Publication Information

{'id': 'https://openalex.org/W1655026638', 'doi': 'https://doi.org/10.1900/rds.2012.9.407', 'title': 'Islet Neogenesis: A Possible Pathway for Beta-Cell Replenishment', 'display_name': 'Islet Neogenesis: A Possible Pathway for Beta-Cell Replenishment', 'publication_year': 2012, 'publication_date': '2012-01-01', 'ids': {'openalex': 'https://openalex.org/W1655026638', 'doi': 'https://doi.org/10.1900/rds.2012.9.407', 'mag': '1655026638', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23804276', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3740706'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1900/rds.2012.9.407', 'pdf_url': 'http://www.soc-bdr.org/content/e4/e887/volRdsVolumes11903/issRdsIssues11918/chpRdsChapters12578/strRdsArticles12587/?preview=preview&showpdf=1', 'source': {'id': 'https://openalex.org/S4210225960', 'display_name': 'The Review of Diabetic Studies', 'issn_l': '1613-6071', 'issn': ['1613-6071', '1614-0575'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.soc-bdr.org/content/e4/e887/volRdsVolumes11903/issRdsIssues11918/chpRdsChapters12578/strRdsArticles12587/?preview=preview&showpdf=1', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008915190', 'display_name': 'Susan Bonner‐Weir', 'orcid': 'https://orcid.org/0000-0003-4682-0656'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Susan Bonner-Weir', 'raw_affiliation_strings': ['Joslin Diabetes Center, Department of Medicine, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA.'], 'affiliations': [{'raw_affiliation_string': 'Joslin Diabetes Center, Department of Medicine, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA.', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041847119', 'display_name': 'Lili Guo', 'orcid': 'https://orcid.org/0000-0002-7036-0234'}, 'institutions': [{'id': 'https://openalex.org/I2801851002', 'display_name': 'Harvard University Press', 'ror': 'https://ror.org/006v7bf86', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I136199984', 'https://openalex.org/I2801851002']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lili Guo', 'raw_affiliation_strings': ['Harvard University'], 'affiliations': [{'raw_affiliation_string': 'Harvard University', 'institution_ids': ['https://openalex.org/I2801851002']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113504726', 'display_name': 'Wan-Chun Li', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Wan-Chun Li', 'raw_affiliation_strings': ['Institute of Oral Biology'], 'affiliations': [{'raw_affiliation_string': 'Institute of Oral Biology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077196833', 'display_name': 'Limor Ouziel-Yahalom', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801851002', 'display_name': 'Harvard University Press', 'ror': 'https://ror.org/006v7bf86', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I136199984', 'https://openalex.org/I2801851002']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Limor Ouziel-Yahalom', 'raw_affiliation_strings': ['Harvard University'], 'affiliations': [{'raw_affiliation_string': 'Harvard University', 'institution_ids': ['https://openalex.org/I2801851002']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087833336', 'display_name': 'Gordon C. Weir', 'orcid': 'https://orcid.org/0000-0003-1456-0546'}, 'institutions': [{'id': 'https://openalex.org/I2801851002', 'display_name': 'Harvard University Press', 'ror': 'https://ror.org/006v7bf86', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I136199984', 'https://openalex.org/I2801851002']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gordon C. Weir', 'raw_affiliation_strings': ['Harvard University'], 'affiliations': [{'raw_affiliation_string': 'Harvard University', 'institution_ids': ['https://openalex.org/I2801851002']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5070508954', 'display_name': 'Arun Sharma', 'orcid': 'https://orcid.org/0000-0002-0607-5455'}, 'institutions': [{'id': 'https://openalex.org/I2801851002', 'display_name': 'Harvard University Press', 'ror': 'https://ror.org/006v7bf86', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I136199984', 'https://openalex.org/I2801851002']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Arun Sharma', 