-derived xenograft study reveals the pharmacology and the role of ESR1 gene aberrations in endocrine therapy resistance of ER positive breast cancer', 'display_name': 'Abstract 5544: Patient-derived xenograft study reveals the pharmacology and the role of ESR1 gene aberrations in endocrine therapy resistance of ER positive breast cancer', 'publication_year': 2014, 'publication_date': '2014-10-01', 'ids': {'openalex': 'https://openalex.org/W1778267513', 'doi': 'https://doi.org/10.1158/1538-7445.am2014-5544', 'mag': '1778267513'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2014-5544', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5042152741', 'display_name': 'Triparna Sen', 'orcid': 'https://orcid.org/0000-0003-4673-7481'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Triparna Sen', 'raw_affiliation_strings': ['Washington University in St Louis, St Louis, MO.'], 'affiliations': [{'raw_affiliation_string': 'Washington University in St Louis, St Louis, MO.', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034234418', 'display_name': 'Shunqiang Li', 'orcid': 'https://orcid.org/0000-0001-9508-7249'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shunqiang Li', 'raw_affiliation_strings': ['Washington University in St Louis, St Louis, MO.'], 'affiliations': [{'raw_affiliation_string': 'Washington University in St Louis, St Louis, MO.', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103281871', 'display_name': 'Jieya Shao', 'orcid': 'https://orcid.org/0000-0003-1859-9384'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jieya Shao', 'raw_affiliation_strings': ['Washington University in St Louis, St Louis, MO.'], 'affiliations': [{'raw_affiliation_string': 'Washington University in St Louis, St Louis, MO.', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109980864', 'display_name': 'Robert J. Crowder', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert Crowder', 'raw_affiliation_strings': ['Washington University in St Louis, St Louis, MO.'], 'affiliations': [{'raw_affiliation_string': 'Washington University in St Louis, St Louis, MO.', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109222114', 'display_name': 'Robert T. Kitchens', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert Kitchens', 'raw_affiliation_strings': ['Washington University in St Louis, St Louis, MO.'], 'affiliations': [{'raw_affiliation_string': 'Washington University in St Louis, St Louis, MO.', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5057135409', 'display_name': 'Matthew J. Ellis', 'orcid': 'https://orcid.org/0000-0002-8467-8534'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Matthew J. Ellis', 'raw_affiliation_strings': ['Washington University in St Louis, St Louis, MO.'], 'affiliations': [{'raw_affiliation_string': 'Washington University in St Louis, St Louis, MO.', 'institution_ids': ['https://openalex.org/I204465549']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.197, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.46039, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 66, 'max': 73}, 'biblio': {'volume': '74', 'issue': '19_Supplement', 'first_page': '5544', 'last_page': '5544'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.7944, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.7944, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13656', 'display_name': 'Science, Research, and Medicine', 'score': 0.6998, 'subfield': {'id': 'https://openalex.org/subfields/2743', 'display_name': 'Reproductive Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13736', 'display_name': 'Steroid Chemistry and Biochemistry', 'score': 0.6885, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/estrogen-receptor-alpha', 'display_name': 'Estrogen receptor alpha', 'score': 0.5568978}], 'concepts': [{'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6726148}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.61132306}, {'id': 'https://openalex.org/C172313692', 'wikidata': 'https://www.wikidata.org/wiki/Q14902310', 'display_name': 'Estrogen receptor alpha', 'level': 5, 'score': 0.5568978}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.53993}, {'id': 'https://openalex.org/C84606932', 'wikidata': 'https://www.wikidata.org/wiki/Q416496', 'display_name': 'Estrogen receptor', 'level': 4, 'score': 0.5023551}, {'id': 'https://openalex.org/C190232843', 'wikidata': 'https://www.wikidata.org/wiki/Q1950808', 'display_name': 'Small hairpin RNA', 'level': 4, 'score': 0.4743242}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.40696234}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.38386118}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.31499493}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.18807745}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2014-5544', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.83, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4390297994', 'https://openalex.org/W4385147205', 'https://openalex.org/W2413319726', 