Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1621802947', 'doi': 'https://doi.org/10.1016/s2352-3018(15)00114-9', 'title': 'Efficacy and safety of grazoprevir (MK-5172) and elbasvir (MK-8742) in patients with hepatitis C virus and HIV co-infection (C-EDGE CO-INFECTION): a non-randomised, open-label trial', 'display_name': 'Efficacy and safety of grazoprevir (MK-5172) and elbasvir (MK-8742) in patients with hepatitis C virus and HIV co-infection (C-EDGE CO-INFECTION): a non-randomised, open-label trial', 'publication_year': 2015, 'publication_date': '2015-08-01', 'ids': {'openalex': 'https://openalex.org/W1621802947', 'doi': 'https://doi.org/10.1016/s2352-3018(15)00114-9', 'mag': '1621802947', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26423374'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s2352-3018(15)00114-9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2531945440', 'display_name': 'The Lancet HIV', 'issn_l': '2352-3018', 'issn': ['2352-3018', '2405-4704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054617732', 'display_name': 'Jürgen K. Rockstroh', 'orcid': 'https://orcid.org/0000-0003-2858-3888'}, 'institutions': [{'id': 'https://openalex.org/I2799391451', 'display_name': 'University Hospital Bonn', 'ror': 'https://ror.org/01xnwqx93', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799391451']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Jürgen K Rockstroh', 'raw_affiliation_strings': ['Bonn University Hospital, Bonn, Germany'], 'affiliations': [{'raw_affiliation_string': 'Bonn University Hospital, Bonn, Germany', 'institution_ids': ['https://openalex.org/I2799391451']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103169075', 'display_name': 'Mark Nelson', 'orcid': 'https://orcid.org/0000-0002-5944-6096'}, 'institutions': [{'id': 'https://openalex.org/I4210136304', 'display_name': 'Chelsea and Westminster Hospital', 'ror': 'https://ror.org/038zxea36', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799869770', 'https://openalex.org/I4210136304']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Mark Nelson', 'raw_affiliation_strings': ['Chelsea and Westminster Hospital, London, UK'], 'affiliations': [{'raw_affiliation_string': 'Chelsea and Westminster Hospital, London, UK', 'institution_ids': ['https://openalex.org/I4210136304']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017386021', 'display_name': 'Christine Katlama', 'orcid': 'https://orcid.org/0000-0002-5093-4800'}, 'institutions': [{'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I4210121705', 'display_name': 'Pitié-Salpêtrière Hospital', 'ror': 'https://ror.org/02mh9a093', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210121705']}, {'id': 'https://openalex.org/I4210133907', 'display_name': 'Institut Pierre Louis d‘Épidémiologie et de Santé Publique', 'ror': 'https://ror.org/02qqh1125', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I4210133907']}, {'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Christine Katlama', 'raw_affiliation_strings': ['APHP Pitié-Salpêtrière Hospital, Paris, France', 'Sorbonne Universities, UPMC University of Paris 06, INSERM UMR_S 1136, Pierre Louis Institute of Epidemiology and Public Health, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'APHP Pitié-Salpêtrière Hospital, Paris, France', 'institution_ids': ['https://openalex.org/I4210097159', 'https://openalex.org/I39804081', 'https://openalex.org/I4210121705']}, {'raw_affiliation_string': 'Sorbonne Universities, UPMC University of Paris 06, INSERM UMR_S 1136, Pierre Louis Institute of Epidemiology and Public Health, Paris, France', 'institution_ids': ['https://openalex.org/I4210133907', 'https://openalex.org/I204730241', 'https://openalex.org/I154526488', 'https://openalex.org/I39804081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002916327', 'display_name': 'Jacob Lalezari', 'orcid': 'https://orcid.org/0000-0002-2744-4918'}, 'institutions': [{'id': 'https://openalex.org/I4210101066', 'display_name': 'Quest Clinical Research (United States)', 'ror': 'https://ror.org/019mfbd19', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210101066']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jay Lalezari', 'raw_affiliation_strings': ['Quest Clinical Research, San Francisco, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'Quest Clinical Research, San Francisco, CA, USA', 'institution_ids': ['https://openalex.org/I4210101066']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057724971', 'display_name': 'Josep Mallolas', 'orcid': 'https://orcid.org/0000-0002-8365-141X'}, 'institutions': [{'id': 'https://openalex.org/I71999127', 'display_name': 'Universitat de Barcelona', 'ror': 'https://ror.org/021018s57', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I71999127']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Josep Mallolas', 'raw_affiliation_strings': ['Hospital Clinic-University