'raw_affiliation_strings': ['Harvard University'], 'affiliations': [{'raw_affiliation_string': 'Harvard University', 'institution_ids': ['https://openalex.org/I2801851002']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.518, 'has_fulltext': False, 'cited_by_count': 56, 'citation_normalized_percentile': {'value': 0.649835, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '9', 'issue': '4', 'first_page': '407', 'last_page': '416'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic function and diabetes', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic function and diabetes', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10560', 'display_name': 'Diabetes Management and Research', 'score': 0.9896, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11171', 'display_name': 'Diabetes and associated disorders', 'score': 0.9882, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neogenesis', 'display_name': 'Neogenesis', 'score': 0.9446497}, {'id': 'https://openalex.org/keywords/enteroendocrine-cell', 'display_name': 'Enteroendocrine cell', 'score': 0.4667224}, {'id': 'https://openalex.org/keywords/pancreatic-islets', 'display_name': 'Pancreatic Islets', 'score': 0.45088917}], 'concepts': [{'id': 'https://openalex.org/C2780093864', 'wikidata': 'https://www.wikidata.org/wiki/Q10797618', 'display_name': 'Neogenesis', 'level': 4, 'score': 0.9446497}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6344466}, {'id': 'https://openalex.org/C2778764654', 'wikidata': 'https://www.wikidata.org/wiki/Q9618', 'display_name': 'Pancreas', 'level': 2, 'score': 0.6077723}, {'id': 'https://openalex.org/C145103041', 'wikidata': 'https://www.wikidata.org/wiki/Q1151519', 'display_name': 'Embryonic stem cell', 'level': 3, 'score': 0.60650253}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.58149177}, {'id': 'https://openalex.org/C165220095', 'wikidata': 'https://www.wikidata.org/wiki/Q207524', 'display_name': 'Islet', 'level': 3, 'score': 0.51884186}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.50532824}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5042571}, {'id': 'https://openalex.org/C201750760', 'wikidata': 'https://www.wikidata.org/wiki/Q1896218', 'display_name': 'Progenitor cell', 'level': 3, 'score': 0.50354093}, {'id': 'https://openalex.org/C103395026', 'wikidata': 'https://www.wikidata.org/wiki/Q5380231', 'display_name': 'Enteroendocrine cell', 'level': 4, 'score': 0.4667224}, {'id': 'https://openalex.org/C2779855799', 'wikidata': 'https://www.wikidata.org/wiki/Q728309', 'display_name': 'Pancreatic islets', 'level': 4, 'score': 0.45088917}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.41550323}, {'id': 'https://openalex.org/C2780130043', 'wikidata': 'https://www.wikidata.org/wiki/Q192360', 'display_name': 'Autoimmunity', 'level': 3, 'score': 0.41020775}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.385456}, {'id': 'https://openalex.org/C46699223', 'wikidata': 'https://www.wikidata.org/wiki/Q11078', 'display_name': 'Endocrine system', 'level': 3, 'score': 0.35153952}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.350223}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.31947398}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.23472136}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.20268154}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.14509833}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.12318635}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D003922', 'descriptor_name': 'Diabetes Mellitus, Type 1', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D050417', 'descriptor_name': 'Insulin-Secreting Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D007515', 'descriptor_name': 'Islets of Langerhans', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003922', 'descriptor_name': 'Diabetes Mellitus, Type 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050417', 'descriptor_name': 'Insulin-Secreting Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007515', 'descriptor_name': 'Islets of Langerhans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1900/rds.2012.9.407', 'pdf_url': 'http://www.soc-bdr.org/content/e4/e887/volRdsVolumes11903/issRdsIssues11918/chpRdsChapters12578/strRdsArticles12587/?preview=preview&showpdf=1', 'source': {'id': 'https://openalex.org/S4210225960', 'display_name': 'The Review of Diabetic Studies', 'issn_l': '1613-6071', 'issn': ['1613-6071', '1614-0575'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3740706', 'pdf_url': 'https://europepmc.org/articles/pmc3740706?