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1365, 1707, 2029, 2361], 'green': [1076, 2475], 'tea': [1077, 1508, 1555, 2476], 'polyphenol': [1078], '(−)-epigallocatechin': [1079], 'gallate': [1080], 'attenuates': [1081], 'beta-amyloid-induced': [1082], 'cultured': [1085], 'hippocampal': [1086, 1120], 'neurons.': [1087, 2149], 'Life': [1088], 'Sci': [1089], '70:': [1090], '603–614.': [1091], 'Chong': [1092], 'YH,': [1093], 'Shin': [1094], 'YJ,': [1095, 1720], 'EO,': [1097], 'Kayed': [1098], 'Glabe': [1100], 'CG,': [1101], 'Tenner': [1102], 'AJ.': [1103], '2006.': [1104, 1471, 2004], 'ERK1/2': [1105], 'activation': [1106, 1113, 2319], 'mediates': [1107], 'Abeta': [1108, 1562, 1871], 'oligomer-induced': [1109], 'via': [1111, 2318], 'caspase-3': [1112], 'tau': [1115], 'cleavage': [1116], 'rat': [1118], 'organotypic': [1119], 'slice': [1121], 'cultures.': [1122], 'Biol': [1124, 1646, 1806, 1850, 2076, 2183, 2352, 2455], 'Chem': [1125, 1590, 1744, 2034, 2077, 2114, 2244, 2377], '281:': [1126], '20315–20325.': [1127], 'Christen': [1128], 'Y.': [1129], '2000.': [1130, 1240, 1529, 2340], 'Oxidative': [1131, 1636, 1842], 'Alzheimer': [1134, 1181, 1462, 1981, 2260, 2451], 'disease.': [1135, 1182, 1349, 1463, 1769, 1834, 1847, 1960, 1982, 2261, 2452], 'Am': [1136, 1673, 2282, 2376], 'Clin': [1138, 1675, 1997], '71:': [1140], '621S–629S.': [1141], 'Moreno': [1144, 1599], 'S,': [1145, 1153, 1201, 1204, 1233, 1256, 1261, 1265, 1391, 1792, 1907, 1945, 2294, 2296, 2333, 2335, 2356], "D'Amelio": [1146], 'M,': [1147, 1503, 1546, 1548, 1602, 2128, 2193, 2214, 2216, 2250, 2337], 'B,': [1151, 1197, 1254, 1501, 1652], 'Falone': [1152, 1200, 1264], 'E,': [1155, 1195, 1258, 1362, 1493, 1499, 2130], 'Carrara': [1156], 'P,': [1157, 1237, 1360, 2122, 2300], 'Fanelli': [1158], 'F,': [1159, 1161, 1163, 1206, 1267, 1296, 1298, 1300, 1302, 1485], 'Cecconi': [1160], 'Amicarelli': [1162, 1205, 1266], 'Cerù': [1164, 1207, 1268], 'MP.': [1165, 1208], '2009a.': [1166], 'Early': [1167, 2254], 'biochemical': [1168], 'morphological': [1170], 'modifications': [1171], 'brain': [1174, 1512, 1766], 'transgenic': [1177], 'mouse': [1178], 'A': [1183, 2016, 2111, 2386], 'role': [1184, 1377, 1622, 2006, 2101], 'peroxisomes.': [1186], 'Alzheimers': [1188], 'Dis': [1189, 2432], '18:': [1190, 2433], '935–952.': [1191], 'Di': [1202, 1259], 'Loreto': [1203, 1260], '2009b.': [1209], 'Neuronal': [1210], 'response': [1211, 2141], 'peroxisomal': [1213], 'peroxisome-related': [1215], 'proteins': [1216], 'chronic': [1218], 'acute': [1220], 'injury.': [1222], 'Curr': [1223, 1291, 2032], 'Alzh': [1224], 'Res': [1225, 1323, 1481, 1788, 2115], '6:': [1226, 2184], '238–250.': [1227], 'Commenges': [1228], 'Scotet': [1230], 'V,': [1231, 1358, 1905, 2220], 