of Barcelona, Barcelona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Hospital Clinic-University of Barcelona, Barcelona, Spain', 'institution_ids': ['https://openalex.org/I71999127']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006710346', 'display_name': 'Mark Boyd', 'orcid': 'https://orcid.org/0000-0002-6848-3307'}, 'institutions': [], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Mark Bloch', 'raw_affiliation_strings': ['Holdsworth House Medical Practice, Darlinghurst, NSW, Australia'], 'affiliations': [{'raw_affiliation_string': 'Holdsworth House Medical Practice, Darlinghurst, NSW, Australia', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054107081', 'display_name': 'Gail Matthews', 'orcid': 'https://orcid.org/0000-0002-1048-6396'}, 'institutions': [{'id': 'https://openalex.org/I4210087284', 'display_name': "St Vincent's Hospital Sydney", 'ror': 'https://ror.org/000ed3w25', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087284']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Gail V Matthews', 'raw_affiliation_strings': ["St Vincent's Hospital, Sydney, NSW, Australia"], 'affiliations': [{'raw_affiliation_string': "St Vincent's Hospital, Sydney, NSW, Australia", 'institution_ids': ['https://openalex.org/I4210087284']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066136225', 'display_name': 'Michael S. Saag', 'orcid': 'https://orcid.org/0000-0002-8866-1043'}, 'institutions': [{'id': 'https://openalex.org/I32389192', 'display_name': 'University of Alabama at Birmingham', 'ror': 'https://ror.org/008s83205', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32389192']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael S Saag', 'raw_affiliation_strings': ['University of Alabama at Birmingham, Birmingham, AL, USA'], 'affiliations': [{'raw_affiliation_string': 'University of Alabama at Birmingham, Birmingham, AL, USA', 'institution_ids': ['https://openalex.org/I32389192']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001419601', 'display_name': 'Philippe J. Zamor', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802101240', 'display_name': 'Carolinas Medical Center', 'ror': 'https://ror.org/0483mr804', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334069289', 'https://openalex.org/I2802101240']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Philippe J Zamor', 'raw_affiliation_strings': ['Division of Hepatology, Carolinas Medical Center, Charlotte, NC, USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Hepatology, Carolinas Medical Center, Charlotte, NC, USA', 'institution_ids': ['https://openalex.org/I2802101240']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013078758', 'display_name': 'Chloe Orkin', 'orcid': 'https://orcid.org/0000-0001-6168-6745'}, 'institutions': [{'id': 'https://openalex.org/I2801259928', 'display_name': 'Royal London Hospital', 'ror': 'https://ror.org/019my5047', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I225661044', 'https://openalex.org/I2801259928']}, {'id': 'https://openalex.org/I225661044', 'display_name': 'Barts Health NHS Trust', 'ror': 'https://ror.org/00b31g692', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I225661044']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Chloe Orkin', 'raw_affiliation_strings': ["Royal London Hospital, Bart's Health NHS Trust, London, UK"], 'affiliations': [{'raw_affiliation_string': "Royal London Hospital, Bart's Health NHS Trust, London, UK", 'institution_ids': ['https://openalex.org/I2801259928', 'https://openalex.org/I225661044']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090481795', 'display_name': 'Jacqueline Gress', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'MSD (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jacqueline Gress', 'raw_affiliation_strings': ['Merck & Co, Inc, Kenilworth, NJ, USA'], 'affiliations': [{'raw_affiliation_string': 'Merck & Co, Inc, Kenilworth, NJ, USA', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050905161', 'display_name': 'Stephanie O. Klopfer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'MSD (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stephanie Klopfer', 'raw_affiliation_strings': ['Merck & Co, Inc, Kenilworth, NJ, USA'], 'affiliations': [{'raw_affiliation_string': 'Merck & Co, Inc, Kenilworth, NJ, USA', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045664569', 'display_name': 'Melissa Shaughnessy', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'MSD (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Melissa Shaughnessy', 'raw_affiliation_strings': ['Merck & Co, Inc, Kenilworth, NJ, USA'], 'affiliations': [{'raw_affiliation_string': 'Merck & Co, Inc, Kenilworth, NJ, USA', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089947807', 'display_name': 'Janice Wahl', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'MSD (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Janice