Lesion Bypass Activities of Human DNA Polymerase μ

Name: Work Video:
Duration: 3 min 30 s
Yanbin Zhang; Xiaohua Wu; Dongyu Guo; Olga Rechkoblit; John‐Stephen Taylor; Nicholas E. Geacintov; Zhi‐Gang Wang
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5742, 5810, 5969, 6050], 'μ': [2, 189, 376, 2734], '(Polμ)': [3, 190, 377, 2735], 'is': [4, 178, 191, 365, 597, 715, 938, 951, 1298, 1335, 1501, 1505, 1554, 1610, 1625, 1660, 1750, 1795, 1847, 2000, 2097, 2175, 2314, 2335, 2402, 2427, 2434, 2480, 2549, 2629, 2648, 2720, 2955, 3073, 3297, 3310, 3658, 3695, 3862, 3866, 3915, 3971, 3986, 4021, 4112, 4157, 4209, 4362, 4459, 4537, 4676, 4697, 4764, 4789, 4796, 4842, 4911, 4991, 5010, 5082, 5177, 5222, 5274, 5428, 5525, 5603, 5743, 5764, 5831, 5857, 5864, 5910, 5979, 6059, 6078, 6150], 'a': [5, 61, 113, 139, 149, 192, 248, 300, 326, 336, 414, 598, 658, 804, 942, 960, 1163, 1260, 1339, 1378, 1483, 1606, 1628, 1762, 1848, 1852, 1986, 2001, 2035, 2067, 2087, 2134, 2143, 2318, 2420, 2546, 2772, 2956, 3016, 3163, 3301, 3319, 3522, 3620, 3699, 3738, 3843, 3967, 3989, 4124, 4210, 4214, 4348, 4363, 4397, 4429, 4449, 4496, 4505, 4680, 4782, 4908, 5189, 5275, 5279, 5414, 5429, 5463, 5495, 5515, 5562, 5571, 5747, 5850, 5976], 'newly': [6, 193, 415, 2773], 'discovered': [7, 42, 194, 229, 416, 2774], 'member': [8, 195, 417, 2775], 'of': [9, 20, 29, 47, 55, 94, 98, 119, 168, 196, 207, 216, 234, 242, 281, 285, 306, 355, 418, 706, 773, 785, 797, 880, 945, 956, 1165, 1167, 1179, 1181, 1254, 1343, 1478, 1497, 1556, 1579, 1598, 1605, 1620, 1650, 1677, 1738, 1764, 1787, 1803, 1818, 1886, 1952, 1991, 2003, 2018, 2038, 2054, 2093, 2145, 2182, 2195, 2198, 2304, 2364, 2373, 2397, 2419, 2462, 2484, 2545, 2624, 2654, 2688, 2710, 2726, 2776, 3064, 3131, 3144, 3156, 3239, 3304, 3315, 3524, 3526, 3538, 3540, 3614, 3703, 3838, 3858, 3917, 3940, 3959, 3966, 3981, 4011, 4039, 4100, 4126, 4149, 4165, 4180, 4248, 4314, 4353, 4365, 4380, 4400, 4416, 4455, 4507, 4544, 4557, 4560, 4666, 4726, 4735, 4759, 4781, 4824, 4846, 4907, 4986, 5016, 5050, 5072, 5088, 5104, 5165, 5191, 5214, 5230, 5245, 5313, 5379, 5419, 5431, 5446, 5466, 5482, 5521, 5573, 5610, 5624, 5627, 5733, 5793, 5802, 5826, 5849, 5892, 5914, 5975, 6054, 6084, 6118, 6140, 6156], 'the': [10, 43, 74, 91, 124, 157, 166, 183, 197, 230, 261, 278, 311, 344, 353, 370, 419, 707, 782, 786, 798, 876, 946, 1168, 1172, 1177, 1186, 1198, 1204, 1208, 1371, 1389, 1399, 1621, 1635, 1648, 1753, 1800, 1883, 1948, 1965, 1982, 2030, 2039, 2051, 2055, 2060, 2072, 2090, 2094, 2105, 2114, 2178, 2193, 2210, 2300, 2352, 2362, 2369, 2395, 2404, 2416, 2439, 2443, 2446, 2454, 2459, 2463, 2488, 2492, 2496, 2512, 2515, 2532, 2643, 2655, 2681, 2684, 2689, 2700, 2707, 2717, 2724, 2727, 2777, 3065, 3141, 3145, 3157, 3235, 3305, 3527, 3531, 3536, 3545, 3557, 3563, 3567, 3731, 3749, 3759, 3982, 3996, 4009, 4115, 4162, 4245, 4310, 4327, 4344, 4392, 4401, 4413, 4417, 4422, 4434, 4452, 4456, 4467, 4476, 4540, 4555, 4572, 4662, 4714, 4724, 4731, 4757, 4766, 4778, 4801, 4805, 4808, 4816, 4821, 4825, 4850, 4854, 4858, 4874, 4877, 4894, 5005, 5017, 5043, 5046, 5051, 5062, 5069, 5079, 5086, 5089, 5180, 5227, 5310, 5375, 5393, 5410, 5458, 5467, 5479, 5483, 5488, 5500, 5518, 5522, 5533, 5542, 5606, 5622, 5639, 5729, 5781, 5791, 5798, 5824, 5833, 5846, 5869, 5873, 5876, 5884, 5889, 5893, 5918, 5922, 5926, 5942, 5945, 5962, 6073, 6085, 6111, 6114, 6119, 6130, 6137, 6147, 6154, 6157], 'X': [12, 199, 420, 787, 1884, 1960, 2778, 3146, 4246, 4322, 5311, 5387], 'family': [13, 185, 200, 372, 421, 486, 788, 800, 878, 948, 1200, 1666, 1802, 1885, 1961, 2779, 2844, 3147, 3159, 3237, 3307, 3559, 4027, 4164, 4247, 4323, 5229, 5312, 5388], 'with': [14, 153, 201, 340, 1197, 1268, 1752, 2066, 2126, 3556, 3628, 4114, 4428, 4488, 5179, 5494, 5554], 'unknown': [15, 202, 2649, 5011, 6079], 'cellular': [16, 203, 961, 1736, 3320, 4098, 5163], 'function.': [17, 204], 'The': [18, 116, 205, 303, 1475, 1989, 2043, 2534, 3835, 4351, 4405, 4896, 5417, 5471, 5964], 'understanding': [19, 28, 206, 215], 'Polμ': [21, 37, 71, 111, 117, 135, 170, 208, 224, 258, 298, 304, 322, 357, 776, 1257, 1297, 1334, 1382, 1462, 1480, 1530, 1553, 1566, 1614, 1652, 1671, 1740, 1749, 1776, 1872, 1954, 1980, 2023, 2085, 2102, 2129, 2184, 2309, 2365, 2374, 2426, 2528, 2703, 3134, 3617, 3657, 3694, 3742, 3822, 3840, 3891, 3914, 3927, 3975, 4013, 4033, 4102, 4111, 4138, 4234, 4316, 4342, 4385, 4447, 4464, 4491, 4546, 4671, 4727, 4736, 4788, 4890, 5065, 5098, 5167, 5176, 5203, 5299, 5381, 5408, 5451, 5513, 5530, 5557, 5612, 5738, 5794, 5803, 5856, 5958, 6133], 'function': [22, 209, 944, 2719, 3303, 5081, 6149], 'should': [23, 210], 'be': [24, 211, 793, 1160, 1464, 1520, 1673, 1957, 2025, 2077, 2209, 2409, 2502, 2520, 3152, 3519, 3824, 3881, 4035, 4319, 4387, 4439, 4571, 4771, 4864, 4882, 5100, 5384, 5453, 5505, 5638, 5838, 5932, 5950], 'facilitated': [25, 212], 'by': [26, 109, 213, 296, 1332, 1338, 1612, 1627, 1744, 1985, 2021, 2027, 2079, 2112, 2141, 2307, 2355, 2411, 2424, 2466, 2508, 2606, 2659, 2694, 3692, 3698, 3973, 3988, 4106, 4347, 4383, 4389, 4441, 4474, 4503, 4669, 4717, 4773, 4786, 4828, 4870, 4968, 5021, 5056, 5171, 5413, 5449, 5455, 5507, 5540, 5569, 5736, 5784, 5840, 5854, 5896, 5938, 6036, 6089, 6124], 'an': [27, 214, 1182, 1616, 2138, 2152, 2412, 2613, 3541, 3977, 4500, 4514, 4774, 4975, 5566, 5580, 5841, 6043], 'its': [30, 217, 1395, 1682, 2188, 3755, 4044, 4550, 5109, 5616], 'biochemical': [31, 39, 218, 226, 783, 806, 1433, 1476, 2359, 3142, 3165, 3793, 3836, 4721, 5788], 'activities.': [32, 219], 'By': [33, 220], 'using': [34, 221], 'purified': [35, 69, 222, 256, 1255, 1819, 2127, 3615, 4181, 4489, 5246, 5555], 'human': [36, 70, 95, 110, 134, 169, 223, 257, 282, 297, 321, 356, 1256, 1333, 1381, 1479, 1565, 1613, 1651, 1739, 1775, 1820, 1953, 1979, 2022, 2080, 2084, 2122, 2128, 2183, 2308, 2356, 2425, 2467, 2477, 2509, 3616, 3693, 3741, 3839, 3926, 3974, 4012, 4101, 4137, 4182, 4315, 4341, 