Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1653152132', 'doi': 'https://doi.org/10.1186/s12974-015-0355-z', 'title': 'β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia', 'display_name': 'β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia', 'publication_year': 2015, 'publication_date': '2015-07-15', 'ids': {'openalex': 'https://openalex.org/W1653152132', 'doi': 'https://doi.org/10.1186/s12974-015-0355-z', 'mag': '1653152132', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26173397', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4502557'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12974-015-0355-z', 'pdf_url': 'https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-015-0355-z', 'source': {'id': 'https://openalex.org/S199572710', 'display_name': 'Journal of Neuroinflammation', 'issn_l': '1742-2094', 'issn': ['1742-2094'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-015-0355-z', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100321874', 'display_name': 'Eun Jung Lee', 'orcid': 'https://orcid.org/0000-0002-7724-8288'}, 'institutions': [{'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Eun-Jung Lee', 'raw_affiliation_strings': ['Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, South Korea.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, South Korea.', 'institution_ids': ['https://openalex.org/I138925566']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109057247', 'display_name': 'Hyun-Myung Ko', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hyun-Myung Ko', 'raw_affiliation_strings': ['Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, South Korea.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, South Korea.', 'institution_ids': ['https://openalex.org/I138925566']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113504635', 'display_name': 'Yeon‐Hui Jeong', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Yeon-Hui Jeong', 'raw_affiliation_strings': ['Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, South Korea.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, South Korea.', 'institution_ids': ['https://openalex.org/I138925566']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018467910', 'display_name': 'Eun‐Mi Park', 'orcid': 'https://orcid.org/0000-0003-2414-3789'}, 'institutions': [{'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Eun-Mi Park', 'raw_affiliation_strings': ['Department of Pharmacology, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, South Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, South Korea', 'institution_ids': ['https://openalex.org/I138925566']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101713488', 'display_name': 'Hee-Sun Kim', 'orcid': 'https://orcid.org/0000-0003-1889-8739'}, 'institutions': [{'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hee-Sun Kim', 'raw_affiliation_strings': ['Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, South Korea.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, South Korea.', 'institution_ids': ['https://openalex.org/I138925566']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2390, 'currency': 'GBP', 'value_usd': 2931, 'provenance': 'doaj'}, 'apc_paid': {'value': 2390, 'currency': 'GBP', 'value_usd': 2931, 'provenance': 'doaj'}, 'fwci': 5.446, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 83, 'citation_normalized_percentile': {'value': 0.999187, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '12', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12356', 'display_name': 'Bioactive Compounds and Antitumor Agents', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/3005', 'display_name': 'Toxicology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12356', 'display_name': 'Bioactive Compounds and Antitumor Agents', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/3005', 'display_name': 'Toxicology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11340', 'display_name': 'Marine Sponges and Natural Products', 'score': 0.9905, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13792', 'display_name': 'Morinda citrifolia extract uses', 'score': 0.9745, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C87753298', 'wikidata': 'https://www.wikidata.org/wiki/Q17157137', 'display_name': 'Neuroinflammation', 'level': 3, 'score': 0.9312171}, {'id': 'https://openalex.org/C2779830541', 'wikidata': 'https://www.wikidata.org/wiki/Q1622829', 'display_name': 'Microglia', 'level': 3, 'score': 0.87959987}, {'id': 'https://openalex.org/C109523444', 'wikidata': 'https://www.wikidata.org/wiki/Q424216', 'display_name': 'Matrix metalloproteinase', 'level': 2, 'score': 