Publication Information

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4619, 4698], 'signaling': [17, 214, 994, 1030, 1036, 3594, 4050, 4998, 5013, 5039], 'cascade': [18, 215, 995, 1031], 'induces': [20, 217, 1487], 'acetylcholine': [21, 91, 157, 218, 288, 354, 395, 712], 'synthesis': [23, 220, 2801, 4160, 4214, 4228, 5020, 5050], 'in': [24, 95, 121, 191, 221, 292, 318, 388, 445, 462, 561, 572, 617, 706, 805, 814, 829, 834, 922, 1217, 1240, 1287, 1447, 1519, 1564, 1705, 1720, 1731, 1736, 1743, 1802, 1965, 1990, 2018, 2040, 2060, 2147, 2446, 2692, 2789, 2802, 3088, 3189, 3226, 3230, 3259, 3299, 3357, 3456, 3572, 3587, 3628, 3634, 3703, 3760, 3847, 3953, 3998, 4351, 4374, 4440, 4525, 4578, 4871, 4946, 5022], 'postsynaptic': [26, 223, 619, 836, 924], 'membrane': [27, 224, 432, 621, 926, 2043, 2182, 2891], 'neuromuscular': [29, 226, 597, 809, 851, 920, 1222, 1241, 1282, 1524, 3709], 'synapses.': [30, 63, 196, 227, 260, 393, 1525], 'In': [31, 228, 4187, 4591, 4818], 'addition': [32, 229, 3616, 3890], 'an': [34, 49, 231, 246, 887, 1127, 2572, 4819, 4837], 'EGF-like': [35, 75, 232, 272, 888, 1134, 1402, 1471, 1540, 2631, 2650, 2816, 3155, 3178, 3388, 3537, 3623, 3675, 3877, 4839], 'domain,': [36, 107, 233, 304, 1463, 2817], 'sufficient': [37, 234, 898], 'for': [38, 81, 176, 235, 278, 373, 850, 899, 1345, 1411, 1492, 1513, 1786, 1808, 1951, 1967, 2028, 2189, 2670, 2859, 2958, 2962, 3002, 3153, 3176, 3288, 3316, 3413, 3440, 3535, 3681, 3985, 4002, 4062, 4382, 4533, 4636, 4732, 4752, 5047, 5077], 'binding': [40, 113, 237, 310, 455, 474, 901, 1000, 1349, 1374, 2049, 2483, 2524, 2533, 2541, 2584, 2964, 4379, 4689, 4767], 'auto-phosphorylation,': [43, 240], 'many': [44, 241, 450], 'spliced': [45, 242, 1121], 'forms': [46, 243, 730, 1122, 1271, 1561, 1836, 2266, 2385], 'also': [47, 244, 722, 1125, 2676, 3923, 3976, 4796], 'have': [48, 245, 453, 481, 1126, 1201, 1233, 1425, 2292, 2704, 2980, 3082, 3604, 3798, 3934, 4633, 4647, 4729], 'IG-like': [50, 69, 106, 111, 247, 266, 303, 308, 1274, 1396, 1462, 1467, 1485, 2250, 2273, 2321, 2335, 2660, 2836, 2938, 3213, 3581, 3619, 3664, 4826, 4890], 'domain': [51, 70, 76, 112, 248, 267, 273, 309, 896, 1130, 1135, 1205, 1275, 1397, 1403, 1468, 1472, 1486, 1541, 1550, 2251, 2274, 2322, 2336, 2651, 2661, 2837, 2939, 3140, 3156, 3179, 3214, 3389, 3538, 3582, 3620, 3624, 3665, 3676, 3878, 4827, 4840, 4891], 'binds': [53, 250, 2469, 3215, 4613], 'HSPGs': [54, 116, 251, 313, 1208, 1262, 2478, 2500, 2620, 2666, 3218, 3586, 3697, 4333, 4451, 4495, 4518, 4560, 4570, 4594, 4642], 'maintains': [56, 253], 'high': [58, 79, 255, 276, 1406, 2766, 2863, 3671, 3754, 4706, 4776], 'concentration': [59, 256, 2953, 3015, 3499], 'neuregulin': [61, 149, 258, 346, 394], 'at': [62, 77, 144, 259, 274, 341, 488, 596, 918, 1292, 1404, 1712, 1726, 1789, 1954, 2031, 2157, 2377, 2846, 3344, 3377, 3486, 4020, 4668, 5075], 'Here,': [64, 261, 1390], 'we': [65, 108, 262, 305, 1391, 1464, 2259, 2291, 2781, 2979, 3362, 3459, 3938, 3949, 4822], 'show': [66, 142, 263, 339, 1465, 3525], 'functions': [71, 268, 560, 1398], 'keep': [73, 270, 1400, 3669, 4797], 'sufficiently': [78, 83, 275, 280, 1405, 1413, 3670], 'concentrations': [80, 277, 1407, 2767, 2848, 2870, 2916, 3563, 3672, 3755, 4707, 4716, 4758, 4781, 4908], 'long': [84, 281, 1414, 3609, 3683], 'period': [85, 282, 1415, 3685, 4005], 'time': [87, 284, 1417, 2983, 3004, 3379, 3687, 4812], 'necessary': [88, 285, 1418, 3534, 4381], 'induce': [90, 287, 1420, 2989, 3158, 3690, 3745, 3779, 3884, 3963, 4070, 4169], 'gene': [93, 159, 290, 356, 446, 1378, 1422, 3063, 3692, 4171], 'expression': [94, 160, 291, 357, 768, 3136, 3270, 3599, 3747, 3784, 4076, 4934, 4942, 4993], 'primary': [96, 293, 1448, 2276], 'chick': [97, 294, 1449, 1684, 1692, 1750, 1784, 2277, 3089, 3848, 3940], 'myotubes.': [98, 295, 2804], 'Using': [99, 296, 1452, 3517], 'recombinant': [100, 297, 1453, 2264, 2284, 2681], 'neuregulins': [101, 186, 298, 383, 547], 'with': [102, 139, 299, 336, 415, 457, 502, 558, 1207, 1272, 1386, 1457, 1478, 1775, 1871, 1893, 1933, 1974, 2000, 2051, 2070, 2185, 2213, 2221, 2227, 2267, 2366, 2479, 2507, 2563, 2567, 2571, 2597, 2618, 2625, 2830, 3012, 3060, 3143, 3296, 3308, 3641, 3943, 3969, 4211, 4330, 4489, 4493, 4774], 'without': [104, 301, 1459, 1777, 1972, 2270, 3352], 'found': [109, 306, 3935, 3950, 4481, 4682], 'endogenous': [115, 312, 1479, 1940, 2477, 2499, 2519, 2568, 2598, 2619, 2665, 3217, 3642, 4494, 4517, 4569, 4765, 4793], 'produces': [117, 314], '4-fold': [119, 316, 2424], 'increase': [120, 317, 793, 2445, 3258, 3265, 3540, 3633, 3811, 3843, 4007, 4524], 'phosphorylation.': [123, 320, 2966], 'This': [124, 321, 702, 1029, 1361, 2553, 2653, 2674, 4949], 'enhancement': [125, 322], 'activity': [127, 324, 1924, 2688, 4458], 'was': [128, 151, 325, 348, 853, 1619, 1688, 1754, 1780, 1794, 1901, 1959, 1988, 2014, 2044, 2150, 2183, 2193, 2423, 2511, 2613, 2857, 2866, 3052, 3072, 3141, 3151, 3174, 3306, 3347, 3393, 3513, 3808, 3840, 3881, 4229], 'blocked': [129, 326, 2539, 2826, 4217, 4687, 4710], 'by': [130, 134, 327, 331, 411, 734, 822, 841, 883, 893, 1356, 1476, 1533, 1844, 2046, 2153, 2169, 2202, 2474, 2505, 2525, 2542, 2640, 2814, 3022, 3054, 3086, 3137, 3386, 4205, 4514, 4519, 4833, 4846, 5001], 'soluble': [131, 328, 1983, 2698, 2769, 2786, 4444, 4672, 4685, 4695, 4727, 4760, 4847], 'heparin': [132, 329, 1346, 2538, 2699, 2770, 2787, 2806, 2823, 2842, 2856, 2865, 2918, 4376, 4445, 4673, 4686, 4696, 4709, 4728, 4761, 4848, 4910], 