4384, 4442, 4446, 4484, 4490, 4545, 4670, 4718, 4787, 4829, 4839, 4871, 5166, 5202, 5247, 5380, 5407, 5450, 5508, 5512, 5550, 5556, 5611, 5737, 5785, 5855, 5897, 5907, 5939], 'for': [38, 225, 1471, 1486, 1825, 2379, 2618, 3831, 3846, 4187, 4741, 4980, 5252, 5808, 6048], 'analyses,': [40, 227], 'we': [41, 228, 1550, 1562, 1668, 1772, 1810, 2014, 2675, 3911, 3923, 4030, 4134, 4172, 4376, 5037, 5095, 5199, 5237, 5442, 6105], 'lesion': [44, 231, 966, 1153, 1173, 1206, 1570, 1779, 1815, 1855, 1949, 1983, 2179, 2305, 2370, 2406, 2440, 2444, 3325, 3512, 3532, 3565, 3931, 4141, 4177, 4217, 4311, 4345, 4541, 4667, 4732, 4768, 4802, 4806, 5206, 5242, 5282, 5376, 5411, 5607, 5734, 5799, 5835, 5870, 5874], 'bypass': [45, 145, 232, 332, 967, 1154, 1158, 1571, 1604, 1619, 1780, 1816, 1950, 2017, 2180, 2306, 2371, 2418, 2455, 2544, 2623, 2658, 2693, 2709, 3326, 3513, 3517, 3932, 3965, 3980, 4142, 4178, 4312, 4379, 4542, 4668, 4733, 4780, 4817, 4906, 4985, 5020, 5055, 5071, 5207, 5243, 5377, 5445, 5608, 5735, 5800, 5848, 5885, 5974, 6053, 6088, 6123, 6139], 'activities': [46, 233, 784, 1572, 1687, 1781, 1817, 2372, 3143, 3933, 4049, 4143, 4179, 4734, 5114, 5208, 5244, 5801], 'this': [48, 144, 235, 331, 485, 1487, 1560, 1765, 1770, 2312, 2380, 2619, 2673, 2843, 3847, 3921, 4127, 4132, 4674, 4742, 4981, 5035, 5192, 5197, 5741, 5809, 6049, 6103], 'in': [50, 148, 237, 335, 484, 593, 657, 813, 1152, 1155, 1212, 1466, 1489, 1573, 1602, 1615, 1675, 1767, 1782, 2012, 2151, 2214, 2321, 2326, 2366, 2394, 2615, 2621, 2667, 2685, 2706, 2713, 2723, 2842, 2951, 3015, 3172, 3511, 3514, 3571, 3826, 3849, 3934, 3963, 3976, 4037, 4129, 4144, 4374, 4513, 4576, 4683, 4688, 4728, 4756, 4977, 4983, 5029, 5047, 5068, 5075, 5085, 5102, 5194, 5209, 5440, 5579, 5643, 5750, 5755, 5795, 5823, 6045, 6051, 6097, 6115, 6136, 6143, 6153], 'response': [51, 238, 1574, 1783, 1963, 3935, 4145, 4325, 5210, 5391], 'to': [52, 89, 182, 239, 276, 369, 655, 717, 792, 952, 964, 1301, 1459, 1575, 1590, 1664, 1784, 1799, 1882, 1956, 1964, 2048, 2071, 2108, 2132, 2208, 2316, 2382, 2438, 2505, 2523, 2526, 2541, 2603, 2636, 2650, 2662, 2678, 3013, 3075, 3151, 3311, 3323, 3661, 3819, 3936, 3951, 4025, 4146, 4161, 4244, 4318, 4326, 4410, 4433, 4470, 4494, 4570, 4678, 4744, 4800, 4867, 4885, 4888, 4903, 4965, 4998, 5012, 5024, 5040, 5211, 5226, 5309, 5383, 5392, 5476, 5499, 5536, 5560, 5637, 5745, 5811, 5868, 5935, 5953, 5956, 5971, 6033, 6066, 6080, 6092, 6108], 'several': [53, 240, 1401, 2199, 3761, 4561, 5628], 'types': [54, 241, 1578, 1786, 3939, 4148, 5213], 'damage.': [57, 244, 1503, 1789, 3864, 4151, 5216], 'When': [58, 245], 'it': [59, 246, 937, 2118, 2377, 2628, 2647, 3296, 4480, 4739, 4990, 5009, 5546, 5806, 6058, 6077], 'encountered': [60, 247], 'template': [62, 140, 249, 327, 1400, 1607, 1637, 1966, 2031, 2041, 2068, 2431, 2470, 3760, 3968, 3998, 4328, 4393, 4403, 4430, 4793, 4832, 5394, 5459, 5469, 5496, 5861, 5900], '8-oxoguanine,': [63, 250, 1969, 4331, 5397], 'abasic': [64, 251], 'site,': [65, 252], 'or': [66, 253, 968, 1174, 1377, 1515, 2099, 2441, 3327, 3533, 3737, 3876, 4461, 4803, 5527, 5871], '1,N': [67, 254, 1970, 4332, 5398], '6-ethenoadenine,': [68, 255, 1971, 4333, 5399], 'efficiently': [72, 259], 'bypassed': [73, 138, 260, 325], 'lesion.': [75, 262, 1187, 2056, 2115, 2533, 3546, 4418, 4477, 4895, 5484, 5543, 5963], 'Even': [76, 263], 'bulky': [77, 104, 264, 291, 1591, 3952], 'adducts': [79, 105, 266, 292, 1594, 3955], 'such': [80, 267, 1387, 2074, 2641, 3747, 4436, 5003, 5502, 6071], 'asN-2-acetylaminofluorene-adducted': [81, 268], 'guanine,': [82, 269, 1973, 4335, 5401], '(+)-': [83, 270, 1975, 4337, 5403], 'and': [84, 103, 171, 271, 290, 358, 490, 710, 714, 775, 882, 887, 1055, 1190, 1207, 1407, 1540, 1587, 1653, 1685, 1747, 1757, 1873, 1878, 1974, 1976, 2187, 2329, 2346, 2388, 2495, 2604, 2665, 2848, 3068, 3072, 3133, 3241, 3246, 3414, 3549, 3566, 3767, 3901, 3948, 4014, 4047, 4109, 4119, 4235, 4240, 4336, 4338, 4549, 4691, 4708, 4750, 4857, 4966, 5027, 5112, 5174, 5184, 5300, 5305, 5402, 5404, 5615, 5758, 5775, 5817, 5925, 6034, 6095], '(−)-trans-anti-benzo[a]pyrene-N': [85, 272, 1977, 4339, 5405], '2-dG': [86, 273], 'were': [87, 274], 'unable': [88, 275, 2677, 5039, 6107], 'block': [90, 277], 'activity': [93, 177, 280, 364, 1659, 1794, 1951, 2174, 2181, 2600, 4020, 4156, 4313, 4536, 4543, 4962, 5221, 5378, 5602, 5609, 6030], 'Polμ.': [96, 283, 2081, 2357, 2468, 2478, 2510, 2695, 4443, 4719, 4830, 4840, 4872, 5057, 5509, 5786, 5898, 5908, 5940, 6125], 'Bypass': [97, 284], 'these': [99, 286, 2007, 2019, 4369, 4381, 5435, 5447], 'simple': [100, 287, 1584, 3945], 'base': [101, 288, 590, 1517, 1534, 1585, 1638, 2069, 2096, 2202, 2398, 2405, 2948, 3878, 3895, 3946, 3999, 4431, 4458, 4564, 4760, 4767, 5497, 5524, 5631, 5827, 5834], 'damage': [102, 289, 1518, 1535, 3879, 3896], 'was': [106, 146, 293, 333, 2119, 4481, 5547], 'predominantly': [107, 294, 1984, 4346, 5412], 'achieved': [108, 147, 295, 334, 1611, 2026, 3972, 4388, 5454], 'through': [112, 299, 1639, 1681, 4000, 4043, 5108], 'deletion': [114, 125, 301, 312, 1340, 1629, 1987, 1999, 2045, 2302, 3700, 3990, 4349, 4361, 4407, 4664, 5415, 5427, 5473, 5731], 'mechanism.': [115, 302, 1988, 4350, 5416, 5844], 'specificity': [118, 305, 1990, 4352, 5418], 'nucleotide': [120, 307, 653, 1170, 1184, 1192, 1992, 2340, 2529, 3011, 3529, 3543, 3551, 4354, 4702, 4891, 5420, 5769, 5959], 'incorporation': [121, 155, 308, 342, 1993, 4355, 5421], 'indicates': [122, 309, 1997, 4359, 5425], 'that': [123, 173, 310, 360, 941, 974, 1263, 1388, 1461, 1507, 1516, 1564, 1631, 1655, 1670, 1735, 1748, 1774, 1998, 2016, 2121, 2311, 2338, 2482, 2597, 2702, 3300, 3333, 3623, 3748, 3821, 3868, 3877, 3925, 3992, 4016, 4032, 4097, 4110, 4136, 4360, 4378, 4483, 4673, 4700, 4844, 4959, 5064, 5097, 5162, 5175, 5201, 5426, 5444, 5549, 5740, 5767, 5912, 6027, 6132], 'resulted': [126, 313], 'from': [127, 314, 1583, 2136, 2177, 2458, 3944, 4498, 4539, 4820, 5564, 