Publication Information

{'id': 'https://openalex.org/W1769244282', 'doi': 'https://doi.org/10.1111/bph.13320', 'title': 'Valproic acid protects against haemorrhagic shock‐induced signalling changes via PPARγ activation in an <i>in vitro</i> model', 'display_name': 'Valproic acid protects against haemorrhagic shock‐induced signalling changes via PPARγ activation in an <i>in vitro</i> model', 'publication_year': 2015, 'publication_date': '2015-09-02', 'ids': {'openalex': 'https://openalex.org/W1769244282', 'doi': 'https://doi.org/10.1111/bph.13320', 'mag': '1769244282', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26333042', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5123713'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/bph.13320', 'pdf_url': 'https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bph.13320', 'source': {'id': 'https://openalex.org/S55107261', 'display_name': 'British Journal of Pharmacology', 'issn_l': '0007-1188', 'issn': ['0007-1188', '1476-5381'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bph.13320', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5058136099', 'display_name': 'Alexandra M.E. Zuckermann', 'orcid': 'https://orcid.org/0000-0002-0242-8815'}, 'institutions': [{'id': 'https://openalex.org/I184558857', 'display_name': 'Royal Holloway University of London', 'ror': 'https://ror.org/04g2vpn86', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I184558857']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Alexandra M E Zuckermann', 'raw_affiliation_strings': ['Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, TW20 0EX, UK.'], 'affiliations': [{'raw_affiliation_string': 'Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, TW20 0EX, UK.', 'institution_ids': ['https://openalex.org/I184558857']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056667622', 'display_name': 'Roberto M. La Ragione', 'orcid': 'https://orcid.org/0000-0001-5861-613X'}, 'institutions': [{'id': 'https://openalex.org/I28290843', 'display_name': 'University of Surrey', 'ror': 'https://ror.org/00ks66431', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I28290843']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Roberto M La Ragione', 'raw_affiliation_strings': ['School of Veterinary Medicine, University of Surrey; Guildford Surrey GU2 7XH UK'], 'affiliations': [{'raw_affiliation_string': 'School of Veterinary Medicine, University of Surrey; Guildford Surrey GU2 7XH UK', 'institution_ids': ['https://openalex.org/I28290843']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016443916', 'display_name': 'Deborah L. Baines', 'orcid': 'https://orcid.org/0000-0001-7229-0244'}, 'institutions': [{'id': 'https://openalex.org/I165862685', 'display_name': "St George's, University of London", 'ror': 'https://ror.org/040f08y74', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I165862685', 'https://openalex.org/I4401726869']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Deborah L Baines', 'raw_affiliation_strings': ["Institute for Infection and Immunity, St George's, University of London, London SW17 0RE, UK."], 'affiliations': [{'raw_affiliation_string': "Institute for Infection and Immunity, St George's, University of London, London SW17 0RE, UK.", 'institution_ids': ['https://openalex.org/I165862685']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5023909682', 'display_name': 'Robin S. B. Williams', 'orcid': 'https://orcid.org/0000-0002-9826-6020'}, 'institutions': [{'id': 'https://openalex.org/I184558857', 'display_name': 'Royal Holloway University of London', 'ror': 'https://ror.org/04g2vpn86', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I184558857']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Robin S B Williams', 'raw_affiliation_strings': ['Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, TW20 0EX, UK.'], 'affiliations': [{'raw_affiliation_string': 'Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, TW20 0EX, UK.', 'institution_ids': ['https://openalex.org/I184558857']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4330, 'currency': 'USD', 'value_usd': 4330, 'provenance': 'doaj'}, 'apc_paid': {'value': 4330, 'currency': 'USD', 'value_usd': 4330, 'provenance': 'doaj'}, 'fwci': 1.855, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 10, 'citation_normalized_percentile': {'value': 0.863717, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '172', 'issue': '22', 'first_page': '5306', 'last_page': '5317'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12229', 'display_name': 'Pharmacological Effects and Toxicity Studies', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12229', 'display_name': 'Pharmacological Effects and Toxicity Studies', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11736', 'display_name': 'Histone Deacetylase Inhibitors Research', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9945, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/valproic-acid', 'display_name': 'Valproic Acid', 'score': 0.75631857}], 'concepts': [{'id': 'https://openalex.org/C2777172819', 'wikidata': 'https://www.wikidata.org/wiki/Q240642', 'display_name': 'Valproic Acid', 'level': 3, 'score': 0.75631857}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5954645}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.58428484}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.45700184}, {'id': 'https://openalex.org/C2781300812', 'wikidata': 'https://www.wikidata.org/wiki/Q178061', 'display_name': 'Shock (circulatory)', 'level': 2, 'score': 0.4425591}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.43745595}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.34736758}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3433714}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.30733913}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.29537618}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.24318916}, {'id': 'https://openalex.org/C2778186239', 'wikidata': 'https://www.wikidata.org/wiki/Q41571', 'display_name': 'Epilepsy', 'level': 2, 'score': 0.09306732}], 'mesh': [{'descriptor_ui': 'D038362', 'descriptor_name': 'Glycogen Synthase Kinase 3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D047495', 'descriptor_name': 'PPAR gamma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020011', 'descriptor_name': 'Protective Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D012771', 'descriptor_name': 'Shock, Hemorrhagic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014635', 'descriptor_name': 'Valproic Acid', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D038362', 'descriptor_name': 'Glycogen Synthase Kinase 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071679', 'descriptor_name': 'Glycogen Synthase Kinase 3 beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006935', 'descriptor_name': 'Hypercapnia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006935', 'descriptor_name': 'Hypercapnia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007035', 'descriptor_name': 'Hypothermia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007035', 'descriptor_name': 'Hypothermia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000860', 'descriptor_name': 'Hypoxia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000860', 'descriptor_name': 'Hypoxia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007770', 'descriptor_name': 'L-Lactate Dehydrogenase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007770', 'descriptor_name': 'L-Lactate Dehydrogenase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D047495', 'descriptor_name': 'PPAR gamma', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': False}, {'descriptor_ui': 'D047495', 'descriptor_name': 'PPAR gamma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D047495', 'descriptor_name': 'PPAR gamma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020011', 'descriptor_name': 'Protective Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012771', 'descriptor_name': 'Shock, Hemorrhagic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014635', 'descriptor_name': 'Valproic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/bph.13320', 'pdf_url': 'https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bph.13320', 'source': {'id': 'https://openalex.org/S55107261', 'display_name': 'British Journal of Pharmacology', 'issn_l': '0007-1188', 'issn': ['0007-1188', '1476-5381'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5123713', 'pdf_url': 'https://europepmc.org/articles/pmc5123713?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123713', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://openaccess.sgul.ac.uk/107483/7/Valporic%20acid.pdf', 'pdf_url': 'http://openaccess.sgul.ac.uk/107483/7/Valporic%20acid.pdf', 'source': {'id': 'https://openalex.org/S4306400552', 'display_name': "St George's Online Research Archive (St George's University of London)", 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I165862685', 'host_organization_name': "St George's, University of London", 'host_organization_lineage': ['https://openalex.org/I165862685'], 'host_organization_lineage_names': ["St George's, University of London"], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26333042', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/bph.13320', 'pdf_url': 'https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bph.13320', 'source': {'id': 'https://openalex.org/S55107261', 'display_name': 'British Journal of Pharmacology', 'issn_l': '0007-1188', 'issn': ['0007-1188', '1476-5381'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.88, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320335935', 'funder_display_name': 'Royal Holloway, University of London', 'award_id': 'N/A'}], 'datasets': [], 'versions': [], 'referenced_works_count': 69, 'referenced_works': ['https://openalex.org/W1503343720', 'https://openalex.org/W1529023379', 'https://openalex.org/W1577837690', 'https://openalex.org/W1668468546', 'https://openalex.org/W1769244282', 'https://openalex.org/W1964410726', 'https://openalex.org/W1967931372', 'https://openalex.org/W1968305447', 'https://openalex.org/W1969590462', 'https://openalex.org/W1971825415', 'https://openalex.org/W1975454216', 'https://openalex.org/W1976584956', 'https://openalex.org/W1984025642', 'https://openalex.org/W1985454477', 'https://openalex.org/W1989186104', 'https://openalex.org/W1989277832', 'https://openalex.org/W1997267372', 'https://openalex.org/W1997755216', 'https://openalex.org/W2008404887', 'https://openalex.org/W2009933732', 'https://openalex.org/W2016777209', 'https://openalex.org/W2025565849', 'https://openalex.org/W2026311526', 'https://openalex.org/W2027329984', 'https://openalex.org/W2028494426', 'https://openalex.org/W2030397096', 'https://openalex.org/W2035711389', 'https://openalex.org/W2040101760', 'https://openalex.org/W2044488698', 'https://openalex.org/W2048146741', 'https://openalex.org/W2048937347', 'https://openalex.org/W2049875806', 'https://openalex.org/W2050094423', 'https://openalex.org/W2050717908', 'https://openalex.org/W2056891806', 'https://openalex.org/W2059030268', 'https://openalex.org/W2059134795', 'https://openalex.org/W2059351132', 'https://openalex.org/W2066323398', 'https://openalex.org/W2071060833', 'https://openalex.org/W2076403167', 'https://openalex.org/W2078461915', 'https://openalex.org/W2082387343', 'https://openalex.org/W2083066201', 'https://openalex.org/W2084253055', 'https://openalex.org/W2098249941', 'https://openalex.org/W2101935092', 'https://openalex.org/W2105566302', 'https://openalex.org/W2108003465', 'https://openalex.org/W2109027708', 'https://openalex.org/W2111125738', 'https://openalex.org/W2111430444', 'https://openalex.org/W2111811744', 'https://openalex.org/W2112925225', 'https://openalex.org/W2115074481', 'https://openalex.org/W2115769793', 'https://openalex.org/W2117691193', 'https://openalex.org/W2118719170', 'https://openalex.org/W2133674420', 'https://openalex.org/W2134773980', 'https://openalex.org/W2143027433', 'https://openalex.org/W2152207188', 'https://openalex.org/W2157889365', 'https://openalex.org/W2165455805', 'https://openalex.org/W2168547139', 'https://openalex.org/W2171497684', 'https://openalex.org/W2274698127', 'https://openalex.org/W2501784776', 'https://openalex.org/W2784906153'], 'related_works': ['https://openalex.org/W4282053666', 'https://openalex.org/W2417320233', 'https://openalex.org/W2378555581', 'https://openalex.org/W2315718491', 'https://openalex.org/W2295548169', 'https://openalex.org/W2132119775', 'https://openalex.org/W2124907104', 'https://openalex.org/W2069277854', 'https://openalex.org/W1980561701', 'https://openalex.org/W1671409019'], 'abstract_inverted_index': {'Background': [0], 'and': [1, 10, 63, 86, 110, 120, 134, 148, 151, 200, 221, 240], 'Purpose': [2], 'Valproic': [3], 'acid': [4], '(VPA),': [5], 'a': [6, 22, 39, 43, 65, 97, 244], 'widely': [7], 'used': [8], 'epilepsy': [9], 'bipolar': [11], 'disorder': [12], 'treatment,': [13], 'provides': [14], 'acute': [15], 'protection': [16, 41], 'against': [17, 42, 196], 'haemorrhagic': [18, 82, 132, 217, 231], 'shock‐induced': [19], 'mortality': [20], 'in': [21, 25, 45, 53, 92, 129, 216, 224, 228, 229, 237, 249], 'range': [23], 'of': [24, 61, 175, 188, 194, 206, 253], 'vivo': [26, 130, 230], 'models': [27, 233], 'through': [28, 145], 'an': [29, 52], 'unknown': [30], 'mechanism.': [31, 67], 'In': [32, 202], 'the': [33, 90, 123, 191, 211, 250], 'liver,': [34], 'this': [35, 58, 135, 241], 'effect': [36, 60, 143, 162, 193], 'occurs': [37], 'with': [38, 103, 169], 'concomitant': [40], 'decrease': [44], 'GSK3β‐Ser': [46, 93, 125, 225], '9': [47, 94, 126, 226], 'phosphorylation.': [48], 'Here,': [49], 'we': [50], 'developed': [51], 'vitro': [54, 238], 'model': [55], 'to': [56, 78, 88], 'investigate': [57, 89], 'protective': [59, 142, 192, 251], 'VPA': [62, 195, 215], 'define': [64], 'molecular': [66], 'Experimental': [68], 'Approach': [69], 'The': [70, 141], 'human': [71], 'hepatocarcinoma': [72], 'cell': [73], 'line': [74], '(Huh7)': [75], 'was': [76, 137, 163], 'exposed': [77], 'conditions': [79], 'occurring': [80], 'during': [81, 131], 'shock': [83, 232], '(hypoxia,': [84], 'hypercapnia': [85], 'hypothermia)': [87], 'changes': [91, 199, 212], 'phosphorylation': [95, 127, 227], 'for': [96, 246], '4': [98], 'h': [99], 'period': [100], 'following': [101], 'treatment': [102], 'VPA,': [104], 'related': [105], 'congeners,': [106], 'PPAR': [107], 'agonists,': [108], 'antagonists': [109], 'siRNA.': [111], 'Key': [112], 'Results': [113], 'Huh7': [114], 'cells': [115], 'undergoing': [116], 'combined': [117], 'hypoxia,': [118], 'hypercapnia,': [119], 'hypothermia': [121], 'reproduced': [122, 164, 210], 'reduced': [124], 'shown': [128], 'shock,': [133], 'change': [136], 'blocked': [138, 190], 'by': [139, 165, 214], 'VPA.': [140, 254], 'occurred': [144], 'upstream': [146], 'PTEN': [147], 'Akt': [149], 'signalling,': [150], 'prevented': [152], 'downstream': [153], 'β‐catenin': [154], 'degradation': [155], 'while': [156], 'increasing': [157], 'histone': [158, 176], '2/3': [159], 'acetylation.': [160], 'This': [161], 'several': [166], 'VPA‐related': [167], 'compounds': [168], 'known': [170], 'PPARγ': [171, 189, 207, 247], 'agonist': [172], 'activity,': [173], 'independent': [174], 'deacetylase': [177], '(HDAC)': [178], 'inhibitory': [179], 'activity.': [180], 'Specific': [181], 'pharmacological': [182], 'inhibition': [183], '(by': [184], 'T0070907)': [185], 'or': [186], 'knockdown': [187], 'these': [197], 'signalling': [198], 'apoptosis.': [201], 'addition,': [203], 'specific': [204], 'activation': [205, 248], 'using': [208], 'ciglitazone': [209], 'induced': [213], 'shock‐like': [218], 'conditions.': [219], 'Conclusion': [220], 'Implications': [222], 'Changes': [223], 'can': [234], 'be': [235], 'modelled': [236], ',': [239], 'has': [242], 'identified': [243], 'role': [245, 252]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1769244282', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2025-01-11T02:03:02.698020', 'created_date': '2016-06-24'}