Wahl', 'raw_affiliation_strings': ['Merck & Co, Inc, Kenilworth, NJ, USA'], 'affiliations': [{'raw_affiliation_string': 'Merck & Co, Inc, Kenilworth, NJ, USA', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015849301', 'display_name': 'Bach Nguyen', 'orcid': 'https://orcid.org/0009-0009-7848-9065'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'MSD (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bach-Yen T Nguyen', 'raw_affiliation_strings': ['Merck & Co, Inc, Kenilworth, NJ, USA'], 'affiliations': [{'raw_affiliation_string': 'Merck & Co, Inc, Kenilworth, NJ, USA', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103540365', 'display_name': 'Eliav Barr', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'MSD (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eliav Barr', 'raw_affiliation_strings': ['Merck & Co, Inc, Kenilworth, NJ, USA'], 'affiliations': [{'raw_affiliation_string': 'Merck & Co, Inc, Kenilworth, NJ, USA', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009233940', 'display_name': 'Heather Platt', 'orcid': 'https://orcid.org/0000-0002-0910-6077'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'MSD (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Heather L Platt', 'raw_affiliation_strings': ['Merck & Co, Inc, Kenilworth, NJ, USA'], 'affiliations': [{'raw_affiliation_string': 'Merck & Co, Inc, Kenilworth, NJ, USA', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080796048', 'display_name': 'Michael Robertson', 'orcid': 'https://orcid.org/0000-0001-8247-1057'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'MSD (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael N Robertson', 'raw_affiliation_strings': ['Merck & Co, Inc, Kenilworth, NJ, USA'], 'affiliations': [{'raw_affiliation_string': 'Merck & Co, Inc, Kenilworth, NJ, USA', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5054201295', 'display_name': 'Mark Sulkowski', 'orcid': 'https://orcid.org/0000-0002-2145-6352'}, 'institutions': [{'id': 'https://openalex.org/I2799853436', 'display_name': 'Johns Hopkins Medicine', 'ror': 'https://ror.org/037zgn354', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799853436']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mark Sulkowski', 'raw_affiliation_strings': ['Johns Hopkins University School of Medicine, Baltimore, MD, USA'], 'affiliations': [{'raw_affiliation_string': 'Johns Hopkins University School of Medicine, Baltimore, MD, USA', 'institution_ids': ['https://openalex.org/I2799853436', 'https://openalex.org/I145311948']}]}], 'countries_distinct_count': 6, 'institutions_distinct_count': 18, 'corresponding_author_ids': ['https://openalex.org/A5054617732'], 'corresponding_institution_ids': ['https://openalex.org/I2799391451'], 'apc_list': {'value': 6300, 'currency': 'USD', 'value_usd': 6300, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 29.566, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 298, 'citation_normalized_percentile': {'value': 0.999825, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '2', 'issue': '8', 'first_page': 'e319', 'last_page': 'e327'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10151', 'display_name': 'Hepatitis C Infection and Treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10151', 'display_name': 'Hepatitis C Infection and Treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10526', 'display_name': 'Efficacy and Safety of Antiretroviral Therapy for HIV', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10351', 'display_name': 'Epidemiology and Management of NAFLD', 'score': 0.9932, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tolerability', 'display_name': 'Tolerability', 'score': 0.8108437}, {'id': 'https://openalex.org/keywords/fixed-dose-combination', 'display_name': 'Fixed-dose combination', 'score': 0.517092}, {'id': 'https://openalex.org/keywords/hiv-infection', 'display_name': 'HIV Infection', 'score': 0.471186}, {'id': 'https://openalex.org/keywords/clinical-endpoint', 'display_name': 'Clinical endpoint', 'score': 0.47039494}, {'id': 'https://openalex.org/keywords/hepatitis-c', 'display_name': 'Hepatitis C', 'score': 0.4444534}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.93190056}, {'id': 'https://openalex.org/C2778375690', 'wikidata': 'https://www.wikidata.org/wiki/Q7814214', 'display_name': 'Tolerability', 'level': 3, 'score': 0.8108437}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6815856}, {'id': 'https://openalex.org/C2776623344', 'wikidata': 'https://www.wikidata.org/wiki/Q5456317', 'display_name': 'Fixed-dose combination', 'level': 2, 'score': 0.517092}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.513156}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.47247216}, {'id': 'https://openalex.org/C203092338', 'wikidata': 'https://www.wikidata.org/wiki/Q1340863', 'display_name': 'Clinical endpoint', 'level': 3, 'score': 