Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1732138571', 'doi': 'https://doi.org/10.18632/oncotarget.3346', 'title': 'Hydrazinobenzoylcurcumin inhibits androgen receptor activity and growth of castration-resistant prostate cancer in mice', 'display_name': 'Hydrazinobenzoylcurcumin inhibits androgen receptor activity and growth of castration-resistant prostate cancer in mice', 'publication_year': 2015, 'publication_date': '2015-01-31', 'ids': {'openalex': 'https://openalex.org/W1732138571', 'doi': 'https://doi.org/10.18632/oncotarget.3346', 'mag': '1732138571', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25704883', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4467427'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3346', 'pdf_url': 'https://www.oncotarget.com/article/3346/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/3346/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100718955', 'display_name': 'Min Wu', 'orcid': 'https://orcid.org/0000-0003-2114-6343'}, 'institutions': [{'id': 'https://openalex.org/I2803043754', 'display_name': 'Henry Ford Hospital', 'ror': 'https://ror.org/0193sb042', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I154057602', 'https://openalex.org/I2803043754']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Min Wu', 'raw_affiliation_strings': ['Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, USA'], 'affiliations': [{'raw_affiliation_string': 'Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, USA', 'institution_ids': ['https://openalex.org/I2803043754']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024556156', 'display_name': 'Sahn-Ho Kim', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2803043754', 'display_name': 'Henry Ford Hospital', 'ror': 'https://ror.org/0193sb042', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I154057602', 'https://openalex.org/I2803043754']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sahn-Ho Kim', 'raw_affiliation_strings': ['Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, USA'], 'affiliations': [{'raw_affiliation_string': 'Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, USA', 'institution_ids': ['https://openalex.org/I2803043754']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011732617', 'display_name': 'Indrani Datta', 'orcid': 'https://orcid.org/0000-0001-8864-473X'}, 'institutions': [{'id': 'https://openalex.org/I2803043754', 'display_name': 'Henry Ford Hospital', 'ror': 'https://ror.org/0193sb042', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I154057602', 'https://openalex.org/I2803043754']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Indrani Datta', 'raw_affiliation_strings': ['Bioinformatics Core, Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA'], 'affiliations': [{'raw_affiliation_string': 'Bioinformatics Core, Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA', 'institution_ids': ['https://openalex.org/I2803043754']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087470378', 'display_name': 'Albert M. Levin', 'orcid': 'https://orcid.org/0000-0002-6993-1669'}, 'institutions': [{'id': 'https://openalex.org/I2803043754', 'display_name': 'Henry Ford Hospital', 'ror': 'https://ror.org/0193sb042', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I154057602', 'https://openalex.org/I2803043754']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Albert Levin', 'raw_affiliation_strings': ['Bioinformatics Core, Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.'], 'affiliations': [{'raw_affiliation_string': 'Bioinformatics Core, Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.', 'institution_ids': ['https://openalex.org/I2803043754']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085956632', 'display_name': 'Gregory Dyson', 'orcid': 'https://orcid.org/0000-0001-9783-8464'}, 'institutions': [{'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}, {'id': 'https://openalex.org/I4210090317', 'display_name': 'The Barbara Ann Karmanos Cancer Institute', 'ror': 'https://ror.org/00ee40h97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2800590384', 'https://openalex.org/I4210090317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gregory Dyson', 'raw_affiliation_strings': ['Biostatistics