'Renaud': [1232], 'Jacqmin-Gadda': [1234], 'H,': [1235, 1886, 2120], 'Barberger-Gateau': [1236, 1359], 'Dartigues': [1238], 'JF.': [1239], 'Intake': [1241], 'flavonoids': [1243, 1783], 'risk': [1245, 1460], 'dementia.': [1247], 'Eur': [1248, 2022], 'Epidemiol': [1250], '16:': [1251, 1631], '357–363.': [1252], 'Santucci': [1255], 'Phani': [1262], 'RA,': [1263, 2057], 'MP,': [1269], 'A.': [1271, 1343], '2009.': [1272, 1506], 'Cerium': [1273], 'oxide': [1274], 'nanoparticles': [1275], 'trigger': [1276], 'neuronal': [1277, 1663, 2316], 'alzheimer': [1282], 'current': [1289], 'nanoscience': [1290], 'Nanosci': [1292], '5:': [1293, 1324], '167–176.': [1294], 'Dajas': [1295], 'Rivera': [1297], 'Blasina': [1299], 'Arredondo': [1301], 'Echeverry': [1303], 'Lafon': [1305], 'Morquio': [1307], 'Heizen': [1309], 'H.': [1310], '2003.': [1311, 1725, 2272], 'Cell': [1312, 2169, 2182, 2484], 'culture': [1313], 'protection': [1314], 'vivo': [1317], 'capacity': [1319, 1735], 'flavonoids.': [1321], 'Neurotox': [1322, 1480], '425–432.': [1325], 'de': [1326], 'Rijk': [1327], 'MC,': [1328, 1403, 2063], 'Breteler': [1329, 1452], 'MM,': [1330, 2269], 'den': [1331], 'Breeijen': [1332], 'Launer': [1334], 'LJ,': [1335, 2416], 'Grobbee': [1336], 'DE,': [1337], 'van': [1338, 1445], 'der': [1339], 'Meché': [1340], 'FG,': [1341], 'Hofman': [1342, 1448], '1997.': [1344, 1841, 2090], 'Dietary': [1345, 1455, 2042], 'Parkinson': [1348], 'Rotterdam': [1351], 'Study.': [1352], 'Arch': [1353, 1983], 'Neurol': [1354, 1836, 1984], '54:': [1355], '762–765.': [1356], 'Deschamps': [1357], 'Peuchant': [1361], 'Orgogozo': [1363], 'JM.': [1364, 1505], 'Nutritional': [1366], 'factors': [1367], 'cerebral': [1369, 2203], 'aging': [1370, 1661], 'dementia:': [1372, 2443], 'arguments': [1374], 'stress.': [1380, 1479], 'Neuroepidemiology': [1381], '220:': [1382], '7–15.': [1383], 'G,': [1385, 1937], 'Kwik-Uribe': [1386], 'Grassi': [1388], 'Necozione': [1390], 'Ghiadoni': [1392], 'Mastroiacovo': [1394], 'Raffaele': [1396], 'Bocale': [1400], 'Lechiara': [1402], 'Marini': [1404], 'C.': [1407, 2003, 2028, 2222], '2012.': [1408, 2439], 'Benefits': [1409], 'cognitive': [1411, 1427, 1558, 1978], 'function,': [1412], 'blood': [1413], 'pressure,': [1414], 'insulin': [1416], 'resistance': [1417], 'through': [1418], 'flavanol': [1420], 'consumption': [1421], 'elderly': [1423], 'subjects': [1424], 'mild': [1426], 'impairment:': [1428], 'Cocoa,': [1430], 'Cognition,': [1431], 'Aging': [1433, 1999], '(CoCoA)': [1434], 'study.': [1435], 'Hypertension': [1436], '60:': [1437], '794–801.': [1438], 'Engelhart': [1439], 'Geerlings': [1441], 'MI,': [1442], 'Ruitenberg': [1443], 'Swieten': [1446], 'JC,': [1447, 1451, 1495], 'Witteman': [1450], 'MM.': [1453], '2002.': [1454, 2041, 2156], 