'https://openalex.org/W2079627504', 'https://openalex.org/W2023001964', 'https://openalex.org/W2021611122', 'https://openalex.org/W2006345152', 'https://openalex.org/W1974120005', 'https://openalex.org/W1510249552', 'https://openalex.org/W146197187'], 'abstract_inverted_index': {'Abstract': [0], 'Background:': [1], 'The': [2], 'study': [3, 249, 299], 'of': [4, 31, 54, 103, 170, 190, 194, 215, 250, 266, 306, 314, 322, 327], 'estrogen-receptor-positive': [5], 'patient-derived': [6], 'xenografts': [7], '(PDXs)': [8], 'from': [9, 90, 123], 'patients': [10, 274], 'with': [11, 75, 100, 275], 'disease': [12], 'progression': [13], 'despite': [14], 'endocrine': [15, 104, 133, 150, 237, 279, 311], 'therapy': [16, 134, 238, 280, 312], 'has': [17], 'revealed': [18], 'recurrent': [19, 56], 'ESR1': [20, 25, 107, 153, 232, 251, 276, 307], 'mutation,': [21], 'gene': [22, 26, 308], 'amplification': [23], 'and': [24, 40, 63, 77, 106, 201, 226, 234, 303], 'translocations': [27], 'as': [28, 65, 67], 'likely': [29], 'drivers': [30], 'resistance.': [32, 239, 281], 'We': [33, 178], 'addressed': [34], 'this': [35, 209], 'hypothesis': [36], 'further': [37], 'using': [38, 94, 99, 115, 157], 'pharmacological': [39, 259, 267], 'genetic': [41], 'approaches': [42, 151], 'in': [43, 73, 96, 116, 127, 198, 199, 205, 224, 227, 310], 'the': [44, 132, 139, 248, 264, 301, 304, 323, 328], 'PDX': [45, 91, 125, 195, 220, 240], 'system.': [46], 'Methodology:': [47], 'ER': [48, 315], 'positive': [49, 316], 'PDXs': [50], 'that': [51, 184, 185, 208, 261], 'harbored': [52], 'one': [53], 'four': [55], 'ligand': [57], 'binding': [58], 'domain': [59], '(LBD)': [60], 'mutations': [61], '(Y537S/N/C': [62], 'D538G)': [64], 'well': [66], 'a': [68, 101, 213], 'ESR1/YAP1': [69], 'translocation': [70], 'were': [71, 93, 113, 179], 'studied': [72], 'parallel': [74], 'T47D': [76], 'MCF7': [78], 'cells': [79], 'expressing': [80], 'these': [81], 'mutants': [82], 'through': [83], 'lentivirus': [84], 'constructs.': [85, 109], 'Single': [86], 'cell': [87, 176, 203], 'suspensions': [88, 122], 'generated': [89], 'models': [92, 126, 159, 166], 'for': [95, 152, 247, 273, 331], 'vitro': [97, 111, 225], 'experiments': [98], 'panel': [102], 'inhibitors': [105], 'shRNA': [108, 187], 'In': [110], 'effects': [112], 'confirmed': [114], 'vivo': [117, 200, 228], 'tumor': [118, 196], 'response.': [119], 'Results:': [120], 'Cell': [121], 'ER+': [124, 219], 'short-term': [128], 'culture': [129], 'successfully': [130, 230], 'reproduced': [131], 'resistant': [135], 'phenotypes': [136], 'exhibited': [137], 'by': [138, 168], 'donor': [140], 'patient,': [141], 'thereby': [142], 'facilitating': [143], 'drugs': [144], 'screens': [145], 'designed': [146, 269], 'to': [147, 182, 229, 270], 'identify': [148], 'new': [149], 'mutant': [154, 171, 277], 'breast': [155, 317], 'cancer': [156], 'authentic': [158], 'rather': [160], 'than': [161], 'an': [162], 'exclusive': [163], 'reliance': [164], 'on': [165], 'derived': [167], 'transfection': [169], 'constructs': [172], 'into': [173], 'standard': [174, 243], 'indicator': [175], 'lines.': [177], 'also': [180], 'able': [181], 'demonstrate': [183], 'lentivirus-driven': [186], 'mediated': [188], 'knockdown': [189], 'ESR1-YAP1': [191], 'caused': [192], 'inhibition': [193], 'growth': [197, 204], 'reduced': [202], 'vitro,': [206], 'confirming': [207], 'chimeric': [210], 'protein': [211], 'is': [212], 'driver': [214], 'estradiol-independent': [216], 'growth.': [217], 'Conclusion:': [218], 'can': [221], 'be': [222], 'manipulated': [223], 'model': [231], 'mutation': [233], 'gene-rearrangement': [235], 'driven': [236, 278], 'studies': [241], 'complement': [242], 'ectopic': [244], 'expression': [245], 'systems': [246], 'mutation-driven': [252], 'resistance': [253, 313], 'and,': [254], 'we': [255], 'hypothesize,': [256], 'will': [257, 262], 'provide': [258], 'data': [260], 'predict': [263], 'activity': [265], 'agents': [268], 'improve': [271], 'outcomes': [272], 'Citation': [282], 'Format:': [283], 'Triparna': [284], 'Sen,': [285], 'Shunqiang': [286], 'Li,': [287], 'Jieya': [288], 'Shao,': [289], 'Robert': [290, 292], 'Crowder,': [291], 'Kitchens,': [293], 'Matthew': [294], 'J.': [295], 'Ellis.': [296], 'Patient-derived': [297], 'xenograft': [298], 'reveals': [300], 'pharmacology': [302], 'role': [305], 'aberrations': [309], 'cancer.': [318], '[abstract].': [319], 'In:': [320], 'Proceedings': [321], '105th': [324], 'Annual': [325], 'Meeting': [326], 'American': [329], 'Association': [330], 'Cancer': [332, 343], 'Research;': [333], '2014': [334], 'Apr': [335], '5-9;': [336], 'San': [337], 'Diego,': [338], 'CA.': [339], 'Philadelphia': [340], '(PA):': [341], 'AACR;': [342], 'Res': [344], '2014;74(19': [345], 'Suppl):Abstract': [346], 'nr': [347], '5544.': [348], 'doi:10.1158/1538-7445.AM2014-5544': [349]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1778267513', 'counts_by_year': [{'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-08T13:05:49.195012', 'created_date': '2016-06-24'}