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740706', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23804276', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1900/rds.2012.9.407', 'pdf_url': 'http://www.soc-bdr.org/content/e4/e887/volRdsVolumes11903/issRdsIssues11918/chpRdsChapters12578/strRdsArticles12587/?preview=preview&showpdf=1', 'source': {'id': 'https://openalex.org/S4210225960', 'display_name': 'The Review of Diabetic Studies', 'issn_l': '1613-6071', 'issn': ['1613-6071', '1614-0575'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.45}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 76, 'referenced_works': ['https://openalex.org/W1958779837', 'https://openalex.org/W1973655151', 'https://openalex.org/W1981362835', 'https://openalex.org/W1982795249', 'https://openalex.org/W1982882974', 'https://openalex.org/W1983101319', 'https://openalex.org/W1987740077', 'https://openalex.org/W1993414114', 'https://openalex.org/W1995513877', 'https://openalex.org/W1995812738', 'https://openalex.org/W1996368148', 'https://openalex.org/W1998039376', 'https://openalex.org/W2003725355', 'https://openalex.org/W2006475805', 'https://openalex.org/W2011710385', 'https://openalex.org/W2014715897', 'https://openalex.org/W2021647007', 'https://openalex.org/W2022911774', 'https://openalex.org/W2025724973', 'https://openalex.org/W2029167057', 'https://openalex.org/W2033936238', 'https://openalex.org/W2036800308', 'https://openalex.org/W2038377972', 'https://openalex.org/W2039486174', 'https://openalex.org/W2041739600', 'https://openalex.org/W2042362312', 'https://openalex.org/W2042829340', 'https://openalex.org/W2044967431', 'https://openalex.org/W2045252815', 'https://openalex.org/W2047886415', 'https://openalex.org/W2057361172', 'https://openalex.org/W2061159176', 'https://openalex.org/W2065426311', 'https://openalex.org/W2067389522', 'https://openalex.org/W2069438759', 'https://openalex.org/W2082763364', 'https://openalex.org/W2084089742', 'https://openalex.org/W2085721222', 'https://openalex.org/W2091982710', 'https://openalex.org/W2093707110', 'https://openalex.org/W2101147942', 'https://openalex.org/W2104383642', 'https://openalex.org/W2105031631', 'https://openalex.org/W2107471483', 'https://openalex.org/W2110392605', 'https://openalex.org/W2113544353', 'https://openalex.org/W2114058685', 'https://openalex.org/W2114552310', 'https://openalex.org/W2118924566', 'https://openalex.org/W2122196783', 'https://openalex.org/W2124307629', 'https://openalex.org/W2127409471', 'https://openalex.org/W2127825630', 'https://openalex.org/W2129808680', 'https://openalex.org/W2133522211', 'https://openalex.org/W2134523762', 'https://openalex.org/W2139265907', 'https://openalex.org/W2141202032', 'https://openalex.org/W2143050701', 'https://openalex.org/W2145534175', 'https://openalex.org/W2147912554', 'https://openalex.org/W2148147368', 'https://openalex.org/W2154202891', 'https://openalex.org/W2154532011', 'https://openalex.org/W2154857534', 'https://openalex.org/W2161350305', 'https://openalex.org/W2164058944', 'https://openalex.org/W2164705177', 'https://openalex.org/W2165110544', 'https://openalex.org/W2167213847', 'https://openalex.org/W2167977281', 'https://openalex.org/W2169337437', 'https://openalex.org/W2416003593', 'https://openalex.org/W2427719183', 'https://openalex.org/W599108204', 'https://openalex.org/W87915922'], 'related_works': ['https://openalex.org/W88528949', 'https://openalex.org/W4293265234', 'https://openalex.org/W2740963940', 'https://openalex.org/W2186423959', 'https://openalex.org/W2171119973', 'https://openalex.org/W2160028030', 'https://openalex.org/W2137446998', 'https://openalex.org/W2019361290', 'https://openalex.org/W2000607179', 'https://openalex.org/W1925269365'], 'abstract_inverted_index': {'The': [0], 'Review': [1], 'of': [2, 46, 66, 84, 95, 110, 113, 142, 152, 184, 194, 203, 217, 243, 257, 285, 301], 'Diabetic': [3], 