'intake': [1456], 'JAMA': [1464], '287:': [1465], '3223–3229.': [1466], 'Fu': [1467], 'Y,': [1468, 1550], 'Koo': [1469], 'MW.': [1470], 'EGCG': [1472], 'protects': [1473, 2071], 'HT-22': [1474], 'against': [1476], 'glutamate-induced': [1477], '10:': [1482, 2117], '23–30.': [1483], 'Guedj': [1484], 'Sébrié': [1486], 'Rivals': [1488], 'I,': [1489], 'Ledru': [1490], 'Paly': [1492], 'Bizot': [1494], 'Smith': [1496, 1946, 2247], 'Rubin': [1498], 'Gillet': [1500], 'Arbones': [1502], 'Delabar': [1504], 'Green': [1507, 1554], 'rescue': [1510], 'defects': [1513], 'induced': [1514, 1585], 'overexpression': [1516], 'DYRK1A.': [1518], 'PLoS': [1519], 'ONE': [1520], '4:': [1521], 'e4606': [1522], 'Hammerstone': [1523], 'JF,': [1524], 'Lazarus': [1525], 'SA,': [1526], 'Schmitz': [1527], 'HH.': [1528], 'Procyanidin': [1530], 'variation': [1533], 'some': [1535], 'commonly': [1536], 'consumed': [1537], 'foods.': [1538], '130:': [1541, 2353], '2086S–2092S.': [1542], 'Haque': [1543], 'AM,': [1544, 2411], 'Hashimoto': [1545], 'Katakura': [1547], 'Hara': [1549], 'Shido': [1551], 'O.': [1552], '2008.': [1553, 2223], 'catechins': [1556], 'prevent': [1557], 'deficits': [1559], 'caused': [1560], '1–40': [1563], 'rats.': [1565], 'Biochem': [1568], '19:': [1569, 1963], '619–626.': [1570], 'Heo': [1571], 'HJ,': [1572, 1682, 1722], 'CY.': [1574, 1724], '2005.': [1575, 1655, 2068, 2200, 2313, 2419], 'Epicatechin': [1576, 1917], 'catechin': [1578], 'inhibit': [1581], 'amyloid': [1582, 1862, 1897, 2096, 2342], 'β': [1583], 'protein': [1584, 2172], 'apoptosis.': [1586], 'Agric': [1588, 1742, 2242], 'Food': [1589, 1743, 2243], '53:': [1591], '1445–1448.': [1592], 'Inestrosa': [1593, 1856, 2066], 'NC,': [1594], 'Alvarez': [1595], 'Perez': [1597], 'CA,': [1598], 'RD,': [1600, 2298], 'Vicente': [1601], 'Linker': [1603], 'Casanueva': [1605], 'OI,': [1606], 'Soto': [1607], 'Garrido': [1609], '1996.': [1611, 1635, 2253, 2401], 'Acetylcholinesterase': [1612], 'accelerates': [1613], 'assembly': [1614], 'amyloid-': [1616], 'beta-peptides': [1617], 'into': [1618], 'fibrils:': [1620], 'Possible': [1621], 'peripheral': [1625], 'site': [1626], 'enzyme.': [1629], 'Neuron': [1630], '881–891.': [1632], 'Jenner': [1633], 'P.': [1634], 'Pathol': [1645], '44:': [1647], '57–64.': [1648], 'Joseph': [1649], 'JA,': [1650, 1821, 2038, 2065, 2409], 'Shukitt-Hale': [1651], 'Casadesus': [1653], 'G.': [1654, 2089, 2252], 'Reversing': [1656], 'deleterious': [1658], 'communication': [1664], 'behavior:': [1666], 'Beneficial': [1667], 'fruit': [1670], 'compounds.': [1672], '81:': [1677], '313S–316S.': [1678], 'Kim': [1679, 1719], 'KW.': [1684], '2010.': [1685], 'Naturally': [1686], 'occurring': [1687], 'phytochemicals': [1688, 1730], 'prevention': [1691], 'Disease.': [1694], 