Publication Information

{'id': 'https://openalex.org/W162695368', 'doi': 'https://doi.org/10.14264/106557', 'title': 'The effects of sonic, desert and Indian hedgehog signalling in skin', 'display_name': 'The effects of sonic, desert and Indian hedgehog signalling in skin', 'publication_year': 2003, 'publication_date': '2003-01-01', 'ids': {'openalex': 'https://openalex.org/W162695368', 'doi': 'https://doi.org/10.14264/106557', 'mag': '162695368'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.14264/106557', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'dissertation', 'type_crossref': 'dissertation', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5082146104', 'display_name': 'Christelle Adolphe', 'orcid': 'https://orcid.org/0000-0002-3908-1843'}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'Christelle Marie. Adolphe', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5082146104'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 59}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling Pathway Studies', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling Pathway Studies', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12355', 'display_name': 'Genetic and rare skin diseases.', 'score': 0.9627, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/indian-hedgehog', 'display_name': 'Indian hedgehog', 'score': 0.77183795}, {'id': 'https://openalex.org/keywords/patched', 'display_name': 'Patched', 'score': 0.6731379}, {'id': 'https://openalex.org/keywords/gli1', 'display_name': 'GLI1', 'score': 0.55932015}], 'concepts': [{'id': 'https://openalex.org/C2778539099', 'wikidata': 'https://www.wikidata.org/wiki/Q6120', 'display_name': 'Hedgehog', 'level': 3, 'score': 0.86796176}, {'id': 'https://openalex.org/C2776637008', 'wikidata': 'https://www.wikidata.org/wiki/Q14860072', 'display_name': 'Sonic hedgehog', 'level': 3, 'score': 0.8427088}, {'id': 'https://openalex.org/C88498014', 'wikidata': 'https://www.wikidata.org/wiki/Q14859918', 'display_name': 'Hedgehog signaling pathway', 'level': 3, 'score': 0.81215674}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7775173}, {'id': 'https://openalex.org/C2776014264', 'wikidata': 'https://www.wikidata.org/wiki/Q1770532', 'display_name': 'Indian hedgehog', 'level': 4, 'score': 0.77183795}, {'id': 'https://openalex.org/C2777994357', 'wikidata': 'https://www.wikidata.org/wiki/Q24781250', 'display_name': 'Patched', 'level': 4, 'score': 0.6731379}, {'id': 'https://openalex.org/C2779933373', 'wikidata': 'https://www.wikidata.org/wiki/Q14886430', 'display_name': 'GLI1', 'level': 4, 'score': 0.55932015}, {'id': 'https://openalex.org/C2778961482', 'wikidata': 'https://www.wikidata.org/wiki/Q25241', 'display_name': 'Vertebrate', 'level': 3, 'score': 0.5324282}, {'id': 'https://openalex.org/C40692019', 'wikidata': 'https://www.wikidata.org/wiki/Q815547', 'display_name': 'Morphogenesis', 'level': 3, 'score': 0.51105464}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.49251327}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.35081613}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.24886724}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.18946806}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.14264/106557', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.57, 'display_name': 'Life on land', 'id': 'https://metadata.un.org/sdg/15'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3008016544', 'https://openalex.org/W2901604565', 'https://openalex.org/W2773386546', 'https://openalex.org/W2100564455', 'https://openalex.org/W2074863882', 'https://openalex.org/W2069797581', 'https://openalex.org/W2060026994', 'https://openalex.org/W1964289678', 'https://openalex.org/W1919928872', 'https://openalex.org/W1529799967'], 'abstract_inverted_index': {'The': [0, 94, 553, 636], 'hedgehog': [1, 28, 69, 77, 173, 177, 243, 282, 292, 312, 742], 'family': [2], 'of': [3, 25, 32, 35, 46, 57, 67, 88, 96, 102, 114, 133, 164, 171, 203, 238, 281, 305, 333, 366, 416, 452, 483, 490, 555, 565, 577, 596, 647, 666, 695, 708, 713, 741, 755, 782], 'signalling': [4, 50, 104, 117, 206, 762], 'molecules': [5, 207, 293], 'play': [6], 'important': [7], 'roles': [8, 689], 'during': [9, 194], 'embryo': [10], 