Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W177395109', 'doi': 'https://doi.org/10.1016/j.jacc.2004.02.028', 'title': 'Genetic basis of pulmonary arterial hypertension', 'display_name': 'Genetic basis of pulmonary arterial hypertension', 'publication_year': 2004, 'publication_date': '2004-06-01', 'ids': {'openalex': 'https://openalex.org/W177395109', 'doi': 'https://doi.org/10.1016/j.jacc.2004.02.028', 'mag': '177395109', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15194176'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.jacc.2004.02.028', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S60865174', 'display_name': 'Journal of the American College of Cardiology', 'issn_l': '0735-1097', 'issn': ['0735-1097', '1558-3597'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1016/j.jacc.2004.02.028', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5075023441', 'display_name': 'John H. Newman', 'orcid': 'https://orcid.org/0000-0003-1867-9093'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John H Newman', 'raw_affiliation_strings': ['Vanderbilt University School of Medicine, Nashville, Tennessee, United Kingdom.'], 'affiliations': [{'raw_affiliation_string': 'Vanderbilt University School of Medicine, Nashville, Tennessee, United Kingdom.', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035332968', 'display_name': 'Richard C. Trembath', 'orcid': 'https://orcid.org/0000-0003-0550-3400'}, 'institutions': [{'id': 'https://openalex.org/I153648349', 'display_name': 'University of Leicester', 'ror': 'https://ror.org/04h699437', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I153648349']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Richard C Trembath', 'raw_affiliation_strings': ['Department of Medicine and Genetics, University of Leicester, Leicester, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine and Genetics, University of Leicester, Leicester, United Kingdom', 'institution_ids': ['https://openalex.org/I153648349']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086520280', 'display_name': 'Jane A. Morse', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jane A Morse', 'raw_affiliation_strings': ['Columbia University College of Physicians and Surgeons New York, New York, USA.'], 'affiliations': [{'raw_affiliation_string': 'Columbia University College of Physicians and Surgeons New York, New York, USA.', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086013885', 'display_name': 'Ekkehard Grünig', 'orcid': 'https://orcid.org/0000-0001-7318-3918'}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ekkehard Grunig', 'raw_affiliation_strings': ['Heidelberg University, Heidelberg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Heidelberg University, Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I223822909']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065762639', 'display_name': 'James E. Loyd', 'orcid': 'https://orcid.org/0000-0002-5042-7390'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James E Loyd', 'raw_affiliation_strings': ['Vanderbilt University School of Medicine, Nashville, Tennessee, United Kingdom.'], 'affiliations': [{'raw_affiliation_string': 'Vanderbilt University School of Medicine, Nashville, Tennessee, United Kingdom.', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004901419', 'display_name': 'Serge Adnot', 'orcid': 'https://orcid.org/0000-0001-5666-3063'}, 'institutions': [], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Serge Adnot', 'raw_affiliation_strings': ['Hopital Henri Mondor, Creteil, France'], 'affiliations': [{'raw_affiliation_string': 'Hopital Henri Mondor, Creteil, France', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002142014', 'display_name': 'Fabio Coccolo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Fabio Coccolo', 'raw_affiliation_strings': ['Columbia University College of Physicians and Surgeons New York, New York, USA.'], 'affiliations': [{'raw_affiliation_string': 'Columbia University College of Physicians and Surgeons New York, New York, USA.', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051416401', 'display_name': 'Carlo Ventura', 'orcid': 'https://orcid.org/0000-0001-9333-0321'}, 'institutions': [{'id': 'https://openalex.org/I9360294', 'display_name': 'University of Bologna', 'ror': 'https://ror.org/01111rn36', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I9360294']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Carlo Ventura', 'raw_affiliation_strings': [' University of Bologna , Bologna, Italy'], 'affiliations': [{'raw_affiliation_string': ' University of Bologna , Bologna, Italy', 'institution_ids': ['https://openalex.org/I9360294']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031316607', 'display_name': 'John A. Phillips', 'orcid': 'https://orcid.org/0000-0002-5769-730X'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John A Phillips', 'raw_affiliation_strings': ['Vanderbilt University School of Medicine, Nashville, Tennessee, United Kingdom.'], 