0.76846063}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.5250173}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.44949365}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.42181417}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.38351482}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3612402}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27882025}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.1086348}], 'mesh': [{'descriptor_ui': 'D000893', 'descriptor_name': 'Anti-Inflammatory Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004660', 'descriptor_name': 'Encephalitis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004660', 'descriptor_name': 'Encephalitis', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D020782', 'descriptor_name': 'Matrix Metalloproteinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017628', 'descriptor_name': 'Microglia', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D009285', 'descriptor_name': 'Naphthoquinones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000893', 'descriptor_name': 'Anti-Inflammatory Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004660', 'descriptor_name': 'Encephalitis', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D004660', 'descriptor_name': 'Encephalitis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051547', 'descriptor_name': 'Heme Oxygenase-1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051547', 'descriptor_name': 'Heme Oxygenase-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016753', 'descriptor_name': 'Interleukin-10', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016753', 'descriptor_name': 'Interleukin-10', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D020782', 'descriptor_name': 'Matrix Metalloproteinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017628', 'descriptor_name': 'Microglia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017628', 'descriptor_name': 'Microglia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009285', 'descriptor_name': 'Naphthoquinones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052247', 'descriptor_name': 'Nitric Oxide Synthase Type II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052247', 'descriptor_name': 'Nitric Oxide Synthase Type II', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009573', 'descriptor_name': 'Nitrites', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009573', 'descriptor_name': 'Nitrites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019716', 'descriptor_name': 'Tissue Inhibitor of Metalloproteinase-2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019716', 'descriptor_name': 'Tissue Inhibitor of Metalloproteinase-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12974-015-0355-z', 'pdf_url': 'https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-015-0355-z', 'source': {'id': 'https://openalex.org/S199572710', 'display_name': 'Journal of Neuroinflammation', 'issn_l': '1742-2094', 'issn': ['1742-2094'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502557', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26173397', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12974-015-0355-z', 'pdf_url': 'https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-015-0355-z', 'source': {'id': 'https://openalex.org/S199572710', 'display_name': 'Journal of Neuroinflammation', 'issn_l': '1742-2094', 'issn': ['1742-2094'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.6, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W1482019136', 'https://openalex.org/W1540258377', 'https://openalex.org/W1600224209', 'https://openalex.org/W1614305545', 'https://openalex.org/W1636928136', 'https://openalex.org/W1937305016', 'https://openalex.org/W1965942744', 'https://openalex.org/W1982012586', 'https://openalex.org/W1985328677', 'https://openalex.org/W1990461254', 'https://openalex.org/W1996024251', 'https://openalex.org/W2003674452', 'https://openalex.org/W2008572209', 'https://openalex.org/W2012000805', 'https://openalex.org/W2032146350', 'https://openalex.org/W2038334863', 'https://openalex.org/W2039046472', 'https://openalex.org/W2039073496', 'https://openalex.org/W2039326711', 'https://openalex.org/W2043037141', 'https://openalex.org/W2046970075', 'https://openalex.org/W2051504363', 'https://openalex.org/W2055535173', 'https://openalex.org/W2056847885', 'https://openalex.org/W2056915902', 'https://openalex.org/W2057514934', 'https://openalex.org/W2068463895', 'https://openalex.org/W2069454029', 'https://openalex.org/W2071773362', 'https://openalex.org/W2075111099', 'https://openalex.org/W2075277951', 'https://openalex.org/W2083743765', 'https://openalex.org/W2085128107', 'https://openalex.org/W2087051641', 'https://openalex.org/W2087286505', 'https://openalex.org/W2088976086', 'https://openalex.org/W2089024157', 'https://openalex.org/W2091305271', 'https://openalex.org/W2108103966', 'https://openalex.org/W2119958966', 'https://openalex.org/W2123819911', 'https://openalex.org/W2124054487', 'https://openalex.org/W2132169664', 