Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1708445842', 'doi': 'https://doi.org/10.1016/s0896-6273(03)00606-8', 'title': 'The Ubiquitin Proteasome System in Neurodegenerative Diseases', 'display_name': 'The Ubiquitin Proteasome System in Neurodegenerative Diseases', 'publication_year': 2003, 'publication_date': '2003-10-01', 'ids': {'openalex': 'https://openalex.org/W1708445842', 'doi': 'https://doi.org/10.1016/s0896-6273(03)00606-8', 'mag': '1708445842', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/14556719'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0896-6273(03)00606-8', 'pdf_url': 'http://www.cell.com/article/S0896627303006068/pdf', 'source': {'id': 'https://openalex.org/S45757444', 'display_name': 'Neuron', 'issn_l': '0896-6273', 'issn': ['0896-6273', '1097-4199'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.cell.com/article/S0896627303006068/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5087180436', 'display_name': 'Aaron Ciechanover', 'orcid': 'https://orcid.org/0000-0001-9184-8944'}, 'institutions': [{'id': 'https://openalex.org/I4210117163', 'display_name': 'Rappaport Family Institute for Research in the Medical Sciences', 'ror': 'https://ror.org/029hzjx43', 'country_code': 'IL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117163']}, {'id': 'https://openalex.org/I174306211', 'display_name': 'Technion – Israel Institute of Technology', 'ror': 'https://ror.org/03qryx823', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I174306211']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Aaron Ciechanover', 'raw_affiliation_strings': ['Department of Biochemistry and the Rappaport Family Institute for Research in the Medical Sciences, the Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and the Rappaport Family Institute for Research in the Medical Sciences, the Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel', 'institution_ids': ['https://openalex.org/I4210117163', 'https://openalex.org/I174306211']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5072622786', 'display_name': 'Patrik Brundin', 'orcid': 'https://orcid.org/0000-0003-2924-5186'}, 'institutions': [{'id': 'https://openalex.org/I187531555', 'display_name': 'Lund University', 'ror': 'https://ror.org/012a77v79', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I187531555']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Patrik Brundin', 'raw_affiliation_strings': ['Section for Neuronal Survival, Wallenberg Neuroscience Center, Biomedical Center (BMC), Department of Physiological Sciences, Lund University, S-221 84 Lund, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Section for Neuronal Survival, Wallenberg Neuroscience Center, Biomedical Center (BMC), Department of Physiological Sciences, Lund University, S-221 84 Lund, Sweden', 'institution_ids': ['https://openalex.org/I187531555']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9080, 'currency': 'USD', 'value_usd': 9080, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 6.393, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 935, 'citation_normalized_percentile': {'value': 0.999688, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '40', 'issue': '2', 'first_page': '427', 'last_page': '446'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin-Proteasome Proteolytic Pathway', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin-Proteasome Proteolytic Pathway', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13481', 'display_name': 'Neurodegeneration with Brain Iron Accumulation', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10085', 'display_name': "Pathophysiology of Parkinson's Disease", 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pathogenesis', 'display_name': 'Pathogenesis', 'score': 0.6117766}, {'id': 'https://openalex.org/keywords/neurodegeneration', 'display_name': 'Neurodegeneration', 'score': 0.569312}, {'id': 'https://openalex.org/keywords/protein-degradation', 'display_name': 'Protein Degradation', 'score': 0.55099}, {'id': 'https://openalex.org/keywords/deubiquitinating-enzymes', 'display_name': 'Deubiquitinating Enzymes', 'score': 0.536175}, {'id': 'https://openalex.org/keywords/parkinsonism', 'display_name': 'Parkinsonism', 'score': 0.530555}, {'id': 