'or': [133, 330, 1943, 1973, 1980, 2111, 2201, 2589, 4065, 4149, 4377, 4446], 'pretreatment': [135, 332], 'muscle': [137, 334, 620, 711, 802, 925, 1643, 2890, 3849, 4536], 'cells': [138, 335, 413, 1714, 1799, 3893, 4210], 'heparitinase.': [140, 337, 2480], 'We': [141, 338, 1138, 1424, 2439, 2461, 2600, 2995, 3027, 3278, 3603, 3933, 3975, 4010, 4480, 4666, 4681, 5070], 'least': [145, 342], '12–24': [146, 343, 3527], 'h': [147, 344, 1495, 1969, 3011, 3044, 3148, 3171, 3290, 3346, 3397, 3417, 3528, 3772, 3804, 3888, 3968, 3988, 4064], 'exposure': [150, 347, 2986, 3173, 3293, 3807, 3839, 3874], 'required': [152, 349, 1498, 2987, 3175, 3439, 3502, 3650, 3688, 3743, 3809, 3984, 4197, 4912, 4935, 4981, 5042], 'turn': [154, 351, 1500, 3652], 'on': [155, 352, 434, 989, 1321, 1375, 1473, 1501, 1646, 1756, 1765, 1860, 1970, 2104, 2208, 2255, 2275, 2323, 2391, 2457, 2583, 2610, 2630, 2710, 2810, 3197, 3252, 3271, 3653, 4359, 4496, 4572, 4674, 4701, 4784, 4963], 'substantial': [156, 353], 'erbB': [164, 178, 361, 375, 1409, 1434, 1839, 2256, 2369, 2472, 2496, 2535, 2587, 2637, 2796, 3243, 3286, 3329, 3410, 3428, 3453, 3463, 3483, 3506, 3635, 3679, 3739, 3992, 4032, 4509, 4583, 4603, 4692, 4778, 4804, 5002], 'receptors': [165, 362, 433, 505, 612, 713, 988, 1410, 1840, 2473, 2497, 2588, 3287, 3330, 3411, 3429, 3680, 3993, 4491], 'need': [166, 175, 363, 372, 3994], 'be': [168, 182, 365, 379, 790, 1383, 2956, 3276, 3438, 3749, 3912, 3996, 4140, 4166, 4438, 4968, 4980], 'kept': [169, 366, 1742, 3327, 3408], 'phosphorylated': [170, 367, 2384, 3331, 3412, 4000], 'during': [171, 368, 2432], 'this': [172, 369, 472, 895, 998, 1204, 2165, 2444, 2603, 2929, 2952, 2971, 3075, 3231, 3573, 3787, 4003, 4012, 4188, 4504, 4523, 4903, 4915, 4985], 'time.': [173, 370], 'The': [174, 371, 468, 546, 983, 1315, 1538, 1613, 1792, 1866, 2181, 3048, 3069, 3340, 3569, 3615, 4564], 'sustained': [177, 374, 1488, 2976, 3425, 3452, 3530, 3546, 3738, 4031, 4045], 'activation': [180, 377, 704, 903, 1379, 1439, 3132, 3426, 3741, 3775, 3789, 4034, 4046, 4138, 4387, 4507], 'may': [181, 378, 1210, 1263, 2919, 2955, 3275, 3437, 3748, 4139, 4452, 4595, 4808, 4967, 4995], 'reason': [184, 381, 3751, 3980], 'why': [185, 382, 1514, 3752, 4030, 4559], 'are': [187, 384, 476, 549, 590, 915, 1325, 1351, 2281, 2315, 2667, 2683, 3758, 4067, 4232, 4334, 4551, 4911, 5041], 'so': [188, 385, 3219], 'highly': [189, 386, 916, 1517], 'concentrated': [190, 387, 917, 1518, 3701], 'extracellular': [193, 390, 464, 532, 1219, 1521, 3577, 3589, 4244, 4331], 'matrix': [194, 391, 465, 1220, 1522, 3590, 4245, 4332], 'heparan-sulfate': [397, 458], 'proteoglycan': [398], 'epidermal': [399, 604, 4268], 'growth': [400, 406, 423, 554, 562, 605, 2712, 4237, 4253, 4256, 4269, 4363, 4372, 4424, 4429, 4461], 'factor': [401, 407, 606, 849, 4270, 4364], 'immunoglobulin': [402], 'glyceraldehyde-3-phosphate': [403], 'dehydrogenase': [404], 'fibroblast': [405, 4252], 'An': [408], 'important': [409, 1238, 4356], 'means': [410], 'which': [412, 815, 914, 4375], 'communicate': [414], 'each': [416], 'other': [417, 1285, 1336, 1387, 1624, 1778, 3403, 4144, 4423, 4786], 'is': [418, 525, 529, 820, 886, 897, 1339, 1497, 1516, 2452, 2490, 2561, 2689, 2900, 2973, 3208, 3224, 3430, 3549, 3649, 3666, 3742, 3776, 3922, 3983, 3989, 4027, 4035, 4151, 4366, 4380, 4512, 4567, 4607, 4755, 4830, 4842, 4869, 4885, 4895, 4925, 5006], 'through': [419, 443, 2947, 3337], 'release': [421, 4762], 'differentiation': [425, 556, 4239], 'factors': [426, 452, 487, 557, 2713, 4148, 4240, 4373, 4462], 'from': [427, 495, 592, 726, 1335, 1353, 1600, 1608, 1621, 1630, 1638, 1652, 1690, 2107, 2114, 2164, 3006, 3045, 3867, 4041, 4347, 4764, 4792, 4800, 4810, 4970], 'one': [428, 1354, 4367], 'cell': [429, 437, 2945, 3199, 3254, 3273, 4071, 4447, 4498, 4537, 4574, 4802, 4965, 5029], 'activates': [431], 'nearby': [436, 4581], 'ultimately': [439, 539], 'changes': [440, 444], 'its': [441, 2564, 2778, 4490], 'properties': [442, 542], 'expression.': [447, 1423, 1506, 2994, 3162, 3658, 3693, 4680, 4704, 4722], 'Once': [448], 'released,': [449], 'polypeptide': [451], 'additional': [454, 2317, 4639], 'interactions': [456, 501, 533, 1320, 1429, 2456, 2596, 2617, 2657, 2949, 3435, 3578, 3640, 4640], 'proteoglycans': [459], '(HSPGs)': [460], 'situated': [461, 4571], 'between': [466, 2494, 2658, 3579, 4641, 4814, 4988], 'cells.': [467], 'functional': [469, 1316], 'consequences': [470, 1317], 'dual': [473], 'interaction': [475, 1477, 2972], 'not': [477, 1326, 1382, 2529, 3225, 3928, 4028, 4788, 5017], 'entirely': [478], 'clear': [479, 528, 4029], 'but': [480, 2527, 3233, 4450, 4795], 'been': [482, 1234, 2331, 2701, 3078, 4162, 4531, 4634, 4648, 4730, 5053], 'proposed': [483, 4635, 4649], 'concentrate': [485, 4576], 'these': [486, 531, 787, 987, 2067, 2907, 3365, 4460], 'sites': [489, 2050], 'where': [490, 3871, 4044, 4638], 'needed,': [491], 'protect': [493, 4345], 'them': [494, 4346], 'proteolysis,': [496], 'modulate': [499, 534, 3591], 'their': [500, 503, 2687, 4360, 4582, 4600], 'cell-surface': [504], '(1Schlessinger': [506, 2714, 4271, 4388], 'J.': [507, 651, 693, 777, 958, 974, 1045, 1050, 1072, 1090, 1109, 1163, 1190, 1576, 1908, 2131, 2299, 2353, 2715, 2736, 3098, 3855, 3895, 3900, 4120, 4174, 4179, 4272, 4389, 4407, 4469, 4651, 4853, 5057, 5062], 'Lax': [508, 2716, 4273, 4390], 'I.': [509, 2717, 4274, 4391], 'Lemmon': [510, 2718, 4275, 4392], 'M.': [511, 667, 932, 2719, 4276, 4316, 4393, 4468], 'Cell.': [512, 