The Binding of Oxidized Low Density Lipoprotein (ox-LDL) to ox-LDL Receptor-1 Reduces the Intracellular Concentration of Nitric Oxide in Endothelial Cells through an Increased Production of Superoxide

Name: Work Video:
Duration: 3 min 30 s
Luciano Cominacini; A. Rigoni; Anna Fratta Pasini; Ulisse Garbin; Anna Davoli; Mario Campagnola; Antonio M. Pastorino; Vincenzo Lo Cascio; Tatsuya Sawamura
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2739, 2812, 2900, 3127, 3179, 3403, 3705], 'incubation': [128, 354, 1774, 1851, 2059, 2890, 3045, 3120, 3159, 4228, 4436], 'with': [129, 169, 355, 395, 458, 1866, 1875, 1984, 2014, 2060, 2159, 2206, 2225, 2234, 2308, 2630, 2673, 2719, 2733, 2806, 2876, 2893, 2952, 3073, 3123, 3160, 3217, 3251, 3303, 3335, 3387, 3404, 3474, 3488, 3698, 3735, 3769, 3855, 3940, 4125, 4214, 4231, 4235, 4416, 4426, 4439, 4443, 4557, 4843, 4900], '(p': [134, 147, 166, 177, 360, 373, 392, 403, 2917, 3279, 3338, 3507], '<': [135, 148, 167, 178, 361, 374, 393, 404, 2830, 2840, 2887, 2918, 2980, 2995, 3010, 3110, 3280, 3339, 3436, 3508], '0.01).': [136, 362, 3011], 'same': [139, 365, 2248], 'experimental': [140, 366, 1788, 1992, 2249, 2433, 2713, 3166, 3692, 4011, 4516, 4832, 5136], 'also': [143, 369, 1631, 2012, 2252, 2429, 2958, 3128, 3169, 3317, 3570, 4176, 4898, 5080, 5189], 'O⨪2': [145, 371, 690, 1590, 1676, 2006, 3141, 3151, 3211, 3240, 3275, 3287, 3324, 3364, 3469, 3581, 3593, 3600, 3676, 4197, 4206, 4243, 4464, 4720, 4796, 4823, 4838, 4880, 4940, 4958, 4995, 5015, 5045, 5083, 5146, 5158, 5186, 5464, 5519], 'generation': [146, 372, 1023, 1591, 1792, 3504, 3601, 4290, 4366, 4721, 4794, 4824, 4941, 5016, 5156, 5187, 5526], '0.001).': [149, 179, 375, 405, 2841, 2888, 3281, 3509], 'presence': [152, 378, 736, 1764, 2046, 2171, 2197, 2324, 2903, 3558, 4990], 'radical': [154, 380, 704, 1893, 3258, 4221, 4423, 4480], 'scavengers': [155, 381, 1894, 4424], 'anti-LOX-1': [157, 383, 1909, 2357, 3304, 3336, 3355, 3374, 3478, 3492, 4296, 4427], 'monoclonal': [158, 384, 1910], 'antibody,': [159, 385], 'O⨪2formation': [160, 386], 'was': [164, 390, 915, 1113, 1167, 1249, 1292, 1322, 1363, 1510, 1534, 1592, 1653, 1677, 1776, 1853, 2068, 2193, 2344, 2449, 2514, 2655, 2671, 2685, 2751, 2765, 2799, 3036, 3194, 3204, 3289, 3316, 3326, 3466, 3517, 3566, 3722, 4187, 4209, 4293, 4306, 4411, 4526, 5527], 'reduced': [165, 391, 2908, 2960, 3270, 3328, 3599, 3618, 3834, 4937, 5000, 5014], '0.001)': [168, 394, 2919], 'contemporary': [171, 397], 'rise': [172, 398], 'did': [181, 407, 2924, 3524, 3590, 4014, 4110, 4716, 4820], 'not': [182, 408, 2925, 2927, 2946, 3143, 3155, 3346, 3525, 3555, 3591, 3609, 3826, 4015, 4111, 4717, 4806, 4821, 4955, 4970, 4980], 'significantly': [183, 409, 2800, 2959, 3156, 3269, 3494, 3526, 3613, 4016, 4718], 'modify': [184, 410, 3527], 'ability': [186, 412, 3529, 4019, 4117], 'synthase': [191, 417, 811, 2757, 3728], 'metabolizel-arginine': [193, 419], 'l-citrulline.': [195, 421], 'The': [196, 422, 632, 735, 1244, 1644, 1773, 2437, 2512, 2652, 2842, 2889, 2948, 3119, 3145, 3396, 3510, 4199, 4405, 4429, 5176, 5409, 5480], 'results': [197, 423, 3451, 3732, 3771, 3782, 3853, 4103, 4172, 4787, 4841, 4896, 4902, 5005, 5590], 'show': [201, 427, 4107, 5010, 5594], 'that': [202, 428, 875, 959, 1012, 1674, 1785, 2079, 3027, 3483, 3588, 3741, 3773, 3823, 4108, 4178, 4226, 4285, 4301, 4354, 4434, 4547, 4712, 4792, 4817, 4874, 4934, 4964, 4987, 5011, 5141, 5154, 5204, 5311, 5506, 5578, 5595], 'one': [203, 429, 4983, 5596], 'pathophysiological': [206, 432, 5599], 'consequences': [207, 433, 5600], 'LOX-1': [212, 438, 796, 1016, 1446, 3295, 3358, 4359, 4804, 5418, 5435, 5605], 'may': [213, 439, 835, 863, 965, 3575, 4460, 5162, 5188, 5606], 'be': [214, 440, 836, 864, 966, 4461, 4986, 5163, 5483, 5607], 'increased': [221, 447, 641, 1796, 2801, 3157, 3614, 4200, 4237, 4447, 4953, 5167, 5614], 'cellular': [222, 448, 4201, 5615], 'production': [223, 449, 524, 1080, 1533, 1635, 2255, 2348, 2780, 2786, 3035, 3175, 3208, 3276, 3669, 4202, 4239, 4449, 4881, 5084, 5616], 'Endothelium-dependent': [452], 'relaxation': [453], 'impaired': [455, 5312], 'animals': [457], 'atherosclerosis': [459], '(1Guerra': [460], 'Jr.,': [461], 'R.': [462, 648, 1193, 1231, 1278, 1402, 1489, 1573, 3794, 4001, 4921, 5286], 'Brotherthon': [463], 'A.F.A.': [464], 'Goodwin': [465], 'P.J.': [466], 'Clark': [467, 5242], 'C.R.': [468, 761], 'Armstrong': [469], 'M.L.': [470], 'Harrison': [471, 676, 2456, 2522, 4040], 'D.G.': [472, 677], 'Blood': [473], 'Vessels.': [474], '1989;': [475, 1380, 5358], '26:': [476, 4753], '300-314PubMed': [477], 'Google': [478, 498, 515, 583, 597, 630, 670, 687, 720, 733, 771, 853, 902, 953, 1004, 1068, 1155, 1208, 1346, 1358, 1387, 1419, 1477, 1506, 1529, 1563, 1587, 1627, 1671, 1698, 1846, 1942, 1980, 2115, 2282, 2388, 2426, 2471, 2487, 2510, 2537, 2553, 2576, 3657, 3763, 3819, 3885, 3902, 3921, 3978, 3992, 4055, 4071, 4094, 4169, 4280, 4350, 4403, 4496, 4510, 4586, 4617, 4635, 4654, 4674, 4693, 4755, 4784, 4870, 4930, 5078, 5105, 5130, 5234, 5262, 5283, 5302, 5351, 5364, 5383, 5407, 5458, 5571], 'Scholar,': [479, 499, 584, 671, 1209, 1347, 2472, 2488, 2538, 2554, 3886, 3979, 3993, 4056, 4072, 4497, 4618, 4636, 4655, 4675, 5235, 5263, 5284, 5352, 5365], '2Girerd': [480], 'X.J.': [481, 571, 5222], 'Hirsh': [482, 572, 5223], 'A.T.': [483, 573, 5224], 'Cooke': [484], 'J.P.': [485, 567, 5218], 'Dzau': [486], 'V.J.': [487, 4642, 4677], 'Creager': [488, 574, 5225], 'M.A.': [489, 575, 757, 1143, 5094, 5226], 'Circ.': [490, 1411, 1498, 2479, 2545, 4063, 4627, 5451], 'Res.': [491, 727, 890, 1200, 1412, 1499, 2278, 2480, 2546, 4064, 4504, 4628, 5097, 5452], '1990;': [492, 714, 1621, 3879, 4005, 4490, 5345], '67:': [493, 