5605, 5888], 'primer': [128, 315, 1372, 1390, 1640, 2004, 2061, 2135, 2343, 3732, 3750, 4001, 4366, 4423, 4497, 4705, 5432, 5489, 5563, 5772], 'realignment': [129, 316, 1345, 1386, 2075, 2354, 3705, 3746, 4437, 4716, 5503, 5783], 'before': [130, 317, 1346, 3706], 'translesion': [131, 175, 318, 362, 969, 1557, 1657, 1792, 1995, 2322, 3328, 3918, 4018, 4154, 4357, 4684, 5219, 5423, 5751], 'synthesis.': [132, 319, 970, 1558, 3329, 3919], 'Purified': [133, 320], 'also': [136, 323], 'effectively': [137, 324, 1632, 3993], 'cis-synTT': [141, 328], 'dimer.': [142, 159, 329, 346], 'However,': [143, 330, 2627, 4989, 6057], 'mainly': [150, 337, 1337, 3697], 'error-free': [151, 338, 1161, 1189, 1617, 2543, 2622, 2690, 2708, 3520, 3548, 3978, 4905, 4984, 5052, 5070, 5973, 6052, 6120, 6138], 'manner': [152, 339, 660, 3018], 'AA': [154, 341, 2451, 4813, 5881], 'opposite': [156, 343, 809, 1171, 1185, 2137, 2531, 3168, 3530, 3544, 4499, 4893, 5565, 5961], 'TT': [158, 345, 1596, 1608, 2422, 2432, 2464, 2471, 2493, 2497, 2513, 2516, 2547, 2656, 2691, 2711, 3957, 3969, 4784, 4794, 4826, 4833, 4855, 4859, 4875, 4878, 4909, 5018, 5053, 5073, 5852, 5862, 5894, 5901, 5923, 5927, 5943, 5946, 5977, 6086, 6121, 6141], 'These': [160, 347, 1431, 1642, 2358, 3791, 4003, 4720, 5787], 'results': [161, 348, 2698, 5060, 6128], 'provide': [162, 349, 1644, 4005], 'new': [163, 350, 1645, 4006], 'insights': [164, 351, 1646, 4007], 'into': [165, 352, 1647, 4008], 'biochemistry': [167, 354, 1649, 4010], 'show': [172, 359, 1654, 4015], 'efficient': [174, 361, 1569, 1656, 1791, 3930, 4017, 4153, 5218], 'synthesis': [176, 363, 601, 808, 1304, 1331, 1347, 1658, 1793, 1996, 2111, 2323, 2390, 2959, 3167, 3664, 3691, 3707, 4019, 4155, 4358, 4473, 4685, 4752, 5220, 5424, 5539, 5752, 5819], 'not': [179, 366, 778, 1661, 1796, 1812, 2501, 2630, 3136, 4022, 4158, 4174, 4863, 4992, 5223, 5239, 5931, 6060], 'strictly': [180, 367, 1662, 1797, 4023, 4159, 5224], 'confined': [181, 368, 1663, 4024], 'Y': [184, 371, 799, 877, 947, 1199, 1665, 1801, 3158, 3236, 3306, 3558, 4026, 4163, 5228], 'polymerases.': [186, 373, 1805, 4028, 4167, 5232], '1The': [378, 396, 2736, 2754], 'abbreviations': [379, 397, 2737, 2755], 'used': [380, 398, 2738, 2756], 'are:': [381, 399, 2739, 2757], 'Pol,': [382, 400, 2740, 2758], 'polymerase;': [384, 402, 2742, 2760], 'BPDE,': [385, 403, 2743, 2761], 'benzo[a]pyrene-trans-7,8-dihydrodiol-9,': [386, 404, 2744, 2762], '10-epoxide;': [387, 405, 2745, 2763], 'AAF,': [388, 406, 2746, 2764], 'N-2-acetylaminofluorene;': [389, 407, 2747, 2765], 'AP,': [390, 408, 2748, 2766], 'apurinic/apyrimidinic;': [391, 409, 2749, 2767], 'NHEJ,': [392, 410, 2750, 2768], 'nonhomologous': [393, 411, 1467, 2751, 2769, 3827], 'end': [394, 412, 1374, 1392, 1468, 2063, 2752, 2770, 3734, 3752, 3828, 4425, 5491], 'joining': [395, 1469, 2753, 3829], 'joiningis': [413, 2771], 'polymerases': [422, 790, 802, 884, 950, 1201, 1271, 1888, 2780, 3149, 3161, 3243, 3309, 3560, 3631, 4250, 5315], '(1Dominguez': [423, 493, 1889, 2781, 2851, 4251, 5316], 'O.': [424, 494, 555, 685, 744, 1890, 2782, 2852, 2913, 3043, 3102, 4252, 5317], 'Ruiz': [425, 495, 563, 1891, 2783, 2853, 2921, 4253, 5318], 'J.F.': [426, 496, 564, 1892, 2784, 2854, 2922, 4254, 5319], 'Lain': [427, 497, 1893, 2785, 2855, 4255, 5320], 'de': [428, 498, 558, 1067, 1894, 2786, 2856, 2916, 3426, 4256, 5321], 'Lera': [429, 499, 559, 1895, 2787, 2857, 2917, 4257, 5322], 'T.': [430, 436, 500, 506, 570, 614, 908, 914, 1132, 1134, 1896, 1902, 2226, 2560, 2562, 2788, 2794, 2858, 2864, 2928, 2972, 3267, 3273, 3491, 3493, 4258, 4264, 4588, 4922, 4924, 5323, 5329, 5655, 5990, 5992], 'Garcia-Diaz': [431, 501, 1897, 2789, 2859, 4259, 5324], 'M.': [432, 502, 553, 566, 681, 740, 1126, 1859, 1898, 2218, 2285, 2291, 2554, 2790, 2860, 2911, 2924, 3039, 3098, 3485, 4221, 4260, 4580, 4647, 4653, 4916, 5286, 5325, 5647, 5714, 5720, 5984], 'Gonzalez': [433, 503, 1899, 2791, 2861, 4261, 5326], 'M.A.': [434, 504, 1900, 2792, 2862, 4262, 5327], 'Kirchhoff': [435, 505, 569, 1901, 2793, 2863, 2927, 4263, 5328], 'Martinez': [437, 507, 684, 743, 1903, 2795, 2865, 3042, 3101, 4265, 5330], 'A.C.': [438, 508, 1904, 2796, 2866, 4266, 5331], 'Bernad': [439, 509, 574, 1905, 2797, 2867, 2932, 4267, 5332], 'A.': [440, 456, 458, 510, 526, 528, 575, 608, 1046, 1078, 1128, 1906, 1922, 1924, 2222, 2241, 2247, 2253, 2556, 2798, 2814, 2816, 2868, 2884, 2886, 2933, 2966, 3405, 3437, 3487, 4268, 4284, 4286, 4584, 4603, 4609, 4615, 4918, 5333, 5349, 5351, 5651, 5670, 5676, 5682, 5986], 'Blanco': [441, 511, 576, 1907, 2799, 2869, 2934, 4269, 5334], 'L.': [442, 466, 512, 536, 577, 910, 1908, 1932, 2159, 2582, 2800, 2824, 2870, 2894, 2935, 3269, 4270, 4294, 4521, 4944, 5335, 5359, 5587, 6012], 'EMBO': [443, 513, 615, 690, 749, 1139, 1909, 2567, 2801, 2871, 2973, 3048, 3107, 3498, 4271, 4929, 5336, 5997], 'J.': [444, 514, 573, 578, 616, 691, 750, 838, 982, 1140, 1237, 1910, 2254, 2568, 2802, 2872, 2931, 2936, 2974, 3049, 3108, 3197, 3341, 3499, 3596, 4272, 4616, 4930, 5337, 5683, 5998], '2000;': [445, 476, 515, 546, 581, 998, 1018, 1047, 1911, 1942, 2294, 2803, 2834, 2873, 2904, 2939, 3357, 3377, 3406, 4273, 4304, 4656, 5338, 5369, 5723], '19:': [446, 516, 1116, 1912, 2804, 2874, 3475, 4274, 5339], '1731-1742Crossref': [447, 517, 1913, 2805, 2875, 4275, 5340], 'PubMed': [448, 479, 518, 549, 584, 620, 633, 645, 672, 695, 731, 754, 766, 822, 849, 869, 931, 987, 1001, 1021, 1050, 1082, 1099, 1118, 1144, 1221, 1248, 1291, 1321, 1364, 1426, 1454, 1704, 1729, 1843, 1866, 1914, 1945, 2170, 2235, 2260, 2275, 2572, 2587, 2806, 2837, 2876, 2907, 2942, 2978, 2991, 3003, 3030, 3053, 3089, 3112, 3124, 3181, 3208, 3228, 3290, 3346, 3360, 3380, 3409, 3441, 3458, 3477, 3503, 3580, 3607, 3651, 3681, 3724, 3786, 3814, 4066, 4091, 4205, 4228, 4276, 4307, 4532, 4597, 4622, 4637, 4934, 4949, 5131, 5156, 5270, 5293, 5341, 5372, 5598, 5664, 5689, 5704, 6002, 6017], 'Google': [449, 480, 519, 550, 587, 623, 636, 