'affiliations': [{'raw_affiliation_string': 'Vanderbilt University School of Medicine, Nashville, Tennessee, United Kingdom.', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101623318', 'display_name': 'James A. Knowles', 'orcid': 'https://orcid.org/0000-0002-3307-5741'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James A Knowles', 'raw_affiliation_strings': ['Columbia University College of Physicians and Surgeons New York, New York, USA.'], 'affiliations': [{'raw_affiliation_string': 'Columbia University College of Physicians and Surgeons New York, New York, USA.', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071563037', 'display_name': 'Bart Janssen', 'orcid': 'https://orcid.org/0000-0002-5871-2831'}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Bart Janssen', 'raw_affiliation_strings': ['Heidelberg University, Heidelberg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Heidelberg University, Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I223822909']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009672774', 'display_name': 'Oliver Eickelberg', 'orcid': 'https://orcid.org/0000-0001-7170-0360'}, 'institutions': [{'id': 'https://openalex.org/I4210148049', 'display_name': 'Giessen School of Theology', 'ror': 'https://ror.org/03kzgcv48', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I4210148049']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Oliver Eickelberg', 'raw_affiliation_strings': ['Giessen University School of Medicine, Giessen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Giessen University School of Medicine, Giessen, Germany', 'institution_ids': ['https://openalex.org/I4210148049']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004381659', 'display_name': 'Saadia Eddahibi', 'orcid': 'https://orcid.org/0000-0002-0374-019X'}, 'institutions': [], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Saadia Eddahibi', 'raw_affiliation_strings': ['Hopital Henri Mondor, Creteil, France'], 'affiliations': [{'raw_affiliation_string': 'Hopital Henri Mondor, Creteil, France', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007413741', 'display_name': 'P Hervé', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I102197404', 'display_name': 'Université Paris-Sud', 'ror': 'https://ror.org/028rypz17', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I102197404']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Phillipe Herve', 'raw_affiliation_strings': ['University Paris Sud, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'University Paris Sud, Paris, France', 'institution_ids': ['https://openalex.org/I102197404']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046246342', 'display_name': 'William C. Nichols', 'orcid': 'https://orcid.org/0000-0003-1242-9237'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William C Nichols', 'raw_affiliation_strings': ['University of Cincinatti Medical School, Cincinatti, Ohio, USA'], 'affiliations': [{'raw_affiliation_string': 'University of Cincinatti Medical School, Cincinatti, Ohio, USA', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5013565958', 'display_name': 'Greg Elliott', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I223532165', 'display_name': 'University of Utah', 'ror': 'https://ror.org/03r0ha626', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I223532165']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gregory Elliott', 'raw_affiliation_strings': ['‡University of Utah School of Medicine, Salt Lake City, Utah, USA'], 'affiliations': [{'raw_affiliation_string': '‡University of Utah School of Medicine, Salt Lake City, Utah, USA', 'institution_ids': ['https://openalex.org/I223532165']}]}], 'institution_assertions': [], 'countries_distinct_count': 5, 'institutions_distinct_count': 8, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 6500, 'currency': 'USD', 'value_usd': 6500, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 7.143, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 247, 'citation_normalized_percentile': {'value': 0.999256, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '43', 'issue': '12', 'first_page': 'S33', 'last_page': 'S39'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10728', 'display_name': 'Diagnosis and Treatment of Pulmonary Hypertension', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10728', 'display_name': 'Diagnosis and Treatment of Pulmonary Hypertension', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12199', 'display_name': 'Diagnosis and Management of Hereditary Hemorrhagic Telangiectasia', 'score': 0.9914, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bmpr2', 'display_name': 'BMPR2', 'score': 0.94247127}, {'id': 'https://openalex.org/keywords/acvrl1', 'display_name': 'ACVRL1', 'score': 0.7431179}, {'id': 'https://openalex.org/keywords/bmpr2-mutations', 'display_name': 'BMPR2 Mutations', 'score': 0.573606}, {'id': 'https://openalex.org/keywords/pulmonary-arteriovenous-malformations', 'display_name': 'Pulmonary