'Studies,2012,9,4,407-416.DOI:10.1900/RDS.2012.9.407Published:February': [4], '2013Type:Review': [5], 'Article': [6], 'Authors:Susan': [7], 'Bonner-Weir,': [8, 26], 'Lili': [9, 27], 'Guo,': [10, 28], 'Wan-Chun': [11, 29], 'Li,': [12, 30], 'Limor': [13, 31], 'Ouziel-Yahalom,': [14, 32], 'Philippe': [15, 33], 'A': [16], 'Lysy,': [17, 35], 'Gordon': [18, 36], 'C': [19], 'Weir,': [20, 38], 'and': [21, 39, 90, 92, 101, 136, 159, 168, 275, 290], 'Arun': [22, 40], 'Sharma': [23, 41], 'Author(s)': [24], 'affiliations:Susan': [25], 'A.': [34], 'C.': [37], 'Joslin': [42, 52], 'Diabetes': [43], 'Center,': [44], 'Department': [45], 'Medicine,': [47], 'Harvard': [48], 'Medical': [49], 'School,': [50], '1': [51, 60, 186], 'Place,': [53], 'Boston,': [54], 'MA': [55], '02215.': [56], 'Abstract:Diabetes,': [57], 'particularly': [58], 'type': [59, 185], 'diabetes,': [61, 74], 'results': [62], 'from': [63, 88, 146, 260, 272, 294], 'the': [64, 80, 85, 108, 133, 140, 175, 182, 195, 239, 244, 265, 283], 'lack': [65], 'pancreatic': [67, 114, 147], 'β-cells.': [68], 'β-cell': [69, 153, 176], 'replenishment': [70, 112, 130], 'can': [71], 'functionally': [72], 'reverse': [73], 'but': [75, 247], 'two': [76], 'critical': [77], 'challenges': [78], 'face': [79], 'field:': [81], '1.': [82], 'protection': [83], 'new': [86, 143], 'β-cells': [87, 96, 115], 'autoimmunity': [89, 122], 'allorejection,': [91], '2.': [93], 'development': [94], 'that': [97, 224, 235], 'are': [98, 155], 'readily': [99], 'available': [100], 'reliably': [102], 'functional.': [103], 'This': [104], 'chapter': [105], 'will': [106], 'examine': [107], 'potential': [109], 'endogenous': [111, 129], 'as': [116, 139, 292], 'a': [117, 191, 210, 221], 'possible': [118], 'therapeutic': [119], 'tool': [120], 'if': [121], 'could': [123, 219, 225], 'be': [124, 209, 226], 'blunted.': [125], 'Two': [126], 'pathways': [127, 151], 'for': [128, 213], 'exist': [131], 'in': [132, 162, 165, 169, 181, 238, 287, 306], 'pancreas:': [134], 'replication': [135, 202], 'neogenesis,': [137], 'defined': [138], 'formation': [141, 242], 'islet': [144], 'cells': [145, 197, 206], 'progenitor/stem': [148], 'cells.': [149], 'These': [150], 'expansion': [154], 'not': [156, 208], 'mutually': [157], 'exclusive': [158], 'both': [160], 'occur': [161], 'embryonic': [163, 241], 'development,': [164], 'postnatal': [166], 'growth,': [167], 'response': [170], 'to': [171], 'some': [172], 'injuries.': [173], 'Since': [174], 'population': [177, 223], 'is': [178, 232], 'dramatically': [179], 'reduced': [180], 'pancreas': [183], 'diabetes': [187], 'patients,': [188], 'with': [189], 'only': [190], 'small': [192], 'fraction': [193], 'β-': [196, 205], 'surviving': [198], 'years': [199], 'after': [200, 251], 'onset,': [201], 'preexisting': [204], 'would': [207], 'reasonable': [211], 'start': [212], 'replenishment.': [214], 'However,': [215, 264], 'induction': [216], 'neogenesis': [218, 236, 286], 'provide': [220], 'starting': [222], 'further': [227], 'expanded': [228], 'by': [229, 298], 'replication.': [230], 'It': [231], 'widely': [233], 'accepted': [234], 'occurs': [237], 'initial': [240], 'endocrine': [245], 'pancreas,': [246], 'its': [248], 'occurrence': [249], 'anytime': [250], 'birth': [252], 'has': [253, 303], 'become': [254], 'controversial': [255], 'because': [256], 'discordant': [258], 'data': [259], 'lineage': [261], 'tracing': [262], 'experiments.': [263], 'concept': [266], 'was': [267], 'built': [268], 'upon': [269], 'many': [270, 278], 'observations': [271], 'different': [273], 'models': [274], 'species': [276], 'over': [277], 'years.': [279], 'Herein,': [280], 'we': [281], 'discuss': [282], 'role': [284], 'normal': [288], 'growth': [289], 'regeneration,': [291], 'learned': [293], 'rodent': [295], 'models,': [296], 'followed': [297], 'an': [299], 'analysis': [300], 'what': [302], 'been': [304], 'found': [305], 'humans.': [307], 'Keywords:Diabetes,': [308], 'Insulin,': [309], 'Islet,': [310], 'Neogenesis,': [311], 'Pancreatic': [312], 'beta-cell,': [313], 'Regeneration,': [314], 'ReplicationView:PDF': [315], '(178.31': [316], 'KB)': [317]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1655026638', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 3}], 'updated_date': '2025-01-10T01:02:27.124483', 'created_date': '2016-06-24'}