1524], '1301-1308Crossref': [494], 'PubMed': [495, 512, 580, 627, 667, 684, 717, 768, 850, 899, 950, 1001, 1065, 1152, 1207, 1355, 1386, 1416, 1474, 1503, 1526, 1560, 1586, 1624, 1697, 1843, 1939, 1977, 2112, 2385, 2423, 2468, 2484, 2507, 2534, 2550, 2573, 3654, 3816, 3882, 3899, 3920, 3975, 3991, 4052, 4068, 4091, 4166, 4277, 4347, 4400, 4493, 4583, 4614, 4632, 4651, 4671, 4781, 4869, 5075, 5102, 5127, 5231, 5259, 5280, 5299, 5348, 5361, 5380, 5404, 5568], 'Scopus': [496, 513, 581, 628, 668, 685, 718, 731, 769, 851, 900, 951, 1002, 1066, 1153, 1344, 1356, 1417, 1475, 1504, 1527, 1561, 1625, 1669, 1844, 1940, 1978, 2113, 2386, 2424, 2469, 2485, 2508, 2535, 2551, 2574, 3655, 3761, 3817, 3883, 3900, 3976, 4053, 4069, 4092, 4167, 4278, 4348, 4401, 4494, 4508, 4584, 4615, 4633, 4652, 4672, 4691, 4782, 4928, 5076, 5103, 5128, 5232, 5260, 5281, 5300, 5349, 5362, 5381, 5405, 5456, 5569], '(242)': [497], '3Drexler': [500], 'H.': [501, 507, 931, 933, 982, 984, 1455, 1457, 1553, 1920, 1922, 1958, 1960, 2093, 2366, 2368, 2404, 2406, 3635, 4748, 5059, 5265, 5267, 5271, 5273, 5356, 5442], 'Zeiher': [502], 'A.M.': [503, 1048, 1233, 1280, 1333, 1826, 4149, 4260, 4330, 4383, 5551], 'Meinzer': [504], 'K.': [505, 2097, 3639, 3796, 3995, 4607, 4644, 5290], 'Just': [506], 'Lancet.': [508, 846], '1991;': [509, 577, 1201, 3896, 3972, 5124, 5228], '338:': [510], '1546-1550Abstract': [511], '(719)': [514], 'Scholar),': [516, 688, 1943, 2389, 3658, 4008, 4095, 4170, 4351, 4587, 4785, 5079, 5303, 5572], 'linked': [520], 'and/or': [525, 5172], '(NO)': [532], '1The': [533], 'abbreviations': [534], 'used': [535, 1422, 2430, 4731], 'are:': [536], 'NOnitric': [537], 'oxideO⨪2superoxideox-LDLoxidized': [538], 'lipoproteinLOX-1lectin-like': [541], 'receptor-1BAEC(s)bovine': [543], 'cell(s)ROSreactive': [546], 'speciesMDA-LDLmalondialdehyde-modified': [548], 'LDLCHOChinese': [549], 'hamster': [550, 793, 1434], 'ovaryBLOX-1bovine': [551], 'LOX-1HEhydroethidinen-LDLnative': [552], 'LDLAc-LDLacetyl-LDLTB4tetrahydrobiopterinl-NMMAl-N-monomethyl': [553], 'argininel-NAMEl-N-arginine': [554], 'methyl': [555, 805, 2023], 'esterDPIdiphenyleneiodoniumeNOSendothelial': [556], 'synthaseMFImean': [559], 'fluorescence': [560, 813, 2746, 3625, 3713], 'intensityd-NMMAd-N-monomethyl': [561], 'arginineDAF-2': [562], 'DA4,5': [563], 'diaminofluorescein': [564, 818], 'diacetate': [565, 819, 1542, 1721], '(4Cooke': [566, 5217], 'Andon': [568, 5219], 'N.A.': [569, 2274, 5220], 'Girerd': [570, 5221], 'Circulation.': [576, 3895, 3971, 4777, 4924, 5227, 5295, 5344, 5357], '83:': [578, 1414, 1501, 3897, 3973, 5229], '1057-1062Crossref': [579, 5230], '(313)': [582, 5233], '5Greene': [585], 'B.': [586], 'Pacitti': [587], 'A.J.': [588], 'Souba': [589], 'W.W.': [590], 'Am.': [591, 1580, 2275, 5250], 'J.': [592, 661, 678, 755, 1054, 1146, 1198, 1237, 1284, 1377, 1404, 1491, 1520, 1581, 1618, 1688, 1832, 2103, 2276, 2501, 2567, 3645, 3811, 3911, 3982, 4085, 4155, 4266, 4336, 4389, 4579, 4608, 4660, 4680, 4746, 4860, 5064, 5120, 5122, 5251, 5557], 'Physiol.': [593, 1582], '1993;': [594, 681, 728, 1557, 2465, 2481, 2531, 2547, 4049, 4065, 4505], '264:': [595, 1381], '351-356PubMed': [596], 'Scholar).': [598, 631, 734, 772, 854, 903, 954, 1005, 1069, 1243, 1290, 1318, 1359, 1388, 1420, 1507, 1530, 1588, 1628, 1699, 1847, 2116, 2283, 2511, 2577, 3820, 3922, 4281, 4404, 4511, 4694, 5131, 5384, 5408], '(6Boger': [614], 'R.H.': [615, 650], 'Bode-Boger': [616], 'S.M.': [617], 'Frolich': [618, 657], 'J.C.': [619, 658], 'Atherosclerosis.': [620], '1996;': [621, 1240, 1287], '127:': [622], '1-11Abstract': [623], 'Full': [624, 896, 1060, 1062, 1204, 1383, 1694, 1838, 1840, 3917, 3988, 4161, 4163, 4272, 4274, 4342, 4344, 4395, 4397, 4666, 4668, 4686, 4688, 4866, 5070, 5072, 5256, 5563, 5565], 'Text': [625, 897, 1061, 1063, 1205, 1384, 1695, 1839, 1841, 3918, 3989, 4162, 4164, 4273, 4275, 4343, 4345, 4396, 4398, 4667, 4669, 4687, 4689, 4867, 5071, 5073, 5257, 5564, 5566], 'PDF': [626, 898, 1064, 1206, 1385, 1696, 1842, 3919, 3990, 4165, 4276, 4346, 4399, 4670, 4690, 4868, 5074, 5258, 5567], '(161)': [629], 'release': [634, 2004, 3579, 5043], 'radicals': [638, 1640], 'sharply': [640], 'atherosclerotic': [643, 746, 842, 5205], 'arteries': [644, 881], '(7Mugge': [645], 'A.': [646, 652, 1036, 1040, 1046, 1191, 1216, 1220, 1223, 1263, 1267, 1270, 1308, 1340, 1814, 1818, 1824, 4137, 4141, 4147, 4248, 4252, 4258, 4318, 4322, 4328, 4371, 4375, 4381, 4913, 5061, 5116, 5292, 5333, 5376, 5539, 5543, 5549], 'Brandes': [647], 'Boger': [649], 'Dwenger': [651], 'Bade-Boger': [653], 'S.': [654, 656, 724, 939, 990, 1339, 1374, 1463, 1928, 1966, 2374, 2412, 2494, 2496, 2560, 2562, 3756, 4078, 4080, 4501, 4851, 4909, 5063, 5269, 5375], 'Kienke': [655], 'Lichtlen': [659], 'P.R.': [660], 'Cardiovasc.': [662], 'Pharmacol.': [663, 712, 4488, 5123], '1994;': [664, 765, 847, 891, 2504, 2570, 3914, 3985, 4088, 4611, 4629], '24:': [665], '994-998Crossref': [666], '(128)': [669], '8Ohara': [672], 'Y.': [673, 935, 941, 986, 992, 1459, 1465, 1924, 1930, 1962, 1968, 2099, 2105, 2370, 2376, 2408, 2414, 3641, 3647, 5092], 'Peterson': [674], 'T.E.': [675], 'Clin.': [679, 1147, 2502, 2568, 4086], 'Invest.': [680, 1148, 2503, 2569, 4087], '91:': [682], '2546-2551Crossref': [683], '(1656)': [686], 'cytotoxic': [703, 4479], 'formed': [707, 4483], '(9Ignarro': [708, 4484], 'R.J.': [709, 1141, 4485], 'Annu.': [710, 4486], 'Rev.': [711, 4487], 'Toxicol.': [713, 4489], '30:': [715, 4491], '535-560Crossref': [716, 4492], '(1224)': [719, 4495], 'Scholar,10Huie': [721], 'R.E.': [722, 4499], 'Padmaja': [723, 4500], 'Free': [725, 4502], 'Radic.': [726, 4503], '18:': [729, 3880, 4506], '195-199Crossref': [730, 