Publication Information

{'id': 'https://openalex.org/W1732266052', 'doi': 'https://doi.org/10.18632/oncotarget.2607', 'title': 'MTOR inhibition enhances NVP-AUY922-induced autophagy-mediated KIT degradation and cytotoxicity in imatinib-resistant gastrointestinal stromal tumors', 'display_name': 'MTOR inhibition enhances NVP-AUY922-induced autophagy-mediated KIT degradation and cytotoxicity in imatinib-resistant gastrointestinal stromal tumors', 'publication_year': 2014, 'publication_date': '2014-10-21', 'ids': {'openalex': 'https://openalex.org/W1732266052', 'doi': 'https://doi.org/10.18632/oncotarget.2607', 'mag': '1732266052', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25375091', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4294368'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.2607', 'pdf_url': 'https://www.oncotarget.com/article/2607/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/2607/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5005305345', 'display_name': 'Yuan‐Shuo Hsueh', 'orcid': 'https://orcid.org/0000-0002-2584-9380'}, 'institutions': [{'id': 'https://openalex.org/I165441096', 'display_name': 'National Health Research Institutes', 'ror': 'https://ror.org/02r6fpx29', 'country_code': 'TW', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I165441096']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Yuan-Shuo Hsueh', 'raw_affiliation_strings': ['National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I165441096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077923494', 'display_name': 'Hui Hua Chang', 'orcid': 'https://orcid.org/0000-0001-7866-5481'}, 'institutions': [{'id': 'https://openalex.org/I91807558', 'display_name': 'National Cheng Kung University', 'ror': 'https://ror.org/01b8kcc49', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I91807558']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Hui Hua Chang', 'raw_affiliation_strings': ['Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng-Kung University, Tainan, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng-Kung University, Tainan, Taiwan.', 'institution_ids': ['https://openalex.org/I91807558']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040496272', 'display_name': 'Nai‐Jung Chiang', 'orcid': 'https://orcid.org/0000-0003-2743-9702'}, 'institutions': [{'id': 'https://openalex.org/I165441096', 'display_name': 'National Health Research Institutes', 'ror': 'https://ror.org/02r6fpx29', 'country_code': 'TW', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I165441096']}, {'id': 'https://openalex.org/I4210158999', 'display_name': 'National Cheng Kung University Hospital', 'ror': 'https://ror.org/04zx3rq17', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158999']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Nai-Jung Chiang', 'raw_affiliation_strings': ['Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan', 'National Institute of Cancer Research; National Health Research Institutes; Tainan, Taiwan; Department of Internal Medicine; National Cheng Kung University Hospital; Tainan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Cancer Research; National Health Research Institutes; Tainan, Taiwan; Department of Internal Medicine; National Cheng Kung University Hospital; Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I165441096']}, {'raw_affiliation_string': 'Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I4210158999']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111546134', 'display_name': 'Chueh‐Chuan Yen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I148366613', 'display_name': 'National Yang Ming Chiao Tung University', 'ror': 'https://ror.org/00se2k293', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I148366613']}, {'id': 'https://openalex.org/I2803004286', 'display_name': 'Taipei Veterans General Hospital', 'ror': 'https://ror.org/03ymy8z76', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2803004286']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Chueh-Chuan Yen', 'raw_affiliation_strings': ['Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; National Yang-Ming University School of Medicine, Taipei, Taiwan.', 'National Yang-Ming University School of Medicine, Taipei, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'National Yang-Ming University School of Medicine, Taipei, Taiwan', 'institution_ids': ['https://openalex.org/I148366613', 'https://openalex.org/I148366613']}, {'raw_affiliation_string': 'Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; National Yang-Ming University School of Medicine, Taipei, Taiwan.', 'institution_ids': ['https://openalex.org/I148366613', 'https://openalex.org/I2803004286']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070326975', 'display_name': 'Chien‐Feng Li', 'orcid': 'https://orcid.org/0000-0002-9527-7576'}, 'institutions': [{'id': 'https://openalex.org/I165441096', 'display_name': 'National Health Research Institutes', 'ror': 'https://ror.org/02r6fpx29', 'country_code': 'TW', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I165441096']}, {'id': 'https://openalex.org/I4210136334', 'display_name': 'Chi Mei Medical Center', 'ror': 