1671, 2088, 2720, 4100, 4277, 4293, 4317, 4394, 4408, 4652], '1995;': [513, 654, 676, 694, 941, 959, 975, 1166, 1579, 2302, 2721, 2739, 3099, 3473, 4101, 4278, 4395, 4856], '83:': [514, 2722, 4279, 4396], '357-360Abstract': [515, 2723, 4280, 4397], 'Full': [516, 1056, 1058, 1675, 2092, 2724, 4088, 4090, 4104, 4126, 4128, 4281, 4297, 4321, 4398, 4412, 4414, 4656, 4658], 'Text': [517, 1057, 1059, 1676, 2093, 2725, 4089, 4091, 4105, 4127, 4129, 4282, 4298, 4322, 4399, 4413, 4415, 4657, 4659], 'PDF': [518, 1060, 1677, 2094, 2726, 4092, 4106, 4130, 4283, 4299, 4323, 4400, 4416, 4660], 'PubMed': [519, 584, 637, 657, 679, 697, 761, 782, 874, 944, 962, 978, 1024, 1061, 1078, 1094, 1115, 1156, 1169, 1196, 1254, 1312, 1582, 1678, 1830, 1912, 2095, 2136, 2305, 2359, 2411, 2727, 2742, 2757, 3102, 3125, 3476, 3732, 3829, 3860, 3905, 4093, 4107, 4131, 4184, 4284, 4300, 4324, 4401, 4417, 4475, 4661, 4744, 4859, 5067], 'Scopus': [520, 585, 658, 680, 698, 762, 875, 945, 963, 979, 1025, 1062, 1079, 1095, 1116, 1170, 1197, 1255, 1583, 1679, 1831, 1913, 2096, 2306, 2360, 2412, 2728, 2743, 2758, 3103, 3126, 3477, 3830, 4094, 4108, 4132, 4285, 4301, 4325, 4402, 4418, 4476, 4662, 4745, 4860], '(450)': [521, 2729, 4286, 4403], 'Google': [522, 587, 638, 660, 682, 700, 764, 783, 877, 947, 965, 981, 1027, 1064, 1081, 1097, 1118, 1157, 1172, 1199, 1257, 1313, 1585, 1681, 1833, 1915, 2098, 2137, 2308, 2362, 2414, 2730, 2745, 2760, 3105, 3128, 3479, 3733, 3832, 3861, 3906, 4096, 4110, 4134, 4185, 4287, 4303, 4327, 4404, 4420, 4478, 4664, 4747, 4862, 5068], 'Scholar).': [523, 588, 701, 784, 878, 982, 1028, 1119, 1258, 1314, 1586, 1682, 1834, 2099, 2138, 2363, 2415, 2761, 3129, 3734, 3862, 3907, 4135, 4186, 4328, 4421, 4479, 4549, 4665, 4748, 4863, 5069], 'What': [524], 'even': [526, 4927], 'less': [527], 'how': [530, 1427, 3576], 'intracellular': [536, 3593], 'events': [537, 3595, 5014], 'change': [540], 'cell.': [545], '(NRGs)1': [548], 'heparin-binding': [553, 1337, 1388, 1461, 2328, 2711, 4267, 4431], 'multiple': [559], 'development': [564, 1296], 'nervous': [567, 1228, 1290], 'system': [568, 1291], 'heart': [570], 'cancer': [573], '(2Fischbach': [574], 'G.D.': [575, 631, 650, 748, 776, 869, 1013, 1150, 1162, 1306, 1575, 1670, 1819, 2087, 2130, 2298, 2400, 2735, 3114, 3726, 3823, 3854, 4542, 4852], 'Rosen': [576, 860, 1663, 2080], 'K.M.': [577, 861, 1664, 2081], 'Annu.': [578, 1248], 'Rev.': [579, 1249], 'Neurosci.': [580, 778, 1250, 2132, 3856, 3901, 4180, 4544, 5063], '1997;': [581, 871, 1091, 2133], '20:': [582], '429-458Crossref': [583], '(254)': [586], 'They': [589], 'released': [591], 'motor': [593], 'nerve': [594], 'endings': [595], 'synapses': [598, 921, 1223, 1283], '(EGF)': [607, 2271], 'kinase': [611, 1043, 1615, 3465, 4017, 4049, 4056], 'erbB2,': [613, 909, 2387], 'erbB3,': [614, 910, 2388], 'erbB4': [616, 912, 2390], '(3Loeb': [622, 1141, 1297, 3717], 'J.A.': [623, 1142, 1160, 1298, 1573, 2128, 2296, 2733, 3718, 4466, 4850], 'Khurana': [624, 1143, 1299, 3719], 'T.S.': [625, 1144, 1300, 3720], 'Robbins': [626, 1145, 1301, 3721], 'J.T.': [627, 1146, 1302, 3722], 'Yee': [628, 642, 1147, 1303, 3723], 'A.G.': [629, 643, 1148, 1304, 3724], 'Fischbach': [630, 649, 747, 775, 868, 1012, 1149, 1161, 1305, 1574, 1669, 1818, 2086, 2129, 2297, 2399, 2734, 3113, 3725, 3822, 3853, 4541, 4851], 'Development': [632, 1151, 1307, 3727], '(Camb.).': [633, 1152, 1308, 3728], '1999;': [634, 1153, 1251, 1309, 3729, 3902, 4123, 4181, 5064], '126:': [635, 1154, 1310, 3730], '781-791Crossref': [636, 1155, 1311, 3731], 'Scholar,': [639, 661, 683, 948, 966, 1065, 1082, 1158, 1173, 2731, 2746, 3106, 4097, 4111, 4288, 4304, 4405], '4Goodearl': [640], 'A.D.': [641], 'Sandrock': [644], 'Jr.,': [645, 856], 'A.W.': [646, 857], 'Corfas': [647, 1665, 2082], 'G.': [648, 774, 1009, 1187, 1666, 1815, 2083, 2350, 2396, 3852], 'Cell': [652, 1073, 1110, 1164, 1191, 1577, 2300, 2354, 2737, 4470, 4854], 'Biol.': [653, 675, 940, 1051, 1074, 1111, 1165, 1192, 1578, 2301, 2355, 2738, 3825, 4121, 4471, 4855], '130:': [655, 1167, 1580, 2303, 2740, 4857], '1423-1434Crossref': [656], '(79)': [659], '5Moscoso': [662], 'L.M.': [663, 928], 'Chu': [664, 929, 1068, 1105], 'G.C.': [665, 930, 1069, 1106], 'Gautam': [666, 931], 'Noakes': [668, 933], 'P.G.': [669, 934], 'Merlie': [670, 749, 935, 1070, 1107], 'J.P.': [671, 750, 936, 972, 1071, 1088, 1108, 3096], 'Sanes': [672, 937], 'J.R.': [673, 938, 1245], 'Dev.': [674, 939, 3824], '172:': [677, 942], '158-169Crossref': [678, 943], '(160)': [681, 946], '6Zhu': [684, 949], 'X.': [685, 950], 'Lai': [686, 951], 'C.': [687, 952, 1179, 2342, 4312], 'Thomas': [688, 953], 'S.': [689, 756, 954, 1019, 1086, 1825, 2406, 2750, 3120, 4115, 4464, 4737], 'Burden': [690, 955], 'S.J.': [691, 956], 'EMBO': [692, 957, 973, 1089, 3097], '14:': [695, 960, 976, 3100], '5842-5848Crossref': [696, 961], '(157)': [699, 964], 'transynaptic': [703], 'results': [705, 1508, 2908, 2934, 3298, 3422, 3552, 3570, 3627, 3660, 3766, 3864, 3952, 4923], 'dramatic': [708], 'up-regulation': [709, 4201], '(AChRs)': [714], 'needed': [715, 3152, 3667, 3777, 3841, 3882, 4068, 4141, 4152, 4167], 'guarantee': [717], 'proper': [718], 'synaptic': [719, 797, 3601, 3705, 3762], 'transmission.': [720], 'NRG': [721, 1124, 1270, 1331, 1454, 1515, 1528, 1774, 1900, 2253, 2265, 2285, 2467, 2489, 2595, 2663, 2832, 2941, 2943, 2985, 3017, 3087, 3292, 3353, 3491, 3584, 3626, 3699, 3757, 3806, 3880, 4024, 4487, 4562, 4577, 4597, 4616, 4688, 4763, 4791, 