4507], '(2028)': [732, 4509], 'peroxynitrite-derived': [738], 'nitrotyrosines': [739], 'recently': [741, 1010], 'demonstrated': [743], 'human': [745], 'lesions': [747, 843], '(11Beckman': [748], 'J.S.': [749, 2461, 2500, 2527, 2566, 4045, 4084, 5237], 'Ye': [750], 'Y.Z.': [751], 'Anderson': [752], 'P.G.': [753], 'Chen': [754], 'Accavitti': [756], 'Tarpey': [758], 'M.M.': [759], 'White': [760], 'Biol.': [762, 1055, 1378, 1620, 1689, 1833, 3912, 3983, 4156, 4267, 4337, 4390, 4610, 4661, 4681, 4861, 5065, 5558], 'Chem.': [763, 1056, 1379, 1690, 1834, 3913, 3984, 4157, 4268, 4338, 4391, 4662, 4682, 4862, 5066, 5559], 'Hoppe-Seyler.': [764], '375:': [766], '81-88Crossref': [767], '(1076)': [770], 'oxidized': [776, 5428], 'cell(s)': [786], 'malondialdehyde-modified': [790], 'LDL': [791, 799, 1129, 1162, 1172, 1247, 1320, 1362, 1744, 2873, 2878, 2884, 3537, 3941, 5395, 5425, 5494], 'Chinese': [792, 1433], 'ovary': [794], 'hydroethidine': [797, 1610], 'native': [798, 1743, 2877, 5424], 'acetyl-LDL': [800, 1746], 'tetrahydrobiopterin': [801, 1771], 'l-N-monomethyl': [802, 2018], 'arginine': [803, 816, 2019, 2050, 2175, 2328, 2445, 4031], 'l-N-arginine': [804], 'ester': [806, 2024], 'diphenyleneiodonium': [807, 2035], 'mean': [812, 2745, 3190, 3218], 'intensity': [814, 2747, 3714], 'd-N-monomethyl': [815], '4,5': [817], 'observed': [827], 'induce': [829, 876], 'abnormalities': [830], 'function,': [833], 'relevant': [837], 'for': [838, 908, 1128, 1177, 1423, 1633, 1732, 1756, 1806, 2039, 2149, 2167, 2208, 2310, 2646, 2709, 2724, 2737, 2810, 2854, 2898, 3069, 3125, 3206, 3226, 3393, 3401, 3629, 3703, 3942, 4310, 4569, 4696, 5200, 5531], 'progression': [840], '(12Witztum': [844], 'J.L.': [845, 5239], '344:': [848], '793-795Abstract': [849], '(1261)': [852], 'functional': [857], 'alterations': [858], 'involved': [865, 967, 4836, 4971, 5144], 'reduction': [868, 1681, 3458, 4536, 5177], 'vasodilation,': [870], 'response': [872, 1890, 2353, 3203, 5515], 'stimuli': [874], 'release,': [878], 'isolated': [880, 1391], 'exposed': [882, 1097, 3687], '(13Noll': [885], 'G.': [886, 1197, 1225, 1272, 1615, 1617, 3890, 3966, 4917], 'Luscher': [887, 3893, 3969], 'T.F.': [888, 3790, 3894, 3970, 4659], 'Thromb.': [889], '74': [892], 'Suppl.': [893], '1:': [894], 'S45-S54Abstract': [895], '(30)': [901], 'Recently,': [904], 'ox-LDL,': [909, 1742, 2062, 2301, 3824], 'called': [910], 'cloned': [916], 'from': [917, 1105, 1859, 2969, 2984, 2999], 'cultured': [918, 1393, 1480, 3906, 3934], '(BAECs)': [923], '(14Sawamura': [924, 975, 1448, 1913, 1951, 2359, 2397], 'T.': [925, 929, 937, 943, 945, 976, 980, 988, 994, 996, 1053, 1398, 1406, 1408, 1410, 1449, 1453, 1461, 1467, 1469, 1485, 1493, 1495, 1497, 1831, 1914, 1918, 1926, 1932, 1934, 1952, 1956, 1964, 1970, 1972, 2101, 2360, 2364, 2372, 2378, 2380, 2398, 2402, 2410, 2416, 2418, 3643, 4154, 4265, 4335, 4388, 4605, 4646, 4923, 5440, 5444, 5446, 5448, 5450, 5556], 'Kume': [926, 977, 1399, 1450, 1486, 1915, 1953, 2361, 2399], 'N.': [927, 978, 1400, 1451, 1487, 1661, 1916, 1954, 2095, 2107, 2362, 2400, 3637, 3649, 3809, 4915, 5438], 'Aoyama': [928, 979, 1452, 1917, 1955, 2363, 2401, 5443], 'Moriwaki': [930, 981, 1454, 1919, 1957, 2365, 2403, 5441], 'Hoshikawa': [932, 983, 1456, 1921, 1959, 2367, 2405], 'Alba': [934, 985, 1458, 1923, 1961, 2369, 2407], 'Tnaka': [936, 987, 1460, 1925, 1963, 2371, 2409], 'Miwa': [938, 989, 1462, 1927, 1965, 2373, 2411], 'Katsura': [940, 991, 1464, 1929, 1967, 2375, 2413], 'Kita': [942, 993, 1409, 1466, 1496, 1931, 1969, 2377, 2415, 5449], 'Masaki': [944, 995, 1407, 1468, 1494, 1933, 1971, 2379, 2417, 5447], 'Nature.': [946, 997, 1470, 1935, 1973, 2381, 2419, 3757, 4004], '1997;': [947, 998, 1471, 1583, 1666, 1936, 1974, 2382, 2420, 4580, 5067], '386:': [948, 999, 1472, 1937, 1975, 2383, 2421], '73-77Crossref': [949, 1000, 1473, 1938, 1976, 2384, 2422], '(1176)': [952, 1003, 1476, 1941, 1979, 2387, 2425], 'It': [955], 'uptake': [961], 'activation': [970], 'or': [971, 1727, 1944, 2390, 2735, 2808, 2912, 3780, 3828, 3933, 5426], 'dysfunction': [972], 'atherogenesis': [974], 'reported': [1011, 1256, 4307, 5528], 'determined': [1017, 1250, 1654, 1678, 2450], 'increase': [1020, 2743, 2750, 2863, 3134, 3241, 3288, 3711, 3786, 4193, 4594], '(ROS)': [1028], '(15Cominacini': [1032, 1810, 4133, 4244, 4314, 4367, 5535], 'L.': [1033, 1042, 1187, 1211, 1229, 1258, 1276, 1811, 1820, 4134, 4143, 4245, 4254, 4315, 4324, 4368, 4377, 4907, 5249, 5536, 5545], 'Fratta': [1034, 1221, 1268, 1812, 4135, 4246, 4316, 4369, 5537], 'Pasini': [1035, 1222, 1269, 1813, 4136, 4247, 4317, 4370, 5538], 'Garbin': [1037, 1188, 1212, 1259, 1815, 4138, 4249, 4319, 4372, 5540], 'U.': [1038, 1189, 1213, 1260, 1338, 1519, 1816, 4139, 4250, 4320, 4373, 5374, 5541], 'Davoli': [1039, 1190, 1219, 1266, 1817, 4140, 4251, 4321, 4374, 5542], 'Tosetti': [1041, 1819, 4142, 4253, 4323, 4376, 5544], 'Campagnola': [1043, 1217, 1264, 1821, 4144, 4255, 4325, 4378, 5546], 'M.': [1044, 1218, 1265, 1657, 1822, 3802, 3875, 4145, 4256, 4326, 4379, 4601, 4603, 4750, 5275, 5547], 'Rigoni': [1045, 1823, 4146, 4257, 4327, 4380, 5548], 'Pastorino': [1047, 1232, 1279, 1825, 4148, 4259, 4329, 4382, 5550], 'Lo': [1049, 1234, 1281, 1827, 4150, 4261, 4331, 4384, 5552], 'Cascio': [1050, 1235, 1282, 1828, 4151, 4262, 4332, 4385, 5553], 'V.': [1051, 1236, 1283, 1829, 4152, 4263, 4333, 4386, 4919, 5114, 5554], 'Sawamura': [1052, 1405, 1492, 1830, 4153, 4264, 4334, 4387, 5445, 5555], '2000;': [1057, 1835, 4158, 4269, 4339, 4392, 4778, 4925, 5560], '275:': [1058, 1836, 4159, 4270, 4340, 4393, 5561], '12633-12638Abstract': [1059, 1837, 4160, 4271, 4341, 4394, 5562], '(472)': [1067, 1845, 4168, 4279, 4349, 4402, 5570], 'report': [1072], 