'https://openalex.org/keywords/ubiquitin-protein-ligases', 'display_name': 'Ubiquitin-Protein Ligases', 'score': 0.5088818}], 'concepts': [{'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.84658504}, {'id': 'https://openalex.org/C27740335', 'wikidata': 'https://www.wikidata.org/wiki/Q14878333', 'display_name': 'Proteasome', 'level': 2, 'score': 0.7837961}, {'id': 'https://openalex.org/C2780596555', 'wikidata': 'https://www.wikidata.org/wiki/Q206901', 'display_name': 'Amyotrophic lateral sclerosis', 'level': 3, 'score': 0.6956303}, {'id': 'https://openalex.org/C2780942790', 'wikidata': 'https://www.wikidata.org/wiki/Q372016', 'display_name': 'Pathogenesis', 'level': 2, 'score': 0.6117766}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5281016}, {'id': 'https://openalex.org/C2908868211', 'wikidata': 'https://www.wikidata.org/wiki/Q4274835', 'display_name': 'Ubiquitin-Protein Ligases', 'level': 5, 'score': 0.5088818}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.48699316}, {'id': 'https://openalex.org/C89611455', 'wikidata': 'https://www.wikidata.org/wiki/Q6804646', 'display_name': 'Mechanism (biology)', 'level': 2, 'score': 0.47267064}, {'id': 'https://openalex.org/C2992195973', 'wikidata': 'https://www.wikidata.org/wiki/Q33123', 'display_name': 'Protein degradation', 'level': 2, 'score': 0.42704386}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3993927}, {'id': 'https://openalex.org/C134459356', 'wikidata': 'https://www.wikidata.org/wiki/Q4274835', 'display_name': 'Ubiquitin ligase', 'level': 4, 'score': 0.36411333}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.22690007}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.22556537}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.18043587}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.15826681}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.108445466}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.07256168}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C111472728', 'wikidata': 'https://www.wikidata.org/wiki/Q9471', 'display_name': 'Epistemology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003546', 'descriptor_name': 'Cysteine Endopeptidases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009097', 'descriptor_name': 'Multienzyme Complexes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019636', 'descriptor_name': 'Neurodegenerative Diseases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003546', 'descriptor_name': 'Cysteine Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003546', 'descriptor_name': 'Cysteine Endopeptidases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009097', 'descriptor_name': 'Multienzyme Complexes', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009097', 'descriptor_name': 'Multienzyme Complexes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019636', 'descriptor_name': 'Neurodegenerative Diseases', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D019636', 'descriptor_name': 'Neurodegenerative Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046988', 'descriptor_name': 'Proteasome Endopeptidase Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0896-6273(03)00606-8', 'pdf_url': 'http://www.cell.com/article/S0896627303006068/pdf', 'source': {'id': 'https://openalex.org/S45757444', 'display_name': 'Neuron', 'issn_l': '0896-6273', 'issn': ['0896-6273', '1097-4199'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/14556719', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0896-6273(03)00606-8', 'pdf_url': 'http://www.cell.com/article/S0896627303006068/pdf', 'source': {'id': 'https://openalex.org/S45757444', 'display_name': 'Neuron', 'issn_l': '0896-6273', 'issn': ['0896-6273', '1097-4199'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.7, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 167, 'referenced_works': ['https://openalex.org/W1481615478', 'https://openalex.org/W1490199421', 'https://openalex.org/W1494477854', 'https://openalex.org/W1511827873', 'https://openalex.org/W1525022089', 'https://openalex.org/W1529474377', 'https://openalex.org/W1531710355', 'https://openalex.org/W1532188427', 'https://openalex.org/W1538925586', 'https://openalex.org/W1539166295', 'https://openalex.org/W1544371346', 'https://openalex.org/W1548441884', 