Core, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA'], 'affiliations': [{'raw_affiliation_string': 'Biostatistics Core, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA', 'institution_ids': ['https://openalex.org/I185443292', 'https://openalex.org/I4210090317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018071939', 'display_name': 'Jing Li', 'orcid': 'https://orcid.org/0000-0002-9924-1386'}, 'institutions': [{'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jing Li', 'raw_affiliation_strings': ['Pharmacology Core, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.'], 'affiliations': [{'raw_affiliation_string': 'Pharmacology Core, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.', 'institution_ids': ['https://openalex.org/I185443292']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083618970', 'display_name': 'Tapas K. Kundu', 'orcid': 'https://orcid.org/0000-0001-7790-214X'}, 'institutions': [{'id': 'https://openalex.org/I147481903', 'display_name': 'Jawaharlal Nehru Centre for Advanced Scientific Research', 'ror': 'https://ror.org/0538gdx71', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I147481903', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210098748', 'https://openalex.org/I4210134808']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Stephanie Kaypee', 'raw_affiliation_strings': ['Jawaharlal Nehru Centre for Advanced Scientific Research;', 'Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, JNCASR, Bangalore, Karnataka, India'], 'affiliations': [{'raw_affiliation_string': 'Jawaharlal Nehru Centre for Advanced Scientific Research;', 'institution_ids': ['https://openalex.org/I147481903']}, {'raw_affiliation_string': 'Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, JNCASR, Bangalore, Karnataka, India', 'institution_ids': ['https://openalex.org/I147481903']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078908829', 'display_name': 'Mahadeva M. M. Swamy', 'orcid': 'https://orcid.org/0000-0001-6635-722X'}, 'institutions': [{'id': 'https://openalex.org/I147481903', 'display_name': 'Jawaharlal Nehru Centre for Advanced Scientific Research', 'ror': 'https://ror.org/0538gdx71', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I147481903', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210098748', 'https://openalex.org/I4210134808']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'M. Mahadeva Swamy', 'raw_affiliation_strings': ['Jawaharlal Nehru Centre for Advanced Scientific Research;', 'Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, JNCASR, Bangalore, Karnataka, India'], 'affiliations': [{'raw_affiliation_string': 'Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, JNCASR, Bangalore, Karnataka, India', 'institution_ids': ['https://openalex.org/I147481903']}, {'raw_affiliation_string': 'Jawaharlal Nehru Centre for Advanced Scientific Research;', 'institution_ids': ['https://openalex.org/I147481903']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102627776', 'display_name': 'Nilesh Gupta', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2803043754', 'display_name': 'Henry Ford Hospital', 'ror': 'https://ror.org/0193sb042', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I154057602', 'https://openalex.org/I2803043754']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nilesh Gupta', 'raw_affiliation_strings': ['Department of Pathology, Henry Ford Hospital, Detroit, MI, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Henry Ford Hospital, Detroit, MI, USA', 'institution_ids': ['https://openalex.org/I2803043754']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067684286', 'display_name': 'Ho Jeong Kwon', 'orcid': 'https://orcid.org/0000-0002-6919-833X'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Ho Jeong Kwon', 'raw_affiliation_strings': ['Department of Biotechnology, Translational Research Center for Protein Function Control, Yonsei University, Seoul, Republic of Korea.