Salinomycin – A New Cancer Drug Candidate

Name: Work Video:
Duration: 3 min 30 s
Description: Very recently, it has been shown that it is possible to selectively kill breast cancer stem cells using the ionophore antibiotic, salinomycin. Its ability to kill cancer stem cells and apoptosis-resistant cancer cells may define salinomycin as a novel anticancer drug.
Adam Huczyński
{'id': 'https://openalex.org/W1730011205', 'doi': 'https://doi.org/10.1111/j.1747-0285.2011.01287.x', 'title': 'Salinomycin – A New Cancer Drug Candidate', 'display_name': 'Salinomycin – A New Cancer Drug Candidate', 'publication_year': 2011, 'publication_date': '2011-12-07', 'ids': {'openalex': 'https://openalex.org/W1730011205', 'doi': 'https://doi.org/10.1111/j.1747-0285.2011.01287.x', 'mag': '1730011205', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22145602'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1747-0285.2011.01287.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S123587420', 'display_name': 'Chemical Biology & Drug Design', 'issn_l': '1747-0277', 'issn': ['1747-0277', '1747-0285'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5028053146', 'display_name': 'Adam Huczyński', 'orcid': 'https://orcid.org/0000-0003-4770-215X'}, 'institutions': [{'id': 'https://openalex.org/I59411706', 'display_name': 'Adam Mickiewicz University in Poznań', 'ror': 'https://ror.org/04g6bbq64', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I59411706']}], 'countries': ['PL'], 'is_corresponding': True, 'raw_author_name': 'Adam Huczynski', 'raw_affiliation_strings': ['Department of Biochemistry, A. Mickiewicz University, Poznan, Poland.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, A. Mickiewicz University, Poznan, Poland.', 'institution_ids': ['https://openalex.org/I59411706']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5028053146'], 'corresponding_institution_ids': ['https://openalex.org/I59411706'], 'apc_list': {'value': 3550, 'currency': 'USD', 'value_usd': 3550, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 6.435, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 100, 'citation_normalized_percentile': {'value': 0.924466, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '79', 'issue': '3', 'first_page': '235', 'last_page': '238'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11924', 'display_name': 'Polyamine Metabolism and Applications', 'score': 0.9212, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/salinomycin', 'display_name': 'Salinomycin', 'score': 0.99821305}], 'concepts': [{'id': 'https://openalex.org/C2777877089', 'wikidata': 'https://www.wikidata.org/wiki/Q411909', 'display_name': 'Salinomycin', 'level': 3, 'score': 0.99821305}, {'id': 'https://openalex.org/C55427017', 'wikidata': 'https://www.wikidata.org/wiki/Q1638475', 'display_name': 'Cancer stem cell', 'level': 3, 'score': 0.7344228}, {'id': 'https://openalex.org/C2779014961', 'wikidata': 'https://www.wikidata.org/wiki/Q415168', 'display_name': 'Ionophore', 'level': 3, 'score': 0.62245774}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.57801765}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.5746757}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.56542295}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.5121505}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.4815512}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.44700408}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.42361498}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.41283157}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.32334235}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.19637418}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.13443676}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.08646366}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.05338323}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011714', 'descriptor_name': 'Pyrans', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050759', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p21', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050759', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p21', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011714', 'descriptor_name': 'Pyrans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1747-0285.2011.01287.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S123587420', 'display_name': 'Chemical Biology & Drug Design', 'issn_l': '1747-0277', 'issn': ['1747-0277', '1747-0285'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22145602', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.88, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W1567719786', 'https://openalex.org/W1967546603', 'https://openalex.org/W1968005886', 'https://openalex.org/W1985796734', 'https://openalex.org/W1987294972', 'https://openalex.org/W2025314771', 'https://openalex.org/W2026742412', 'https://openalex.org/W2027012849', 'https://openalex.org/W2029816858', 'https://openalex.org/W2032986953', 'https://openalex.org/W2035766185', 'https://openalex.org/W2051011734', 'https://openalex.org/W2053389649', 'https://openalex.org/W2058499983', 'https://openalex.org/W2063208847', 'https://openalex.org/W2092296527', 'https://openalex.org/W2095344789', 'https://openalex.org/W2107872425', 'https://openalex.org/W2120656656', 'https://openalex.org/W2147967887', 'https://openalex.org/W2155507705', 'https://openalex.org/W2174107598', 'https://openalex.org/W2314039805', 'https://openalex.org/W2330181923', 'https://openalex.org/W2468828447', 'https://openalex.org/W2950713395', 'https://openalex.org/W4235229030'], 'related_works': ['https://openalex.org/W4285734747', 'https://openalex.org/W2906265158', 'https://openalex.org/W2899076528', 'https://openalex.org/W2888241297', 'https://openalex.org/W2792190094', 'https://openalex.org/W2563253855', 'https://openalex.org/W2107450069', 'https://openalex.org/W2061134917', 'https://openalex.org/W2032986953', 'https://openalex.org/W2002601186'], 'abstract_inverted_index': {'Very': [0], 'recently,': [1], 'it': [2, 7], 'has': [3], 'been': [4], 'shown': [5], 'that': [6], 'is': [8], 'possible': [9], 'to': [10, 24], 'selectively': [11], 'kill': [12, 25], 'breast': [13], 'cancer': [14, 26, 31], 'stem': [15, 27], 'cells': [16, 28, 32], 'using': [17], 'the': [18], 'ionophore': [19], 'antibiotic,': [20], 'salinomycin.': [21], 'Its': [22], 'ability': [23], 'and': [29], 'apoptosis-resistant': [30], 'may': [33], 'define': [34], 'salinomycin': [35], 'as': [36], 'a': [37], 'novel': [38], 'anticancer': [39], 'drug.': [40]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1730011205', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 19}, {'year': 2013, 'cited_by_count': 14}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-26T13:47:38.766586', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