'https://openalex.org/W1552448470', 'https://openalex.org/W1554099072', 'https://openalex.org/W1557235501', 'https://openalex.org/W1588279803', 'https://openalex.org/W1592870082', 'https://openalex.org/W1617816798', 'https://openalex.org/W1618846043', 'https://openalex.org/W1681758390', 'https://openalex.org/W1744223828', 'https://openalex.org/W1780544763', 'https://openalex.org/W1832030339', 'https://openalex.org/W1848907877', 'https://openalex.org/W1877873625', 'https://openalex.org/W1892455234', 'https://openalex.org/W1909955981', 'https://openalex.org/W1917032649', 'https://openalex.org/W1940638574', 'https://openalex.org/W1963962397', 'https://openalex.org/W1966900166', 'https://openalex.org/W1971411115', 'https://openalex.org/W1972939055', 'https://openalex.org/W1976345822', 'https://openalex.org/W1977733590', 'https://openalex.org/W1983882750', 'https://openalex.org/W1983959956', 'https://openalex.org/W1986188355', 'https://openalex.org/W1986413832', 'https://openalex.org/W1989400359', 'https://openalex.org/W1989699053', 'https://openalex.org/W1990726987', 'https://openalex.org/W1992119447', 'https://openalex.org/W1992277668', 'https://openalex.org/W1997369314', 'https://openalex.org/W2005317701', 'https://openalex.org/W2005927762', 'https://openalex.org/W2006808229', 'https://openalex.org/W2008093868', 'https://openalex.org/W2010388034', 'https://openalex.org/W2011035933', 'https://openalex.org/W2011603170', 'https://openalex.org/W2013135033', 'https://openalex.org/W2013679718', 'https://openalex.org/W2016974059', 'https://openalex.org/W2017492499', 'https://openalex.org/W2021605503', 'https://openalex.org/W2022376508', 'https://openalex.org/W2023219143', 'https://openalex.org/W2024035831', 'https://openalex.org/W2026043555', 'https://openalex.org/W2027649342', 'https://openalex.org/W2032161390', 'https://openalex.org/W2034692278', 'https://openalex.org/W2037024974', 'https://openalex.org/W2039376206', 'https://openalex.org/W2039824115', 'https://openalex.org/W2040671431', 'https://openalex.org/W2041156762', 'https://openalex.org/W2042978244', 'https://openalex.org/W2046241482', 'https://openalex.org/W2047211900', 'https://openalex.org/W2048640332', 'https://openalex.org/W2055124287', 'https://openalex.org/W2056867819', 'https://openalex.org/W2059737503', 'https://openalex.org/W2060750433', 'https://openalex.org/W2060750718', 'https://openalex.org/W2064394604', 'https://openalex.org/W2066412377', 'https://openalex.org/W2066536601', 'https://openalex.org/W2067952583', 'https://openalex.org/W2068806054', 'https://openalex.org/W2069719894', 'https://openalex.org/W2070795929', 'https://openalex.org/W2071191421', 'https://openalex.org/W2073815612', 'https://openalex.org/W2074180389', 'https://openalex.org/W2074314807', 'https://openalex.org/W2076196975', 'https://openalex.org/W2076344205', 'https://openalex.org/W2077404304', 'https://openalex.org/W2079250951', 'https://openalex.org/W2081103757', 'https://openalex.org/W2085880812', 'https://openalex.org/W2088962120', 'https://openalex.org/W2089199332', 'https://openalex.org/W2090839709', 'https://openalex.org/W2091265794', 'https://openalex.org/W2091681614', 'https://openalex.org/W2093761069', 'https://openalex.org/W2094478098', 'https://openalex.org/W2095053755', 'https://openalex.org/W2096410114', 'https://openalex.org/W2097062199', 'https://openalex.org/W2097336990', 'https://openalex.org/W2097965815', 'https://openalex.org/W2101362932', 'https://openalex.org/W2103467758', 'https://openalex.org/W2103551853', 'https://openalex.org/W2104382960', 'https://openalex.org/W2105346492', 'https://openalex.org/W2105470017', 'https://openalex.org/W2105729193', 'https://openalex.org/W2105796226', 'https://openalex.org/W2107769595', 'https://openalex.org/W2108102646', 'https://openalex.org/W2110580010', 'https://openalex.org/W2110780830', 'https://openalex.org/W2113777884', 'https://openalex.org/W2113998330', 'https://openalex.org/W2115373986', 'https://openalex.org/W2116552323', 'https://openalex.org/W2116598203', 'https://openalex.org/W2117138295', 'https://openalex.org/W2120293274', 'https://openalex.org/W2120947942', 'https://openalex.org/W2121506107', 'https://openalex.org/W2122922661', 'https://openalex.org/W2123781000', 