Arteriovenous Malformations', 'score': 0.517434}, {'id': 'https://openalex.org/keywords/genetic-disorder', 'display_name': 'Genetic disorder', 'score': 0.41400135}], 'concepts': [{'id': 'https://openalex.org/C73834784', 'wikidata': 'https://www.wikidata.org/wiki/Q17849752', 'display_name': 'BMPR2', 'level': 4, 'score': 0.94247127}, {'id': 'https://openalex.org/C175554068', 'wikidata': 'https://www.wikidata.org/wiki/Q14914463', 'display_name': 'ACVRL1', 'level': 5, 'score': 0.7431179}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6079851}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.60573}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.5567712}, {'id': 'https://openalex.org/C2781228645', 'wikidata': 'https://www.wikidata.org/wiki/Q4941575', 'display_name': 'Bone morphogenetic protein receptor', 'level': 4, 'score': 0.54260457}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.52710474}, {'id': 'https://openalex.org/C180754005', 'wikidata': 'https://www.wikidata.org/wiki/Q80726', 'display_name': 'Allele', 'level': 3, 'score': 0.4343931}, {'id': 'https://openalex.org/C2778908642', 'wikidata': 'https://www.wikidata.org/wiki/Q200779', 'display_name': 'Genetic disorder', 'level': 3, 'score': 0.41400135}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.382334}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.3284529}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3179015}, {'id': 'https://openalex.org/C31507581', 'wikidata': 'https://www.wikidata.org/wiki/Q425383', 'display_name': 'Bone morphogenetic protein', 'level': 3, 'score': 0.29993618}, {'id': 'https://openalex.org/C6061869', 'wikidata': 'https://www.wikidata.org/wiki/Q18250377', 'display_name': 'Endoglin', 'level': 4, 'score': 0.21039662}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C10205521', 'wikidata': 'https://www.wikidata.org/wiki/Q4035578', 'display_name': 'CD34', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D006976', 'descriptor_name': 'Hypertension, Pulmonary', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011651', 'descriptor_name': 'Pulmonary Artery', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052006', 'descriptor_name': 'Bone Morphogenetic Protein Receptors, Type II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005544', 'descriptor_name': 'Forecasting', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020022', 'descriptor_name': 'Genetic Predisposition to Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020022', 'descriptor_name': 'Genetic Predisposition to Disease', 'qualifier_ui': 'Q000453', 'qualifier_name': 'epidemiology', 'is_major_topic': False}, {'descriptor_ui': 'D020022', 'descriptor_name': 'Genetic Predisposition to Disease', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005820', 'descriptor_name': 'Genetic Testing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005820', 'descriptor_name': 'Genetic Testing', 'qualifier_ui': 'Q000639', 'qualifier_name': 'trends', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006976', 'descriptor_name': 'Hypertension, Pulmonary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006976', 'descriptor_name': 'Hypertension, Pulmonary', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}, {'descriptor_ui': 'D006976', 'descriptor_name': 'Hypertension, Pulmonary', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011651', 'descriptor_name': 'Pulmonary Artery', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012307', 'descriptor_name': 'Risk Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.jacc.2004.02.028', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S60865174', 'display_name': 'Journal of the American College of Cardiology', 'issn_l': '0735-1097', 'issn': ['0735-1097', '1558-3597'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15194176', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.jacc.2004.02.028', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S60865174', 'display_name': 'Journal of the American College of Cardiology', 'issn_l': '0735-1097', 'issn': ['0735-1097', '1558-3597'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.72, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1575497543', 'https://openalex.org/W1606441445', 'https://openalex.org/W1663371441', 'https://openalex.org/W169420071', 'https://openalex.org/W1788457121', 'https://openalex.org/W1969591792', 'https://openalex.org/W1974303297', 'https://openalex.org/W1988233595', 'https://openalex.org/W1995410973', 'https://openalex.org/W1996915488', 'https://openalex.org/W1999275474', 'https://openalex.org/W2009214240', 'https://openalex.org/W2013169184', 'https://openalex.org/W2014751423', 'https://openalex.org/W2021100234', 'https://openalex.org/W2025947830', 'https://openalex.org/W2029399343', 'https://openalex.org/W2030470655', 'https://openalex.org/W2055638366', 'https://openalex.org/W2056297572', 'https://openalex.org/W2061067032', 'https://openalex.org/W2068416476', 'https://openalex.org/W2071788329', 'https://openalex.org/W2074891186', 