'investigated': [1074], 'relationship': [1076, 3665], 'between': [1077, 1429, 3666], 'ROS': [1082, 1532, 1791, 2347, 3139, 3149, 3238, 3273, 3671, 4195, 4204, 4241, 4292, 4305, 4365, 4451, 4570, 4596, 4701, 5410, 5517, 5525], 'O⨪2and': [1087], 'cultures': [1094], 'BAECs': [1096, 1389, 1629, 1701, 2010, 2118, 2207, 2309, 2579, 2718, 2805, 2892, 2951, 3066, 3122, 3278, 3330, 3473, 3487, 3686, 3697, 3777, 4213, 4232, 4415, 4440, 4826, 5018], 'ox-LDL.': [1099, 1643, 3232, 3689, 3951, 5021, 5522], 'Whole': [1100], 'blood,': [1101], 'obtained': [1102, 2186], 'venipuncture': [1104], 'healthy': [1106], 'volunteers': [1107], '12': [1109, 2837, 2992], 'h': [1110, 1179], 'fasting,': [1112], 'collected': [1114], 'into': [1115, 1649, 4032], 'Vacutainer': [1116], 'tubes': [1117], '(Becton': [1118], 'Dickinson,': [1119], 'Meylan,': [1120], 'France)': [1121], 'containing': [1122, 1157, 1713, 1869, 2145, 2228], 'EDTA': [1123, 2674], '(1': [1124], 'mg/ml)': [1125], 'processed': [1127], 'separation': [1130], 'within': [1131, 5388], 'day': [1133], 'sequential': [1135], 'flotation': [1136], 'NaBr': [1138], 'solution': [1139], '(16Havel': [1140], 'Eder': [1142], 'Bragdon': [1144], 'J.M.': [1145, 1685, 5367], '1955;': [1149], '34:': [1150, 2280], '1345-1353Crossref': [1151], '(6498)': [1154], 'Scholar)': [1156, 1478, 1564, 1672, 1981, 2427, 3764, 3903, 4756, 4871, 4931, 5106, 5459], 'mg/ml': [1159], 'EDTA.': [1160], 'Cu2+-modified': [1161], '(1.7': [1163, 2675], 'mg': [1164, 2846], 'protein/ml)': [1166, 1740, 2299, 3078, 3409], 'prepared': [1168, 1323], 'exposure': [1170, 2843, 3584, 3775, 5161], '5': [1174, 1757, 1766, 1906, 2037, 2048, 2168, 2173, 2326, 2738, 2852, 2899, 3126, 3178, 3402], 'βm': [1175, 1719, 1729, 1770, 2053, 2178, 2331, 2613, 2721, 3700], 'CuS04': [1176], '18': [1178, 2855], 'at': [1180, 1426, 1759, 2042, 2152, 2649, 2658, 2727, 2813, 2856, 2934, 3706, 4113], '37': [1181, 1760, 2043, 2153, 2650, 2728, 2814, 2857, 3707], '°C': [1182, 1761, 2044, 2729, 2815, 2858, 3708], 'described': [1184, 1328, 1395, 1482, 1547, 2269, 2452, 3452], 'previously': [1185, 1327, 1396, 1483, 1596, 2270, 2453], '(17Cominacini': [1186], 'Micciolo': [1192, 1230, 1277], 'Bosello': [1194], 'O.': [1195], 'Gaviraghi': [1196], 'Lipid': [1199, 1238, 1285], '32:': [1202], '349-358Abstract': [1203], '18Cominacini': [1210], 'De': [1214, 1261], 'Santis': [1215, 1262], 'Faccini': [1224, 1271], 'Pasqualini': [1226, 1273], 'E.': [1227, 1274, 3804, 3806], 'Bertozzo': [1228, 1275], 'Med.': [1239, 1286, 3812], '13:': [1241, 1288], '19-33Google': [1242, 1289], 'extent': [1245], 'oxidation': [1248, 1539, 5393, 5422], 'thiobarbituric': [1252, 2865], 'acid-reactive': [1253, 2866], 'substances': [1254, 2867], '(18Cominacini': [1257], 'Protein': [1291], 'measured': [1293, 3213, 5511], 'Pierce': [1296], 'BCA': [1297], 'protein': [1298, 2957], 'assay': [1299, 2513, 2653, 2670, 2681], 'reagent': [1300], '(19Smith': [1301], 'P.K.': [1302], 'Krohn': [1303], 'R.I.': [1304], 'Hermanson': [1305], 'G.T.': [1306], 'Mallia': [1307], 'Gartner': [1309], 'F.H.': [1310], 'Provenzano': [1311], 'A.C.': [1312, 5337], 'Anal.': [1313, 1350, 1664], 'Biochem.': [1314, 1351, 1555, 1665, 3876, 5095], '1985;': [1315], '105:': [1316], '293-299Google': [1317], 'Malondialdehyde-modified': [1319], '(MDA-LDL)': [1321], 'according': [1324, 1512], 'method': [1329, 1515], '(20Haberland': [1330], 'M.E.': [1331, 5294], 'Fogelman': [1332], 'Proc.': [1334, 5370], 'Natl.': [1335, 5371], 'Acad.': [1336, 5372], 'Sci.': [1337, 5373], '1988;': [1341, 3758, 3813, 5377, 5401], '82:': [1342], '2693-2697Crossref': [1343], '(86)': [1345], '21Habeeb': [1348], 'A.F.': [1349, 4776], '1966;': [1352], '14:': [1353], '328-336Crossref': [1354], '(1936)': [1357], 'Acetylation': [1360], 'achieved': [1364], 'repeated': [1366, 2672], 'additions': [1367], 'acetic': [1369], 'anhydride': [1370], '(22Sparrow': [1371], 'C.P.': [1372], 'Parthasarathy': [1373], 'Steinberg': [1375], 'D.': [1376, 3792, 5110, 5118], '2599-2604Abstract': [1382], 'were': [1390, 1425, 1479, 1630, 1705, 1750, 1863, 1982, 2011, 2122, 2156, 2204, 2221, 2306, 2428, 2581, 2628, 3067, 3152, 3345, 3385, 3398], '(23Murase': [1397, 1484], 'Korenaga': [1401, 1488], 'Ando': [1403, 1490], '1998;': [1413, 1500, 2109, 3651, 5099, 5453], '328-333Crossref': [1415, 1502], '(188)': [1418, 1505], 'Cells': [1421, 2155], 'experiments': [1424, 3100, 3427], 'passage': [1427], 'levels': [1428, 2258, 2793, 2965, 4726], '2': [1430, 2603], '4.': [1432], 'ovary-K1': [1435], '(CHO-K1)': [1436], 'CHO-K1': [1440, 3301, 3343], 'cell': [1441, 2066, 2263, 4574, 4944], 'line': [1442], 'stably': [1443], 'expressing': [1444], '(BLOX-1-CHO)': [1447], 'Cell': [1508, 2620, 4609], 'survival': [1509], 'monitored': [1511, 1535], 'Landegren': [1517], '(24Landegren': [1518], 'Immunol.': [1521], 'Methods.': [1522], '1984;': [1523, 5296], '379-385Crossref': [1525], '(603)': [1528], 'Intracellular': [1531, 1589], 'following': [1537], '2′,7′-dichlorofluorescin': [1541, 1720], 'flow': [1544, 1598, 1881, 2090, 2240], 'cytometry': [1545, 1599, 1882, 2091, 2241], 'Royall': [1549], '(25Royall': [1550], 'J.A.': [1551, 2498, 2564, 4082, 5327], 'Ischiropoulos': [1552], 'Arch.': [1554], 'Biophys.': [1556, 5096, 5399], '302:': [1558], '348-355Crossref': [1559], '(1050)': [1562], 'slightly': [1566, 3153, 3596], 'modified': [1567, 1709, 3832], 'Zulueta': [1569], '(26Zulueta': [1570], 'J.J.': [1571, 4774], 'Sawhney': [1572], 'Feng': [1574], 'S.Y.': [1575], 'Cote': [1576], 'C.C.': [1577], 'Hassoun': [1578], 'P.M.': [1579, 5354], '272:': [1584, 5068], '897-902Crossref': [1585], 'detected': [1593], 'using': [1594, 2697], 'established': [1597], 'technique': [1600], 'based': [1601], 'O⨪2-induced': [1604], 