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology, Translational Research Center for Protein Function Control, Yonsei University, Seoul, Republic of Korea.', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046280416', 'display_name': 'Mani Menon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2803043754', 'display_name': 'Henry Ford Hospital', 'ror': 'https://ror.org/0193sb042', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I154057602', 'https://openalex.org/I2803043754']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mani Menon', 'raw_affiliation_strings': ['Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, USA'], 'affiliations': [{'raw_affiliation_string': 'Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, USA', 'institution_ids': ['https://openalex.org/I2803043754']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083618970', 'display_name': 'Tapas K. Kundu', 'orcid': 'https://orcid.org/0000-0001-7790-214X'}, 'institutions': [{'id': 'https://openalex.org/I147481903', 'display_name': 'Jawaharlal Nehru Centre for Advanced Scientific Research', 'ror': 'https://ror.org/0538gdx71', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I147481903', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210098748', 'https://openalex.org/I4210134808']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Tapas K. Kundu', 'raw_affiliation_strings': ['Jawaharlal Nehru Centre for Advanced Scientific Research;', 'Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, JNCASR, Bangalore, Karnataka, India'], 'affiliations': [{'raw_affiliation_string': 'Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, JNCASR, Bangalore, Karnataka, India', 'institution_ids': ['https://openalex.org/I147481903']}, {'raw_affiliation_string': 'Jawaharlal Nehru Centre for Advanced Scientific Research;', 'institution_ids': ['https://openalex.org/I147481903']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5068470636', 'display_name': 'G. Prem‐Veer Reddy', 'orcid': 'https://orcid.org/0000-0002-7394-5465'}, 'institutions': [{'id': 'https://openalex.org/I2803043754', 'display_name': 'Henry Ford Hospital', 'ror': 'https://ror.org/0193sb042', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I154057602', 'https://openalex.org/I2803043754']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'G. Prem-Veer Reddy', 'raw_affiliation_strings': ['Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, USA'], 'affiliations': [{'raw_affiliation_string': 'Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, USA', 'institution_ids': ['https://openalex.org/I2803043754']}]}], 'countries_distinct_count': 3, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.042, 'has_fulltext': False, 'cited_by_count': 16, 'citation_normalized_percentile': {'value': 0.847783, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '6', 'issue': '8', 'first_page': '6136', 'last_page': '6150'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Advancements in Prostate Cancer Research', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Advancements in Prostate Cancer Research', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11319', 'display_name': 'Bioavailability and Health Effects of Curcumin', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12465', 'display_name': 'Lipid Metabolism in Cancer Pathogenesis', 'score': 0.9892, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/androgen-receptor', 'display_name': 'Androgen Receptor', 'score': 0.465164}], 'concepts': [{'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.85747635}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.780406}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7129053}, {'id': 'https://openalex.org/C2779256933', 'wikidata': 'https://www.wikidata.org/wiki/Q58929', 'display_name': 'Castration', 'level': 3, 'score': 0.5336975}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.5197489}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.44256333}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4383867}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.413581}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.41000494}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.38419104}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.32251745}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.13216206}], 'mesh': [{'descriptor_ui': 'D003474', 'descriptor_name': 'Curcumin', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D064129', 'descriptor_name': 'Prostatic Neoplasms, Castration-Resistant', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D003474', 'descriptor_name': 