4829, 4894, 4937], 'promotes': [723], 'transition': [725], 'embryonic': [727, 1639, 3695], 'adult': [729, 3715], 'mammalian': [732], 'AChRs': [733, 833, 2057, 2069, 3817, 4962, 5026], 'inducing': [735], 'switch': [737], 'ε': [740, 4220], 'AChR': [741, 1006, 1322, 1421, 1441, 1502, 2038, 2048, 2139, 2800, 2860, 2886, 2897, 2990, 2997, 3030, 3049, 3134, 3160, 3195, 3250, 3266, 3441, 3457, 3541, 3654, 3691, 3746, 3780, 3885, 3964, 4008, 4170, 4203, 4219, 4679, 4702, 4711, 4720, 4876, 4930, 4940, 4947, 4975, 4989, 5035, 5081], 'subunit': [742, 2141, 3051, 3071, 3076, 4221, 5083], '(7Martinou': [743], 'J.C.': [744], 'Falls': [745, 1010, 1816, 2397, 3109], 'D.L.': [746, 1011, 1662, 1817, 2079, 2398, 3110], 'Proc.': [751, 1014, 1820, 2401, 3115], 'Natl.': [752, 1015, 1821, 2402, 3116], 'Acad.': [753, 1016, 1822, 2403, 3117], 'Sci.': [754, 1017, 1823, 2404, 3118], 'U.': [755, 1018, 1183, 1824, 2346, 2405, 3119], 'A.': [757, 1020, 1826, 2407, 2748, 3121, 3469, 3471, 4735], '1991;': [758, 4294], '88:': [759], '7669-7673Crossref': [760], '(121)': [763], 'Scholar)': [765, 1098, 1200, 1916, 2309, 3480, 3833], 'voltage-gated': [770, 3844], 'sodium': [771, 3845], 'channels': [772, 3846], '(8Corfas': [773, 3851], '1993;': [779, 1021, 1672, 1827, 2089, 2408, 3857, 4472], '13:': [780, 3858], '2118-2125Crossref': [781, 3859], 'All': [785, 1623], 'effects': [788, 1371, 2709, 2784, 2913, 3611, 4670, 4725], 'would': [789, 1381], 'expected': [791], 'efficacy': [795], 'transmission': [798, 852], 'as': [799, 1658, 1811, 2075, 2124, 2373, 2648, 2818, 2820, 2921, 3185, 3355, 4053, 4427, 4557, 5044, 5051], 'target': [801], 'fiber': [803], 'increases': [804, 4561, 4957, 4974], 'size': [806], 'junction': [810, 1242], 'matures.': [811], 'Consistently,': [812], 'mice': [813], 'Type': [817, 2286], 'INRG1': [818], 'allele': [819], 'disrupted': [821], 'homologous': [823], 'recombination': [824], 'exhibited': [825], '50%': [827], 'reduction': [828], 'density': [831], 'membrane,': [837, 2063], 'when': [839, 891, 3937], 'challenged': [840], 'low': [842, 2869, 2915, 4715, 4757], 'doses': [843], 'curare,': [845], 'reduced': [847, 2522, 2636], 'safety': [848], 'demonstrated': [854, 2487], '(9Sandrock': [855], 'Dryer': [858], 'S.E.': [859], 'Gozani': [862], 'S.N.': [863], 'Kramer': [864], 'R.': [865], 'Theill': [866], 'L.E.': [867], 'Science.': [870, 3472], '276:': [872], '599-603Crossref': [873], '(245)': [876], 'A': [879, 2481, 3034, 4527], 'common': [880], 'feature': [881, 1329], 'shared': [882], 'all': [884, 2847], 'NRGs': [885, 1216], 'domain.': [889], 'Even': [890, 2840], 'expressed': [892, 1563], 'itself,': [894], 'homo-': [905], 'heterodimers': [907], 'receptors,': [913, 4584], '(5Moscoso': [927], '10Altiok': [967], 'N.': [968, 1084, 3092], 'Bessereau': [969, 3093], 'J.L.': [970, 3094], 'Changeux': [971, 1087, 3095], '4258-4266Crossref': [977, 3101], '(131)': [980, 3104], 'rapid': [984, 3630], 'autophosphorylation': [985], 'residues': [991], 'initiates': [992], 'translates': [997], 'initial': [999, 3303], 'event': [1001], 'into': [1002], 'induction': [1004, 2898, 2998, 3085], 'genes': [1007, 1442, 4079], '(11Corfas': [1008, 1814, 2395], '90:': [1022, 1828, 2409], '1624-1628Crossref': [1023, 1829, 2410], '(71)': [1026, 1832, 2413], 'involves': [1032], 'number': [1034, 4235, 4553], 'pathways,': [1037], 'including': [1038, 1231, 4247], 'both': [1039, 1556, 2495, 2705, 2788, 3325, 3606, 3955, 4929], 'mitogen-activated': [1041, 4054], 'protein': [1042, 1505, 2993, 3269, 3444, 3657, 3783, 4055, 4061, 4156, 4159, 4213, 4703, 4712, 4721, 4877, 4933, 4941, 4992, 5019, 5049], '(12Si': [1044], 'Luo': [1046], 'Z.': [1047], 'Mei': [1048, 3898, 4177, 5060], 'L.': [1049, 3899, 4178, 5061], 'Chem.': [1052, 4122], '1996;': [1053, 1075, 1112, 2754, 4085, 4741], '271:': [1054], '19752-19759Abstract': [1055], '(96)': [1063], '13Tansey': [1066], 'M.G.': [1067, 1104], '134:': [1076, 1113], '465-476Crossref': [1077, 1114], '(117)': [1080, 1117], '14Altiok': [1083], 'Altiok': [1085], '16:': [1092], '717-725Crossref': [1093], '(111)': [1096], 'phosphatidylinositol': [1100], '3-kinase': [1101], 'pathways': [1102, 4051, 4999, 5040], '(13Tansey': [1103], 'Most': [1120], 'immunoglobulin-like': [1128], '(IG-like)': [1129], 'NH2-terminal': [1131], '(Fig.': [1136, 1567, 2437, 2621, 2838, 2892, 3041, 3201, 3381, 3492], '1).': [1137, 2312], 'others': [1140], '15Loeb': [1159, 2732], '127-135Crossref': [1168, 1581, 2304, 2741, 4858], '(114)': [1171, 1584, 2307, 2744, 4861], '16Meier': [1174], 'T.': [1175, 2338, 4306], 'Masciulli': [1176, 2339], 'F.': [1177, 1181, 2340, 2344], 'Moore': [1178, 2341], 'Schoumacher': [1180, 2343], 'Eppenberger': [1182, 2345], 'Denzer': [1184, 2347], 'A.J.': [1185, 2348], 'Jones': [1186, 2349], 'Brenner': [1188, 2351], 'H.R.': [1189, 2352], '1998;': [1193, 2356], '141:': [1194, 2357], '715-726Crossref': [1195, 2358], '(97)': [1198, 2361], 'shown': [1202, 2702, 3079, 3799, 4163], 'interacts': [1206], 'lead': [1211], 'deposition': [1214], 'within': [1225, 3395], 'central': [1227], 'system.': [1229], 'HSPGs,': [1230, 2590, 4246, 4449, 4794], 'agrin,': [1232], 'identified': [1235, 3605], 'play': [1237, 4355], 'roles': [1239, 4358], 'formation': [1243], '(17Sanes': [1244], 'Lichtman': [1246], 'J.W.': [1247], '22:': [1252], '389-442Crossref': [1253], '(1230)': [1256], 'For': [1259, 4422], 'NRGs,': [1261], 'serve': [1264], '"direct"': [1266], 'accumulation': [1268], 'basal': [1278, 3706, 3763], 'lamina': [1279, 3707], 