Title: Cerebral blood flow changes in limbic regions induced by unsolvable anagram tasks
Abstract: Back to table of contents Previous article Next article No AccessCerebral blood flow changes in limbic regions induced by unsolvable anagram tasksPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.153.2.206AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractOBJECTIVE: The study addressed the question of whether unsolvable as opposed to solvable cognitive problems activate discrete neuronal systems in the human brain. METHOD: Twelve healthy humans tried to solve unsolvable anagrams. Solvable anagrams and a resting baseline after each anagram task served as control conditions in a within- subject design. Activation was measured with the equilibrium infusion method by using 15O-labeled water and positron emission tomography, with absolute quantitation of anatomically defined regional cerebral blood flow (CBF). RESULTS: Compared to rest, both anagram tasks increased activity in frontal and temporal regions. The soluble task condition increased hippocampal activation and decreased mammillary bodies activity, while unsolvable anagrams were associated with increased CBF to the mamillary bodies and amygdala and decreased hippocampal activity. CONCLUSIONS: A limbic network integrating negative emotion and cognition seems reflected in reciprocal diencephalic and limbic activation with solvable and unsolvable anagrams. Since unsolvable anagrams have been used to induce learned helplessness in humans, this finding may provide an initial step toward clarifying its neural substrate. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited ByDopamine, religiosity, and utilitarian moral judgment2 September 2021 | Social Neuroscience, Vol. 16, No. 6Weighted RSA: An Improved Framework on the Perception of Audio-visual Affective Speech in Left Insula and Superior Temporal GyrusNeuroscience, Vol. 469Subjective Uncontrollability over Aversive Events Reduces Working Memory Performance and Related Large-Scale Network Interactions14 December 2019 | Cerebral Cortex, Vol. 30, No. 5, Vol. 163Physiological Self-Regulation Buffers the Relationship between Impulsivity and Externalizing Behaviors among Nonclinical Adolescents12 May 2017 | Journal of Youth and Adolescence, Vol. 47, No. 4Frontiers in Behavioral Neuroscience, Vol. 11American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 171, No. 1Cognition, Vol. 146International Journal of Psychophysiology, Vol. 106Social Cognitive and Affective Neuroscience, Vol. 10, No. 2Social Cognitive and Affective Neuroscience, Vol. 9, No. 6Chinese Science Bulletin, Vol. 58, No. 13Behavioral and Brain Sciences, Vol. 36, No. 6PLoS ONE, Vol. 8, No. 10Forensische Psychiatrie, Psychologie, Kriminologie, Vol. 6, No. 2Biomedical Optics Express, Vol. 3, No. 10Gastroenterology, Vol. 141, No. 3The Function of Personality in CreativityNeural basis of thinking: laboratory problems versus real‐world problems25 May 2010 | WIREs Cognitive Science, Vol. 1, No. 4NeuroImage, Vol. 50, No. 2Biological Psychology, Vol. 80, No. 2Neuroscience & Biobehavioral Reviews, Vol. 32, No. 7Acta Psychiatrica Scandinavica, Vol. 117, No. 6Brain Research, Vol. 1120, No. 1NeuroImage, Vol. 29, No. 3Cognitive Neuropsychiatry, Vol. 11, No. 3Annals of the New York Academy of Sciences, Vol. 935, No. 1Behavior Research Methods, Vol. 38, No. 2Cerebral Cortex, Vol. 15, No. 8International Journal of Behavioral Medicine, Vol. 12, No. 3Life and Death Decisions: Psychological and Ethical Considerations in End-of-Life CareJACK C. SCHOENHOLTZ, M.D., 22 December 2014 | American Journal of Psychiatry, Vol. 161, No. 10Well–being and affective style: neural substrates and biobehavioural correlates29 September 2004 | Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, Vol. 359, No. 1449Cognitive Brain Research, Vol. 21, No. 2Effect of Chronic Administration of Selective Glucocorticoid Receptor Antagonists on the Rat Hypothalamic–Pituitary–Adrenocortical Axis19 December 2002 | Neuropsychopharmacology, Vol. 28, No. 6NeuroImage, Vol. 20, No. 2Neuropsychopharmacology, Vol. 28, No. S1Psychophysiology, Vol. 40, No. 2Modulation of Amygdalar Activity by the Conscious Regulation of Negative EmotionJournal of Cognitive Neuroscience, Vol. 14, No. 6Is the Human Amygdala Critical for the Subjective Experience of Emotion? Evidence of Intact Dispositional Affect in Patients with Amygdala LesionsJournal of Cognitive Neuroscience, Vol. 14, No. 5Biological Psychiatry, Vol. 51, No. 1Cognitive Brain Research, Vol. 14, No. 3Depression as a spreading adjustment disorder of monoaminergic neurons: a case for primary implication of the locus coeruleusBrain Research Reviews, Vol. 38, No. 1-2The neural circuitry of emotion and affective style: prefrontal cortex and amygdala contributions30 June 2016 | Social Science Information, Vol. 40, No. 1Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 25, No. 3Neuroreport, Vol. 12, No. 8Arquivos de Neuro-Psiquiatria, Vol. 59, No. 3BThe amygdala: vigilance and emotion14 December 2000 | Molecular Psychiatry, Vol. 6, No. 1Neuroscience & Biobehavioral Reviews, Vol. 24, No. 6Psychological Bulletin, Vol. 126, No. 6Biological Psychiatry, Vol. 45, No. 7International Journal of Psychophysiology, Vol. 33, No. 2Trends in Cognitive Sciences, Vol. 3, No. 1Inherited Hypohedonia Leads to Learned Helplessness: A Conjecture Updated1 December 1998 | Review of General Psychology, Vol. 2, No. 4NeuroImage, Vol. 8, No. 1Neuroscience and Behavioral Physiology, Vol. 28, No. 6Linking Mind and Brain in the Study of Mental Illnesses: A Project for a Scientific PsychopathologyScience, Vol. 275, No. 5306Neuropsychologia, Vol. 35, No. 10Current Opinion in Neurobiology, Vol. 7, No. 2Current Opinion in Psychiatry, Vol. 10, No. 2Neuron, Vol. 17, No. 5 Volume 153Issue 2 February 1996Pages 206-212 Metrics PDF download History Published online 1 April 2006 Published in print 1 February 1996
Publication Year: 1996
Publication Date: 1996-02-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 86
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot