Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1619637593', 'doi': 'https://doi.org/10.1186/1471-2229-10-182', 'title': 'Strictosidine activation in Apocynaceae: towards a "nuclear time bomb"?', 'display_name': 'Strictosidine activation in Apocynaceae: towards a "nuclear time bomb"?', 'publication_year': 2010, 'publication_date': '2010-08-19', 'ids': {'openalex': 'https://openalex.org/W1619637593', 'doi': 'https://doi.org/10.1186/1471-2229-10-182', 'mag': '1619637593', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20723215', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3095312'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/1471-2229-10-182', 'pdf_url': 'https://bmcplantbiol.biomedcentral.com/track/pdf/10.1186/1471-2229-10-182', 'source': {'id': 'https://openalex.org/S6444338', 'display_name': 'BMC Plant Biology', 'issn_l': '1471-2229', 'issn': ['1471-2229'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://bmcplantbiol.biomedcentral.com/track/pdf/10.1186/1471-2229-10-182', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5047978588', 'display_name': 'Grégory Guirimand', 'orcid': 'https://orcid.org/0000-0001-7978-7771'}, 'institutions': [{'id': 'https://openalex.org/I110017253', 'display_name': 'Université de Tours', 'ror': 'https://ror.org/02wwzvj46', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I110017253']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Grégory Guirimand', 'raw_affiliation_strings': ['Université François Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales, Tours, France'], 'affiliations': [{'raw_affiliation_string': 'Université François Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales, Tours, France', 'institution_ids': ['https://openalex.org/I110017253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033726981', 'display_name': 'Vincent Courdavault', 'orcid': 'https://orcid.org/0000-0001-8902-4532'}, 'institutions': [{'id': 'https://openalex.org/I110017253', 'display_name': 'Université de Tours', 'ror': 'https://ror.org/02wwzvj46', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I110017253']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Vincent Courdavault', 'raw_affiliation_strings': ['Université François Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales, Tours, France'], 'affiliations': [{'raw_affiliation_string': 'Université François Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales, Tours, France', 'institution_ids': ['https://openalex.org/I110017253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003358386', 'display_name': 'Arnaud Lanoue', 'orcid': 'https://orcid.org/0000-0002-7377-8177'}, 'institutions': [{'id': 'https://openalex.org/I110017253', 'display_name': 'Université de Tours', 'ror': 'https://ror.org/02wwzvj46', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I110017253']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Arnaud Lanoue', 'raw_affiliation_strings': ['Université François Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales, Tours, France'], 'affiliations': [{'raw_affiliation_string': 'Université François Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales, Tours, France', 'institution_ids': ['https://openalex.org/I110017253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047518017', 'display_name': 'Samira Mahroug', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210125514', 'display_name': 'Université Djilali de Sidi Bel Abbès', 'ror': 'https://ror.org/0378szg41', 'country_code': 'DZ', 'type': 'education', 'lineage': ['https://openalex.org/I4210125514']}, {'id': 'https://openalex.org/I110017253', 'display_name': 'Université de Tours', 'ror': 'https://ror.org/02wwzvj46', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I110017253']}], 'countries': ['DZ', 'FR'], 'is_corresponding': False, 'raw_author_name': 'Samira Mahroug', 'raw_affiliation_strings': ['Laboratoire Biodiversité Végétale, Conservation et Valorisation, Faculté des Sciences, Université Djillali Liabés, Sidi Bel Abbes, Algérie', 'Université François Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales, Tours, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire Biodiversité Végétale, Conservation et Valorisation, Faculté des Sciences, Université Djillali Liabés, Sidi Bel Abbes, Algérie', 'institution_ids': ['https://openalex.org/I4210125514']}, {'raw_affiliation_string': 'Université François Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales, Tours, France', 'institution_ids': ['https://openalex.org/I110017253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056513056', 'display_name': 'Anthony Guihur', 'orcid': 'https://orcid.org/0000-0001-5353-1428'}, 'institutions': [{'id': 'https://openalex.org/I110017253', 'display_name': 'Université de Tours', 'ror': 'https://ror.org/02wwzvj46', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I110017253']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Anthony Guihur', 'raw_affiliation_strings': ['Université François Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales, Tours, France'], 'affiliations': [{'raw_affiliation_string': 'Université François Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales, Tours, France', 'institution_ids': ['https://openalex.org/I110017253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005401680', 'display_name': 'Didier Courbet', 'orcid': 'https://orcid.org/0000-0002-4090-777X'}, 'institutions': [{'id': 'https://openalex.org/I110017253', 'display_name': 'Université de Tours', 'ror': 'https://ror.org/02wwzvj46', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I110017253']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Nathalie Blanc', 'raw_affiliation_strings': ['Université François Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales, Tours, France'], 'affiliations': [{'raw_affiliation_string': 'Université François Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales, Tours, France', 'institution_ids': ['https://openalex.org/I110017253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090141786', 'display_name': 'Nathalie Giglioli-Guivarc’h', 'orcid': 'https://orcid.org/0000-0003-4261-5137'}, 'institutions': [{'id': 'https://openalex.org/I110017253', 'display_name': 'Université de Tours', 'ror': 'https://ror.org/02wwzvj46', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I110017253']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': "Nathalie Giglioli-Guivarc'h", 'raw_affiliation_strings': ['Université François Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales, Tours, France'], 'affiliations': [{'raw_affiliation_string': 'Université François Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales, Tours, France', 'institution_ids': ['https://openalex.org/I110017253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076326010', 'display_name': 'Benoit St‐Pierre', 'orcid': 'https://orcid.org/0000-0002-9077-2949'}, 'institutions': [{'id': 'https://openalex.org/I110017253', 'display_name': 'Université de Tours', 'ror': 'https://ror.org/02wwzvj46', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I110017253']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Benoit St-Pierre', 'raw_affiliation_strings': ['Université François Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales, Tours, France'], 'affiliations': [{'raw_affiliation_string': 'Université François Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales, Tours, France', 'institution_ids': ['https://openalex.org/I110017253']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5053394879', 'display_name': 'Vincent Burlat', 'orcid': 'https://orcid.org/0000-0002-0897-6011'}, 'institutions': [{'id': 'https://openalex.org/I134560555', 'display_name': 'Université Toulouse III - Paul Sabatier', 'ror': 'https://ror.org/02v6kpv12', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I134560555']}, {'id': 'https://openalex.org/I17866349', 'display_name': 'Université de Toulouse', 'ror': 'https://ror.org/004raaa70', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I17866349']}, {'id': 'https://openalex.org/I110017253', 'display_name': 'Université de Tours', 'ror': 'https://ror.org/02wwzvj46', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I110017253']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Vincent Burlat', 'raw_affiliation_strings': ['CNRS; UMR 5546, Castanet-Tolosan, France', 'Université François Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales, Tours, France', 'Université de Toulouse; UPS; UMR 5546, Surfaces Cellulaires et Signalisation chez les Végétaux, Castanet-Tolosan, France'], 'affiliations': [{'raw_affiliation_string': 'Université de Toulouse; UPS; UMR 5546, Surfaces Cellulaires et Signalisation chez les Végétaux, Castanet-Tolosan, France', 'institution_ids': ['https://openalex.org/I134560555', 'https://openalex.org/I17866349']}, {'raw_affiliation_string': 'Université François Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales, Tours, France', 'institution_ids': ['https://openalex.org/I110017253']}, {'raw_affiliation_string': 'CNRS; UMR 5546, Castanet-Tolosan, France', 'institution_ids': ['https://openalex.org/I1294671590']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1690, 'currency': 'GBP', 'value_usd': 2072, 'provenance': 'doaj'}, 'apc_paid': {'value': 1690, 'currency': 'GBP', 'value_usd': 2072, 'provenance': 'doaj'}, 'fwci': 14.74, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 141, 'citation_normalized_percentile': {'value': 0.967265, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '10', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12649', 'display_name': 'Pharmacology of Kratom Alkaloids and Related Compounds', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12649', 'display_name': 'Pharmacology of Kratom Alkaloids and Related Compounds', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10240', 'display_name': 'Elicitor Signal Transduction for Metabolite Production', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11613', 'display_name': 'Medicinal Plants: Chemical Constituents and Biological Activities', 'score': 0.9957, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/catharanthus-roseus', 'display_name': 'Catharanthus roseus', 'score': 0.907874}, {'id': 'https://openalex.org/keywords/apocynaceae', 'display_name': 'Apocynaceae', 'score': 0.5632731}, {'id': 'https://openalex.org/keywords/bimolecular-fluorescence-complementation', 'display_name': 'Bimolecular fluorescence complementation', 'score': 0.5189507}, {'id': 'https://openalex.org/keywords/indole-alkaloid', 'display_name': 'Indole alkaloid', 'score': 0.49811697}, {'id': 'https://openalex.org/keywords/indole-alkaloids', 'display_name': 'Indole Alkaloids', 'score': 0.47973}], 'concepts': [{'id': 'https://openalex.org/C2779906556', 'wikidata': 'https://www.wikidata.org/wiki/Q161093', 'display_name': 'Catharanthus roseus', 'level': 2, 'score': 0.907874}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.810405}, {'id': 'https://openalex.org/C2777135210', 'wikidata': 'https://www.wikidata.org/wiki/Q409439', 'display_name': 'Tryptamine', 'level': 2, 'score': 0.60741395}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.5769738}, {'id': 'https://openalex.org/C2780007248', 'wikidata': 'https://www.wikidata.org/wiki/Q173756', 