'developing': [1281, 1289], 'locations': [1286], 'key': [1293], 'stages': [1294], 'NRG-HSPG': [1319, 1428, 3434, 3613], 'expression,': [1323, 4713], 'however,': [1324, 3561, 3648, 4039], 'known.': [1327], 'One': [1328, 4749, 4918], 'distinguishes': [1333], 'it': [1334, 1341, 2635, 3207, 3921, 4606, 4771, 4798, 4884], 'ligands': [1338, 2682, 4622], 'has': [1342, 2330, 2700, 3077, 4161, 4530, 5052], 'distinct': [1343, 4969], 'domains': [1344], 'separated': [1352], 'another': [1355], 'glycosylated,': [1358], 'spacer': [1359], 'region.': [1360], 'gave': [1362], 'us': [1363], 'unique': [1365], 'ability': [1366, 2774, 2793], 'determine': [1368], 'direct': [1370], 'HSPG': [1373, 1482, 2455, 2948, 4378, 4766], 'readily': [1384, 4339], 'possible': [1385, 3924, 4555, 4608, 4750, 4887, 5007], 'ligands.': [1389], 'provide': [1392, 1509, 2975, 4337], 'evidence': [1393], 'near': [1408, 3677], 'examined': [1426, 2601, 2981, 3280], 'affect': [1430], 'NRG-erbB': [1431, 1489, 3645], 'binding,': [1433, 2503], 'autophosphorylation,': [1436], 'downstream': [1438], 'newly': [1444, 2036, 2055, 2884, 4190], 'synthesized': [1445, 2056], 'proteins': [1446, 2039, 2887, 3040, 3196, 3251], 'myotube': [1450, 1636, 1929, 1963, 2042, 2278, 2459, 3917, 3941], 'cultures.': [1451, 2279], 'β1': [1455, 1560, 2288], 'isoforms': [1456, 2289], 'potentiates': [1469], 'phosphorylation': [1475, 1491, 2612, 2638, 2798, 2812, 2828, 2845, 2905, 3282, 3304, 3343, 3376, 3455, 3485, 3508, 3532, 3548, 3637, 4511, 4677, 4867], 'HSPGs.': [1480, 2569, 2599, 2696, 3643], 'Through': [1481], 'interactions,': [1483], 'over': [1493, 3986, 4881, 4898], '8': [1494, 3170, 3416, 3771, 3987], 'mRNA': [1503, 2238, 2991, 3031, 3135, 3161, 3267, 3442, 3542, 3655, 3781, 3886, 3965, 4195, 4204, 4222, 4931, 4990], 'These': [1507, 2280, 3421, 3659], 'molecular': [1511], 'rationale': [1512], 'Recombinant': [1526], 'human': [1527, 1559], 'polypeptides': [1529], 'were': [1530, 1562, 1598, 1606, 1628, 1644, 1710, 1763, 1800, 1842, 1868, 1931, 2102, 2162, 2240, 3533, 3553, 3567, 4196], 'generously': [1531], 'provided': [1532, 2152], 'Amgen': [1534], '(Thousand': [1535], 'Oaks,': [1536], 'CA).': [1537, 1634, 2180], 'isolated': [1539], 'corresponds': [1542, 1551], 'amino': [1544, 1553], 'acids': [1545, 1554], '177–246,': [1546], 'IG-EGF': [1549, 2325, 2421, 2450, 2509, 2608, 2642, 3139, 3187, 3222, 3310, 3406, 3557, 3960], '14–246;': [1555], 'Escherichia': [1565], 'coli': [1566], '1)': [1568], 'used': [1570, 2293, 3460], 'previously': [1571, 1660, 1813, 2077, 2126, 2294, 3080], '(15Loeb': [1572, 2295, 4849], 'Heparin': [1587], '(porcine': [1588], 'intestinal': [1589], 'mucosa,': [1590], 'Mr∼13,000)': [1591], 'bovine': [1593, 2007], 'serum': [1594, 2008], 'albumin': [1595], '(Fraction': [1596], 'V)': [1597], 'purchased': [1599, 1607, 1620, 1629], 'Sigma.': [1601], 'Heparitinase': [1602], 'chondroitinase': [1604, 1944], 'ABC': [1605], 'Seikagaku': [1609], 'America': [1610], '(Falmouth,': [1611], 'MA).': [1612], 'inhibitor': [1616, 3466, 3501, 3566, 4215], 'tyrphostin': [1617], 'AG1478': [1618, 3467], 'Calbiochem.': [1622], 'tissue': [1625, 1717, 1738], 'culture': [1626, 1718, 1739, 3918], 'reagents': [1627, 1779, 1895], 'Invitrogen-Life': [1631], 'Technologies': [1632], '(Carlsbad,': [1633], 'Chick': [1635, 1928], 'cultures': [1637, 1930, 1964, 3850, 3942], 'day': [1640, 1768], '11': [1641], 'pectoral': [1642], 'cultured': [1645, 2803], '50': [1647], 'μg/ml': [1648, 1982, 2822], 'collagen': [1649], 'type': [1650], 'I': [1651, 2287], 'rat': [1653], 'tail': [1654], '(Collaborative': [1655], 'Biomedical': [1656], 'Products)': [1657], 'described': [1659, 1812, 2076, 2125, 4532, 4731, 5054], '(18Falls': [1661, 2078], 'Lane': [1667, 2084], 'W.S.': [1668, 2085], '72:': [1673, 2090], '801-815Abstract': [1674, 2091], '(552)': [1680, 2097], '2%': [1683, 1691, 1749], 'embryo': [1685, 1693, 1751], 'extract': [1686, 1752], 'medium': [1687, 1724, 1735, 1753, 1793, 2004], 'made': [1689, 4191], 'extract,': [1694], '10%': [1695], 'horse': [1696], 'serum,': [1697], '1%': [1698, 1700, 1703], 'penicillin/streptomysin,': [1699], 'glutamine,': [1701], 'pyruvate': [1704], 'minimum': [1706, 2002], 'essential': [1707, 2003], 'medium.': [1708], 'Cells': [1709], 'plated': [1711], '60,000': [1713], 'per': [1715], '48-well': [1716, 2115], 'plate': [1719], '300': [1721], 'μl': [1722, 2020], '3': [1727], '×': [1728], '105': [1729], 'cells/dish': [1730], '2': [1732, 1968, 3319, 3323], 'ml': [1733], '35-mm': [1737, 2109], 'dishes': [1740], '5%': [1745, 1862], 'CO2': [1746], 'incubator.': [1747], 'Fresh': [1748], 'changed': [1755], '4thday': [1758], 'after': [1759, 1769, 1857, 1891, 1996, 2016, 2211, 2999, 3322, 3367, 3398, 3418, 3489, 3889, 3966, 4023], 'plating,': [1760], 'experiments': [1762, 4978], 'done': [1764], '7th': [1767], 'plating.': [1770], 'Each': [1771], 'form': [1772, 2422, 2430, 2451, 2609, 2643, 2833, 3188, 3223, 3311, 3315], 'applied': [1781, 1960], '7-day-old': [1783], 'myotubes': [1785, 3001, 3090], '45': [1787, 2434, 3368, 4872], 'min': [1788, 1810, 1953, 2030, 2435, 3008, 3369, 3972], '37': [1790, 1955], '°C.': [1791, 1956], 'then': [1795, 1869, 2065, 2225, 3028, 3373], 'discarded,': [1796], 'solubilized': [1801], 'SDS': [1803], 'sample': [1804], 'buffer': [1805], 'boiled': [1807], '5': [1809, 2821, 3803], 'Phosphorylated': [1835], '(p185)': [1841, 2829], 'detected': [1843], 'Western': [1845, 2393], 'blot': [1846, 2394, 3056], 'analysis': [1847, 2204, 3057], 'using': [1848, 