0.47039494}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.45482945}, {'id': 'https://openalex.org/C2777214474', 'wikidata': 'https://www.wikidata.org/wiki/Q147778', 'display_name': 'Cirrhosis', 'level': 2, 'score': 0.4530213}, {'id': 'https://openalex.org/C2776455275', 'wikidata': 'https://www.wikidata.org/wiki/Q154869', 'display_name': 'Hepatitis C', 'level': 2, 'score': 0.4444534}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.31514373}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D001572', 'descriptor_name': 'Benzofurans', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D015658', 'descriptor_name': 'HIV Infections', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': True}, {'descriptor_ui': 'D015658', 'descriptor_name': 'HIV Infections', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D019698', 'descriptor_name': 'Hepatitis C, Chronic', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': True}, {'descriptor_ui': 'D019698', 'descriptor_name': 'Hepatitis C, Chronic', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D011810', 'descriptor_name': 'Quinoxalines', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000577', 'descriptor_name': 'Amides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001315', 'descriptor_name': 'Australia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001572', 'descriptor_name': 'Benzofurans', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D001572', 'descriptor_name': 'Benzofurans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001572', 'descriptor_name': 'Benzofurans', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D002219', 'descriptor_name': 'Carbamates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060085', 'descriptor_name': 'Coinfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060085', 'descriptor_name': 'Coinfection', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': False}, {'descriptor_ui': 'D060085', 'descriptor_name': 'Coinfection', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D003521', 'descriptor_name': 'Cyclopropanes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004334', 'descriptor_name': 'Drug Administration Schedule', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004338', 'descriptor_name': 'Drug Combinations', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005060', 'descriptor_name': 'Europe', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005838', 'descriptor_name': 'Genotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015658', 'descriptor_name': 'HIV Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016174', 'descriptor_name': 'Hepacivirus', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D016174', 'descriptor_name': 'Hepacivirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019698', 'descriptor_name': 'Hepatitis C, Chronic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D008103', 'descriptor_name': 'Liver Cirrhosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008103', 'descriptor_name': 'Liver Cirrhosis', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': False}, {'descriptor_ui': 'D008103', 'descriptor_name': 'Liver Cirrhosis', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011810', 'descriptor_name': 'Quinoxalines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011810', 'descriptor_name': 'Quinoxalines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D011810', 'descriptor_name': 'Quinoxalines', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014481', 'descriptor_name': 'United States', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019562', 'descriptor_name': 'Viral Load', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s2352-3018(15)00114-9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2531945440', 'display_name': 'The Lancet HIV', 'issn_l': '2352-3018', 'issn': ['2352-3018', '2405-4704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26423374', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.85}], 'grants': [{'funder': 'https://openalex.org/F4320332932', 'funder_display_name': 'Merck Sharp and Dohme', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1970780901', 'https://openalex.org/W1985671731', 'https://openalex.org/W2007894379', 'https://openalex.org/W2012873354', 'https://openalex.org/W2017960775', 'https://openalex.org/W2018798881', 'https://openalex.org/W2023892508', 'https://openalex.org/W2030470608', 'https://openalex.org/W2042063943', 'https://openalex.org/W2042871541', 'https://openalex.org/W2047156711', 'https://openalex.org/W2094778224', 'https://openalex.org/W2096150523', 'https://openalex.org/W2098521993', 'https://openalex.org/W2118684050', 'https://openalex.org/W2121616634', 'https://openalex.org/W2124509162', 'https://openalex.org/W2126536198', 'https://openalex.org/W2155762300', 'https://openalex.org/W2161578383', 'https://openalex.org/W2346493665', 'https://openalex.org/W4210961054'], 