Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1766576124', 'doi': 'https://doi.org/10.18632/oncotarget.5013', 'title': 'Bax-PGAM5L-Drp1 complex is required for intrinsic apoptosis execution', 'display_name': 'Bax-PGAM5L-Drp1 complex is required for intrinsic apoptosis execution', 'publication_year': 2015, 'publication_date': '2015-08-31', 'ids': {'openalex': 'https://openalex.org/W1766576124', 'doi': 'https://doi.org/10.18632/oncotarget.5013', 'mag': '1766576124', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26356820', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4745779'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5013', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5013&path%5B%5D=12356', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5013&path%5B%5D=12356', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100540576', 'display_name': 'Xu Wenjuan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I58200834', 'display_name': 'Southern Medical University', 'ror': 'https://ror.org/01vjw4z39', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I58200834']}, {'id': 'https://openalex.org/I4210103346', 'display_name': 'Nanfang Hospital', 'ror': 'https://ror.org/01eq10738', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210103346']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wenjuan Xu', 'raw_affiliation_strings': ['Nanfang Hospital, Southern Medical University, Guangzhou, China', 'School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Nanfang Hospital, Southern Medical University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I58200834', 'https://openalex.org/I4210103346']}, {'raw_affiliation_string': 'School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I58200834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101586337', 'display_name': 'Linlin Jing', 'orcid': 'https://orcid.org/0000-0001-5705-020X'}, 'institutions': [{'id': 'https://openalex.org/I4210140387', 'display_name': 'TCM-Intigrated Cancer Center of Southern Medical University', 'ror': 'https://ror.org/030xn5j74', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140387']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Linlin Jing', 'raw_affiliation_strings': ['TCM-Integrated Hospital of Southern Medical University, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'TCM-Integrated Hospital of Southern Medical University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I4210140387']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067011239', 'display_name': 'Quanshi Wang', 'orcid': 'https://orcid.org/0000-0003-2003-3603'}, 'institutions': [{'id': 'https://openalex.org/I58200834', 'display_name': 'Southern Medical University', 'ror': 'https://ror.org/01vjw4z39', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I58200834']}, {'id': 'https://openalex.org/I4210103346', 'display_name': 'Nanfang Hospital', 'ror': 'https://ror.org/01eq10738', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210103346']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Quanshi Wang', 'raw_affiliation_strings': ['Nanfang Hospital, Southern Medical University, Guangzhou, China,'], 'affiliations': [{'raw_affiliation_string': 'Nanfang Hospital, Southern Medical University, Guangzhou, China,', 'institution_ids': ['https://openalex.org/I58200834', 'https://openalex.org/I4210103346']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006134319', 'display_name': 'Chung‐Chih Lin', 'orcid': 'https://orcid.org/0000-0002-3390-882X'}, 'institutions': [{'id': 'https://openalex.org/I148366613', 'display_name': 'National Yang Ming Chiao Tung University', 'ror': 'https://ror.org/00se2k293', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I148366613']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Chung-Chih Lin', 'raw_affiliation_strings': ['Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan', 'institution_ids': ['https://openalex.org/I148366613']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100715042', 'display_name': 'Xiaoting Chen', 'orcid': 'https://orcid.org/0000-0002-3782-3962'}, 'institutions': [{'id': 'https://openalex.org/I4210120929', 'display_name': 'Zhujiang Hospital', 'ror': 'https://ror.org/02mhxa927', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210120929']}, {'id': 'https://openalex.org/I58200834', 'display_name': 'Southern Medical University', 'ror': 'https://ror.org/01vjw4z39', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I58200834']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaoting Chen', 'raw_affiliation_strings': ['Zhujiang Hospital, Southern Medical University, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Zhujiang Hospital, Southern Medical University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I4210120929', 'https://openalex.org/I58200834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101016033', 'display_name': 'Jianxin Diao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I58200834', 'display_name': 'Southern Medical University', 'ror': 'https://ror.org/01vjw4z39', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I58200834']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jianxin Diao', 'raw_affiliation_strings': ['School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I58200834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034091195', 'display_name': 'Yuanliang Liu', 'orcid': 'https://orcid.org/0000-0002-4920-8502'}, 'institutions': [{'id': 'https://openalex.org/I58200834', 'display_name': 'Southern Medical University', 'ror': 'https://ror.org/01vjw4z39', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I58200834']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yuanliang Liu', 'raw_affiliation_strings': ['School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I58200834']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5088208982', 'display_name': 'Xuegang Sun', 'orcid': 'https://orcid.org/0000-0001-6581-0520'}, 'institutions': [{'id': 'https://openalex.org/I58200834', 'display_name': 'Southern Medical University', 'ror': 'https://ror.org/01vjw4z39', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I58200834']}, {'id': 'https://openalex.org/I4210103346', 'display_name': 'Nanfang Hospital', 'ror': 'https://ror.org/01eq10738', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210103346']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xuegang Sun', 'raw_affiliation_strings': ['Nanfang Hospital, Southern Medical University, Guangzhou, China', 'School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Nanfang Hospital, Southern Medical University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I58200834', 'https://openalex.org/I4210103346']}, {'raw_affiliation_string': 'School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I58200834']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.407, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 100, 'citation_normalized_percentile': {'value': 0.865308, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '6', 'issue': '30', 'first_page': '30017', 'last_page': '30034'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10294', 'display_name': 'Molecular Mechanisms of Apoptosis and Cell Death', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10294', 'display_name': 'Molecular Mechanisms of Apoptosis and Cell Death', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'Mechanisms and Applications of RNA Interference', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12763', 'display_name': 'ATP Synthase Function and Regulation', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/staurosporine', 'display_name': 'Staurosporine', 'score': 0.93424916}, {'id': 'https://openalex.org/keywords/apoptosis', 'display_name': 'Apoptosis', 'score': 0.494788}], 'concepts': [{'id': 'https://openalex.org/C2779084600', 'wikidata': 'https://www.wikidata.org/wiki/Q5957181', 'display_name': 'Staurosporine', 'level': 4, 'score': 0.93424916}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.67031056}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5376668}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5045136}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.49582824}, {'id': 'https://openalex.org/C17619807', 'wikidata': 'https://www.wikidata.org/wiki/Q6881852', 'display_name': 'Mitochondrial fission', 'level': 3, 'score': 0.49262577}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.4500747}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.40067884}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.38926107}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.35980338}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.18576929}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15233472}, {'id': 'https://openalex.org/C195794163', 'wikidata': 'https://www.wikidata.org/wiki/Q420877', 'display_name': 'Protein kinase C', 'level': 3, 'score': 0.06368825}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020558', 'descriptor_name': 'GTP