Title: Efffects of Xuanshen participation group element (XPGE) on the proliferation of granulocyte haemopoitic preginitor cells (CFU-G).
Abstract: Objective To evaluate the curative effect of XPGE on radiation induced acute bone marrow disease and the mechanistic actions on haemopoietic system. Methods XPGE was prepared from Xuanshen and 11 selected traditional Chinese medicines.Mice were subcutaneously injected with XPGE and the change of peripheral blood cells,thymus weight, bone marrow nucleated cells, granulocyte colony forming unit (CFU-G) and the growth of bone marrow cells in thymus cell co-culture. Results XPGE was found to enhance the maturation and release of granulocytes. There was a 1.5-fold increase in the release of granulocyte at day-6 after XPGE injection. At 8 days after injection, the thymus weight, number of bone marrow nucleated cells and spleen index of mice receiving XPGE was (85.9±5.6)mg,(8.9±1.3)×10~6/fermus and 1.42, respectively. The values were significantly higher than mice in the control group [thymus weight: (74.2±6.2), bone marrow nucleated cells, (6.8±0.5)×10~6/fermus; spleen index: 1.0]. In the thymus cells and bone marrow cells co-culture, there was a 1.5-fold increase in CFU-G in the XPGE group. Conclusion XPGE can significantly increase the number of peripheral blood cells,the thymus weight,the number of bone marrow nucleated cells and CFU-G. Activated thymus cells can enhance the proliferation of CFU-G.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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