648, 675, 698, 734, 757, 769, 825, 834, 852, 872, 934, 988, 1004, 1024, 1053, 1085, 1102, 1121, 1147, 1224, 1233, 1251, 1294, 1324, 1367, 1429, 1457, 1707, 1732, 1844, 1869, 1915, 1946, 2171, 2238, 2263, 2278, 2297, 2575, 2590, 2807, 2838, 2877, 2908, 2945, 2981, 2994, 3006, 3033, 3056, 3092, 3115, 3127, 3184, 3193, 3211, 3231, 3293, 3347, 3363, 3383, 3412, 3444, 3461, 3480, 3506, 3583, 3592, 3610, 3654, 3684, 3727, 3789, 3817, 4069, 4094, 4206, 4231, 4277, 4308, 4533, 4600, 4625, 4640, 4659, 4937, 4952, 5134, 5159, 5271, 5296, 5342, 5373, 5599, 5667, 5692, 5707, 5726, 6005, 6020], 'Scholar,': [450, 520, 551, 624, 637, 676, 735, 758, 826, 835, 853, 989, 1005, 1025, 1086, 1103, 1122, 1225, 1234, 1916, 2239, 2264, 2279, 2576, 2808, 2878, 2909, 2982, 2995, 3034, 3093, 3116, 3185, 3194, 3212, 3348, 3364, 3384, 3445, 3462, 3481, 3584, 3593, 4278, 4601, 4626, 4641, 4938, 5343, 5668, 5693, 5708, 6006], '2Aoufouchi': [451, 521, 1917, 2809, 2879, 4279, 5344], 'S.': [452, 462, 522, 532, 912, 1045, 1060, 1077, 1136, 1857, 1918, 1928, 2220, 2224, 2266, 2564, 2580, 2810, 2820, 2880, 2890, 3271, 3404, 3419, 3436, 3495, 4219, 4280, 4290, 4582, 4586, 4628, 4926, 4942, 5284, 5345, 5355, 5649, 5653, 5695, 5994, 6010], 'Flatter': [453, 523, 1919, 2811, 2881, 4281, 5346], 'E.': [454, 524, 1920, 2812, 2882, 4282, 5347], 'Dahan': [455, 525, 1921, 2813, 2883, 4283, 5348], 'Faili': [457, 527, 1923, 2815, 2885, 4285, 5350], 'Bertocci': [459, 529, 1925, 2817, 2887, 4287, 5352], 'B.': [460, 530, 1926, 2251, 2818, 2888, 4288, 4613, 5353, 5680], 'Storck': [461, 531, 1927, 2819, 2889, 4289, 5354], 'Delbos': [463, 533, 1929, 2821, 2891, 4291, 5356], 'F.': [464, 534, 687, 746, 898, 1138, 1280, 1310, 1353, 1415, 1443, 1693, 1930, 2566, 2822, 2892, 3045, 3104, 3257, 3497, 3640, 3670, 3713, 3775, 3803, 4055, 4292, 4928, 5120, 5357, 5996], 'Cocea': [465, 535, 1931, 2823, 2893, 4293, 5358], 'Gupta': [467, 537, 1933, 2825, 2895, 4295, 5360], 'N.': [468, 538, 689, 748, 1934, 2228, 2268, 2826, 2896, 3047, 3106, 4296, 4590, 4630, 5361, 5657, 5697], 'Weill': [469, 539, 1935, 2827, 2897, 4297, 5362], 'J.C.': [470, 540, 1936, 2828, 2898, 4298, 5363], 'Reynaud': [471, 541, 1937, 2829, 2899, 4299, 5364], 'C.A.': [472, 542, 1938, 2830, 2900, 4300, 5365], 'Nucleic': [473, 543, 1837, 1939, 2164, 2831, 2901, 4199, 4301, 4526, 5264, 5366, 5592], 'Acids': [474, 544, 1838, 1940, 2165, 2832, 2902, 4200, 4302, 4527, 5265, 5367, 5593], 'Res.': [475, 545, 641, 818, 997, 1217, 1839, 1941, 2166, 2293, 2833, 2903, 2999, 3177, 3356, 3576, 4201, 4303, 4528, 4655, 5266, 5368, 5594, 5722], '28:': [477, 547, 1943, 2835, 2905, 4305, 5370], '3684-3693Crossref': [478, 548, 1944, 2836, 2906, 4306, 5371], 'Scholar).': [481, 588, 649, 699, 770, 873, 935, 1295, 1325, 1368, 1430, 1708, 1870, 2172, 2298, 2591, 2839, 2946, 3007, 3057, 3128, 3232, 3294, 3611, 3655, 3685, 3728, 3790, 4070, 4232, 4534, 4660, 4953, 5135, 5297, 5600, 5727, 6021], 'Additional': [482, 2840], 'members': [483, 2841], 'include': [487, 2845], 'Polβ,': [488, 2846], 'Polλ,': [489, 2847], 'terminal': [491, 2849], 'deoxynucleotidyltransferase': [492, 651, 2850, 3009], '3Garcia-Diaz': [552, 2910], 'Dominguez': [554, 2912], 'Lopez-Fernandez': [556, 2914], 'L.A.': [557, 678, 737, 2915, 3036, 3095], 'L.T.': [560, 2918], 'Saniger': [561, 2919], 'M.L.': [562, 2920], 'Parraga': [565, 2923], 'Garcia-Ortiz': [567, 2925], 'M.J.': [568, 2926], 'del': [571, 2929], 'Mazo': [572, 2930], 'Mol.': [579, 829, 921, 1016, 1112, 1228, 1285, 1315, 1358, 1420, 1448, 1698, 1723, 2255, 2937, 3188, 3280, 3375, 3471, 3587, 3645, 3675, 3718, 3780, 3808, 4060, 4085, 4617, 5125, 5150, 5684], 'Biol.': [580, 839, 1114, 1238, 1287, 1317, 1360, 1422, 1450, 1700, 1725, 2256, 2938, 3198, 3473, 3597, 3647, 3677, 3720, 3782, 3810, 4062, 4087, 4618, 5127, 5152, 5685], '301:': [582, 2940], '851-867Crossref': [583, 2941], 'Scopus': [585, 621, 634, 646, 673, 696, 732, 755, 767, 823, 850, 870, 932, 1002, 1022, 1051, 1083, 1100, 1119, 1145, 1222, 1249, 1292, 1322, 1365, 1427, 1455, 1705, 1730, 1867, 2236, 2261, 2276, 2573, 2588, 2943, 2979, 2992, 3004, 3031, 3054, 3090, 3113, 3125, 3182, 3209, 3229, 3291, 3361, 3381, 3410, 3442, 3459, 3478, 3504, 3581, 3608, 3652, 3682, 3725, 3787, 3815, 4067, 4092, 4229, 4598, 4623, 4638, 4935, 4950, 5132, 5157, 5294, 5665, 5690, 5705, 6003, 6018], '(246)': [586, 2944], 'During': [589, 2947], 'excision': [591, 2413, 2949, 4775, 5842], 'repair': [592, 600, 2414, 2950, 2958, 4776, 5843], 'higher': [594, 2952], 'eukaryotes,': [595, 875, 2953, 3234], 'Polβ': [596, 1821, 1874, 2954, 4183, 4236, 5248, 5301], 'major': [599, 943, 2211, 2319, 2957, 3302, 4573, 4681, 5640, 5748], '(4Kubota': [603, 2961], 'Y.': [604, 1828, 2962, 4190, 5255], 'Nash': [605, 2963], 'R.A.': [606, 2964], 'Klungland': [607, 2965], 'Schar': [609, 2967], 'P.': [610, 2968], 'Barnes': [611, 2969], 'D.E.': [612, 2970], 'Lindahl': [613, 2971], '1996;': [617, 2232, 2975, 4594, 5661], '15:': [618, 2976], '6662-6670Crossref': [619, 2977], '(688)': [622, 2980], '5Wood': [625, 2983], 'R.D.': [626, 1092, 2984, 3451], 'Shivji': [627, 2985], 'M.K.': [628, 2986], 'Carcinogenesis.': [629, 2987], '1997;': [630, 2988], '18:': [631, 1142, 2570, 2989, 3501, 4932, 6000], '605-610Crossref': [632, 2990], '(144)': [635, 2993], '6Wilson': [638, 2996], 'S.H.': [639, 2997], 'Mutat.': [640, 817, 996, 1216, 2998, 3176, 3355, 3575], '1998;': [642, 2272, 3000, 4634, 5701], '407:': [643, 3001], '203-215Crossref': [644, 3002], '(264)': [647, 3005], 'Terminal': [650, 3008], 'catalyzes': [652, 3010], 'additions': [654, 3012], 'template-independent': [659, 3017], '(7Chang': [661, 720, 3019, 3078], 'L.M.': [662, 721, 1090, 3020, 3079, 3449], 'Bollum': [663, 722, 3021, 3080], 'F.J.': [664, 723, 3022, 3081], 'CRC': [665, 724, 3023, 3082], 'Crit.': [666, 725, 3024, 3083], 'Rev.': [667, 726, 3025, 3084], 'Biochem.': [668, 727, 3026, 3085], '1986;': [669, 728, 3027, 3086], '21:': [670, 729, 1289, 1319, 1362, 1424, 1452, 