'related_works': ['https://openalex.org/W4311628015', 'https://openalex.org/W3191427281', 'https://openalex.org/W2783315223', 'https://openalex.org/W2418162775', 'https://openalex.org/W2327656059', 'https://openalex.org/W2305775430', 'https://openalex.org/W2087016115', 'https://openalex.org/W2003942209', 'https://openalex.org/W1990197915', 'https://openalex.org/W1490050402'], 'abstract_inverted_index': {'Background': [0], 'Hepatitis': [1], 'C': [2], 'virus': [3], '(HCV)': [4], 'infection': [5, 61], 'is': [6, 162], 'a': [7, 114, 217], 'leading': [8], 'cause': [9], 'of': [10, 28, 139, 157, 190, 203, 216, 259, 299], 'morbidity': [11], 'and': [12, 26, 38, 62, 81, 173, 181, 220, 250, 280], 'mortality': [13], 'in': [14, 34, 74, 113, 302, 312], 'patients': [15, 35, 52, 104, 150, 178, 205, 222, 233, 264, 284], 'with': [16, 36, 53, 65, 89, 164, 234, 286, 288, 296], 'HIV-1.': [17], 'The': [18, 123, 142, 238], 'C-EDGE': [19], 'CO-INFECTION': [20], 'study': [21, 158, 161], 'assessed': [22], 'the': [23, 79, 137, 303], 'efficacy,': [24], 'safety,': [25], 'tolerability': [27], 'grazoprevir': [29, 106, 183], '(MK-5172)': [30], 'plus': [31, 109, 184], 'elbasvir': [32, 110, 185], '(MK-8742)': [33], 'HCV': [37, 55, 273], 'HIV': [39, 63, 269, 287], 'co-infection.': [40], 'Methods': [41], 'In': [42], 'this': [43, 300], 'uncontrolled,': [44], 'non-randomised,': [45], 'phase': [46, 313], '3,': [47], 'open-label,': [48], 'single-arm': [49], 'study,': [50], 'treatment-naive': [51], 'chronic': [54], 'genotype': [56], '1,': [57], '4,': [58], 'or': [59, 66, 94, 289], '6': [60], 'co-infection,': [64], 'without': [67, 223, 290], 'cirrhosis,': [68], 'were': [69, 84, 179, 243], 'enrolled': [70, 180], 'from': [71], '37': [72], 'centres': [73], 'nine': [75], 'countries': [76], 'across': [77], 'Europe,': [78], 'USA,': [80], 'Australia.': [82], 'Patients': [83], 'either': [85], 'naive': [86], 'to': [87, 277, 309], 'treatment': [88, 257, 274], 'any': [90], 'antiretroviral': [91], 'therapy': [92, 140], '(ART)': [93], 'stable': [95], 'on': [96], 'ART': [97, 266], 'for': [98, 120, 145, 186, 283], 'at': [99, 153, 194], 'least': [100, 154], '8': [101], 'weeks.': [102, 122], 'All': [103, 231], 'received': [105, 152, 182], '100': [107], 'mg': [108, 112], '50': [111], 'fixed-dose': [115], 'combination': [116], 'tablet': [117], 'once': [118], 'daily': [119], '12': [121, 134, 187], 'primary': [124, 143], 'endpoint': [125], 'was': [126, 148, 198], 'sustained': [127], 'virological': [128], 'response': [129], '(HCV': [130], 'RNA': [131], '<15': [132], 'IU/mL)': [133], 'weeks': [135], 'after': [136], 'end': [138], '(SVR12).': [141], 'population': [144], 'efficacy': [146], 'analyses': [147], 'all': [149, 189], 'who': [151], 'one': [155], 'dose': [156], 'treatment.': [159], 'This': [160, 272, 306], 'registered': [163], 'ClinicalTrials.gov,': [165], 'number': [166], 'NCT02105662.': [167], 'Findings': [168], 'Between': [169], 'June': [170], '11,': [171], '2014,': [172, 176], 'Aug': [174], '29,': [175], '218': [177, 204], 'weeks,': [188], 'whom': [191], 'completed': [192], 'follow-up': [193], 'week': [195], '12.': [196], 'SVR12': [197, 214], 'achieved': [199, 236], 'by': [200], '210': [201], '(96%)': [202], '(95%': [206], 'CI': [207], '92·9–98·4).': [208], 'One': [209], 'patient': [210, 255], 'did': [211], 'not': [212], 'achieve': [213], 'because': [215, 258], 'non-virological': [218], 'reason,': [219], 'seven': [221], 'cirrhosis': [224, 235], 'relapsed': [225], '(two': [226], 'subsequently': [227], 'confirmed': [228], 'as': [229], 'reinfections).': [230], '35': [232], 'SVR12.': [237], 'most': [239], 'common': [240], 'adverse': [241, 261], 'events': [242], 'fatigue': [244], '(29;': [245], '13%),': [246], 'headache': [247], '(27;': [248], '12%),': [249], 'nausea': [251], '(20;': [252], '9%).': [253], 'No': [254], 'discontinued': [256], 'an': [260], 'event.': [262], 'Two': [263], 'receiving': [265], 'had': [267], 'transient': [268], 'viraemia.': [270], 'Interpretation': [271], 'regimen': [275, 301, 307], 'seems': [276], 'be': [278, 310], 'effective': [279], 'well': [281], 'tolerated': [282], 'co-infected': [285], 'cirrhosis.': [291], 'These': [292], 'data': [293], 'are': [294], 'consistent': [295], 'previous': [297], 'trials': [298], 'monoinfected': [304], 'population.': [305], 'continues': [308], 'studied': [311], '3': [314], 'trials.': [315], 'Funding': [316], 'Merck': [317], 'Sharp': [318], '&': [319], 'Dohme': [320], 'Corp.': [321]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1621802947', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 17}, {'year': 2021, 'cited_by_count': 25}, {'year': 2020, 'cited_by_count': 27}, {'year': 2019, 'cited_by_count': 37}, {'year': 2018, 'cited_by_count': 55}, {'year': 2017, 'cited_by_count': 65}, {'year': 2016, 'cited_by_count': 54}, {'year': 2015, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-09-11T12:07:59.190636', 'created_date': '2016-06-24'}