'https://openalex.org/W2126588190', 'https://openalex.org/W2129089207', 'https://openalex.org/W2131020698', 'https://openalex.org/W2131155959', 'https://openalex.org/W2131426455', 'https://openalex.org/W2131575598', 'https://openalex.org/W2134783787', 'https://openalex.org/W2134786936', 'https://openalex.org/W2135387829', 'https://openalex.org/W2136000143', 'https://openalex.org/W2138483928', 'https://openalex.org/W2139946382', 'https://openalex.org/W2141871877', 'https://openalex.org/W2142780460', 'https://openalex.org/W2145683656', 'https://openalex.org/W2148869194', 'https://openalex.org/W2148966536', 'https://openalex.org/W2149761960', 'https://openalex.org/W2150123812', 'https://openalex.org/W2150656456', 'https://openalex.org/W2154761807', 'https://openalex.org/W2157513658', 'https://openalex.org/W2157618233', 'https://openalex.org/W2159317313', 'https://openalex.org/W2165589182', 'https://openalex.org/W2168302341', 'https://openalex.org/W2169482727', 'https://openalex.org/W2171114341', 'https://openalex.org/W2317804643', 'https://openalex.org/W3187806412', 'https://openalex.org/W4250374989', 'https://openalex.org/W4250968818', 'https://openalex.org/W4252368281', 'https://openalex.org/W4362221370', 'https://openalex.org/W69871636', 'https://openalex.org/W78144967', 'https://openalex.org/W89892064'], 'related_works': ['https://openalex.org/W4376133051', 'https://openalex.org/W4366748257', 'https://openalex.org/W4303954706', 'https://openalex.org/W2999996443', 'https://openalex.org/W2467992412', 'https://openalex.org/W2112142795', 'https://openalex.org/W2097763804', 'https://openalex.org/W2088980243', 'https://openalex.org/W2037487430', 'https://openalex.org/W1966031852'], 'abstract_inverted_index': {'The': [0], 'ubiquitin-proteasome': [1], 'system': [2, 39, 68, 95], 'targets': [3], 'numerous': [4], 'cellular': [5, 62], 'proteins': [6, 14, 18], 'for': [7, 117, 130], 'degradation.': [8], 'In': [9], 'addition,': [10], 'modifications': [11], 'by': [12], 'ubiquitin-like': [13], 'as': [15, 17, 40, 42, 73, 108, 110], 'well': [16, 41, 109], 'containing': [19], 'ubiquitin-interacting': [20], 'and': [21, 34, 45, 86, 105, 129], '-associated': [22], 'motifs': [23], 'modulate': [24], 'many': [25, 43], 'others.': [26], 'This': [27, 114], 'tightly': [28], 'controlled': [29], 'process': [30], 'involves': [31], 'multiple': [32], 'specific': [33], 'general': [35], 'enzymes': [36], 'of': [37, 60, 83, 101, 121, 133], 'the': [38, 67, 81, 94, 99, 122, 131], 'modifying': [44], 'ancillary': [46], 'proteins.': [47], 'Thus,': [48], 'it': [49], 'is': [50, 96], 'not': [51], 'surprising': [52], 'that': [53, 93], 'ubiquitin-mediated': [54], 'degradation/processing/modification': [55], 'regulates': [56], 'a': [57, 74, 118], 'broad': [58], 'array': [59], 'basic': [61], 'processes.': [63], 'Moreover,': [64], 'aberrations': [65], 'in': [66, 80, 98, 126], 'have': [69], 'been': [70], 'implicated,': [71], 'either': [72], 'primary': [75], 'cause': [76], 'or': [77], 'secondary': [78], 'consequence,': [79], 'pathogenesis': [82, 100], 'both': [84], 'inherited': [85], 'acquired': [87], 'neurodegenerative': [88], 'diseases.': [89], 'Recent': [90], 'findings': [91], 'indicate': [92], 'involved': [97, 125], "Parkinson's,": [102], "Alzheimer's,": [103], "Huntington's,": [104], 'Prion': [106], 'diseases': [107, 128], 'amyotrophic': [111], 'lateral': [112], 'sclerosis.': [113], 'raises': [115], 'hopes': [116], 'better': [119], 'understanding': [120], 'pathogenetic': [123], 'mechanisms': [124], 'these': [127], 'development': [132], 'novel,': [134], 'mechanism-based': [135], 'therapeutic': [136], 'modalities.': [137]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1708445842', 'counts_by_year': [{'year': 2024, 'cited_by_count': 17}, {'year': 2023, 'cited_by_count': 28}, {'year': 2022, 'cited_by_count': 25}, {'year': 2021, 'cited_by_count': 24}, {'year': 2020, 'cited_by_count': 37}, {'year': 2019, 'cited_by_count': 32}, {'year': 2018, 'cited_by_count': 32}, {'year': 2017, 'cited_by_count': 40}, {'year': 2016, 'cited_by_count': 31}, {'year': 2015, 'cited_by_count': 48}, {'year': 2014, 'cited_by_count': 52}, {'year': 2013, 'cited_by_count': 38}, {'year': 2012, 'cited_by_count': 68}], 'updated_date': '2024-09-17T01:41:00.668521', 'created_date': '2016-06-24'}