1702, 3028, 3087, 3649, 3679, 3722, 3784, 3812, 4064, 5129], '27-52Crossref': [671, 730, 3029, 3088], '(60)': [674, 733, 3032, 3091], '8Bentolila': [677, 736, 3035, 3094], 'Fanton': [679, 738, 3037, 3096], "d'Andon": [680, 739, 3038, 3097], 'Nguyen': [682, 741, 3040, 3099], 'Q.T.': [683, 742, 3041, 3100], 'Rougeon': [686, 745, 3044, 3103], 'Doyen': [688, 747, 3046, 3105], '1995;': [692, 751, 763, 3050, 3109, 3121], '14:': [693, 752, 3051, 3110], '4221-4229Crossref': [694, 753, 3052, 3111], '(44)': [697, 756, 3055, 3114], 'This': [700, 2173, 3058, 4535, 5601], 'enzyme': [701, 3059], 'functions': [702, 772, 3060, 3130], 'during': [703, 958, 1492, 1547, 1994, 2324, 2391, 2453, 3061, 3317, 3852, 3908, 4356, 4686, 4753, 4815, 5422, 5753, 5820, 5883], 'V(D)J': [704, 3062], 'recombination': [705, 3063], 'immunoglobulin': [708, 1493, 3066, 3853], 'genes': [709, 713, 3067, 3071], 'T-cell': [711, 3069], 'receptor': [712, 3070], 'restricted': [716, 3074], 'lymphoid': [718, 3076], 'tissues': [719, 3077], '9Weaver': [759, 3117], 'D.T.': [760, 3118], 'Adv.': [761, 3119], 'Immunol.': [762, 3120], '58:': [764, 3122], '29-85Crossref': [765, 3123], '(59)': [768, 3126], 'Cellular': [771, 3129], 'Polλ': [774, 3132], 'have': [777, 1194, 1258, 3135, 3553, 3618], 'been': [779, 1195, 1266, 3137, 3554, 3626], 'clearly': [780, 3138], 'defined.Although': [781], 'appear': [791, 2207, 3150, 4569, 5636], 'quite': [794, 3153], 'diverse,': [795, 3154], 'all': [796, 3155], 'share': [803, 1875, 3162, 4237, 5302], 'common': [805, 3164], 'activity:': [807, 3166], 'lesions': [811, 1514, 1624, 2009, 2020, 2349, 3170, 3875, 3985, 4371, 4382, 4711, 5437, 5448, 5778], '(reviewed': [812, 1211, 3171, 3570], 'Refs.': [814, 1213, 3173, 3572], '10Wang': [815, 1214, 3174, 3573], 'Z.': [816, 828, 837, 906, 918, 995, 1031, 1215, 1227, 1236, 1282, 1284, 1312, 1314, 1355, 1357, 1417, 1419, 1445, 1447, 1695, 1697, 1836, 3175, 3187, 3196, 3265, 3277, 3354, 3390, 3574, 3586, 3595, 3642, 3644, 3672, 3674, 3715, 3717, 3777, 3779, 3805, 3807, 4057, 4059, 4198, 5122, 5124, 5263], '2001;': [819, 831, 841, 861, 923, 1218, 1230, 1240, 1288, 1318, 1361, 1423, 1451, 1701, 1840, 3178, 3190, 3200, 3220, 3282, 3577, 3589, 3599, 3648, 3678, 3721, 3783, 3811, 4063, 4202, 5128, 5267], '486:': [820, 1219, 3179, 3578], '59-70Crossref': [821, 1220, 3180, 3579], '(85)': [824, 1223, 3183, 3582], '11Wang': [827, 1226, 3186, 3585], 'Interv.': [830, 1229, 3189, 3588], '1:': [832, 1231, 3191, 3590], '269-281PubMed': [833, 1232, 3192, 3591], '12Livneh': [836, 1235, 3195, 3594], 'Chem.': [840, 1239, 3199, 3598], '276:': [842, 1241, 3201, 3600], '25639-25642Abstract': [843, 1242, 3202, 3601], 'Full': [844, 846, 864, 866, 926, 928, 1243, 1245, 3203, 3205, 3223, 3225, 3285, 3287, 3602, 3604], 'Text': [845, 847, 865, 867, 927, 929, 1244, 1246, 3204, 3206, 3224, 3226, 3286, 3288, 3603, 3605], 'PDF': [848, 868, 930, 1247, 3207, 3227, 3289, 3606], '(112)': [851, 1250, 3210, 3609], '13Friedberg': [854, 3213], 'E.C.': [855, 892, 3214, 3251], 'Fischhaber': [856, 3215], 'P.L.': [857, 3216], 'Kisker': [858, 3217], 'C.': [859, 1124, 2552, 3218, 3483, 4914, 5982], 'Cell.': [860, 922, 1113, 1286, 1316, 1359, 1421, 1449, 1699, 1724, 3219, 3281, 3472, 3646, 3676, 3719, 3781, 3809, 4061, 4086, 5126, 5151], '107:': [862, 3221], '9-12Abstract': [863, 3222], '(110)': [871, 3230], 'In': [874, 1559, 1769, 3233, 3920, 4131, 5196, 5390], 'consists': [879, 3238], 'REV1': [881, 975, 3240, 3334], 'η,': [885, 3244], 'ι,': [886, 3245], 'κ': [888, 3247], '(14Ohmori': [889, 3248], 'H.': [890, 3249], 'Friedberg': [891, 3250], 'Fuchs': [893, 2160, 3252, 4522, 5588], 'R.P.P.': [894, 2161, 3253, 4523, 5589], 'Goodman': [895, 3254], 'M.F.': [896, 3255], 'Hanaoka': [897, 1137, 2565, 3256, 3496, 4927, 5995], 'Hinkle': [899, 1012, 3258, 3371], 'D.': [900, 1071, 1107, 3259, 3430, 3466], 'Kunkel': [901, 3260], 'T.A.': [902, 3261], 'Lawrence': [903, 1014, 1036, 3262, 3373, 3395], 'C.W.': [904, 1015, 1037, 3263, 3374, 3396], 'Livneh': [905, 3264], 'Nohmi': [907, 3266], 'Prakash': [909, 911, 2579, 2581, 3268, 3270, 4941, 4943, 6009, 6011], 'Todo': [913, 3272], 'Walker': [915, 3274], 'G.C.': [916, 3275], 'Wang': [917, 994, 1028, 1283, 1313, 1356, 1418, 1446, 1696, 1835, 3276, 3353, 3387, 3643, 3673, 3716, 3778, 3806, 4058, 4197, 5123, 5262], 'Woodgate': [919, 3278], 'R.': [920, 1130, 2245, 2558, 3279, 3489, 4607, 4920, 5674, 5988], '8:': [924, 3283], '7-8Abstract': [925, 3284], '(731)': [933, 3292], 'Thus,': [936, 1790, 2082, 3295, 4152, 4444, 5217, 5510], 'generally': [939, 3298], 'believed': [940, 3299], 'copy': [953, 3312], 'damaged': [954, 1509, 1636, 2040, 3313, 3870, 3997, 4402, 5468], 'sites': [955, 1510, 1589, 3314, 3871, 3950], 'replication,': [959, 3318], 'process': [962, 3321], 'referred': [963, 3322], 'as': [965, 1162, 1176, 1542, 1544, 2146, 2148, 2642, 2722, 3324, 3521, 3535, 3903, 3905, 4508, 4510, 5004, 5084, 5574, 5576, 6072, 6152], 'Genetic': [971, 3330], 'studies': [972, 1253, 3331, 3613], 'indicate': [973, 3332], '(15Larimer': [976, 3335], 'F.W.': [977, 3336], 'Perry': [978, 3337], 'J.R.': [979, 1007, 3338, 3366], 'Hardigree': [980, 3339], 'A.A.': [981, 3340], 'Bacteriol.': [983, 3342], '1989;': [984, 3343], '171:': [985, 3344], '230-237Crossref': [986, 3345], '16Rajpal': [990, 3349], 'D.K.,': [991, 3350], 'Wu,': [992, 1277, 1307, 1350, 1412, 1440, 1690, 1831, 3351, 3637, 3667, 3710, 3772, 3800, 4052, 4193, 5117, 5258], 'X.': [993, 1278, 1308, 1351, 1413, 1441, 1691, 1832, 3352, 3638, 3668, 3711, 3773, 3801, 4053, 4194, 5118, 5259], '461:': [999, 3358], '133-143Crossref': [1000, 3359], '(37)': [1003, 3362], '17Nelson': [1006, 3365], 'Gibbs': [1008, 3367], 'P.E.': [1009, 1027, 3368, 3386], 'Nowicka': [1010, 3369], 'A.M.': [1011, 2163, 3370, 4525, 5591], 'D.C.': [1013, 3372], 'Microbiol.': [1017, 3376], '37:': [1019, 2273, 3378, 4635, 5702], '549-554Crossref': [1020, 3379], '(183)': [1023, 3382], '18Gibbs': [1026, 3385], 'X.D.,': [1029, 3388], 