'Neurochem': [1696, 2151], '112:': [1697], '1415–1430.': [1698], "Lamuela-Ravento's": [1699, 1908], 'RM,': [1700], "Andre's-Lacueva": [1701], 'Permanyer': [1703, 1910], 'Izquierdo-Pulido': [1705, 1914], 'M.': [1706, 1915, 2360], 'More': [1708], 'cocoa.': [1711], '131:': [1714], '834.': [1715, 2407], 'K.': [1717, 1988], 'W,': [1718], 'has': [1727], 'phenoloc': [1729], 'higher': [1733], 'antioxidant': [1734, 1761, 1829], 'teas': [1737], 'wine.': [1740], '51:': [1745], '7292–7295.': [1746], 'Lovell': [1747], 'MA,': [1748, 1939, 2248], 'Ehmann': [1749], 'WD,': [1750], 'Butler': [1751], 'SM,': [1752], 'Markesbery': [1753, 1839], 'WR.': [1754, 1840], '1995.': [1755], 'Elevated': [1756], 'thiobarbituric': [1757], 'acid-reactive': [1758], 'substances': [1759], 'enzyme': [1762, 1830], 'activity': [1763, 1831, 2143], 'Neurology': [1770], '45:': [1771], '1594–1601.': [1772], 'Manach': [1773], 'Donovan': [1775, 2399], 'JL.': [1776, 2400], '2004.': [1777, 1795, 1916, 2168], 'Pharmacokinetics': [1778], 'metabolism': [1780], 'humans.': [1785], 'Free': [1786, 1804, 1848, 2453], 'Radic': [1787, 1805, 1849, 2454], '38:': [1789], '771–785.': [1790], 'Mandel': [1791], 'Youdim': [1793], 'MB.': [1794], 'Catechin': [1796], 'polyphenols:': [1797], 'Neurodegeneration': [1798], 'Med': [1807, 1851, 2033, 2456], '37:': [1808], '304–317.': [1809], 'Marcus': [1810], 'DL,': [1811], 'Thomas': [1812], 'Rodriguez': [1814], 'Simberkoff': [1816], 'K,': [1817, 1888, 1890, 1943], 'Tsai': [1818], 'JS,': [1819], 'Strafaci': [1820], 'Freedman': [1822], 'ML.': [1823], 'Increased': [1825], 'peroxidation': [1826], 'reduced': [1828], 'Exp': [1835], '150:': [1837], '40–44.': [1838], 'hypothesis': [1844], '23:': [1852], '134–147.': [1853], 'Munõz': [1854], 'FJ,': [1855], 'NC.': [1857, 2067], '1999.': [1858, 1948], 'Neurotoxicity': [1859], 'acetylcholinesterase': [1861], 'beta-peptide': [1863], 'aggregates': [1864], 'dependent': [1866], 'type': [1869], 'peptide': [1872], 'AChE': [1875], 'concentration': [1876], 'present': [1877], 'complexes.': [1880], 'FEBS': [1881], 'Lett': [1882, 2263], '450:': [1883], '205–209.': [1884], 'Naiki': [1885], 'Higuchi': [1887], 'Nakakuki': [1889], 'Takeda': [1891], 'T.': [1892], '1991.': [1893], 'Kinetic': [1894], 'analysis': [1895], 'fibril': [1898], 'polymerization.': [1899], 'Lab': [1900], 'Invest': [1901], '65:': [1902], '104–110.': [1903], "Noe'": [1904], 'Pen˜uelas': [1906], 'RS,': [1909], 'Ciudad': [1912], 'CJ,': [1913], 'modulate': [1923], 'gene': [1924], 'expression': [1925], 'Caco-2.': [1928], 'Cells': [1929], '134:': [1932], '2509–2516.': [1933], 'Nunomura': [1934], 'Perry': [1936, 2088, 2251], 'Pappolla': [1938], 'Wade': [1940], 'Hirai': [1942], 'Chiba': [1944], 'MA.': [1947], 'RNA': [1949], 'oxidation': [1950], 