1917, 2117, 2172, 2196, 3509, 3555, 4013], 'phosphotyrosine': [1850, 2392], 'monoclonal': [1851], 'antibody': [1852], 'PY': [1853], '20': [1854], '(Transduction': [1855], 'Laboratories)': [1856], 'first': [1858, 2462, 3318], 'resolving': [1859], 'overrun': [1861], 'reducing': [1863], 'SDS-polyacrylamide': [1864], 'gels.': [1865], 'filters': [1867], 'probed': [1870], 'goat': [1873], 'anti-mouse': [1874], 'IgG': [1875], 'coupled': [1876], 'peroxidase': [1878], '(Roche': [1879], 'Molecular': [1880], 'Biochemicals': [1881], 'Corp.)': [1882], 'exposed': [1884], 'X-blue': [1886], 'film': [1887], '(Eastman': [1888], 'Kodak': [1889], 'Co.)': [1890], 'treatment': [1892, 2365, 2624, 3150, 3354, 4521], 'chemiluminescence': [1894], '(PerkinElmer': [1896], 'Life': [1897], 'Sciences).': [1898], '125I-IG-EGF': [1899], 'prepared': [1902, 2163], '(19Hunter': [1903], 'W.M.': [1904], 'Greenwood': [1905], 'F.C.': [1906, 4081], 'Biochem.': [1907], '1964;': [1909], '91:': [1910], '43-56Crossref': [1911], '(133)': [1914], 'chloramine-T': [1919], 'method': [1920], 'yielding': [1921], 'specific': [1923, 2532, 3462, 3487, 4015, 4078], '9,000': [1926], 'Ci/nmol.': [1927], 'pretreated': [1932], 'either': [1934, 2108, 2195, 2586], 'heparitinase': [1935, 2549, 2626, 4520], '(0.04': [1936, 1945], 'unit/ml,': [1937, 1946], 'remove': [1939, 1948], 'heparan': [1941, 2520, 4610], 'sulfates)': [1942, 1950], 'chondroitin': [1949, 2577], '90': [1952], '0.1': [1957], 'nm125I-IG-EGF': [1958], 'prechilled': [1962], 'quadruplicates': [1966], 'ice': [1971], '1': [1975, 2022, 3396, 3515], 'μm': [1976], 'cold': [1977, 2001, 2052, 2508, 2551], 'ligand': [1978, 3239, 3982, 4589], '(IG-EGF)': [1979, 2268, 2486], '500': [1981], 'heparin.': [1984], 'Total': [1985], 'counts/min': [1986, 2012], 'bound': [1987, 2013], 'measured': [1989, 2015, 2996, 3029, 3053, 3374], 'γ': [1992], 'counter': [1993], '(Packard': [1994], 'Instruments)': [1995], 'washing': [1997], 'three': [1998], 'times': [1999, 3488, 4022], 'containing': [2005, 2834], '0.1%': [2006], 'albumin,': [2009], 'total': [2011, 2515, 2523, 2540], 'solubilization': [2017], '100': [2019], 'n': [2023], 'NaOH,': [2024], '0.5': [2025], 'mg/ml': [2026], 'deoxycholate': [2027], '10': [2029, 2875, 3518], 'room': [2032], 'temperature.': [2033], 'Measurement': [2034], 'inserted': [2037, 2885], 'achieved': [2045, 3142, 4439], 'blocking': [2047, 2506], 'α-bungarotoxin,': [2053], 'allowing': [2054], 'appear': [2059], 'plasma': [2062], 'measuring': [2066], 'new': [2068, 3038, 3194, 3249, 3816, 4155, 4719, 4939, 4961, 5034, 5048], '125I-α-bungarotoxin': [2071], '(Amersham': [2072], 'Pharmacia': [2073], 'Biotech)': [2074], 'Northern': [2100, 3055], 'blots': [2101], 'performed': [2103, 2194], 'RNA': [2105], 'extracted': [2106], 'plates': [2110, 2116], 'pooled': [2112], 'wells': [2113], 'Ultraspec': [2118], '(Biotecx': [2119], 'Laboratories,': [2120], 'Inc.,': [2121], 'Houston,': [2122], 'TX)': [2123], '(20Loeb': [2127], '17:': [2134, 4086], '1416-1424Crossref': [2135], 'α': [2140, 3050, 3070, 5082], 'exon': [2142], '7': [2143], 'flanking': [2145], 'sequence': [2146], 'vector': [2148], 'pBluescript': [2149], 'kindly': [2151, 5078], 'Dr.': [2154, 5072], 'Jakob': [2155, 5073], 'Schmidt': [2156, 5074], 'SUNY,': [2158], '32P-labeled': [2160], 'probes': [2161], '399-base': [2166], 'pair': [2167], 'fragment': [2168], 'random': [2170], 'priming': [2171], 'Prime': [2173], 'It': [2174, 4026, 5005], 'II': [2175], 'kit': [2176], '(Stratagene,': [2177], 'La': [2178], 'Jolla,': [2179], 're-probed': [2184], 'a32P-labeled': [2186], 'GAPDH': [2187, 2243, 3064], 'probe': [2188], 'normalization': [2190], 'purposes.': [2191], 'Quantitation': [2192], 'PhosphorImager': [2198], '(Molecular': [2199], 'Dynamics)': [2200], 'image': [2203], 'x-ray': [2206], 'films': [2207], 'nonsaturated': [2209], 'images': [2210], 'scanning': [2212], 'Power': [2215], 'Look': [2216], '(UMAX)': [2217], 'flat': [2218], 'bed': [2219], 'scanner': [2220], 'transparency': [2222], 'adapter': [2223], 'analyzing': [2226], 'Metamorph': [2229], 'Imaging': [2230, 2235], 'system,': [2231], 'version': [2232], '4.0': [2233], '(Universal': [2234], 'Corp.).': [2236], 'Relative': [2237], 'levels': [2239, 3032, 3351], 'normalized': [2241], 'levels.': [2244], 'To': [2245], 'assess': [2246], 'contribution': [2248], 'makes': [2254], 'phosphorylation,': [2258, 2634, 4694], 'compared': [2260, 2463, 3059], 'potency': [2262, 2447, 2605, 2961], 'biologically': [2282], 'active,': [2283], '(see': [2310], 'Fig.': [2311, 2762, 3300, 3494, 3520], 'Although': [2313], 'there': [2314, 3713], 'some': [2316, 4352, 5009], 'sequences': [2318], 'besides': [2319], 'construct,': [2326], 'portion': [2329], 'localized': [2332], '(16Meier': [2337], 'After': [2364], 'NRG,': [2367, 2510, 4248, 4434], 'complex': [2371], 'appears': [2372], 'diffuse': [2375], 'band': [2376], '∼185': [2378], 'KDa': [2379], 'called': [2380], '"p185"': [2381], 'includes': [2383], 'Employing': [2416], 'equal': [2417], 'molar': [2418], 'amounts,': [2419], 'more': [2425, 3168, 3769, 3801, 4066, 4625, 4921, 5037], 'potent': [2426], 'than': [2427, 2903, 3169, 3312, 3770, 3802], 'alone': [2431], 'assay': [2436, 2899, 4868, 4879, 4904], '2).': [2438], 'investigated': [2440], 'possibility': [2442, 4807], 'due': [2453, 2614, 3913], 'surface.': [2460, 4499], 'proportion': [2465, 2558, 4485], 'HSPGsversus': [2471], 'selectively': [2475, 2575], 'removing': [2476, 2518], 'competitive': [2482], 'study': [2484], 