'Li,': [1030, 3389], 'McManus': [1032, 3391], 'T.P.': [1033, 3392], 'McGregor': [1034, 3393], 'W.G.': [1035, 1105, 3394, 3464], 'Maher': [1038, 1108, 3397, 3467], 'V.M.': [1039, 1088, 1109, 3398, 3447, 3468], 'Proc.': [1040, 1072, 3399, 3431], 'Natl.': [1041, 1073, 3400, 3432], 'Acad.': [1042, 1074, 3401, 3433], 'Sci.': [1043, 1075, 3402, 3434], 'U.': [1044, 1076, 3403, 3435], '97:': [1048, 3407], '4186-4191Crossref': [1049, 3408], '(162)': [1052, 3411], 'Scholar)': [1054, 1148, 1458, 1733, 3413, 3507, 3818, 4095, 5160], 'Polη': [1056, 2550, 2599, 2633, 2660, 2718, 3415, 4912, 4961, 4995, 5022, 5080, 5980, 6029, 6063, 6090, 6148], '(19Lehman': [1057, 3416], 'A.R.': [1058, 3417], 'Kirk-Bell': [1059, 3418], 'Arlett': [1061, 3420], 'C.F.': [1062, 3421], 'Paterson': [1063, 3422], 'M.C.': [1064, 3423], 'Lohman': [1065, 3424], 'P.H.': [1066, 3425], 'Weerd-Kastelein': [1068, 3427], 'E.A.': [1069, 3428], 'Bootsma': [1070, 3429], '1975;': [1079, 3438], '72:': [1080, 3439], '219-223Crossref': [1081, 3440], '(523)': [1084, 3443], '20Maher': [1087, 3446], 'Ouellette': [1089, 3448], 'Curren': [1091, 3450], 'McCormick': [1093, 1110, 3452, 3469], 'J.J.': [1094, 1111, 3453, 3470], 'Nature.': [1095, 1862, 3454, 4224, 5289], '1976;': [1096, 3455], '261:': [1097, 3456], '593-595Crossref': [1098, 3457], '(266)': [1101, 3460], '21McGregor': [1104, 3463], 'Wei': [1106, 3465], '1999;': [1115, 1141, 2569, 2584, 3474, 3500, 4931, 4946, 5999, 6014], '147-154Crossref': [1117, 3476], '(68)': [1120, 3479], '22Masutani': [1123, 3482], 'Araki': [1125, 2553, 3484, 4915, 5983], 'Yamada': [1127, 2555, 3486, 4917, 5985], 'Kusumoto': [1129, 2557, 3488, 4919, 5987], 'Nogimori': [1131, 2559, 3490, 4921, 5989], 'Maekawa': [1133, 2561, 3492, 4923, 5991], 'Iwai': [1135, 2563, 3494, 4925, 5993], '3491-3501Crossref': [1143, 2571, 3502, 4933, 6001], '(384)': [1146, 2574, 3505, 4936, 6004], 'are': [1149, 1742, 2130, 2601, 2676, 3508, 4104, 4492, 4963, 5038, 5169, 5558, 6031, 6106], 'indeed': [1150, 1567, 3509, 3928], 'involved': [1151, 1465, 1674, 3510, 3825, 4036, 5101], 'cells.': [1156, 2671, 2731, 3515, 5033, 5093, 6101, 6161], 'Lesion': [1157, 3516], 'can': [1159, 1383, 1393, 2064, 2407, 3518, 3743, 3753, 4426, 4769, 5492, 5836], 'result': [1164, 1178, 2002, 2457, 3523, 3537, 4364, 4819, 5430, 5887], 'insertion': [1166, 1180, 2452, 2530, 3525, 3539, 4814, 4892, 5882, 5960], 'correct': [1169, 3528], 'error-prone': [1175, 1191, 3534, 3550], 'incorrect': [1183, 3542], 'Both': [1188, 3547], 'insertions': [1193, 3552], 'observed': [1196, 1267, 3555, 3627], 'depending': [1202, 3561], 'on': [1203, 1398, 2050, 2445, 3562, 3758, 4412, 4807, 5478, 5875], 'specific': [1205, 1209, 3564, 3568], 'Scholar).Biochemical': [1252], 'uncovered': [1259, 3619], 'unique': [1261, 1958, 3621, 4320, 5385], 'property': [1262, 3622], 'has': [1264, 3624], 'never': [1265, 3625], 'any': [1269, 1814, 3629, 4176, 5241], 'other': [1270, 1622, 2536, 2637, 3630, 3983, 4898, 4999, 5966, 6067], 'studied': [1272, 3632], 'so': [1273, 3633], 'far': [1274, 3634], '(23Zhang': [1275, 1305, 1348, 1410, 1688, 3635, 3665, 3708, 3770, 4050, 5115], 'Y.,': [1276, 1306, 1349, 1411, 1439, 1689, 3636, 3666, 3709, 3771, 3799, 4051, 5116], 'Yuan': [1279, 1309, 1352, 1414, 1442, 1692, 1829, 3639, 3669, 3712, 3774, 3802, 4054, 4191, 5119, 5256], 'Xie': [1281, 1311, 1354, 1416, 1444, 1694, 3641, 3671, 3714, 3776, 3804, 4056, 5121], '7995-8006Crossref': [1290, 1320, 1363, 1425, 1453, 1703, 3650, 3680, 3723, 3785, 3813, 4065, 5130], '(80)': [1293, 1323, 1366, 1428, 1456, 1706, 3653, 3683, 3726, 3788, 3816, 4068, 5133], 'Human': [1296, 2592, 3656, 4954, 6022], 'highly': [1299, 3659], 'prone': [1300, 3660], 'frameshift': [1302, 3662], 'At': [1326, 3686], 'single-nucleotide': [1327, 3687], 'repeat': [1328, 3688], 'sequences,': [1329, 3689], 'mediated': [1336, 1626, 3696, 3987], 'mechanism': [1341, 1630, 2303, 3701, 3991, 4665, 5732], 'because': [1342, 2483, 3702, 4845, 5913], 'primer-template': [1344, 1385, 2106, 2353, 3704, 3745, 4468, 4715, 5534, 5782], 'Furthermore,': [1369, 2368, 3729, 4730, 5797], 'when': [1370, 2083, 2716, 3730, 4445, 5078, 5511, 6146], '3′': [1373, 1391, 2062, 2344, 2447, 3733, 3751, 4424, 4706, 4809, 5490, 5773, 5877], 'contains': [1375, 3735], 'one': [1376, 3736], 'few': [1379, 3739], 'mismatches,': [1380, 3740], 'promote': [1384, 2351, 3744, 4713, 5780], 'find': [1394, 3754], 'complementary': [1396, 3756], 'sequences': [1397, 3757], 'nucleotides': [1402, 3762], 'downstream,': [1403, 3763], 'achieving': [1404, 3764], 'microhomology': [1405, 1408, 1538, 1683, 2384, 2386, 3765, 3768, 3899, 4045, 4746, 4748, 5110, 5813, 5815], 'search': [1406, 1539, 3766, 3900], 'pairing': [1409, 1686, 3769, 4048, 5113], 'striking': [1432, 3792], 'properties': [1434, 1477, 2360, 3794, 3837, 4722, 5789], 'led': [1435, 3795], 'Zhang': [1436, 3796], 'et': [1437, 1712, 3797, 4074, 5139], 'al.(23Zhang': [1438, 3798], 'propose': [1460, 2015, 3820, 4377, 5443], 'may': [1463, 1511, 1519, 1672, 2024, 2500, 2519, 2704, 3823, 3872, 3880, 4034, 4386, 4862, 4881, 5066, 5099, 5452, 5930, 5949, 6134], '(NHEJ)': [1470, 3830], 'double-strand': [1472, 1499, 1524, 1678, 3832, 3860, 3885, 4040, 5105], 'repair.': [1474, 3834], 'ruled': [1481, 3841], 'out': [1482, 2029, 3842, 4391, 5457], 'significant': [1484, 3844], 'role': [1485, 1763, 2320, 2363, 2617, 3845, 4125, 4682, 4725, 4979, 5190, 5749, 5792, 6047], 'somatic': [1490, 3850], 'hypermutation': [1491, 3851], 'development.One': [1494], 'important': [1495, 2614, 3856, 4976, 6044], 'cause': [1496, 3857], 'breaks': [1500, 1680, 3861, 4042, 5107], 'It': [1504, 2334, 2479, 3865, 4696, 4841, 5763, 5909], 'conceivable': [1506, 3867], 'some': [1508, 1523, 3869, 3884], 'contain': [1512, 3873], 'clustered': [1513, 3874], 'contained': [1521, 3882], 'near': [1522, 2442, 3883, 4804, 5872], 'breaks.': [1526, 3887], 'Under': [1527, 1806, 3888, 4168, 5233], 'those': [1528, 3889], 'circumstances,': [1529, 3890], 