'Curcumin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003474', 'descriptor_name': 'Curcumin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D041681', 'descriptor_name': 'NIH 3T3 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064129', 'descriptor_name': 'Prostatic Neoplasms, Castration-Resistant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064129', 'descriptor_name': 'Prostatic Neoplasms, Castration-Resistant', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D064129', 'descriptor_name': 'Prostatic Neoplasms, Castration-Resistant', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D064129', 'descriptor_name': 'Prostatic Neoplasms, Castration-Resistant', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011897', 'descriptor_name': 'Random Allocation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3346', 'pdf_url': 'https://www.oncotarget.com/article/3346/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4467427', 'pdf_url': 'https://europepmc.org/articles/pmc4467427?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467427', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25704883', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3346', 'pdf_url': 'https://www.oncotarget.com/article/3346/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.53, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 53, 'referenced_works': ['https://openalex.org/W1963574701', 'https://openalex.org/W1964184380', 'https://openalex.org/W1976194786', 'https://openalex.org/W1978312592', 'https://openalex.org/W1980811940', 'https://openalex.org/W1983165668', 'https://openalex.org/W1985990006', 'https://openalex.org/W1990485709', 'https://openalex.org/W1998700867', 'https://openalex.org/W2004154055', 'https://openalex.org/W2005658600', 'https://openalex.org/W2007250004', 'https://openalex.org/W2019216606', 'https://openalex.org/W2021051883', 'https://openalex.org/W2022789859', 'https://openalex.org/W2024648144', 'https://openalex.org/W2029100117', 'https://openalex.org/W2036765013', 'https://openalex.org/W2037603560', 'https://openalex.org/W2039370462', 'https://openalex.org/W2039393537', 'https://openalex.org/W2052366943', 'https://openalex.org/W2057652006', 'https://openalex.org/W2059182387', 'https://openalex.org/W2059379142', 'https://openalex.org/W2059886358', 'https://openalex.org/W2064778017', 'https://openalex.org/W2077438659', 'https://openalex.org/W2078400569', 'https://openalex.org/W2079817613', 'https://openalex.org/W2084715195', 'https://openalex.org/W2086594864', 'https://openalex.org/W2090075034', 'https://openalex.org/W2092740775', 'https://openalex.org/W2093565522', 'https://openalex.org/W2093863429', 'https://openalex.org/W2099302717', 'https://openalex.org/W2107277218', 'https://openalex.org/W2120385383', 'https://openalex.org/W2123230966', 'https://openalex.org/W2131422252', 'https://openalex.org/W2142008762', 'https://openalex.org/W2145985979', 'https://openalex.org/W2161817637', 'https://openalex.org/W2161996879', 'https://openalex.org/W2164092182', 'https://openalex.org/W2164566492', 'https://openalex.org/W2165846310', 'https://openalex.org/W2171020858', 'https://openalex.org/W2172712627', 'https://openalex.org/W2310189218', 'https://openalex.org/W2322485784', 'https://openalex.org/W2329080756'], 'related_works': ['https://openalex.org/W4387341186', 'https://openalex.org/W3111390827', 'https://openalex.org/W2888003396', 'https://openalex.org/W2611803138', 'https://openalex.org/W2169608764', 'https://openalex.org/W2131077462', 'https://openalex.org/W2071753433', 'https://openalex.org/W2033566079', 'https://openalex.org/W2017700331', 'https://openalex.org/W1864918391'], 'abstract_inverted_index': {'//': [0, 149], 'Min': [1], 'Wu': [2], '1': [3, 7, 45, 55, 56], ',': [4, 8, 12, 16, 20, 24, 28, 33, 37, 42, 46], 'Sahn-Ho': [5], 'Kim': [6], 'Indrani': [9], 'Datta': [10], '2': [11, 15, 66], 'Albert': [13], 'Levin': [14], 'Gregory': [17], 'Dyson': [18], '3': [19, 78], 'Jing': [21], 'Li': [22], '4': [23, 90], 'Stephanie': [25], 'Kaypee': [26], '5': [27, 32, 50, 102], 'M.': [29], 'Mahadeva': [30], 'Swamy': [31], 'Nilesh': [34], 'Gupta': [35], '6': [36, 116], 'Ho': [38], 'Jeong': [39], 'Kwon': [40], '7': [41, 126], 'Mani': [43], 'Menon': [44], 'Tapas': [47], 'K.': [48], 'Kundu': [49], 'and': [51, 104, 