'https://ror.org/02y2htg06', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136334']}, {'id': 'https://openalex.org/I92582371', 'display_name': 'Southern Taiwan University of Science and Technology', 'ror': 'https://ror.org/0029n1t76', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I92582371']}, {'id': 'https://openalex.org/I152743029', 'display_name': 'Kaohsiung Medical University', 'ror': 'https://ror.org/03gk81f96', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I152743029']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Chien-Feng Li', 'raw_affiliation_strings': ['Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan', 'Department of Pathology, Chi-Mei Foundation Medical Center, Tainan, Taiwan', 'Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan', 'National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I165441096']}, {'raw_affiliation_string': 'Department of Pathology, Chi-Mei Foundation Medical Center, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I4210136334']}, {'raw_affiliation_string': 'Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I92582371']}, {'raw_affiliation_string': 'Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan', 'institution_ids': ['https://openalex.org/I152743029']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5102820625', 'display_name': 'Li‐Tzong Chen', 'orcid': 'https://orcid.org/0000-0003-3250-7167'}, 'institutions': [{'id': 'https://openalex.org/I2802587341', 'display_name': 'Kaohsiung Medical University Chung-Ho Memorial Hospital', 'ror': 'https://ror.org/02xmkec90', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802587341']}, {'id': 'https://openalex.org/I4210158999', 'display_name': 'National Cheng Kung University Hospital', 'ror': 'https://ror.org/04zx3rq17', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158999']}, {'id': 'https://openalex.org/I152743029', 'display_name': 'Kaohsiung Medical University', 'ror': 'https://ror.org/03gk81f96', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I152743029']}, {'id': 'https://openalex.org/I165441096', 'display_name': 'National Health Research Institutes', 'ror': 'https://ror.org/02r6fpx29', 'country_code': 'TW', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I165441096']}, {'id': 'https://openalex.org/I91807558', 'display_name': 'National Cheng Kung University', 'ror': 'https://ror.org/01b8kcc49', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I91807558']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Li-Tzong Chen', 'raw_affiliation_strings': ['Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwann', 'Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan', 'Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan', 'National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwann', 'institution_ids': ['https://openalex.org/I2802587341', 'https://openalex.org/I152743029']}, {'raw_affiliation_string': 'Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I4210158999']}, {'raw_affiliation_string': 'National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I165441096']}, {'raw_affiliation_string': 'Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I91807558']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 9, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.338, 'has_fulltext': False, 'cited_by_count': 21, 'citation_normalized_percentile': {'value': 0.879548, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '5', 'issue': '22', 'first_page': '11723', 'last_page': '11736'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11485', 'display_name': 'Gastrointestinal Tumor Research and Treatment', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2715', 'display_name': 'Gastroenterology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11485', 'display_name': 'Gastrointestinal Tumor Research and Treatment', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2715', 'display_name': 'Gastroenterology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10253', 'display_name': 'Sarcoma Diagnosis and Treatment', 'score': 0.9686, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10980', 'display_name': 'Vascular Malformations and Hemangiomas', 'score': 0.9629, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/stromal-tumor', 'display_name': 'Stromal tumor', 'score': 0.42421865}, {'id': 'https://openalex.org/keywords/pharmaceutical-sciences', 'display_name': 'Pharmaceutical Sciences', 'score': 0.42314258}, {'id': 'https://openalex.org/keywords/hematology', 'display_name': 'Hematology', 'score': 0.41190928}], 'concepts': [{'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.67323047}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6093035}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.5661467}, {'id': 'https://openalex.org/C2777583451', 'wikidata': 'https://www.wikidata.org/wiki/Q177094', 'display_name': 'Imatinib', 'level': 3, 'score': 0.47874612}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.447457}, {'id': 'https://openalex.org/C16930146', 'wikidata': 'https://www.wikidata.org/wiki/Q4381253', 'display_name': 'Stromal cell', 'level': 2, 'score': 0.44623265}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.438591}, {'id': 'https://openalex.org/C2775922572', 'wikidata': 