Publication Information

{'id': 'https://openalex.org/W1663580115', 'doi': None, 'title': 'The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L.', 'display_name': 'The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L.', 'publication_year': 1998, 'publication_date': '1998-07-23', 'ids': {'openalex': 'https://openalex.org/W1663580115', 'mag': '1663580115', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9673365'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9673365', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5108449766', 'display_name': 'David R. Worthen', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'D R Worthen', 'raw_affiliation_strings': ['Natural Products Chemistry Laboratory, Tobacco and Health Research Institute, Lexington, KY 40536, USA.'], 'affiliations': [{'raw_affiliation_string': 'Natural Products Chemistry Laboratory, Tobacco and Health Research Institute, Lexington, KY 40536, USA.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013995395', 'display_name': 'O A Ghosheh', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'O A Ghosheh', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101967021', 'display_name': 'Peter A. Crooks', 'orcid': 'https://orcid.org/0000-0002-1312-6150'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'P A Crooks', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.762, 'has_fulltext': False, 'cited_by_count': 380, 'citation_normalized_percentile': {'value': 0.999445, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '18', 'issue': '3A', 'first_page': '1527', 'last_page': '32'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12750', 'display_name': 'Nigella sativa pharmacological applications', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12750', 'display_name': 'Nigella sativa pharmacological applications', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9891, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12429', 'display_name': 'Chemotherapy-induced organ toxicity mitigation', 'score': 0.9734, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/thymoquinone', 'display_name': 'Thymoquinone', 'score': 0.9103112}, {'id': 'https://openalex.org/keywords/nigella-sativa', 'display_name': 'Nigella sativa', 'score': 0.54926735}, {'id': 'https://openalex.org/keywords/rhodamine-123', 'display_name': 'Rhodamine 123', 'score': 0.4354204}, {'id': 'https://openalex.org/keywords/p-glycoprotein', 'display_name': 'P-glycoprotein', 'score': 0.42975327}, {'id': 'https://openalex.org/keywords/quinine', 'display_name': 'Quinine', 'score': 0.42585403}], 'concepts': [{'id': 'https://openalex.org/C2779034068', 'wikidata': 'https://www.wikidata.org/wiki/Q7799650', 'display_name': 'Thymoquinone', 'level': 3, 'score': 0.9103112}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.84085256}, {'id': 'https://openalex.org/C2778119113', 'wikidata': 'https://www.wikidata.org/wiki/Q418817', 'display_name': 'Etoposide', 'level': 3, 'score': 0.5914352}, {'id': 'https://openalex.org/C2781303535', 'wikidata': 'https://www.wikidata.org/wiki/Q18936', 'display_name': 'Doxorubicin', 'level': 3, 'score': 0.58489394}, {'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.56879175}, {'id': 'https://openalex.org/C2993714443', 'wikidata': 'https://www.wikidata.org/wiki/Q160575', 'display_name': 'Nigella sativa', 'level': 2, 'score': 0.54926735}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5334357}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.5292268}, {'id': 'https://openalex.org/C133936738', 'wikidata': 'https://www.wikidata.org/wiki/Q643839', 'display_name': 'Multiple drug resistance', 'level': 3, 'score': 0.52269614}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.43561146}, {'id': 'https://openalex.org/C2778589691', 'wikidata': 'https://www.wikidata.org/wiki/Q3429577', 'display_name': 'Rhodamine 123', 'level': 4, 'score': 0.4354204}, {'id': 'https://openalex.org/C2778707650', 'wikidata': 'https://www.wikidata.org/wiki/Q412902', 'display_name': 'P-glycoprotein', 'level': 4, 'score': 0.42975327}, {'id': 'https://openalex.org/C2777617192', 'wikidata': 'https://www.wikidata.org/wiki/Q189522', 'display_name': 'Quinine', 'level': 3, 'score': 0.42585403}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.40478638}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3825079}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.32417715}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3160544}, {'id': 'https://openalex.org/C556039675', 'wikidata': 'https://www.wikidata.org/wiki/Q771035', 'display_name': 'Traditional medicine', 'level': 1, 'score': 0.21782944}, {'id': 'https://openalex.org/C2778004101', 'wikidata': 'https://www.wikidata.org/wiki/Q133948', 'display_name': 'Antioxidant', 'level': 2, 'score': 0.17639086}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.16390094}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.15426672}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.14503703}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C2778048844', 'wikidata': 'https://www.wikidata.org/wiki/Q12156', 'display_name': 'Malaria', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D016227', 'descriptor_name': 'Benzoquinones', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D018432', 'descriptor_name': 'Drug Resistance, Multiple', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D010936', 'descriptor_name': 'Plant Extracts', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D010946', 'descriptor_name': 