'of125I-NRG': [2485], 'distributed': [2491], 'fairly': [2492], 'equally': [2493], '(Fig.3A).': [2501], 'Specific': [2502], 'assessed': [2504], 'about': [2512], '25%': [2513], 'binding.': [2516], 'Similarly,': [2517, 3163], 'sulfates': [2521], '25%,': [2526], 'did': [2528, 3927], 'reduce': [2530], 'receptors.': [2536, 3244, 4604, 4779, 4805], 'Soluble': [2537], '50%,': [2543], 'similar': [2544, 2557, 3183, 3951, 4484, 4528], 'combination': [2547], 'NRG.': [2552, 3026, 3795, 3932, 4206], 'suggests': [2554, 2655, 2677, 4951], '125I-NRG': [2560], 'associated': [2562], 'Pretreatment': [2570, 4207], 'enzyme': [2573], 'degrades': [2576], 'sulfate': [2578, 4611], '(chondroitinase)': [2579], 'had': [2580, 2627, 2807, 4697], 'no': [2581, 2628, 2808, 4843], 'effect': [2582, 2629, 2809, 2954, 4700], 'demonstrating': [2591], 'specificity': [2593], 'whether': [2602], 'increased': [2604, 2672, 4513], 'directly': [2615, 2668], '3B).': [2622], 'While': [2623, 3130, 3908], 'domain-induced': [2632], 'induced': [2639, 2813, 3385], 'same': [2646, 2691, 3014], 'level': [2647, 3336, 3341], 'alone.': [2652], 'result': [2654, 2923, 4502, 5021], 'responsible': [2669, 2957], 'potency.': [2673, 4526, 4563], 'experiment': [2675], 'two': [2680, 4816], 'correctly': [2684], 'folded,': [2685], 'since': [2686], 'absence': [2694, 4442], 'Adding': [2697], 'stimulatory': [2706, 2912], 'inhibitory': [2708], '21Krufka': [2747], 'Guimond': [2749, 4736], 'Rapraeger': [2751, 4738], 'A.C.': [2752, 4739], 'Biochemistry.': [2753, 4740], '35:': [2755, 4742], '11131-11141Crossref': [2756, 4743], '(59)': [2759, 4746], '3A': [2763], 'shows': [2764, 3496], 'effectively': [2771, 4626], 'block': [2772, 3482, 3505], "NRG's": [2773, 2792, 2960], 'receptor.': [2779], 'Here': [2780, 2978], 'explored': [2782], 'modulating': [2790], 'stimulate': [2795, 4627], 'Whereas': [2805], 'little': [2819], 'almost': [2824], 'completely': [2825, 3504], '4A).': [2839], 'though': [2841, 4928], 'inhibited': [2843, 4845], 'above': [2849, 3349, 3514], '1.0': [2850], 'μg/ml,': [2851, 2876], 'biphasic': [2853, 4699, 4724], 'response': [2854, 3184, 3305, 3384, 4059], 'observed': [2858], 'induction.': [2861, 3445], 'At': [2862], 'concentrations,': [2864], 'inhibitory,': [2867], 'while': [2868, 4684], 'heparin,': [2872, 4783], 'up': [2873, 3835], 'actually': [2877, 4717], 'stimulated': [2878, 4718], 'rate': [2880, 3814], 'appearance': [2882, 3247], 'onto': [2888], '4B).': [2893], 'Given': [2894], 'considerably': [2901, 3866], 'longer': [2902, 2926, 4844, 4900], 'assay,': [2906, 3232], 'suggest': [2909, 2935, 3423, 3661, 3977], 'occur': [2920], 'course': [2927, 4901], 'assay.': [2930], 'Thus': [2931], 'far,': [2932], 'our': [2933, 3204, 3297, 4753], 'concentrates': [2942], 'along': [2944], 'surfaces': [2946], 'increasing': [2959, 4586], 'Another': [2967, 4806], 'potential': [2968], 'function': [2969, 4453], 'signaling.': [2977], 'treating': [3000], 'different': [3003, 3916, 4021, 4997], 'periods': [3005], '15': [3007, 3971], '24': [3010, 3043, 3147, 3289, 3338, 3345, 3887, 3967, 4882], '(EGF': [3018], 'versus': [3019], 'IG-EGF)': [3020], 'followed': [3021], '"washing': [3023], 'out"': [3024], '(Fig.5,': [3033], 'B)': [3036], 'surface': [3039, 3200, 3255, 3274, 4448, 4575, 4803, 4966], '5C)': [3042], 'start.': [3047], 'housekeeping': [3062], 'normalize': [3066], 'data.': [3068], 'chosen,': [3073], 'because': [3074, 3990], 'greatest': [3084], '(10Altiok': [3091], '22Harris': [3107], 'D.A.': [3108], 'Dill-Devor': [3111], 'R.M.': [3112], '1988;': [3122], '85:': [3123], '1983-1987Crossref': [3124], '(70)': [3127], 'maximal': [3131], '15-min': [3145], 'treatment,': [3146, 3371], 'significant': [3159, 3165], 'lag': [3166], 'get': [3181], 'promoting': [3190], 'insertion': [3192, 3813, 4878, 4959], '5C).': [3202], 'From': [3203], 'earlier': [3205, 4820, 5012], 'results,': [3206], 'most': [3209, 4565], 'likely': [3210, 4566], 'fact': [3227], 'washed': [3228, 3363, 3939], 'out': [3229, 3364, 4984], 'provides': [3234], 'steady': [3236], 'source': [3237], 'Unexpectedly,': [3245], 'preceded': [3256, 4943], 'mRNA,': [3260, 5036], 'suggesting': [3261, 3544, 4224], 'mechanisms': [3263, 4632], 'distinct.': [3277], 'next': [3279], 'state': [3283, 4001], '(Fig.6A).': [3294], 'Consistent': [3295], '2,': [3301], 'greater': [3307], 'h.': [3320, 3339], 'However,': [3321], 'h,': [3324, 4883], 'constructs': [3326, 3366, 3961], 'similar,': [3334], 'lower': [3335], 'significantly': [3348], 'background': [3350], 'seen': [3356], 'blank': [3359], 'lane.': [3360], 'When': [3361], 'p185': [3375], 'indicated': [3378], 'points': [3380], '6B),': [3382], 'decayed': [3390], 'rapidly': [3391], 'lost': [3394], 'wash.': [3400, 3420], 'On': [3401], 'hand,': [3404, 4787], 'construct': [3407, 3512, 3558], 'full': [3415], 'consequence': [3432], 'Finally,': [3446, 4605], 'demonstrate': [3448, 3767], 'importance': [3450], 'induction,': [3458], '(23Levitzki': [3468], 'Gazit': [3470], '267:': [3474], '1782-1788Crossref': [3475], '(1619)': [3478], 'adding': [3490], '7).': [3493], '7A': [3495], 'μm.': [3516], 'μmAG1478,': [3519], '7,': [3521], 'B': [3522], 'C,': [3524], 'levels,': [3543], 'needed.': [3550, 4036, 4230], 'Similar': [3551, 4631, 4723], 'obtained': [3554], 'NRG;': [3560], 'higher': [3562, 4601, 4907], 'required.': [3568], 'presented': [3571], 'paper': [3574], 'examine': [3575], 'regulate': [3597], 'AChRs.': [3602], 'short': [3607], 'term': [3610], 'interactions.': [3614], 'transient': [3632], 