'https://openalex.org/W2092089214', 'https://openalex.org/W2096393477', 'https://openalex.org/W2099297386', 'https://openalex.org/W2099966045', 'https://openalex.org/W2112210014', 'https://openalex.org/W2116020190', 'https://openalex.org/W2121932914', 'https://openalex.org/W2124656992', 'https://openalex.org/W2130433216', 'https://openalex.org/W2134794588', 'https://openalex.org/W2140148084', 'https://openalex.org/W2144429046', 'https://openalex.org/W2152456558', 'https://openalex.org/W2152907844', 'https://openalex.org/W2154573929', 'https://openalex.org/W2162125686', 'https://openalex.org/W2170076817', 'https://openalex.org/W2171679921', 'https://openalex.org/W2329065056', 'https://openalex.org/W2337969762', 'https://openalex.org/W2341035105', 'https://openalex.org/W2400211101', 'https://openalex.org/W2407452745', 'https://openalex.org/W2412524125', 'https://openalex.org/W2988610037', 'https://openalex.org/W3023130045', 'https://openalex.org/W4230841938'], 'related_works': ['https://openalex.org/W3098619255', 'https://openalex.org/W2596721131', 'https://openalex.org/W2488122475', 'https://openalex.org/W2181470104', 'https://openalex.org/W2144429046', 'https://openalex.org/W2055992003', 'https://openalex.org/W2048652884', 'https://openalex.org/W2042853244', 'https://openalex.org/W2029399343', 'https://openalex.org/W177395109'], 'abstract_inverted_index': {'Mutations': [0, 134], 'in': [1, 17, 56, 60, 73, 114, 135, 146, 169, 234, 247, 259], 'two': [2], 'receptors': [3], 'of': [4, 20, 22, 30, 33, 52, 63, 76, 101, 124, 143, 165, 180, 191, 206, 209, 245, 251, 256], 'the': [5, 18, 31, 98, 115, 163, 166, 188], 'transforming': [6], 'growth': [7], 'factor-beta': [8], 'family': [9, 102], 'have': [10, 107, 130], 'recently': [11], 'been': [12], 'shown': [13], 'to': [14, 91, 140, 215], 'be': [15, 153, 177], 'present': [16], 'majority': [19], 'cases': [21, 103], 'inherited': [23], '(familial)': [24], 'pulmonary': [25], 'arterial': [26], 'hypertension': [27], '(PAH).': [28], 'Study': [29], 'biology': [32], 'these': [34], 'receptors,': [35], 'bone': [36], 'morphogenetic': [37], 'protein': [38], 'receptor': [39], 'type-2': [40], '(BMPR2),': [41], 'and': [42, 68, 82, 174, 202, 229, 239, 253], 'activin-like': [43], 'kinase': [44], 'type-1': [45], '(ALK-1)': [46], 'will': [47], 'certainly': [48], 'reveal': [49], 'pathogenic': [50], 'mechanisms': [51], 'disease.': [53], 'Exonic': [54], 'mutations': [55, 70, 106], 'BMPR2': [57, 110, 132, 136], 'are': [58, 71, 195], 'found': [59, 72], 'about': [61, 122], '50%': [62, 100], 'patients': [64, 77, 125, 210], 'with': [65, 78, 126], 'familial': [66, 86], 'PAH,': [67], 'ALK1': [69], 'a': [74, 138, 147, 172], 'minority': [75], 'hereditary': [79], 'hemorrhagic': [80], 'telangiectasia': [81], 'co-existent': [83], 'PAH.': [84], 'Because': [85], 'PAH': [87, 129, 145, 192, 252], 'is': [88, 95], 'highly': [89], 'linked': [90], 'chromosome': [92], '2q33,': [93], 'it': [94], 'likely': [96, 214], 'that': [97, 158], 'remaining': [99], 'without': [104], 'exonic': [105], 'either': [108, 159], 'intronic': [109], 'abnormalities': [111], 'or': [112, 117, 155, 161], 'alterations': [113], 'promoter': [116], 'regulatory': [118], 'genes.': [119], 'Also,': [120], 'only': [121], '10%': [123], '"sporadic"': [127], 'idiopathic': [128], 'identifiable': [131], 'mutations.': [133], 'confer': [137], '15%': [139], '20%': [141], 'chance': [142], 'developing': [144], "carrier's": [148], 'lifetime.': [149], 'Thus,': [150], 'there': [151, 175], 'must': [152, 176], 'gene-gene': [154], 'gene-environment': [156], 'interactions': [157], 'enhance': [160], 'prevent': [162], 'development': [164], 'vascular': [167], 'disease': [168, 219, 246], 'persons': [170], 'carrying': [171], 'mutation,': [173], 'other': [178], 'patterns': [179], 'susceptibility': [181], 'based': [182], 'on': [183], 'genetic': [184, 189, 207, 235], 'makeup.': [185], 'To': [186], 'elucidate': [187], 'basis': [190], 'further,': [193], 'investigations': [194], 'needed,': [196], 'including': [197], 'genome': [198], 'scanning': [199], 'for': [200, 211, 218], 'major': [201], 'minor': [203], 'genes,': [204], 'analysis': [205], 'profiles': [208], 'candidate': [212], 'genes': [213], 'modify': [216], 'risk': [217, 250], '(e.g.,': [220], 'serotonin': [221], 'transporter': [222], 'alleles,': [223], 'nitric': [224], 'oxide-synthases),': [225], 'proteomics,': [226], 'transgenic': [227], 'mice,': [228], 'altered': [230], 'signal': [231], 'transduction.': [232], 'Advances': [233], 'testing,': [236], 'presymptomatic': [237], 'screening,': [238], 'biomarkers': [240], 'should': [241], 'permit': [242], 'early': [243], 'detection': [244], 'those': [248], 'at': [249], 'allow': [254], 'trials': [255], 'preventive': [257], 'therapy': [258], 'carriers.': [260]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W177395109', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 14}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-09-19T03:39:57.039384', 'created_date': '2016-06-24'}