'development': [11, 37, 306, 712], 'and': [12, 49, 73, 86, 107, 149, 166, 175, 187, 227, 246, 253, 257, 261, 326, 362, 369, 378, 414, 438, 468, 493, 507, 528, 535, 551, 570, 607, 640, 656, 672, 676, 693, 739, 744, 753, 759], 'adult': [13], 'homeostasis.': [14], 'In': [15, 599, 725], 'Drosophila': [16, 39], 'melanogaster,': [17], 'developmental': [18, 55, 217], 'processes': [19], 'are': [20, 62, 128, 179, 294, 307, 623], 'controlled': [21, 308], 'by': [22, 310, 562, 573, 768, 776], 'the': [23, 33, 43, 54, 65, 83, 100, 129, 168, 201, 235, 268, 290, 314, 330, 363, 448, 473, 563, 574, 582, 589, 592, 597, 644, 670, 711, 714, 730, 737, 748, 751], 'activity': [24, 66, 79, 587, 668, 746, 763], 'a': [26, 161, 182, 210, 298, 663, 705, 780], 'single': [27], 'gene': [29, 47], '(hh).': [30], 'One': [31], 'characteristics': [34], 'evolutionary': [36], 'from': [38, 229, 472, 602, 628, 729], 'to': [40, 139, 181, 212, 266, 322, 386, 411, 503, 533, 543, 612, 618, 625, 682, 722], 'vertebrates': [41], 'is': [42, 80, 99, 118, 158, 198, 662, 703], 'increasing': [44], 'complexity': [45], 'families': [48], 'pathways,': [51], 'such': [52, 219, 407], 'that': [53, 112, 200, 220, 258, 585, 616, 638, 701, 718, 733, 760], 'requirements': [56], 'vertebrate': [58, 91, 195, 204, 291], 'complex': [59], 'organ': [60, 92], 'systems': [61], 'dependent': [63], 'on': [64], 'three': [68], 'genes': [70, 222, 244], '(sonic,': [71], 'desert': [72, 176], 'indian': [74], 'hedgehog).': [75], 'Sonic': [76], '(Shh)': [78], 'required': [81], 'for': [82, 581], 'growth,': [84, 498], 'patterning': [85], 'morphogenesis': [87], 'many': [89, 500], 'different': [90, 221, 231, 303], 'systems.': [93], 'focus': [95], 'this': [97, 698], 'project': [98, 699, 731], 'role': [101], 'Shh': [103, 116, 156, 252, 340, 508, 527, 586, 639, 667, 709], 'in': [105, 121, 160, 297, 329, 342, 375, 447, 465, 588, 643, 651, 669, 686, 710, 735, 747, 764, 773], 'epidermal': [106, 115, 431, 481, 567, 629, 756], 'hair': [108, 398, 633], 'follicle': [109, 634], 'morphogenesis,': [110], 'given': [111, 234], 'perturbation': [113], 'involved\n': [119], 'basal': [122, 331, 645, 769], 'cell': [123, 594, 658, 770], 'carcinoma': [124], '(BCC)': [125], 'formation.': [126], 'BCCs': [127, 622], 'most': [130], 'common': [131], 'form': [132, 280], 'skin': [134, 388, 391, 396, 423, 429, 442, 463, 466, 475, 516, 537, 548, 558, 590, 601, 749], 'cancer,': [135], 'yet': [136], 'much': [137], 'remains': [138], 'be': [140, 224, 720], 'elucidated': [141], 'about': [142], 'their': [143, 146, 230, 376, 387], 'aetiology,': [144], 'including': [145], 'cellular': [147], 'origin': [148], 'how': [150], 'they': [151], 'attain': [152], 'self-renewing': [153], 'potential.': [154, 784], 'While': [155], 'expression': [157, 169], 'found': [159], 'wide': [162], 'range': [163], 'organs': [165], 'tissues,': [167], 'pattern': [170], 'Indian': [172], '(Ihh)': [174], '(Dhh)': [178], 'limited': [180], 'few': [183], 'areas,': [184], 'suggesting': [185], 'Ihh': [186, 262, 327, 511, 520, 677, 702], 'Dhh': [188, 260, 325, 529, 641, 661], 'have': [189, 263, 678], 'evolved': [190, 208], 'more': [191], 'specialised': [192], 'functions': [193], 'development.': [196], 'It': [197], 'thought': [199], 'diversification': [202], 'hedgehog-patched': [205], 'as': [209, 408, 525, 684], 'mechanism': [211], 'allow': [213], 'tighter': [214], 'control': [215], 'over': [216], 'processes,': [218], 'can': [223, 295], 'appropriately': [225], 'activated': [226], 'inactivated': [228], 'promoters.': [232], 'However,': [233], 'high': [236], 'degree': [237], 'sequence': [239], 'homology': [240], 'between': [241], 'mammalian': [242], '(Shh': [245, 743], 'Ihh:': [247], '90%': [248], 'amino': [249], 'acid': [250], 'identity,': [251], 'Dhh:': [254], '80%': [255], 'identity),': [256], 'Shh,': [259, 324], 'been': [264, 680], 'shown': [265, 681], 'bind': [267], 'patched': [269], 'receptors': [270], '(Ptc1': [271], 'and\n': [272], 'Ptc2)': [274], 'with': [275, 403, 427, 461, 479, 604, 779], 'equal': [276], 'affinity,': [277], 'suggests': [278, 660], 'some': [279], 'functional': [283, 664], 'redundancy': [284], 'may': [285, 719], 'exist.': [286], 'To': [287], 'identify': [288], 'whether': [289, 302], 'act': [296], 