'would': [1531, 2076, 2375, 2634, 3892, 4438, 4737, 4996, 5504, 5804, 6064], 'encounter': [1532, 3893], 'while': [1536, 3897], 'performing': [1537, 3898], 'pairing,': [1541, 2387, 3902, 4749, 5816], 'well': [1543, 3904], 'synthesis,': [1546, 3907], 'NHEJ.': [1548, 1768, 2367, 3909, 4130, 4729, 5195, 5796], 'Hence,': [1549, 3910], 'asked': [1551, 3912], 'whether': [1552, 3913], 'capable': [1555, 3916], 'report,': [1561, 3922], 'demonstrate': [1563, 3924], 'possesses': [1568, 1777, 3929, 4139, 5204], 'very': [1576, 3937], 'different': [1577, 2176, 3938, 4538, 5604], 'damage,': [1581, 3942], 'ranging': [1582, 3943], 'modifications': [1586, 3947], 'baseless': [1588, 3949], 'chemical': [1592, 3953], 'andcis-syn': [1595, 3956], 'dimer': [1597, 1609, 2423, 2465, 2494, 2548, 2657, 2692, 3958, 3970, 4785, 4827, 4856, 4910, 5019, 5054, 5853, 5895, 5924, 5978, 6087, 6122], 'UV': [1599, 2607, 2625, 3960, 4969, 4987, 6037, 6055], 'radiation.': [1600, 3961], 'Although': [1601, 3140, 3962], 'vitro': [1603, 3964], 'manner,': [1618, 3979], 'tested': [1623, 3984], 'avoids': [1633, 3994], 'copying': [1634, 2037, 2461, 3995, 4399, 4823, 5465, 5891], 'realignment.': [1641, 2005, 4002, 4367, 5433], 'findings': [1643, 4004], 'polymerases.DISCUSSIONPreviously,': [1667], 'proposed': [1669, 4031, 5096], 'NHEJ': [1676, 1754, 2392, 2401, 4038, 4116, 4754, 4763, 5103, 5181, 5821, 5830], 'searching': [1684, 4046, 5111], 'Most': [1709, 2116, 4071, 4478, 5136, 5544], 'recently,': [1710, 2117, 4072, 4479, 5137, 5545], 'Mahajan': [1711, 4073, 5138], 'al.': [1713, 4075, 5140], '(33Mahajan': [1714, 4076, 5141], 'K.N.': [1715, 4077, 5142], 'Nick': [1716, 4078, 5143], 'McElhinny': [1717, 4079, 5144], 'S.A.': [1718, 4080, 5145], 'Mitchell': [1719, 4081, 5146], 'B.S.': [1720, 4082, 5147], 'Ramsden': [1721, 4083, 5148], 'D.A.': [1722, 4084, 5149], '2002;': [1726, 2167, 4088, 4529, 5153, 5595], '22:': [1727, 4089, 5154], '5194-5202Crossref': [1728, 4090, 5155], '(245)': [1731, 4093, 5158], 'reported': [1734, 2120, 2185, 4096, 4482, 4547, 5161, 5548, 5613], 'levels': [1737, 4099, 5164], 'protein': [1741, 4103, 5168], 'increased': [1743, 4105, 5170], 'ionizing': [1745, 4107, 5172], 'radiation,': [1746, 4108, 5173], 'associated': [1751, 4113, 5178], 'proteins': [1755, 4117, 5182], 'Ku': [1756, 4118, 5183], 'XRCC4-ligase': [1758, 4120, 5185], 'IV,': [1759, 4121, 5186], 'further': [1760, 4122, 5187], 'supporting': [1761, 4123, 5188], 'study,': [1771, 4133, 5198], 'found': [1773, 4135, 5200], 'various': [1785, 4147, 5212], 'limited': [1798, 4160, 5225], 'similar': [1807, 4169, 5234], 'experimental': [1808, 4170, 5235], 'conditions,': [1809, 4171, 5236], 'did': [1811, 4173, 5238], 'detect': [1813, 4175, 5240], '(Fig.': [1822, 2449, 4184, 4811, 5249, 5879], '7),': [1823, 4185, 5250], 'except': [1824, 4186, 5251], '8-oxoguanine': [1826, 4188, 5253], '(34Zhang': [1827, 4189, 5254], 'F.,': [1830, 4192, 5257], 'Taylor': [1833, 4195, 5260], 'J.-S.': [1834, 4196, 5261], '29:': [1841, 4203, 5268], '928-935Crossref': [1842, 4204, 5269], 'Scholar),': [1845, 1947, 4207, 4309, 5272, 5374], 'which': [1846, 4208, 5273], 'miscoding': [1849, 4211, 5276], 'rather': [1850, 2204, 4212, 4566, 5277, 5633], 'than': [1851, 2205, 4213, 4567, 5278, 5634], 'strong': [1853, 4215, 5280], 'blocking': [1854, 4216, 5281], '(35Shibutani': [1856, 4218, 5283], 'Takeshita': [1858, 4220, 5285], 'Grollman': [1860, 2229, 2269, 2288, 4222, 4591, 4631, 4650, 5287, 5658, 5698, 5717], 'A.P.': [1861, 2230, 2270, 2289, 4223, 4592, 4632, 4651, 5288, 5659, 5699, 5718], '1991;': [1863, 4225, 5290], '349:': [1864, 4226, 5291], '431-434Crossref': [1865, 4227, 5292], '(2023)': [1868, 4230, 5295], 'Because': [1871, 2006, 2429, 4233, 4368, 4791, 5298, 5434, 5859], 'sequence': [1876, 2052, 2433, 4238, 4414, 4795, 5303, 5480, 5863], 'homologies': [1877, 4239, 5304], 'they': [1879, 2611, 4241, 4973, 5306, 6041], 'both': [1880, 4242, 5307], 'belong': [1881, 4243, 5308], 'appears': [1955, 2047, 4317, 4409, 5382, 5475], 'among': [1959, 4321, 5386], 'members.In': [1962, 4324], 'AP': [1967, 4329, 5395], 'site': [1968, 4330, 5396], 'AAF-adducted': [1972, 2139, 4334, 4501, 5400, 5567], '2-dG,': [1978, 4340, 5406], 'bypasses': [1981, 4343, 5409], 'differ': [2010, 4372, 5438], 'dramatically': [2011, 4373, 5439], 'structure,': [2013, 4375, 5441], 'looping': [2028, 4390, 5456], 'lesion,': [2032, 2073, 2088, 4394, 4435, 4450, 5460, 5501, 5516], 'thus': [2033, 2610, 4395, 4972, 5461, 6040], 'avoiding': [2034, 4396, 5462], 'direct': [2036, 2460, 4398, 4822, 5464, 5890], 'base.': [2042, 4404, 5470], 'exact': [2044, 4406, 5472], 'size': [2046, 4408, 5474], 'depend': [2049, 4411, 5477], 'context': [2053, 4415, 5481], 'For': [2057, 4419, 5485], 'example,': [2058, 4420, 5486], 'if': [2059, 2089, 4421, 4451, 5487, 5517], 'pair': [2065, 4427, 5493], '5′': [2070, 2437, 4432, 4799, 5498, 5867], 'preferred': [2078, 4440, 5506], 'encounters': [2086, 4448, 5514], 'coding': [2091, 4453, 5519], 'capacity': [2092, 4454, 5520], 'modified': [2095, 4457, 5523], 'lost': [2098, 4460, 5526], 'significantly': [2100, 4462, 5528], 'altered,': [2101, 4463, 5529], 'simply': [2103, 4465, 5531], 'realigns': [2104, 4466, 5532], 'strands': [2107, 4469, 5535], 'continue': [2109, 4471, 5537], 'skipping': [2113, 4475, 5541], 'cell': [2123, 4485, 5551], 'extracts': [2124, 4486, 5552], 'supplemented': [2125, 4487, 5553], 'able': [2131, 4493, 5559], 'extend': [2133, 4495, 5561], 'guanine': [2140, 4502, 5568], 'adding': [2142, 4504, 5570], 'ladder': [2144, 4506, 5572], 'many': [2147, 2347, 4509, 4709, 5575, 5776], '15': [2149, 4511, 5577], 'guanines': [2150, 4512, 5578], 'apparently': [2153, 4515, 5581], 'nontemplated': [2154, 4516, 5582], 'reaction': [2155, 4517, 5583], '(36Duvauchelle': [2156, 4518, 5584], 'J.