'prominent': [1953], 'feature': [1954], 'vulnerable': [1956], 'neurons': [1957], 'Neurosci': [1962, 2262, 2329], '1959–1964.': [1964], 'Oken': [1965], 'BS,': [1966], 'Storzbach': [1967], 'DM,': [1968, 2382], 'Kaye': [1969], 'JA.': [1970], 'efficacy': [1973], 'Ginkgo': [1975], 'biloba': [1976], 'function': [1979], '55:': [1985], '1409–1415.': [1986], 'Rahman': [1987], 'Studies': [1990], 'free': [1992, 2103, 2344], 'radicals,': [1993], 'antioxidants,': [1994], 'co-factors.': [1996], 'Interv': [1998], '22:': [2000, 2052], '219–236.': [2001], 'Ramassamy': [2002, 2221], 'Emerging': [2005], 'treatment': [2012], 'diseases:': [2015], 'their': [2019], 'intracellular': [2020], 'targets.': [2021], 'Pharmacol': [2024], '545:': [2025], '51–64.': [2026], 'Rice-Evans': [2027, 2131], 'Flavonoid': [2030], 'antioxidants.': [2031], '8:': [2035], '797–807.': [2036], 'Ross': [2037], 'Kasum': [2039], 'CM.': [2040], 'flavonoids:': [2043, 2276], 'Bioavailability,': [2044, 2234], 'metabolic': [2045], 'effects,': [2046], 'safety.': [2048], 'Annu': [2049], '19–34.': [2053], 'Santos': [2054], 'Quintanilla': [2056], 'Toro': [2058], 'Grandy': [2060], 'Dinamarca': [2062], 'Godoy': [2064], 'Peroxisomal': [2069], 'proliferation': [2070], 'β-Amyloid': [2073], 'neurodegeneration.': [2074], '80:': [2078], '41057–41068.': [2079], 'Sayre': [2080], 'LM,': [2081], 'Zagorski': [2082], 'MG,': [2083], 'Surewicz': [2084], 'Krafft': [2086], 'GA,': [2087], 'Mechanisms': [2091], 'associated': [2094], 'beta': [2097, 2387], 'deposition': [2098], 'radicals': [2104], 'pathogenesis': [2107], 'disease:': [2110, 2233], 'critical': [2112], 'appraisal.': [2113], 'Toxicol': [2116], '518–526.': [2118], 'Schroeter': [2119], 'Bahia': [2121], 'Spencer': [2123, 2437], 'JP,': [2124], 'Sheppard': [2125], 'O,': [2126], 'Rattray': [2127], 'Cadenas': [2129], 'Williams': [2133, 2435], 'RJ.': [2134], '(−)Epicatechin': [2136], 'stimulates': [2137], 'ERK-dependent': [2138], 'cyclic': [2139], 'AMP': [2140], 'element': [2142], 'up-regulates': [2145], 'GluR2': [2146], 'cortical': [2148], '101:': [2152, 2393], '1596–1606.': [2153], 'Selkoe': [2154, 2166, 2383], 'DJ.': [2155, 2167, 2384], 'synaptic': [2161], 'failure.': [2162], 'Science': [2163], '298:': [2164], '789–791.': [2165], 'biology': [2170], 'misfolding:': [2173], 'examples': [2175], 'Nat': [2181], '1054–1061.': [2185], 'Simonyi': [2186], 'Wang': [2188], 'Q,': [2189], 'Miller': [2190], 'RL,': [2191], 'Yusof': [2192], 'Shelat': [2194], 'PB,': [2195], 'Sun': [2196, 2198], 'AY,': [2197], 'GY.': [2199], 'Polyphenols': [2201], 'ischemia:': [2204], 'Novel': [2205], 'targets': [2206], 'neuroprotection.': [2208], 'Mol': [2209], 'Neurobiol': [2210, 2431], '31:': [2211], '135–147.': [2212], 'Singh': [2213], 'Arseneault': [2215], 