Title: Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family.
Abstract: Research Article1 December 1987free access Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family. R. de Martin R. de Martin Sandoz Forschungsinstitut, Wien, Austria. Search for more papers by this author B. Haendler B. Haendler Sandoz Forschungsinstitut, Wien, Austria. Search for more papers by this author R. Hofer-Warbinek R. Hofer-Warbinek Sandoz Forschungsinstitut, Wien, Austria. Search for more papers by this author H. Gaugitsch H. Gaugitsch Sandoz Forschungsinstitut, Wien, Austria. Search for more papers by this author M. Wrann M. Wrann Sandoz Forschungsinstitut, Wien, Austria. Search for more papers by this author H. Schlüsener H. Schlüsener Sandoz Forschungsinstitut, Wien, Austria. Search for more papers by this author J. M. Seifert J. M. Seifert Sandoz Forschungsinstitut, Wien, Austria. Search for more papers by this author S. Bodmer S. Bodmer Sandoz Forschungsinstitut, Wien, Austria. Search for more papers by this author A. Fontana A. Fontana Sandoz Forschungsinstitut, Wien, Austria. Search for more papers by this author E. Hofer E. Hofer Sandoz Forschungsinstitut, Wien, Austria. Search for more papers by this author R. de Martin R. de Martin Sandoz Forschungsinstitut, Wien, Austria. Search for more papers by this author B. Haendler B. Haendler Sandoz Forschungsinstitut, Wien, Austria. Search for more papers by this author R. Hofer-Warbinek R. Hofer-Warbinek Sandoz Forschungsinstitut, Wien, Austria. Search for more papers by this author H. Gaugitsch H. Gaugitsch Sandoz Forschungsinstitut, Wien, Austria. Search for more papers by this author M. Wrann M. Wrann Sandoz Forschungsinstitut, Wien, Austria. Search for more papers by this author H. Schlüsener H. Schlüsener Sandoz Forschungsinstitut, Wien, Austria. Search for more papers by this author J. M. Seifert J. M. Seifert Sandoz Forschungsinstitut, Wien, Austria. Search for more papers by this author S. Bodmer S. Bodmer Sandoz Forschungsinstitut, Wien, Austria. Search for more papers by this author A. Fontana A. Fontana Sandoz Forschungsinstitut, Wien, Austria. Search for more papers by this author E. Hofer E. Hofer Sandoz Forschungsinstitut, Wien, Austria. Search for more papers by this author Author Information R. Martin1, B. Haendler1, R. Hofer-Warbinek1, H. Gaugitsch1, M. Wrann1, H. Schlüsener1, J. M. Seifert1, S. Bodmer1, A. Fontana1 and E. Hofer1 1Sandoz Forschungsinstitut, Wien, Austria. The EMBO Journal (1987)6:3673-3677https://doi.org/10.1002/j.1460-2075.1987.tb02700.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Human glioblastoma cells secrete a peptide, termed glioblastoma-derived T cell suppressor factor (G-TsF), which has suppressive effects on interleukin-2-dependent T cell growth. As shown here, complementary DNA for G-TsF reveals that G-TsF shares 71% amino acid homology with transforming growth factor-beta (TGF-beta). In analogy to TGF-beta it is apparently synthesized as the carboxy-terminal end of a precursor polypeptide which undergoes proteolytic cleavage to yield the 112 amino-acid-long mature form of G-TsF. Comparison of the amino-terminal sequence of G-TsF with that of porcine TGF-beta 2 and bovine cartilage-inducing factor B shows complete homology, which indicates that we have cloned the human analogue of these factors. It is tempting to consider a role for G-TsF in tumor growth where it may enhance tumor cell proliferation in an autocrine way and/or reduce immunosurveillance of tumor development. Previous ArticleNext Article Volume 6Issue 121 December 1987In this issue RelatedDetailsLoading ...