-B.': [2157, 4519, 5585], 'Blance': [2158, 4520, 5586], 'Cordonnier': [2162, 4524, 5590], '30:': [2168, 4530, 5596], '2061-2067Crossref': [2169, 4531, 5597], 'here,': [2186, 4548, 5614], 'functional': [2189, 4551, 5617], 'significance': [2190, 4552, 5618], 'remains': [2191, 4553, 5619], 'unknown.On': [2192, 4554], 'basis': [2194, 4556, 5623], 'mutation': [2196, 4558, 5625], 'spectra': [2197, 4559, 5626], 'lesions,': [2201, 4563, 5630], 'substitutions': [2203, 4565, 5632], 'deletions': [2206, 4568, 5635], 'mutational': [2212, 4574, 5641], 'events': [2213, 4575, 5642], 'mammalian': [2215, 4577, 5644], 'cells': [2216, 2328, 2596, 4578, 4690, 4958, 5645, 5757, 6026], '(37Moriya': [2217, 4579, 5646], 'Spiegel': [2219, 4581, 5648], 'Fernandes': [2221, 4583, 5650], 'Amin': [2223, 4585, 5652], 'Liu': [2225, 4587, 5654], 'Geacintov': [2227, 4589, 5656], 'Biochemistry.': [2231, 2271, 4593, 4633, 5660, 5700], '35:': [2233, 4595, 5662], '16646-16651Crossref': [2234, 4596, 5663], '(122)': [2237, 4599, 5666], '38Gentil': [2240, 4602, 5669], 'Cabral-Neto': [2242, 4604, 5671], 'J.B.': [2243, 4605, 5672], 'Mariage-Samson': [2244, 4606, 5673], 'Margot': [2246, 4608, 5675], 'Imbach': [2248, 4610, 5677], 'J.L.': [2249, 4611, 5678], 'Rayner': [2250, 4612, 5679], 'Sarasin': [2252, 4614, 5681], '1992;': [2257, 4619, 5686], '227:': [2258, 4620, 5687], '981-984Crossref': [2259, 4621, 5688], '(93)': [2262, 4624, 5691], '39Shibutani': [2265, 4627, 5694], 'Suzuki': [2267, 4629, 5696], '12034-12041Crossref': [2274, 4636, 5703], '(61)': [2277, 4639, 5706], '40Levine': [2280, 4642, 5709], 'R.L.': [2281, 4643, 5710], 'Yang': [2282, 4644, 5711], 'I.Y.': [2283, 4645, 5712], 'Hossain': [2284, 4646, 5713], 'Pandya': [2286, 4648, 5715], 'G.A.': [2287, 4649, 5716], 'Moriya': [2290, 4652, 5719], 'Cancer': [2292, 4654, 5721], '60:': [2295, 4657, 5724], '4098-4104PubMed': [2296, 4658, 5725], 'Therefore,': [2299, 2646, 4661, 5008, 5728, 6076], 'prevailing': [2301, 4663, 5730], 'suggests': [2310, 4672, 5739], 'unlikely': [2315, 4677, 5744], 'play': [2317, 4679, 5746], 'replication': [2325, 4687, 5754], 'normal': [2327, 2331, 4689, 4693, 5756, 5760], 'under': [2330, 4692, 5759], 'growth': [2332, 4694, 5761], 'conditions.': [2333, 4695, 5762], 'now': [2336, 4698, 5765], 'clear': [2337, 4699, 5766], 'single': [2339, 4701, 5768], 'repeats,': [2341, 4703, 5770], 'mismatched': [2342, 4704, 5771], 'ends,': [2345, 4707, 5774], 'greatly': [2350, 4712, 5779], 'support': [2361, 4723, 5790], 'make': [2376, 4738, 5805], 'possible': [2378, 2481, 4740, 4843, 5807, 5911], 'perform': [2383, 2542, 4745, 4904, 5812, 5972], 'search,': [2385, 4747, 5814], 'even': [2393, 4755, 5822], 'presence': [2396, 4758, 5825], 'lesions.': [2399, 2626, 4761, 4988, 5828, 6056], 'After': [2400, 4762, 5829], 'complete,': [2403, 4765, 5832], 'then': [2408, 4770, 5837], 'removed': [2410, 4772, 5839], 'mechanism.Remarkably,': [2415, 4777], 'effective': [2417, 4779, 5847], 'cis-syn': [2421, 4783, 5851], 'error-free.': [2428, 4790, 5858], 'no': [2430, 4792, 5860], 'present': [2435, 2682, 4797, 5044, 5865, 6112], 'anywhere': [2436, 4798, 5866], 'side': [2448, 4810, 5878], '6),': [2450, 4812, 5880], 'must': [2456, 4818, 5886], 'A': [2469, 4831, 5899], '(6-4)': [2472, 2498, 2517, 4834, 4860, 4879, 5902, 5928, 5947], 'photoproduct,': [2473, 4835, 5903], 'however,': [2474, 4836, 5904], 'completely': [2475, 4837, 5905], 'blocks': [2476, 4838, 5906], 'covalent': [2485, 4847, 5915], 'linkage': [2486, 4848, 5916], 'between': [2487, 4849, 5917], 'two': [2489, 4851, 5919], 'thymine': [2490, 4852, 5920], 'bases,': [2491, 4853, 5921], 'photoproduct': [2499, 2518, 4861, 4880, 5929, 5948], 'flexible': [2503, 4865, 5933], 'enough': [2504, 4866, 5934], 'allow': [2506, 2527, 4868, 4889, 5936, 5957], 'loop-out': [2507, 4869, 5937], 'Unlike': [2511, 4873, 5941], 'dimer,': [2514, 4876, 5944], 'too': [2521, 4883, 5951], 'distorting': [2522, 4884, 5952], 'structure': [2525, 4887, 5955], 'only': [2535, 4897, 5965], 'eukaryotic': [2537, 4899, 5967], 'known': [2540, 2631, 4902, 4993, 5970, 6061], '(22Masutani': [2551, 4913, 5981], '41Johnson': [2577, 4939, 6007], 'R.E.': [2578, 4940, 6008], 'Science.': [2583, 4945, 6013], '283:': [2585, 4947, 6015], '1001-1004Crossref': [2586, 4948, 6016], '(692)': [2589, 4951, 6019], 'xeroderma': [2593, 2668, 2728, 4955, 5030, 5090, 6023, 6098, 6158], 'pigmentosum': [2594, 2669, 2729, 4956, 5031, 5091, 6024, 6099, 6159], 'variant': [2595, 2670, 2730, 4957, 5032, 5092, 6025, 6100, 6160], 'lack': [2598, 4960, 6028], 'sensitive': [2602, 4964, 6032], 'hypermutable': [2605, 4967, 6035], 'radiation': [2608, 4970, 6038], '(19–21,42);': [2609, 4971, 6039], 'establish': [2612, 4974, 6042], 'vivo': [2616, 2686, 4978, 5048, 6046, 6116], 'how': [2632, 4994, 6062], 'respond': [2635, 4997, 6065], 'cyclobutane': [2638, 5000, 6068], 'pyrimidine': [2639, 5001, 6069], 'dimers': [2640, 2712, 5002, 5074, 6070, 6142], 'C-containing': [2644, 5006, 6074], 'dimers.': [2645, 5007, 6075], 'what': [2651, 5013, 6081], 'extent': [2652, 5014, 6082], 'loss': [2653, 5015, 6083], 'contributes': [2661, 5023, 6091], 'UV-induced': [2663, 5025, 6093], 'sensitivity': [2664, 5026, 6094], 'mutagenesis': [2666, 5028, 6096], 'With': [2672, 5034, 6102], 'uncertainty,': [2674, 5036, 6104], 'assess': [2679, 5041, 6109], 'at': [2680, 5042, 6110], 'time': [2683, 5045, 6113], 'importance': [2687, 5049, 6117], 'Nevertheless,': [2696, 5058, 6126], 'our': [2697, 5059, 6127], 'raised': [2699, 5061, 6129], 'possibility': [2701, 5063, 6131], 'participate': [2705, 5067, 6135], 'cells,': [2714, 5076, 6144], 'especially': [2715, 5077, 6145], 'compromised,': [2721, 5083, 6151], 'case': [2725, 5087, 6155], 'defined.': [3139], 'Biochemical': [3612], 'development.': [3854], 'One': [3855], 'DISCUSSIONPreviously,': [4029], 'Previously,': [5094], 'members.': [5389], 'unknown.': [5620], 'On': [5621], 'Remarkably,': [5845]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1642306226', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2025-01-08T14:39:57.449841', 'created_date': '2016-06-24'}
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