'Sanderson': [2217], 'T,': [2218], 'Murthy': [2219], 'Challenges': [2224], 'research': [2226], 'foods': [2230], 'mechanisms.': [2240], '4855–4873.': [2246], 'Tabaton': [2249], 'contribution': [2255], 'glycation': [2258], '217:': [2264], '210–211.': [2265], 'Steinberg': [2266], 'FM,': [2267], 'Bearden': [2268], 'Keen': [2270], 'CL.': [2271], 'chocolate': [2275], 'Implications': [2277], 'cardiovascular': [2279], 'health.': [2280], 'Diet': [2283], 'Assoc': [2284], '103:': [2285], '215–223.': [2286], 'Teng': [2287, 2289], 'HK,': [2288], 'KK,': [2290], 'Wright': [2293], 'Tevar': [2295], 'Almeida': [2297], 'Kermani': [2299], 'Torkin': [2301], 'Chen': [2303], 'ZY,': [2304], 'FS,': [2306], 'Kraemer': [2307], 'RT,': [2308], 'Nykjaer': [2309], 'Hempstead': [2311], 'BL.': [2312], 'ProBDNF': [2314], 'induces': [2315], 'apoptosis': [2317], 'receptor': [2322], 'complex': [2323], 'p75NTR': [2325], 'sortilin.': [2327], '25:': [2330], '5455–5463.': [2331], 'Varadarajan': [2332, 2355], 'Yatin': [2334], 'Aksenova': [2336, 2359], 'Butterfield': [2338], 'DA.': [2339], 'beta-peptide-associated': [2343], 'radical': [2345], 'neurotoxicity.': [2349], 'Struct': [2351], '184–208.': [2354], 'Kanski': [2357], 'Different': [2362], 'Aβ(1–42)': [2371], '(25–35).': [2374], 'Soc': [2378], '123:': [2379], '5625–5631.': [2380], 'Walsh': [2381], 'oligomers—A': [2388], 'decade': [2389], 'discovery.': [2391], 'J.Neurochem': [2392], '1172–1184.': [2394], 'Waterhouse': [2395], 'Shirley': [2397], 'JR,': [2398], 'Antioxidants': [2402], 'chocolate.': [2404], 'Lancet': [2405], '348:': [2406], 'White': [2408], 'Manelli': [2410], 'Holmberg': [2412], 'KH,': [2413], 'Van': [2414], 'Eldik': [2415], 'Ladu': [2417], 'MJ.': [2418], 'Differential': [2420], 'oligomeric': [2423], 'fibrillar': [2425], 'amyloid-beta': [2426], '1–42': [2427], 'astrocyte-mediated': [2429], 'inflammation.': [2430], '459–465.': [2434], 'RJ,': [2436], 'JP.': [2438], 'Flavonoids,': [2440], 'cognition,': [2441], 'Actions,': [2444], 'mechanisms,': [2445], 'potential': [2447], 'therapeutic': [2448], 'utility': [2449], '52:': [2457], '35–45.': [2458], 'Zhao': [2459], 'BL,': [2460], 'Li': [2461], 'XJ,': [2462], 'He': [2463], 'RG,': [2464], 'Cheng': [2465], 'SJ,': [2466], 'Xin': [2467], 'WJ.': [2468], '1989.': [2469], 'Scavenging': [2470], 'extracts': [2473], 'natural': [2478], 'active': [2481], 'radicals.': [2483], 'Biophys': [2485], '14:': [2486], '175–185.': [2487], 'Citing': [2488], 'Literature': [2489], 'Volume114,': [2490], 'Issue10October': [2491], '2013Pages': [2492], 'ReferencesRelatedInformation': [2494]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1776548714', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2024-08-31T13:49:57.157131', 'created_date': '2016-06-24'}