'https://www.wikidata.org/wiki/Q83567', 'display_name': 'GiST', 'level': 3, 'score': 0.4311884}, {'id': 'https://openalex.org/C2777007597', 'wikidata': 'https://www.wikidata.org/wiki/Q16869243', 'display_name': 'Stromal tumor', 'level': 3, 'score': 0.42421865}, {'id': 'https://openalex.org/C178855305', 'wikidata': 'https://www.wikidata.org/wiki/Q614304', 'display_name': 'Pharmaceutical sciences', 'level': 2, 'score': 0.42314258}, {'id': 'https://openalex.org/C194409129', 'wikidata': 'https://www.wikidata.org/wiki/Q103824', 'display_name': 'Hematology', 'level': 2, 'score': 0.41190928}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3993687}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.36649477}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.29974717}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.21274209}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.1826149}, {'id': 'https://openalex.org/C2778729363', 'wikidata': 'https://www.wikidata.org/wiki/Q11688946', 'display_name': 'Myeloid leukemia', 'level': 2, 'score': 0.096370906}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D046152', 'descriptor_name': 'Gastrointestinal Stromal Tumors', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D019009', 'descriptor_name': 'Proto-Oncogene Proteins c-kit', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D058570', 'descriptor_name': 'TOR Serine-Threonine Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001549', 'descriptor_name': 'Benzamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001549', 'descriptor_name': 'Benzamides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D016923', 'descriptor_name': 'Cell Death', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046152', 'descriptor_name': 'Gastrointestinal Stromal Tumors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018841', 'descriptor_name': 'HSP90 Heat-Shock Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018841', 'descriptor_name': 'HSP90 Heat-Shock Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000068877', 'descriptor_name': 'Imatinib Mesylate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020128', 'descriptor_name': 'Inhibitory Concentration 50', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007555', 'descriptor_name': 'Isoxazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007555', 'descriptor_name': 'Isoxazoles', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016688', 'descriptor_name': 'Mice, Inbred NOD', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016513', 'descriptor_name': 'Mice, SCID', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009336', 'descriptor_name': 'Necrosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009368', 'descriptor_name': 'Neoplasm Transplantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D019009', 'descriptor_name': 'Proto-Oncogene Proteins c-kit', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012118', 'descriptor_name': 'Resorcinols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012118', 'descriptor_name': 'Resorcinols', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D020123', 'descriptor_name': 'Sirolimus', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D020123', 'descriptor_name': 'Sirolimus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058570', 'descriptor_name': 'TOR Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.2607', 'pdf_url': 'https://www.oncotarget.com/article/2607/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4294368', 'pdf_url': 'https://europepmc.org/articles/pmc4294368?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294368', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25375091', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.2607', 'pdf_url': 'https://www.oncotarget.com/article/2607/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.47}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1487612715', 'https://openalex.org/W1516279414', 'https://openalex.org/W1602232463', 'https://openalex.org/W1752417546', 'https://openalex.org/W1975317091', 'https://openalex.org/W1976823322', 'https://openalex.org/W1991278906', 'https://openalex.org/W1991711063', 'https://openalex.org/W1999715990', 'https://openalex.org/W2022738422', 'https://openalex.org/W2024104654', 'https://openalex.org/W2025447556', 'https://openalex.org/W2025935112', 'https://openalex.org/W2038905417', 'https://openalex.org/W2042328377', 'https://openalex.org/W2047788533', 'https://openalex.org/W2052117124', 'https://openalex.org/W2062686313', 'https://openalex.org/W2068079378', 'https://openalex.org/W2070794726', 'https://openalex.org/W2071193766', 'https://openalex.org/W2077533945', 'https://openalex.org/W2077945404', 'https://openalex.org/W2078558213', 'https://openalex.org/W2080099280', 'https://openalex.org/W2095974037', 'https://openalex.org/W2100214216', 'https://openalex.org/W2104381422', 'https://openalex.org/W2106501766', 'https://openalex.org/W2108431450', 'https://openalex.org/W2111567059', 'https://openalex.org/W2115974767', 'https://openalex.org/W2116725504', 'https://openalex.org/W2116922255', 'https://openalex.org/W2120129511', 'https://openalex.org/W2125561235', 'https://openalex.org/W2127063807', 'https://openalex.org/W2131384028', 