109, 210, 238, 287, 329, 339, 363], 'G.': [52, 144], 'Prem-Veer': [53], 'Reddy': [54], 'Vattikuti': [57], 'Urology': [58], 'Institute,': [59, 83, 95], 'Henry': [60, 72, 120], 'Ford': [61, 73, 121], 'Hospital,': [62, 74, 122], 'Detroit,': [63, 75, 87, 99, 123], 'MI,': [64, 76, 88, 100, 124], 'USA': [65, 77, 89, 101, 125], 'Bioinformatics': [67], 'Core,': [68, 80, 92], 'Public': [69], 'Health': [70], 'Sciences,': [71], 'Biostatistics': [79], 'Karmanos': [81, 93], 'Cancer': [82, 94], 'Wayne': [84, 96], 'State': [85, 97], 'University,': [86, 98, 138], 'Pharmacology': [91], 'Transcription': [103], 'Disease': [105], 'Laboratory,': [106], 'Molecular': [107], 'Biology': [108], 'Genetics': [110], 'Unit,': [111], 'JNCASR,': [112], 'Bangalore,': [113], 'Karnataka,': [114], 'India': [115], 'Department': [117, 127], 'of': [118, 128, 141, 191, 198, 235, 242, 304, 319, 343, 367, 372], 'Pathology,': [119], 'Biotechnology,': [129], 'Translational': [130], 'Research': [131], 'Center': [132], 'for': [133, 181, 195, 369], 'Protein': [134], 'Function': [135], 'Control,': [136], 'Yonsei': [137], 'Seoul,': [139], 'Republic': [140], 'Korea': [142], 'Correspondence:': [143], 'Prem': [145], 'Veer': [146], 'Reddy,': [147], 'email:': [148], 'Keywords': [150], ':': [151, 161, 166, 171], 'Androgen': [152], 'receptor,': [153], 'calmodulin,': [154], 'Hydrazinobenzoylcurcumin,': [155], 'CTK7A,': [156], 'castration-resistant': [157, 199], 'prostate': [158, 200, 284], 'cancer': [159, 201, 285], 'Received': [160], 'November': [162], '24,': [163], '2014': [164], 'Accepted': [165], 'January': [167, 172], '20,': [168], '2015': [169, 174], 'Published': [170], '31,': [173], 'Abstract': [175], 'There': [176], 'is': [177], 'a': [178, 301, 317], 'critical': [179], 'need': [180], 'therapeutic': [182], 'agents': [183], 'that': [184, 216, 272, 279, 294, 353], 'can': [185], 'target': [186], 'the': [187, 196, 207, 240, 336, 341, 360], 'amino-terminal': [188], 'domain': [189], '(NTD)': [190], 'androgen': [192], 'receptor': [193], '(AR)': [194], 'treatment': [197, 371], '(CRPC).': [202], 'Calmodulin': [203], '(CaM)': [204], 'binds': [205, 220], 'to': [206, 222, 244, 267], 'AR': [208, 212, 225, 229, 236, 243, 356, 361], 'NTD': [209, 362], 'regulates': [211], 'activity.': [213, 226], 'We': [214], 'discovered': [215], 'Hydrazinobenzoylcurcumin': [217], '(HBC),': [218], 'which': [219], 'exclusively': [221], 'CaM,': [223, 232], 'inhibited': [224, 340], 'HBC': [227, 262, 276, 291, 305, 320, 331, 354, 368], 'abrogated': [228], 'interaction': [230], 'with': [231, 311, 327], 'suppressed': [233], 'phosphorylation': [234], 'Serine81,': [237], 'blocked': [239], 'binding': [241], 'androgen-response': [245], 'elements.': [246], 'RNA-Seq': [247], 'analysis': [248, 270], 'identified': [249], '57': [250], 'androgen-regulated': [251, 307], 'genes': [252, 273, 288, 322], 'whose': [253], 'expression': [254, 309], 'was': [255, 332], 'significantly': [256], '(p': [257], '≤': [258], '0.002)': [259], 'altered': [260], 'in': [261, 283, 298, 323, 347], 'treated': [263], 'cells': [264], 'as': [265], 'compared': [266], 'controls.': [268], 'Oncomine': [269], 'revealed': [271, 316], 'repressed': [274], 'by': [275, 290, 358], 'are': [277, 280, 292, 295], 'those': [278, 293], 'usually': [281], 'overexpressed': [282], '(PCa)': [286], 'stimulated': [289], 'often': [296], 'down-regulated': [297], 'PCa,': [299], 'suggesting': [300], 'reversing': [302], 'effect': [303], 'on': [306], 'gene': [308], 'associated': [310, 326], 'PCa.': [312], 'Ingenuity': [313], 'Pathway': [314], 'Analysis': [315], 'role': [318], 'affected': [321], 'cellular': [324], 'functions': [325], 'proliferation': [328], 'survival.': [330], 'readily': [333], 'absorbed': [334], 'into': [335], 'systemic': [337], 'circulation': [338], 'growth': [342], 'xenografted': [344], 'CRPC': [345], 'tumors': [346], 'nude': [348], 'mice.': [349], 'These': [350], 'observations': [351], 'demonstrate': [352], 'inhibits': [355], 'activity': [357], 'targeting': [359], 'suggest': [364], 'potential': [365], 'usefulness': [366], 'effective': [370], 'CRPC.': [373]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1732138571', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}], 'updated_date': '2024-08-23T11:20:16.590557', 'created_date': '2016-06-24'}