'conversion': [1605, 4028], 'oxidant-sensitive': [1608], 'dye,': [1609], '(HE)': [1611], 'ethidium': [1613], '(27Rothe': [1614], 'Valet': [1616], 'Leukocyte': [1619], '47:': [1622], '440-446Crossref': [1623], '(783)': [1626], 'tested': [1632], 'H2O2': [1637, 1647, 3193], 'amount': [1645], 'released': [1648], 'culture': [1651, 3684], 'medium': [1652, 1711, 1755], 'fluorimetrically': [1655], '(28Zhou': [1656], 'Diwu': [1658], 'Z.': [1659], 'Panhuk-Voloshina': [1660], 'Haugland': [1662], 'R.P.': [1663], '15:': [1667], '162-168Crossref': [1668], '(1126)': [1670], 'and,': [1673], 'photometrically': [1679], 'cytochrome': [1683, 3215], 'c(29McCord': [1684], 'Fridovich': [1686], 'I.': [1687], '1969;': [1691], '244:': [1692], '6049-6055Abstract': [1693], 'Confluent': [1700, 2117], '24-well': [1703, 2120], 'plates': [1704, 2121], 'incubated': [1706, 1983, 2123, 2307, 3068, 3400], "Dulbecco's": [1708], "Eagle's": [1710], '(Sigma)': [1712], '10%': [1714], 'fetal': [1715], 'serum,': [1717], '10': [1718, 2146, 2150, 2589, 2600, 2606, 2644, 2720, 2725, 2811, 3699, 3704], '(Eastman': [1722], 'Kodak': [1723], 'Co.,': [1724], 'Rochester,': [1725], 'NY),': [1726], 'HE': [1730], '(Kodak)': [1731], '20': [1733, 2647], 'min.': [1734, 3395], 'Increasing': [1735], 'concentrations': [1736, 2343], '(50–150': [1737, 2296], 'βg': [1738, 2297, 2625, 2939, 2954, 3076, 3184, 3228, 3407], '(n-LDL),': [1745], '(Ac-LDL),': [1747], 'MDA-LDL': [1749, 2065, 2305], 'then': [1751, 1804, 2157, 2222, 3399], 'added': [1752], 'mmarginine': [1767], '3': [1769, 2052, 2177, 2330], '(TB4).': [1772], 'time': [1775, 1852, 3017, 3112, 5203], 'chosen': [1777, 1854], 'basis': [1780, 3448, 5026], 'previous': [1782], 'data': [1783, 4128, 4224, 4430], 'showing': [1784, 3772], 'these': [1787, 4812], 'rapidly': [1797, 3841], 'first': [1800], '5–6': [1801], 'plateaued': [1805], 'longer': [1807, 4311, 5532], 'incubations': [1809, 2716, 3695, 4313, 5534], 'Furthermore': [1848, 3282, 4282, 4814], 'short': [1850], 'avoid': [1856], 'interferences': [1857], 'derived': [1858], 'internalization.': [1861], 'Samples': [1862, 2220], 'washed': [1864, 2223], 'twice': [1865, 2224], 'phosphate-buffered': [1867, 2226], 'saline': [1868, 2227], 'serum': [1871, 2230], 'albumin': [1872, 2231], 'analyzed': [1874, 2233, 3571], '7000': [1876, 2235], 'per': [1878, 2237], 'sample': [1879, 2238], '(Coulter': [1883, 2242], 'Electronics': [1884, 2243], 'GmBH,': [1885, 2244], 'Germany).': [1886, 2245], 'To': [1887, 1996, 2180, 2284, 2333, 2661, 3233], 'test': [1888, 2351, 3234, 3455], 'specificity,': [1891, 2354], 'some': [1892], 'such': [1895], 'vitamin': [1897, 2355, 3267, 3311, 3350, 3475, 3489], 'C,': [1898, 2356], 'trolox,': [1899, 3264], 'probucol': [1901], '(at': [1902], 'βm;': [1907], 'Sigma),': [1908], 'antibody': [1911], '(mAb)': [1912], 'comparable': [1945, 2391, 3379], 'amounts': [1946, 2016, 2295, 2392, 2895, 3380], 'nonimmune': [1948, 2394, 3382], 'mouse': [1949, 2395, 3383], 'IgG': [1950, 2396, 3384], 'BAECs,': [1985, 3023, 3246, 3298, 3366, 3388], 'CHO-K1,': [1986], 'BLOX-1-CHO': [1988, 3332], 'under': [1990, 2086, 2431, 2516, 3745, 4035, 4883, 4945], 'specified': [1994, 2435], 'above.': [1995, 2436], 'determine': [1997, 2662], 'oxidative': [1999, 3573, 5038, 5386, 5580], 'systems': [2000, 3574], 'contribute': [2001, 3576, 5461], 'exposure,': [2009], 'preincubated': [2013, 2205, 3248, 3297, 3334, 3386, 3472], 'different': [2015, 3252, 4215, 4417], '(l-NMMA;': [2020], '200': [2021, 2026, 2772, 2953], 'βm),l-N-arginine': [2022], '(l-NAME;': [2025], 'βm),': [2027, 2030, 2033, 2636, 2639, 3373], 'allopurinol': [2028, 3589, 4713, 4728], '(500': [2029], 'aspirin': [2031, 3595, 4715, 4730], '(100': [2032, 3075, 3406], '(DPI;': [2036], 'βm)': [2038, 2203, 2645], '30': [2040, 2209, 3394, 4542], 'mm': [2049, 2127, 2130, 2133, 2136, 2139, 2165, 2174, 2327, 2590, 2598], 'TB4.': [2054, 2179, 2332], 'our': [2056, 2712, 3165, 3691, 4010, 4131, 4515, 4831, 4895, 4966, 5135], 'conditions,': [2057, 3167, 4833], 'n-LDL,': [2061, 2302], 'Ac-LDL,': [2063, 2303], 'viability': [2067], 'always': [2069], 'greater': [2070], '95%.': [2072], 'DAF-2': [2073, 2191, 2215, 2317, 2722, 2905, 3083, 3627, 3701], 'DA': [2074, 2148, 2192, 2216, 2318, 2723, 3084, 3702], 'fluorescent': [2077, 2184], 'indicator': [2078], 'enables': [2080], 'direct': [2082, 3630], 'detection': [2083, 3631], 'physiological': [2087], '(30Kojima': [2092, 3634], 'Nakatsubo': [2094, 3636], 'Kikuchi': [2096, 3638], 'Urano': [2098, 3640], 'Higuchi': [2100, 3642], 'Tanaka': [2102, 3644], 'Kudo': [2104, 3646], 'Nagano': [2106, 3648], 'NeuroReport.': [2108, 3650], '9:': [2110, 3652], '3345-3348Crossref': [2111, 3653], '(189)': [2114, 3656], 'KRP': [2125], '(120': [2126], 'NaCl,': [2128], '4.8': [2129], 'KCl,': [2131], '0.54': [2132], 'CaCl2,': [2134], '1.2': [2135], 'MgSO4,': [2137], '11': [2138], 'glucose,': [2140], '15.9': [2141], 'mmNa3PO3,': [2142], 'pH': [2143, 2616], '7.2)': [2144], 'βmDAF-2': [2147], '°C.': [2154, 2651], '100': [2160, 2659], 'nm': [2161], 'bradykinin': [2162, 2734, 2807, 2823, 2983, 3161, 3781], '150': [2164], 'thrombin': [2166, 2736, 2809, 2833, 2998, 3779], 'verify': [2181, 2334, 3284], 'signal': [2185, 4533], 'addition': [2189, 2213, 2315, 3081, 3412], 'dependent': [2194, 2345, 3290, 3467], 'NO,': [2199], 'l-': [2200], 'andd-NMMA': [2201, 2774], '(200': [2202, 2938], 'before': [2211], 'agonists.': [2219, 3087], 'evaluated': [2253, 2790], 'measuring': [2257, 2792], 'nitrite': [2260, 2795, 2967], 'media': [2264, 2798], 'Griess': [2266], '(31Schneider': [2271], 'N.R.': [2272], 'Yeary': [2273], 'Vet.': [2277], '1973;': [2279], '133-135PubMed': [2281], 'evaluate': [2285], 'concentration,': [2293], 'increasing': [2294, 