'requires': [3639, 3790], 'Sustained': [3644, 4136], 'activation,': [3647], 'enough': [3684], 'During': [3694], 'development,': [3696], 'become': [3700], 'coincidently': [3702], 'junctions': [3710], 'remain': [3712], 'throughout': [3714], 'life': [3716], 'Our': [3735, 3765, 3863], 'observation': [3736, 4529, 4950], 'such': [3753, 4052, 4426, 5043], 'maintained': [3759, 3997], 'lamina.': [3764], 'continuous': [3792], 'presence': [3793], 'Earlier': [3796], 'studies': [3797], '(24Buc-Caron': [3818], 'M.H.': [3819], 'Nystrom': [3820], 'P.': [3821], '1983;': [3826], '95:': [3827], '378-386Crossref': [3828], '(33)': [3831], '12-h': [3838], 'differ': [3865], 'recent': [3869], 'report': [3870], 'only': [3872, 3970, 4789], '1-min': [3873], 'C2C12': [3892, 4209], '(25Si': [3894, 4173, 5056], 'Wang': [3896, 4175, 5058], 'Q.': [3897, 4176, 5059], '19:': [3903, 4182, 5065], '8498-8508Crossref': [3904, 4183, 5066], 'difference': [3910, 4813], 'could': [3911, 3962, 4624], 'systems': [3919], 'used,': [3920], 'they': [3926], '"wash': [3929], 'away"': [3930], 'PBS': [3944], 'instead': [3945], 'serum-containing': [3947], 'medium,': [3948], 'exposure.': [3974], 'entire': [4004], 'mRNA.': [4009, 4948, 4976], 'showed': [4011, 4823], 'antagonist': [4018], 'added': [4019], 'addition.': [4025], 'There': [4037, 4231, 4550], 'are,': [4038], 'examples': [4040], 'literature': [4043], 'cAMP': [4058], 'element-binding': [4060], '4': [4063], 'differentiation,': [4072], 'migration,': [4073], '(26Liu': [4080], 'Graybiel': [4082], 'A.M.': [4083], 'Neuron.': [4084], '1133-1144Abstract': [4087], '(163)': [4095], '27Marshall': [4098], 'C.J.': [4099], '80:': [4102], '179-185Abstract': [4103], '(4232)': [4109], '28McCawley': [4112], 'L.J.': [4113], 'Li': [4114], 'Wattenberg': [4116], 'E.V.': [4117], 'Hudson': [4118], 'L.G.': [4119], '274:': [4124], '4347-4353Abstract': [4125], '(192)': [4133], 'recruit': [4143], 'and/or': [4146, 4193], 'transcription': [4147, 4172], 'perhaps': [4150], 'synthesis.': [4157], 'New': [4158], 'recently': [4164, 5055], 'report,': [4189], 'c-JUN': [4192], 'c-FOS': [4194], 'mediate': [4199], 'cycloheximide': [4216], 'NRG-induced': [4218, 4506, 4675, 4691], 'completely,': [4223], 'de': [4226], 'novoprotein': [4227], 'growing': [4234], 'acidic': [4249], 'basic': [4251], 'factors,': [4254, 4343, 4425], 'transforming': [4255, 4428], 'factor-β,': [4257, 4430], 'granulocyte-macrophage': [4258], 'colony-stimulating': [4259], 'factor,': [4260], 'interleukin-3,': [4261], 'interferon': [4262], 'γ,': [4263], 'netrins,': [4265], '29Ruoslahti': [4289], 'E.': [4290], 'Yamaguchi': [4291], 'Y.': [4292], '64:': [4295], '867-869Abstract': [4296], '(1167)': [4302], '30Serafini': [4305], 'Kennedy': [4307], 'T.E.': [4308], 'Galko': [4309], 'M.J.': [4310], 'Mirzayan': [4311], 'Jessell': [4313], 'T.M.': [4314], 'Tessier-Lavigne': [4315], '1994;': [4318], '78:': [4319], '409-424Abstract': [4320], '(1161)': [4326], 'Interactions': [4329], 'thought': [4335], 'accessible': [4340], 'store': [4341], 'proteolytic': [4348, 4916], 'degradation,': [4349], 'instances,': [4353], 'regulatory': [4357], 'functions.': [4361], 'Fibroblast': [4362], '(FGF)': [4365], 'best': [4370], 'studied': [4371], 'FGF': [4383, 4645, 4733], 'dimerization': [4385, 4436], '31Schlessinger': [4406], '2000;': [4409, 4546, 4653], '103:': [4410, 4654], '211-225Abstract': [4411, 4655], '(3523)': [4419, 4663], 'EGF,': [4432], 'can': [4437], 'enhance': [4455], 'biological': [4457], '(32Higashiyama': [4463], 'Abraham': [4465], 'Klagsbrun': [4467], '122:': [4473], '933-940Crossref': [4474], '(313)': [4477], 'associates': [4488], 'As': [4500], 'interaction,': [4505], '4-fold.': [4515], 'Removing': [4516], 'eliminates': [4522], 'L6': [4535], 'line': [4538], '(33Han': [4539], 'B.': [4540], 'Soc.': [4543], 'Abstr.': [4545], '25:': [4547], '43Google': [4548], 'explanations': [4556], 'micro-environment': [4580], 'thus': [4585, 4769], 'local': [4588], 'concentration.': [4590], 'addition,': [4592], 'present': [4596], 'molecules': [4598], 'affinity': [4602, 4777], 'simultaneously': [4612], 'several': [4615], 'monomers': [4617], 'producing': [4618], 'multimer': [4620], 'multimeric': [4628], 'activation.': [4630, 5004], 'FGF,': [4637], '(31Schlessinger': [4650], 'looked': [4667], 'Specifically,': [4705], 'whereas': [4714, 4874, 5031], '(21Krufka': [4734], 'explanation': [4751], 'observations': [4754], 'sites,': [4768], 'freeing': [4770], 'interact': [4773], 'High': [4780], 'free': [4790], 'far': [4799], 'come': [4809], 'assays.': [4817], 'study,': [4821], 'preferentially': [4831, 4896], 'degraded': [4832, 4897], 'proteases': [4834], 'produce': [4836], 'active': [4838], 'Since': [4864], 'complete': [4870], 'min,': [4873], 'takes': [4880], 'quite': [4886], 'prevent': [4914], 'degradation.': [4917], 'surprising': [4922], 'here': [4924], 'prolonged': [4936, 5038], 'exposure,': [4938], 'rise': [4945], 'cell-signaling': [4954], 'mechanism': [4955, 4972], 'Further': [4977], 'will': [4979], 'sort': [4983], 'apparent': [4986], 'dissociation': [4987], 'involve': [4996], 'initiated': [5000], 'do': [5016], 'require': [5018], 'movement': [5023], 'pre-existing': [5025], 'surface,': [5030], 'make': [5033], 'requirement': [5046], 'thank': [5071], 'SUNY': [5076], 'providing': [5079], 'vector.': [5084]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1646754425', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2025-01-15T08:59:35.644822', 'created_date': '2016-06-24'}