'redundant': [299], 'manner': [300], 'or': [301, 397, 632], 'aspects': [304], 'soley': [309], 'distinct': [311], 'molecules,': [313], 'human': [315], 'keratin': [316], '14': [317], '(hK14)': [318], 'promoter': [319], 'was': [320], 'used': [321], 'drive': [323], 'overexpression': [328, 341, 512, 530, 642], 'cells': [332, 492, 631, 646, 778], 'mouse': [334], 'epithelial': [335, 648], 'tissues.': [336], 'Previous': [337], 'data': [338, 728], 'concerning': [339], 'mice': [343, 455, 506], '(Oro': [344, 456], 'et': [345, 457], 'al,': [346, 458], '1997)': [347], 'identified': [348], 'transgenic': [349, 355, 424, 454, 521], 'embryos': [350, 356, 367, 372, 425, 445, 522, 603], 'were': [351, 357, 379, 523], 'perinatally': [352], 'lethal,': [353], 'thus': [354, 518], 'dissected': [358], 'at': [359], 'either': [360], 'E17.5orE18.5,': [361], 'gross': [364], 'phenotypes': [365, 406, 609, 659], 'noted': [368], 'photographed.': [370], 'Transgenic': [371], 'varied': [373], 'significantly': [374], 'severity': [377], 'categorised': [380], 'into': [381], 'four': [382], '(4)': [383], 'groups': [384], 'according': [385], 'phenotype.': [389], 'Regular': [390, 534], 'phenotype': [392], 'transgenics': [393, 443], 'displayed': [394, 513], 'no': [395, 514], 'follicles': [399], 'anomalies,': [400], 'but': [401, 539], 'presented': [402, 426, 478], 'mild': [404], 'limb': [405, 439, 496], 'nubbins': [409], 'posterior': [410], 'digit': [412, 417], 'V': [413], 'bi-furcations': [415], 'I': [418], 'or\n': [419], 'II.': [421], 'Wrinkled': [422, 550, 606], 'excess': [428], 'folds,': [430], 'hyperplasia,': [432], 'BCC-like': [433, 469, 486, 613], 'lesions,': [434, 487, 614], 'supernumerary': [435, 566], 'stem': [436, 491, 568, 578, 593, 630, 657, 757], 'cells,': [437, 485, 569, 579, 758, 766], 'polysyndactyly.': [440], 'Taut': [441, 536], 'paralleled': [444], 'described': [446], 'previously': [449], 'published': [450], 'report': [451], 'K14-Shh': [453], '1997),': [459], 'presenting': [460], 'opaque': [462], 'lacking': [464], 'folds': [467], 'lesions.': [470], 'Transgenics': [471], 'final': [474], 'phenotype,': [476, 517, 549], 'Translucent,': [477, 571], 'an': [480, 488, 716], 'bi-layer': [482], 'differentiated': [484], 'ablation': [489, 576], 'compromised': [494], 'proximaldistal': [495], 'bud': [497], 'displaying': [499], 'phenotypic': [501], 'similarities': [502], 'p63': [504], 'null': [505, 509], 'mice.': [510], 'overt': [515], 'all': [519], 'classified': [524], 'Regular.': [526], 'gave': [531, 541, 610], 'rise': [532, 542, 611], 'phenotypes,': [538, 559], 'also': [540], 'two': [544, 556], 'distinctly': [545], 'novel\n': [546], 'Translucent.': [552], 'identification': [554], 'novel': [557], 'Wrinkled,': [560], 'characterized': [561, 572, 767], 'presence': [564], 'paradoxical': [575], 'indicates': [580], 'first': [583], 'time': [584], 'regulates': [591, 750], 'population': [595], 'epidermis.': [598], 'addition,': [600], 'both': [605, 736], 'Translucent': [608], 'indicating': [615], 'contrary': [617], 'recent': [619], 'hypotheses': [620], 'Shh-induced': [621], 'unlikely': [624], 'originate': [626], 'specifically': [627], 'structures.': [635], 'observation': [637, 717], 'tissues': [649], 'results': [650, 772], 'identical': [652], 'epidermal,': [653], 'limb,': [654], 'craniofacial': [655], 'homologue': [665, 707], 'skin,': [671, 715], 'although': [673], 'Shh\n': [674], 'since': [679], 'function': [683, 706], 'homologues': [685], 'other': [687], 'hedgehog-specific': [688], '(left-right': [690], 'asymmetry,': [691], 'chondrogenesis': [692], 'specification': [694], 'motor': [696], 'neurons),': [697], 'shows': [700], 'not': [704], 'attributable': [721], 'epidermal-mesenchymal': [723], 'interactions.': [724], 'conclusion,': [726], 'these': [727], 'suggest': [732], 'differences': [734], 'levels': [738], 'timing': [740], 'Dhh)': [745], 'proliferation': [752], 'maintenance': [754], 'aberrant': [761], 'Shh-responsive': [765], 'characteristics,': [771], 'tumour': [774], 'formation': [775], 'providing': [777], 'gain': [781], 'proliferative': [783]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W162695368', 'counts_by_year': [], 'updated_date': '2024-12-10T20:09:12.828777', 'created_date': '2016-06-24'}