2894], '0.5–15': [2311], 'agonists,': [2321], 'mAb': [2358, 3337, 3356, 3375, 3493, 4297], 'eNOS': [2442, 3515, 3531, 4021, 4100, 4834, 4968, 4992, 5108, 5142], 'metabolism': [2443, 4760], 'of3H': [2444], '3H': [2447, 4030, 4033], 'citrulline': [2448, 3521], '(32Sessa': [2454, 2520, 4038], 'W.C.': [2455, 2474, 2492, 2521, 2540, 2558, 4039, 4058, 4076], 'J.K.': [2457, 2523, 3910, 3981, 4041], 'Luthin': [2458, 2524, 4042], 'D.R.': [2459, 2525, 4043], 'Pollock': [2460, 2526, 4044], 'Lynch': [2462, 2477, 2528, 2543, 4046, 4061], 'K.R.': [2463, 2478, 2529, 2544, 3873, 4047, 4062], 'Hypertension.': [2464, 2530, 4048], '21:': [2466, 2532, 4050], '934-938Crossref': [2467, 2533, 4051], '(82)': [2470, 2536, 4054], '33Sessa': [2473, 2539, 4057], 'Barber': [2475, 2541, 4059], 'C.M.': [2476, 2542, 3892, 3968, 4060], '72:': [2482, 2548, 4066], '921-924Crossref': [2483, 2549, 4067], '(132)': [2486, 2552, 4070], '34Rosenkranz-Weiss': [2489, 2555, 4073], 'P.': [2490, 2556, 3798, 3871, 4074, 5343], 'Sessa': [2491, 2557, 4075], 'Milstien': [2493, 2559, 4077], 'Kaufman': [2495, 2561, 4079], 'Watson': [2497, 2563, 4081], 'Pober': [2499, 2565, 4083], '93:': [2505, 2571, 4089], '2236-2243Crossref': [2506, 2572, 4090], '(344)': [2509, 2575, 4093], 'performed': [2515, 2686, 3101, 3428], 'apparent': [2517], 'Vmax': [2518], 'Briefly': [2578], 'lysates': [2580, 2621], 'suspended': [2582], 'cold': [2584], 'lysis': [2585], 'buffer': [2586], '(0.3': [2587], 'msucrose,': [2588], 'HEPES,': [2591], '1%': [2592], 'Nonidet': [2593], 'P-40,': [2594], '0.1': [2595], 'mmEDTA,': [2596], 'dithiothreitol,': [2599], 'βg/ml': [2601, 2604, 2607], 'leupeptin,': [2602], 'aprotinin,': [2605], 'soybean': [2608], 'trypsin': [2609], 'inhibitor,': [2610], '50': [2612, 3183, 3227], 'phenylmethylsulfonyl': [2614], 'fluoride,': [2615], '7.4)': [2617], 'vortexed.': [2619], '(150': [2622], '250': [2624], 'protein)': [2627, 2874], 'combined': [2629], 'NADPH': [2631, 5054, 5170], '(2': [2632], 'mm),': [2633], 'CaCl2': [2634], '(230': [2635], 'TB4': [2637], '(3': [2638], '3H-arginine': [2641], '(0.2': [2642], 'βCi,': [2643], 'volume': [2654], 'kept': [2656], 'constant': [2657], 'βl.': [2660], 'altered': [2665], 'inducible': [2666, 3564], 'NOS': [2667, 3565, 4879], 'mm)': [2676], 'replacing': [2677], 'calcium': [2678], 'buffers.': [2682], 'Statistical': [2683], 'analysis': [2684, 2688], 'variance': [2690], 'subsequently': [2692], 'post': [2694], 'hoc': [2695], 'analysis,': [2696], 'SYSTAT': [2699], 'program': [2700], 'statistical': [2702], 'software': [2703], 'manual': [2704], '(SYSTAT': [2705], 'Inc.,': [2706], 'Evanston,': [2707], 'IL)': [2708], 'Macintosh.': [2710], 'followed': [2730], 'stimulation': [2732, 2803], 'generated': [2740, 3709, 3744], 'sharp': [2742, 3131, 3785], '(MFI).': [2748], 'This': [2749], 'dose-dependently': [2752, 2907, 3723], 'suppressed': [2753, 3724], 'inhibitorl-NMMA': [2758], 'whereas': [2759, 2922, 3341, 3594, 3615], 'd-NMMA,': [2760], 'optical': [2762], 'isomer': [2763], 'ofl-NMMA,': [2764], 'inactive.': [2766], 'Fig.': [2767, 3480], '1shows': [2768], 'βml-NMMA': [2773], 'BAECs.': [2782, 3065, 3603, 3621, 4723], 'Also': [2783], 'cumulative': [2785], '(basal': [2816, 2968], '=': [2817, 2824, 2834, 3538, 3546, 3554], '110': [2818], '±': [2819, 2826, 2836, 2869, 2880, 2971, 2976, 2986, 2991, 3001, 3006, 3097, 3196, 3222, 3424, 3540, 3548], '7': [2820], 'pmol/well/h;': [2821], '370': [2825], '14': [2827, 3002], 'pmol/well/h,': [2828, 2838, 2978, 2993, 3008], 'p': [2829, 2839, 2886, 2979, 2994, 3009, 3109, 3553], '0.001;': [2831], '410': [2835], '1.7': [2845], 'protein/ml': [2848, 3186, 3230], 'n-LDL': [2850, 2923, 3827], 'βmCu2+': [2853], 'resulted': [2859], '(11.9': [2868], '1.1': [2870], 'nmol/mg': [2871, 2882], 'compared': [2875], '(0.24': [2879], '0.04': [2881], 'protein;': [2885], 'DA,': [2906, 3628], 'bradykinin-': [2911], 'thrombin-induced': [2913], '(Fig.': [2920], '2)': [2921], '(data': [2926, 2945, 3142], 'shown).': [2928, 2947, 3144], 'Similarly': [2929], 'Ac-LDL': [2930], 'MDA-LDL,': [2932], 'even': [2933, 4540], 'highest': [2936], 'protein/ml),': [2941], 'had': [2942], 'no': [2943, 3956], 'preincubation': [2949, 3485], '102': [2970], '6': [2972, 3481], 'pmol/well/h': [2973, 2988, 3003], '44': [2975], '4': [2977], '0.01;': [2981, 2996], '352': [2985], '15': [2987], '121': [2990], '401': [3000], '184': [3005], '9': [3007], 'From': [3012], 'evaluation': [3014], 'course': [3018, 5498], 'nonstimulated': [3020], 'it': [3024, 4544, 5138, 5196], 'evident': [3026], 'already': [3037, 4736], 'present': [3038], '60': [3042], 's': [3043], '(Figs.3,': [3046], 'a–c).Figure': [3047], '3Effect': [3048], 'time-course': [3053], '(A)': [3059], '(B': [3062], 'C)': [3064, 3353], 'indicated': [3071, 4592], 'times': [3072], 'Results': [3088, 3415], 'are': [3089, 3094, 3416, 3421, 3733, 3766, 3936, 4565, 4897, 5208, 5574], 'expressed': [3090, 3417], 'MFI': [3092, 3419], 'means': [3096, 3423], 'S.D.': [3098, 3425], 'triplicate': [3103, 3430], 'six': [3105, 3432], 'separate': [3106, 3433], 'occasions.': [3107, 3434], '*,': [3108], '0.001versus': [3111], '0.View': [3113], 'Large': [3114, 3441], 'Image': [3115, 3442], 'Figure': [3116, 3443], 'ViewerDownload': [3117, 3444], '(PPT)': [3118, 3445], 'but': [3154, 3597, 3608, 3825], 'thrombin.': [3163], 'triggered': [3170], 'strong': [3172], 'H2O2after': [3177], 'incubation.': [3181], 'With': [3182], 'value': [3191], '1.19': [3195], '0.3': [3197], 'nmol/106': [3198, 3224], 'cells.': [3199, 3851], 'An': [3200], 'almost': [3201, 3567, 4572], 'identical': [3202], 'seen': [3205, 3927], 'extracellular': [3210], 'C': [3216, 3268, 3312, 3351, 3371, 3476, 3490], 'values': [3219], '5.9': [3221], '0.4': [3223], 