Phosphohydrolases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D024101', 'descriptor_name': 'Mitochondrial Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051028', 'descriptor_name': 'bcl-2-Associated X Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002018', 'descriptor_name': 'Bufanolides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002018', 'descriptor_name': 'Bufanolides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002018', 'descriptor_name': 'Bufanolides', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034281', 'descriptor_name': 'Dynamins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020558', 'descriptor_name': 'GTP Phosphohydrolases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020558', 'descriptor_name': 'GTP Phosphohydrolases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045325', 'descriptor_name': 'HCT116 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061986', 'descriptor_name': 'MCF-7 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018613', 'descriptor_name': 'Microscopy, Confocal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D024101', 'descriptor_name': 'Mitochondrial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024101', 'descriptor_name': 'Mitochondrial Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D046912', 'descriptor_name': 'Multiprotein Complexes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046912', 'descriptor_name': 'Multiprotein Complexes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D046912', 'descriptor_name': 'Multiprotein Complexes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010749', 'descriptor_name': 'Phosphoprotein Phosphatases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019311', 'descriptor_name': 'Staurosporine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019311', 'descriptor_name': 'Staurosporine', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D019311', 'descriptor_name': 'Staurosporine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051028', 'descriptor_name': 'bcl-2-Associated X Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051028', 'descriptor_name': 'bcl-2-Associated X Protein', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5013', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5013&path%5B%5D=12356', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4745779', 'pdf_url': 'https://europepmc.org/articles/pmc4745779?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745779', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26356820', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5013', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5013&path%5B%5D=12356', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.67, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1550247880', 'https://openalex.org/W1974124666', 'https://openalex.org/W1976779549', 'https://openalex.org/W1976881265', 'https://openalex.org/W1990349494', 'https://openalex.org/W1996271683', 'https://openalex.org/W1997914932', 'https://openalex.org/W1998723340', 'https://openalex.org/W2002196794', 'https://openalex.org/W2006483529', 'https://openalex.org/W2012884456', 'https://openalex.org/W2023283007', 'https://openalex.org/W2024927514', 'https://openalex.org/W2026912679', 'https://openalex.org/W2030864103', 'https://openalex.org/W2039426833', 'https://openalex.org/W2050338578', 'https://openalex.org/W2052605153', 'https://openalex.org/W2059009119', 'https://openalex.org/W2064470328', 'https://openalex.org/W2068197112', 'https://openalex.org/W2075667307', 'https://openalex.org/W2075996457', 'https://openalex.org/W2077626349', 'https://openalex.org/W2080103633', 'https://openalex.org/W2083489445', 'https://openalex.org/W2086764184', 'https://openalex.org/W2088523363', 'https://openalex.org/W2104197685', 'https://openalex.org/W2113088032', 'https://openalex.org/W2120626244', 'https://openalex.org/W2128347259', 'https://openalex.org/W2133475822', 'https://openalex.org/W2138760860', 'https://openalex.org/W2139131640', 'https://openalex.org/W2149128081', 'https://openalex.org/W2155643523', 'https://openalex.org/W2159190959', 'https://openalex.org/W2161557809', 'https://openalex.org/W2169961966', 'https://openalex.org/W2219978888', 'https://openalex.org/W2223837994'], 'related_works': ['https://openalex.org/W2475319420', 'https://openalex.org/W2466761488', 'https://openalex.org/W2413108750', 'https://openalex.org/W2367160289', 'https://openalex.org/W2337011353', 'https://openalex.org/W2124883708', 'https://openalex.org/W2086380477', 