Abstract: A general scheme to seek for the relations between entanglement and bservables is proposed in principle. In two-qubit systems with enough general Hamiltonian, we find the entanglement to be the functions of observables for six kinds of chosen state sets and verify how these functions be invariant with time evolution. Moreover, we demonstrate and illustrate the cases with entanglement versus a set of commutable observables under eight kinds of given initial states. Our conclusions show how entanglement become observable even measurable by experiment, and they are helpful for understanding of the nature of entanglement in physics.