'https://openalex.org/W2132708067', 'https://openalex.org/W2134628479', 'https://openalex.org/W2139815913', 'https://openalex.org/W2142699482', 'https://openalex.org/W2146180881', 'https://openalex.org/W2147180300', 'https://openalex.org/W2186470498', 'https://openalex.org/W2315084782', 'https://openalex.org/W2318397082'], 'related_works': ['https://openalex.org/W4390463473', 'https://openalex.org/W4310076785', 'https://openalex.org/W4281290245', 'https://openalex.org/W3107395714', 'https://openalex.org/W2965172925', 'https://openalex.org/W2946580071', 'https://openalex.org/W2804482952', 'https://openalex.org/W2803817550', 'https://openalex.org/W2365450153', 'https://openalex.org/W2049658025'], 'abstract_inverted_index': {'β-Lapachone': [0], '(β-LAP)': [1], 'is': [2], 'a': [3], 'natural': [4], 'naphthoquinone': [5], 'compound': [6], 'isolated': [7], 'from': [8], 'the': [9, 28, 50, 90, 99, 113, 134, 154, 159, 171, 197, 206, 240, 264, 271, 278], 'lapacho': [10], 'tree': [11], '(Tabebuia': [12], 'sp.),': [13], 'and': [14, 25, 41, 59, 71, 83, 89, 105, 130, 140, 147, 170, 196, 203, 223, 252, 268], 'it': [15], 'has': [16, 35], 'been': [17], 'used': [18], 'for': [19, 291], 'treatment': [20], 'of': [21, 47, 52, 93, 116, 136, 161, 174, 180, 199, 244, 257, 266, 284], 'rheumatoid': [22], 'arthritis,': [23], 'infection,': [24], 'cancer.': [26], 'In': [27], 'present': [29], 'study,': [30], 'we': [31], 'investigated': [32], 'whether': [33], 'β-LAP': [34, 48, 117, 157, 181, 192, 215, 230, 258, 285], 'anti-inflammatory': [36, 114, 162, 178, 217], 'effects': [37, 46, 115, 218, 256, 283], 'under': [38], 'in': [39, 42, 65, 98, 150, 184, 205, 227], 'vitro': [40], 'vivo': [43], 'neuroinflammatory': [44, 293], 'conditions.The': [45], 'on': [49], 'expression': [51, 91, 135, 241], 'inducible': [53], 'nitric': [54], 'oxide': [55], 'synthase': [56], '(iNOS),': [57], 'cytokines,': [58, 139, 202], 'matrix': [60], 'metalloproteinases': [61], '(MMPs)': [62], 'were': [63, 96], 'examined': [64], 'lipopolysaccharide': [66], '(LPS)-stimulated': [67], 'BV2': [68], 'microglial': [69, 194], 'cells': [70], 'rat': [72], 'primary': [73], 'microglia': [74], 'by': [75, 103, 120, 219, 238], 'ELISA,': [76], 'reverse': [77], 'transcription': [78], 'polymerase': [79], 'chain': [80], 'reaction': [81], '(RT-PCR),': [82], 'Western': [84, 128], 'blot': [85], 'analysis.': [86, 107], 'Microglial': [87], 'activation': [88, 195], 'levels': [92, 149], 'proinflammatory': [94, 138, 201], 'molecules': [95, 163], 'measured': [97], 'LPS-injected': [100, 207], 'mouse': [101, 189, 208], 'brain': [102], 'immunohistochemistry': [104], 'RT-PCR': [106, 131], 'The': [108, 177, 254], 'detailed': [109], 'molecular': [110], 'mechanism': [111], 'underlying': [112], 'was': [118, 182], 'analyzed': [119], 'electrophoretic': [121], 'mobility': [122], 'shift': [123], 'assay,': [124, 127], 'reporter': [125], 'gene': [126], 'blot,': [129], 'analysis.β-LAP': [132], 'inhibited': [133, 193, 232], 'iNOS,': [137, 200], 'MMPs': [141, 204], '(MMP-3,': [142], 'MMP-8,': [143], 'MMP-9)': [144], 'at': [145], 'mRNA': [146], 'protein': [148], 'LPS-stimulated': [151, 228], 'microglia.': [152, 229], 'On': [153], 'other': [155], 'hand,': [156], 'upregulated': [158], 'expressions': [160, 198], 'such': [164, 249], 'as': [165, 250], 'IL-10,': [166], 'heme': [167], 'oxygenase-1': [168], '(HO-1),': [169], 'tissue': [172], 'inhibitor': [173], 'metalloproteinase-2': [175], '(TIMP-2).': [176], 'effect': [179], 'confirmed': [183], 'an': [185], 'LPS-induced': [186], 'systemic': [187], 'inflammation': [188], 'model.': [190], 'Thus,': [191], 'brain.': [209], 'Further': [210], 'mechanistic': [211], 'studies': [212], 'revealed': [213], 'that': [214], 'exerts': [216], 'inhibiting': [220], 'MAPKs,': [221], 'PI3K/AKT,': [222], 'NF-κB/AP-1': [224], 'signaling': [225], 'pathways': [226], 'also': [231], 'reactive': [233], 'oxygen': [234], 'species': [235], '(ROS)': [236], 'production': [237], 'suppressing': [239], 'and/or': [242, 277], 'phosphorylation': [243], 'NADPH': [245], 'oxidase': [246], 'subunit': [247], 'proteins,': [248], 'p47(phox)': [251], 'gp91(phox).': [253], 'anti-oxidant': [255], 'appeared': [259], 'to': [260], 'be': [261], 'related': [262], 'with': [263], 'increase': [265], 'HO-1': [267], 'NQO1': [269], 'via': [270], 'Nrf2/anti-oxidant': [272], 'response': [273], 'element': [274], '(ARE)': [275], 'pathway': [276], 'PKA': [279], 'pathway.The': [280], 'strong': [281], 'anti-inflammatory/anti-oxidant': [282], 'may': [286], 'provide': [287], 'preventive': [288], 'therapeutic': [289], 'potential': [290], 'various': [292], 'disorders.': [294]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1653152132', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 17}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 2}], 'updated_date': '2024-12-24T01:01:43.237336', 'created_date': '2016-06-24'}