'https://openalex.org/W2131822545', 'https://openalex.org/W2132400114', 'https://openalex.org/W2134175129', 'https://openalex.org/W2136709809', 'https://openalex.org/W2138780264', 'https://openalex.org/W2139511378', 'https://openalex.org/W2141332502', 'https://openalex.org/W2142765998', 'https://openalex.org/W2143329461', 'https://openalex.org/W2147423147', 'https://openalex.org/W2160215400', 'https://openalex.org/W2162107265', 'https://openalex.org/W2286032795'], 'related_works': ['https://openalex.org/W3030678391', 'https://openalex.org/W2890832111', 'https://openalex.org/W2355085683', 'https://openalex.org/W2320924585', 'https://openalex.org/W2320850214', 'https://openalex.org/W2115652972', 'https://openalex.org/W2075104739', 'https://openalex.org/W2067326946', 'https://openalex.org/W2053542552', 'https://openalex.org/W2024811231'], 'abstract_inverted_index': {'//': [0, 144, 148], 'Yuan-Shuo': [1], 'Hsueh': [2], '1': [3, 25], ',': [4, 9, 13, 17], 'Hui': [5], 'Hua': [6], 'Chang': [7], '2': [8, 37], 'Nai-Jung': [10], 'Chiang': [11], '1,3': [12], 'Chueh-Chuan': [14], 'Yen': [15], '4,5': [16], 'Chien-Feng': [18, 145], 'Li': [19], '1,6,7,8': [20], 'and': [21, 42, 70, 109, 201, 211, 217, 221, 243, 245, 256, 265, 292, 295, 321], 'Li-Tzong': [22, 141], 'Chen': [23], '1,2,3,9': [24], 'National': [26, 31, 48, 59, 82], 'Institute': [27, 38, 115], 'of': [28, 39, 46, 56, 68, 73, 86, 92, 102, 107, 116, 119, 128, 230, 241, 248, 277, 312], 'Cancer': [29], 'Research,': [30], 'Health': [32], 'Research': [33], 'Institutes,': [34], 'Tainan,': [35, 52, 64, 98, 111], 'Taiwan': [36, 53, 65, 80, 89, 99, 105, 112, 125], 'Clinical': [40], 'Pharmacy': [41], 'Pharmaceutical': [43], 'Sciences,': [44], 'College': [45, 118], 'Medicine,': [47, 58, 74, 87, 117, 120, 130], 'Cheng': [49, 60], 'Kung': [50, 61], 'University,': [51, 123, 137], '3': [54], 'Department': [55, 72, 91, 101, 127], 'Internal': [57, 129], 'University': [62, 84, 106, 133], 'Hospital,': [63, 78, 134], '4': [66], 'Division': [67], 'Hematology': [69], 'Oncology,': [71], 'Taipei': [75], 'Veterans': [76], 'General': [77], 'Taipei,': [79, 88], '5': [81], 'Yang-Ming': [83], 'School': [85], '6': [90], 'Pathology,': [93], 'Chi-Mei': [94], 'Foundation': [95], 'Medical': [96, 122, 132, 136], 'Center,': [97], '7': [100], 'Biotechnology,': [103], 'Southern': [104], 'Science': [108], 'Technology,': [110], '8': [113], 'Graduate': [114], 'Kaohsiung': [121, 131, 135], 'Kaohsiung,': [124, 138], '9': [126], 'Taiwann': [139], 'Correspondence:': [140], 'Chen,': [142], 'email:': [143, 147], 'Li,': [146], 'Keywords': [149], ':': [150, 164, 169, 174], 'gastrointestinal': [151, 193], 'stromal': [152, 194], 'tumor,': [153], 'KIT,': [154], 'heat': [155], 'shock': [156], 'protein': [157], '90': [158], 'inhibitor,': [159, 161, 186], 'MTOR': [160, 209, 314], 'autophagy': [162, 212, 231, 260], 'Received': [163], 'June': [165], '19,': [166], '2014': [167, 172, 177], 'Accepted': [168], 'October': [170, 175], '21,': [171, 176], 'Published': [173], 'Abstract': [178], 'Our': [179, 307], 'previous': [180], 'study': [181], 'demonstrated': [182], 'NVP-AUY922,': [183], 'a': [184, 208, 313], 'HSP90AA1': [185], 'could': [187, 214], 'enhance': [188, 222], 'mutant': [189, 328], 'KIT': [190, 234, 242, 249, 287], 'degradation': [191], 'in': [192, 224, 232, 272, 303, 327], 'tumor': [195, 293, 297], '(GIST)': [196], 'cells': [197, 270], 'through': [198], 'both': [199], 'proteasome-': [200], 'autophagy-mediated': [202], 'pathways.': [203], 'Herein,': [204], 'we': [205], 'showed': [206], 'rapamycin,': [207], 'inhibitor': [210, 315], 'inducer,': [213], 'reduce': [215, 317], 'total': [216], 'phospho-KIT': [218], 'expression': [219, 250], 'levels': [220], 'apoptosis': [223], 'imatinib-resistant': [225], 'GIST': [226, 269], 'cells.': [227], 'The': [228, 275], 'involvement': [229], 'rapamycin-induced': [233], 'downregulation': [235], 'was': [236], 'further': [237], 'confirmed': [238], 'by': [239, 252], 'co-localization': [240], 'autophagosome,': [244], 'partial': [246], 'recovery': [247], 'level': [251], 'either': [253], 'siRNA-mediated': [254], 'BECN1': [255], 'ATG5': [257], 'silencing': [258], 'or': [259], 'inhibitors': [261], 'after': [262], 'rapamycin.': [263], 'Rapamycin': [264], 'NVP-AUY922': [266, 279, 301, 318], 'synergistically': [267], 'inhibited': [268], 'growth': [271, 298], 'vitro': [273], '.': [274], 'combination': [276], 'low-dose': [278], 'with': [280], 'rapamycin': [281], 'had': [282], 'comparable': [283], 'effects': [284], 'on': [285], 'reducing': [286], 'expression,': [288], 'increasing': [289], 'MAP1LC3B': [290], 'puncta': [291], 'necrosis,': [294], 'inhibiting': [296], 'as': [299], 'high-dose': [300], 'did': [302], 'GIST430': [304], 'xenograft': [305], 'model.': [306], 'results': [308], 'suggest': [309], 'the': [310], 'addition': [311], 'may': [316], 'dose': [319], 'requirement': [320], 'potentially': [322], 'improve': [323], 'its': [324], 'therapeutic': [325], 'index': [326], 'KIT-expressing': [329], 'GISTs.': [330]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1732266052', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 4}], 'updated_date': '2024-12-17T10:09:11.353335', 'created_date': '2016-06-24'}