'specificity': [3236], 'antioxidants,': [3253], 'work': [3256, 4219, 4421], 'scavengers.': [3259, 4222], 'As': [3260, 3319, 4695], 'shown': [3261, 3320, 4738], 'Fig.4,': [3263], 'probucol,': [3265], 'ox-LDL-induced': [3272, 3314, 3361, 4939, 4973], 'BLOX-1-CHO,': [3299, 3367, 3389], 'mAb.': [3305, 3479, 4428], 'For': [3306], 'comparison': [3307], 'O⨪2generation': [3315], 'considered.': [3318], 'Fig.5,': [3322], 'markedly': [3327], '0.001),': [3340], 'control': [3342], 'affected.Figure': [3347], '5Effect': [3348], '(Vit.': [3352], '(': [3357], 'Ab)': [3359], 'variations': [3362], 'CHO': [3369, 3391], 'cells.Vitamin': [3370], '(5': [3372], '(30': [3376], 'βg/ml),': [3377], 'HE.': [3414], '*,p': [3435], '0.001': [3437], 'versus': [3438], 'alone.View': [3440], 'On': [3446], 'above,': [3453], 'generation,': [3470, 5147, 5465], 'shows': [3482], 'counteracted': [3495], 'the3H': [3520], 'assay.': [3522], 'metabolize': [3533, 4023], 'l-arginine': [3534, 4024, 4892, 4935], 'tol-citrulline': [3535], '(native': [3536], '64.6': [3539], '9.4': [3541], 'pmol': [3542, 3550], 'citrulline/mg': [3543, 3551], 'protein/min;': [3544], '58.7': [3547], '8.9': [3549], 'protein/min,': [3552], 'significant).': [3556], 'EDTA,': [3560], 'undetectable.': [3568], 'We': [3569, 3586, 3821], '(Fig.7).': [3585], 'found': [3587, 3822, 4711, 4873], 'insignificantly': [3598], 'contrast,': [3605], 'l-NAME': [3606, 4818], 'andl-NMMA': [3607, 4819], 'd-NAME': [3610], 'd-NMMA': [3612], 'DPI': [3616, 5012], 'drastically': [3617, 4936, 5013], 'O⨪2production': [3619], 'Using': [3622], 'novel': [3624], 'indicator,': [3626], 'agonist-stimulated': [3719], 'cells,': [3720], 'inhibitor': [3729, 5052], 'l-NMMA.': [3730], 'These': [3731, 3923, 4223], 'consistent': [3734, 4899], 'several': [3736, 4589], 'lines': [3737], 'evidences': [3739], 'suggesting': [3740, 3945], '(35Palmer': [3751], 'R.M.J.': [3752], 'Ashton': [3753], 'D.S.': [3754, 4855], 'Moncada': [3755], '336:': [3759], '664-666Crossref': [3760], '(4127)': [3762], 'agreement': [3768, 3957, 4124], 'published': [3770, 4129], '5-min': [3774], '(36Luscher': [3789], 'Diederich': [3791], 'Siebermann': [3793], 'Lehmann': [3795], 'Stulz': [3797], 'Yang': [3799], 'Z.H.': [3800, 4640], 'Turina': [3801], 'Gradel': [3803], 'Weber': [3805], 'Buhler': [3807], 'F.R.': [3808], 'Engl.': [3810], '319:': [3814], '462-467Crossref': [3815], '(473)': [3818], 'other': [3829], 'forms': [3830], 'LDL,': [3833, 5429], 'fashion': [3838], 'very': [3840, 4126, 4530, 5209], 'Our': [3852, 4840, 4948], 'agree': [3854, 4842], 'series': [3857], 'studies': [3859], 'addressing': [3860], 'effects': [3862, 3924], 'arterial': [3866], 'rings': [3867], '(37Plane': [3868], 'F.': [3869, 4911], 'Kerr': [3870], 'Bruckdorfer': [3872], 'Jacobs': [3874], 'Soc.': [3877], 'Trans.': [3878], '1177-1178Crossref': [3881], '(16)': [3884], '38Tanner': [3887], 'F.C.': [3888, 3964], 'Noll': [3889, 3965], 'Boulanger': [3891, 3967], '2012-2020Crossref': [3898, 3974], '(304)': [3901, 3977], '(39Liao': [3909], '269:': [3915, 3986], '12987-12992Abstract': [3916, 3987], 'have': [3925, 4591, 4735, 5190], 'occur': [3929], 'when': [3930], 'segments': [3932], 'placed': [3937], 'contact': [3939], 'long': [3943, 5202], 'periods': [3944], 'inhibition': [3946], 'synthesis': [3949], 'Even': [3952, 4975], 'if': [3953, 4976], 'there': [3954], 'regarding': [3958], 'interpretation': [3959], 'phenomenon': [3962, 4978, 5481], '(38Tanner': [3963], '39Liao': [3980], '40Kugiyama': [3994], 'Kerns': [3996], 'S.A.': [3997], 'Morrisett': [3998], 'J.D.': [3999, 4624], 'Roberts': [4000], 'Henry': [4002], 'P.D.': [4003], '66:': [4006], '18-27Google': [4007], 'alter': [4017], 'tol-citrulline.': [4025], 'Because': [4026, 4724, 4886], 'citrulline,': [4034], 'apparentVmax': [4036], 'measure': [4098], 'levels,': [4101], 'alter,': [4112], 'least': [4114], 'quantitatively,': [4115], 'produce': [4119], 'NO.': [4120, 5002, 5586], 'Interestingly': [4121], 'recent': [4127], 'group': [4132], 'demonstrate': [4177], 'rapid': [4180, 5514], 'parallelled': [4188], 'specular': [4191], 'fast': [4192], 'formation.': [4198], 'prevented': [4210, 4294, 4412], 'preincubating': [4212, 4414], 'antioxidants': [4216, 4418], 'confirm': [4225], 'associated': [4234, 4442], 'fact': [4284, 4300, 4816, 5505], 'persist': [4309, 5530], 'strongly': [4352], 'support': [4353, 4431, 4961], 'ligation': [4357, 4599, 4800, 5414], 'plays': [4360], 'role': [4362], 'conclusion': [4433, 4963, 5149, 5500, 5588], 'receptor-dependent,': [4445], 'abnormally': [4446], 'therefore': [4459], 'secondary': [4462, 4553], 'formation,': [4465], '10Huie': [4498], 'Furthermore,': [4512], 'because': [4513, 5133, 5524], 'receptor-mediated': [4527], 'consequently': [4529], 'fast,': [4531], 'being': [4537], 'clearly': [4538, 5009], 'visible': [4539], 's,': [4543], 'unlikely': [4546, 5140], 'intracellularly': [4558], 'internalized': [4559], 'lipid': [4561], 'peroxyl': [4562], 'radicals.': [4563], 'There': [4564], 'many': [4566], 'enzymatic': [4567], 'sources': [4568, 4699], 'all': [4573], 'types': [4575], '(41Lander': [4576], 'H.M': [4577], 'FASEB': [4578], '11:': [4581], '118-124Crossref': [4582], '(823)': [4585], 'findings': [4590, 4845, 4949], 'upon': [4597], '(42Ohba': [4600], 'Shibanuma': [4602], 'Kuroki': [4604], 'Nose': [4606], '126:': [4612], '1079-1088Crossref': [4613], '(436)': [4616], '43Griendling': [4619], 'K.K.': [4620], 'Minieri': [4621], 'C.A.': [4622, 4766], 'Ollerenshaw': [4623], 'Alexander': [4625], 'R.W.': [4626], '74:': [4630], '1141-1148Crossref': [4631], '(2411)': [4634], '44Sunderasan': [4637], 'M.,': [4638], 'Yu,': [4639], 'Ferrans': [4641], 'Irani': [4643], 'Finkel': [4645], 'Science.': [4647, 5276], '1995;': [4648, 