'Plants, Medicinal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020168', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily B, Member 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020168', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily B, Member 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016227', 'descriptor_name': 'Benzoquinones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004121', 'descriptor_name': 'Dimethyl Sulfoxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004121', 'descriptor_name': 'Dimethyl Sulfoxide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D005047', 'descriptor_name': 'Etoposide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005047', 'descriptor_name': 'Etoposide', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016166', 'descriptor_name': 'Free Radical Scavengers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016166', 'descriptor_name': 'Free Radical Scavengers', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007938', 'descriptor_name': 'Leukemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017239', 'descriptor_name': 'Paclitaxel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017239', 'descriptor_name': 'Paclitaxel', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D010190', 'descriptor_name': 'Pancreatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010936', 'descriptor_name': 'Plant Extracts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010938', 'descriptor_name': 'Plant Oils', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010938', 'descriptor_name': 'Plant Oils', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D011803', 'descriptor_name': 'Quinine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011803', 'descriptor_name': 'Quinine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D012509', 'descriptor_name': 'Sarcoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014594', 'descriptor_name': 'Uterine Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9673365', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2999660709', 'https://openalex.org/W2980599319', 'https://openalex.org/W2335276322', 'https://openalex.org/W2132081356', 'https://openalex.org/W2065723669', 'https://openalex.org/W2049178799', 'https://openalex.org/W1983628873', 'https://openalex.org/W1971289691', 'https://openalex.org/W1930062278', 'https://openalex.org/W1663580115'], 'abstract_inverted_index': {'A': [0], 'crude': [1], 'gum,': [2], 'a': [3, 156], 'fixed': [4], 'oil': [5, 47], 'and': [6, 16, 29, 54, 75, 91, 106, 126, 207, 224], 'two': [7], 'purified': [8], 'components': [9], 'of': [10, 43, 50, 60, 110, 139, 150, 168, 172, 175, 186, 198, 215], 'Nigella': [11], 'sativa': [12], 'seed,': [13], 'thymoquinone': [14], '(TQ)': [15], 'dithymoquinone': [17], '(DIM),': [18], 'were': [19, 56, 101], 'assayed': [20], 'in': [21, 116, 155, 180], 'vitro': [22], 'for': [23, 26, 58, 212], 'their': [24, 76, 97, 233], 'cytotoxicity': [25, 138, 185], 'several': [27, 213], 'parental': [28, 72, 99], 'multi-drug': [30], 'resistant': [31, 83], '(MDR)': [32], 'human': [33, 216], 'tumor': [34, 217], 'cell': [35, 63, 73, 122, 148], 'lines.': [36], 'Although': [37], 'as': [38, 40, 94, 189, 191], 'much': [39, 190], '1%': [41], 'w/v': [42], 'the': [44, 61, 71, 85, 111, 117, 137, 151, 176, 181, 184], 'gum': [45], 'or': [46, 141, 200], 'was': [48], 'devoid': [49], 'cytotoxicity,': [51], 'both': [52], 'TQ': [53, 105, 140, 161, 199, 206], 'DIM': [55, 163], 'cytotoxic': [57, 211, 234], 'all': [59], 'tested': [62], 'lines': [64, 74], "(IC50's": [65], '78': [66], 'to': [67, 84, 96, 104, 124, 130, 232], '393': [68], 'microM).': [69], 'Both': [70], 'corresponding': [77], 'MDR': [78, 113, 120, 146, 222], 'variants,': [79], 'over': [80], '10-fold': [81], 'more': [82], 'standard': [86], 'antineoplastic': [87], 'agents': [88], 'doxorubicin': [89], '(DOX)': [90], 'etoposide': [92], '(ETP),': [93], 'compared': [95], 'respective': [98], 'controls,': [100], 'equally': [102], 'sensitive': [103], 'DIM.': [107, 142, 201], 'The': [108, 170], 'inclusion': [109, 171], 'competitive': [112], 'modulator': [114], 'quinine': [115], 'assay': [118, 182], 'reversed': [119], 'Dx-5': [121, 147], 'resistance': [123], 'DOX': [125, 187], 'ETP': [127], 'by': [128, 188], '6-': [129], '16-fold,': [131], 'but': [132, 193], 'had': [133], 'no': [134], 'effect': [135], 'on': [136], 'Quinine': [143], 'also': [144], 'increased': [145], 'accumulation': [149, 167], 'P-glycoprotein': [152], 'substrate': [153], '3H-taxol': [154], 'dose-dependent': [157], 'manner.': [158], 'However,': [159], 'neither': [160], 'nor': [162], 'significantly': [164], 'altered': [165], 'cellular': [166], '3H-taxol.': [169], '0.5%': [173], 'v/v': [174], 'radical': [177, 226], 'scavenger': [178], 'DMSO': [179], 'reduced': [183], '39%,': [192], 'did': [194], 'not': [195, 220, 229], 'affect': [196], 'that': [197, 205, 225], 'These': [202], 'studies': [203], 'suggest': [204], 'DIM,': [208], 'which': [209], 'are': [210], 'types': [214], 'cells,': [218], 'may': [219, 228], 'be': [221, 230], 'substrates,': [223], 'generation': [227], 'critical': [231], 'activity.': [235]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1663580115', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 20}, {'year': 2016, 'cited_by_count': 21}, {'year': 2015, 'cited_by_count': 22}, {'year': 2014, 'cited_by_count': 37}, {'year': 2013, 'cited_by_count': 33}, {'year': 2012, 'cited_by_count': 26}], 'updated_date': '2024-12-14T09:47:48.270954', 'created_date': '2016-06-24'}