'https://openalex.org/W2041618534', 'https://openalex.org/W1991588439', 'https://openalex.org/W1970200331'], 'abstract_inverted_index': {'//': [0], 'Wenjuan': [1], 'Xu': [2], '1,': [3, 14, 35], '2,': [4], '*': [5, 10, 15, 89], ',': [6, 11, 16, 20, 24, 28, 32], 'Linlin': [7], 'Jing': [8], '3,': [9], 'Quanshi': [12], 'Wang': [13], 'Chung-Chih': [17], 'Lin': [18], '4': [19, 66], 'Xiaoting': [21], 'Chen': [22], '5': [23, 81], 'Jianxin': [25], 'Diao': [26], '2': [27, 31, 36, 45], 'Yuanliang': [29], 'Liu': [30], 'Xuegang': [33, 100], 'Sun': [34], '1': [37], 'Nanfang': [38], 'Hospital,': [39, 83], 'Southern': [40, 51, 61, 84], 'Medical': [41, 52, 62, 85], 'University,': [42, 53, 63, 78, 86], 'Guangzhou,': [43, 54, 64, 87], 'China': [44, 55, 65, 88], 'School': [46], 'of': [47, 60, 68, 73, 136, 141, 171, 178, 201, 205, 215, 220, 257, 291], 'Traditional': [48], 'Chinese': [49], 'Medicine,': [50], '3': [56], 'TCM': [57], 'Integrated': [58], 'Hospital': [59], 'Department': [67], 'Life': [69], 'Sciences': [70], 'and': [71, 131, 154, 203, 209, 225, 233, 240, 263, 278, 282, 299, 306, 309], 'Institute': [72], 'Genome': [74], 'Sciences,': [75], 'National': [76], 'Yang-Ming': [77], 'Taipei,': [79], 'Taiwan': [80], 'Zhujiang': [82], 'These': [90], 'authors': [91], 'have': [92], 'contributed': [93], 'equally': [94], 'to': [95, 222], 'this': [96], 'work': [97], 'Correspondence': [98], 'to:': [99], 'Sun,': [101], 'e-mail:': [102], '[email protected]': [103], 'Keywords:': [104], 'PGAM5L,': [105, 191], 'Bax,': [106], 'DRP1,': [107], 'intrinsic': [108, 181, 212, 328], 'apoptosis,': [109], 'cancer': [110], 'Received:': [111], 'April': [112], '03,': [113], '2015 ': [114, 118], 'Accepted:': [115], 'August': [116, 120], '20,': [117], 'Published:': [119], '31,': [121], '2015': [122], 'ABSTRACT': [123], 'Intrinsic': [124], 'apoptosis': [125, 182, 329], 'eliminates': [126], 'cells': [127, 132, 303], 'with': [128, 133, 289], 'damaged': [129], 'DNA': [130], 'dysregulated': [134], 'expression': [135], 'oncogene.': [137], 'PGAM5,': [138], 'a': [139, 196], 'member': [140], 'the': [142, 168, 176, 190, 199, 218, 223, 255, 258], 'phosphoglycerate': [143], 'mutase': [144], 'family,': [145], 'has': [146, 160], 'two': [147], 'splicing': [148], 'variants:': [149], 'PGAM5L': [150, 216, 232], '(the': [151, 156], 'long': [152], 'form)': [153], 'PGAM5S': [155, 194], 'short': [157], 'form).': [158], 'It': [159], 'been': [161], 'well': [162], 'established': [163], 'that': [164, 189, 290, 322], 'PGAM5': [165, 179], 'is': [166, 183, 195, 295, 325], 'at': [167], 'convergent': [169], 'point': [170], 'multiple': [172], 'necrosis': [173], 'pathways.': [174], 'However,': [175], 'role': [177], 'in': [180, 207, 237, 247, 260, 276, 297, 304, 307, 313], 'still': [184], 'controversial.': [185], 'Here': [186], 'we': [187], 'report': [188], 'but': [192, 245], 'not': [193, 246], 'prerequisite': [197], 'for': [198, 327], 'activation': [200], 'Bax': [202, 221, 249, 252, 267], 'dephosphorylation': [204], 'Drp1': [206, 234], 'arenobufagin': [208, 239, 262, 298, 308], 'staurosporine': [210, 241, 264, 300], 'induced': [211], 'apoptosis.': [213], 'Knockdown': [214], 'inhibits': [217], 'translocation': [219], 'mitochondria': [224], 'reduces': [226], 'mitochondrial': [227], 'fission.': [228], 'The': [229], 'interaction': [230], 'between': [231], 'was': [235], 'observed': [236], 'both': [238, 261, 275], 'treated': [242, 301, 311], 'HCT116': [243, 248, 266], 'cells,': [244], '−/−': [250, 268], 'cells.': [251, 269], 'transfection': [253], 'rescues': [254], 'formation': [256], 'triplex': [259], 'stimulated': [265], 'Arenobufagin': [270], 'shows': [271], 'remarkable': [272], 'anti-cancer': [273], 'effects': [274, 286], 'orthotropic': [277], 'heterotropic': [279], 'CRC': [280, 302], 'models': [281], 'demonstrates': [283], 'less': [284], 'toxic': [285], 'as': [287, 315], 'compared': [288], 'cisplatin.': [292], 'Bax-PGAM5L-Drp1': [293, 323], 'complex': [294, 324], 'detected': [296], 'vitro': [305], 'cisplatin': [310], 'tumor': [312], 'vivo': [314], 'well.': [316], 'In': [317], 'summary,': [318], 'our': [319], 'results': [320], 'demonstrate': [321], 'required': [326], 'execution.': [330]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1766576124', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 15}, {'year': 2021, 'cited_by_count': 15}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 17}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 5}], 'updated_date': '2024-09-17T14:37:49.404715', 'created_date': '2016-06-24'}