4663, 4683], '270:': [4649, 4664, 4684], '296-299Crossref': [4650], '(2322)': [4653], '45Lo': [4656], 'Y.Y.': [4657], 'Cruz': [4658], '11727-11730Abstract': [4665], '(474)': [4673], '46Thannickal': [4676], 'Fanburg': [4678], 'B.L.': [4679], '3033-3038Abstract': [4685], '(381)': [4692], 'potential': [4698], 'LOX-1,': [4709], 'completely': [4740, 4981], 'block': [4741], 'xantine': [4742], 'oxidase': [4743, 5055, 5171], '(47Maclouf': [4745], 'Sors': [4747], 'Rigaud': [4749], 'Biomedicine.': [4751], '1977;': [4752, 5253], '362-375PubMed': [4754], 'arachidonic': [4758], 'acid': [4759], 'cycloxygenase': [4762], '(48Berry': [4763], 'C.': [4764], 'Hamilton': [4765], 'Brosnan': [4767], 'M.J.': [4768], 'Magill': [4769], 'F.G.': [4770], 'Berg': [4771], 'G.A.': [4772], 'McMurray': [4773], 'Dominikzac': [4775], '101:': [4779], '2206-2212Crossref': [4780], '(288)': [4783], 'indicate': [4791], 'related': [4807, 5164], 'enzymes.': [4813], 'reduce': [4822], 'reasonably': [4827], 'excludes': [4828], 'that,': [4829], 'generation.': [4839], 'Pou': [4847, 4852], 'et': [4848], 'al.': [4849, 4905], '(49Pou': [4850], 'W.S.': [4853], 'Bredt': [4854], 'Snyder': [4856], 'S.H.': [4857], 'Rosen': [4858], 'G.M.': [4859], '1992;': [4863], '267:': [4864], '24173-24176Abstract': [4865], 'who': [4872, 4932], 'l-NMMA': [4875, 4952], 'blocked': [4876], 'neuronal': [4877], 'brain': [4878], 'only': [4882, 5512], 'uncoupling': [4884, 4946], 'conditions.': [4885, 4947], 'worked': [4888], 'excess': [4890], 'TB4,': [4894], 'Vergnaniet': [4904], '(50Vergnani': [4906], 'Hatrik': [4908], 'Ricci': [4910], 'Passaro': [4912], 'Manzoli': [4914], 'Zuliani': [4916], 'Brovkovych': [4918], 'Fellin': [4920], 'Malinski': [4922], '102:': [4926], '1261-1266Crossref': [4927], '(220)': [4929], 'showed': [4933], 'thatl-NAME': [4950], 'further': [4960, 5463], 'O⨪2generation.': [4974], 'clear,': [4982], 'hypothesis': [4984], 'could': [4985, 5419, 5433, 5467, 5482], 'inhibitors,': [4993], 'quenched': [4997], 'Finally': [5003], 'Of': [5022, 5497], 'course,': [5023], 'result': [5029, 5184], 'cannot': [5031], 'draw': [5032], 'any': [5033], 'conclusive': [5034], 'assumption': [5035], 'system': [5039], 'contributes': [5040], 'exposure.': [5048], 'DPI,': [5049], 'selective': [5051], '(51Bhunia': [5056], 'A.K.': [5057], 'Han': [5058], 'Snowden': [5060], 'Chatterjee': [5062], '15642-15649Abstract': [5069], '(180)': [5077], 'inhibits': [5081], 'mitochondrial': [5082, 5173], 'NADH': [5086], 'ubiquinone': [5087], 'oxidoreductase': [5088], '(complex': [5089], 'I)': [5090], '(52Li': [5091], 'Trush': [5093], 'Commun.': [5098], '253:': [5100], '295-299Crossref': [5101], '(402)': [5104], '(53Salvemini': [5109], 'Radziszewsky': [5111], 'W.': [5112], 'Mollace': [5113], 'Moore': [5115], 'Willoughty': [5117], 'Vane': [5119, 5368], 'Eur.': [5121], '199:': [5125], '15-18Crossref': [5126], '(44)': [5129], 'However,': [5132, 5523], 'another': [5148], 'complex': [5174], '1.': [5175], 'implications': [5191], 'vivo.': [5193], 'fact,': [5195], 'recognized': [5199], 'blood': [5206], 'vessels': [5207], 'susceptible': [5210], 'development': [5213], 'vasospasmin': [5215], 'vivo': [5216], '54Schroeder': [5236], 'Bolen': [5238], 'Quint': [5240], 'R.A.': [5241], 'D.A.': [5243], 'Hayden': [5244], 'W.G.': [5245], 'Higgins': [5246], 'C.B.': [5247, 5329], 'Wexler': [5248], 'Cardiol.': [5252], '40:': [5254], '487-491Abstract': [5255], '(228)': [5261], '55Shimokawa': [5264], 'Tomoike': [5266], 'Nabeyama': [5268], 'Yamamoto': [5270], 'Araki': [5272], 'Nakamura': [5274], '1983;': [5277], '221:': [5278], '560-561Crossref': [5279], '(271)': [5282], '56Ginsburg': [5285], 'Britow': [5287], 'M.R.': [5288], 'Davis': [5289], 'Dibiase': [5291], 'Billingham': [5293], '69:': [5297], '430-440Crossref': [5298], '(168)': [5301], 'current': [5306], 'weight': [5307], 'evidence': [5309], 'suggests': [5310], 'vasodilatation': [5314], 'predominant': [5317], 'mechanism': [5318], 'underlying': [5319], 'inappropriate': [5320], 'constriction': [5321], 'leading': [5322], 'ischemic': [5324], 'manifestations': [5325], '(57Vita': [5326], 'Treasure': [5328], 'Nabel': [5330], 'E.G.': [5331], 'McLenachan': [5332], 'Fish': [5334], 'R.D.': [5335], 'Yeung': [5336], 'Vekstein': [5338], 'V.I.': [5339], 'Selwyn': [5340], 'A.P.': [5341], 'Ganz': [5342], '81:': [5346, 5454], '491-497Crossref': [5347], '(1091)': [5350], '58Vanhoutte': [5353], 'Shimokawa': [5355], '80:': [5359], '1-9Crossref': [5360], '(284)': [5363], '59Sneddon': [5366], 'J.R.': [5369], '85:': [5378], '2800-2804Crossref': [5379], '(241)': [5382], 'Increased': [5385], 'stress': [5387, 5581], 'wall': [5391], 'facilitates': [5392], '(60Steinbrecher': [5396], 'U.P.': [5397], 'Biochim.': [5398], 'Acta.': [5400], '959:': [5402], '20-30Crossref': [5403], '(202)': [5406], 'produced': [5411], 'facilitate': [5420], 'partially': [5427], 'turn': [5432], 'up-regulate': [5434], 'expression': [5436], '(61Kume': [5437], 'Murase': [5439], '322-327Crossref': [5455], '(278)': [5457], 'finally': [5468], 'amplified': [5484], 'pathological': [5486], 'situations': [5487], 'characterized': [5488], 'higher': [5490], 'plasma': [5491], 'like': [5495], 'hypercholesterolemia.': [5496], 'limited': [5502], 'tempted': [5575], 'speculate': [5577], 'would': [5582], 'continue': [5583]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1754453110', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 12}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 12}, {'year': 2014, 'cited_by_count': 22}, {'year': 2013, 'cited_by_count': 19}, {'year': 2012, 'cited_by_count': 17}], 'updated_date': '2024-12-14T09:33:24.989506', 'created_date': '2016-06-24'}
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