'display_name': 'Apocynaceae', 'level': 2, 'score': 0.5632731}, {'id': 'https://openalex.org/C123243835', 'wikidata': 'https://www.wikidata.org/wiki/Q863465', 'display_name': 'Bimolecular fluorescence complementation', 'level': 3, 'score': 0.5189507}, {'id': 'https://openalex.org/C2776734949', 'wikidata': 'https://www.wikidata.org/wiki/Q408452', 'display_name': 'Indole alkaloid', 'level': 3, 'score': 0.49811697}, {'id': 'https://openalex.org/C192527728', 'wikidata': 'https://www.wikidata.org/wiki/Q1465700', 'display_name': 'Indole test', 'level': 2, 'score': 0.27247953}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.19431391}, {'id': 'https://openalex.org/C2779222958', 'wikidata': 'https://www.wikidata.org/wiki/Q45422', 'display_name': 'Yeast', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D019759', 'descriptor_name': 'Carbon-Nitrogen Lyases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D030008', 'descriptor_name': 'Catharanthus', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D005959', 'descriptor_name': 'Glucosidases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011926', 'descriptor_name': 'Rauwolfia', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D014748', 'descriptor_name': 'Vinca Alkaloids', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019759', 'descriptor_name': 'Carbon-Nitrogen Lyases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019759', 'descriptor_name': 'Carbon-Nitrogen Lyases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D030008', 'descriptor_name': 'Catharanthus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D030008', 'descriptor_name': 'Catharanthus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018506', 'descriptor_name': 'Gene Expression Regulation, Plant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005959', 'descriptor_name': 'Glucosidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005959', 'descriptor_name': 'Glucosidases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D039821', 'descriptor_name': 'Monoterpenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D039821', 'descriptor_name': 'Monoterpenes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D035261', 'descriptor_name': 'Plant Components, Aerial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035261', 'descriptor_name': 'Plant Components, Aerial', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D030821', 'descriptor_name': 'Plants, Genetically Modified', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D030821', 'descriptor_name': 'Plants, Genetically Modified', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D030821', 'descriptor_name': 'Plants, Genetically Modified', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D055503', 'descriptor_name': 'Protein Multimerization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011926', 'descriptor_name': 'Rauwolfia', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011926', 'descriptor_name': 'Rauwolfia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014617', 'descriptor_name': 'Vacuoles', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014617', 'descriptor_name': 'Vacuoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014748', 'descriptor_name': 'Vinca Alkaloids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/1471-2229-10-182', 'pdf_url': 'https://bmcplantbiol.biomedcentral.com/track/pdf/10.1186/1471-2229-10-182', 'source': {'id': 'https://openalex.org/S6444338', 'display_name': 'BMC Plant Biology', 'issn_l': '1471-2229', 'issn': ['1471-2229'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/c4dd0957c9cf4567acd03425ddee1c4b', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095312', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20723215', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/1471-2229-10-182', 'pdf_url': 'https://bmcplantbiol.biomedcentral.com/track/pdf/10.1186/1471-2229-10-182', 'source': {'id': 'https://openalex.org/S6444338', 'display_name': 'BMC Plant Biology', 'issn_l': '1471-2229', 'issn': ['1471-2229'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Life on land', 'id': 'https://metadata.un.org/sdg/15', 'score': 0.61}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 61, 'referenced_works': ['https://openalex.org/W1548591053', 'https://openalex.org/W1593869902', 'https://openalex.org/W1964021154', 'https://openalex.org/W1966464284', 'https://openalex.org/W1973428594', 'https://openalex.org/W1977120796', 'https://openalex.org/W1984732025', 'https://openalex.org/W1995522818', 'https://openalex.org/W2020559553', 'https://openalex.org/W2026332858', 'https://openalex.org/W2036868831', 'https://openalex.org/W2037786946', 'https://openalex.org/W2038348067', 'https://openalex.org/W2038853975', 'https://openalex.org/W2039751420', 'https://openalex.org/W2041057241', 'https://openalex.org/W2044825930', 'https://openalex.org/W2045339214', 'https://openalex.org/W2045889119', 'https://openalex.org/W2052163269', 'https://openalex.org/W2054839555', 'https://openalex.org/W2058584183', 'https://openalex.org/W2060088582', 'https://openalex.org/W2060921851', 'https://openalex.org/W2060957622', 'https://openalex.org/W2065098894', 'https://openalex.org/W2065123516', 'https://openalex.org/W2065439398', 'https://openalex.org/W2066469697', 'https://openalex.org/W2069611962', 'https://openalex.org/W2075774117', 'https://openalex.org/W2077958668', 'https://openalex.org/W2083435624', 'https://openalex.org/W2088612494', 'https://openalex.org/W2092672870', 'https://openalex.org/W2100805313', 'https://openalex.org/W2105537485', 'https://openalex.org/W2105945817', 'https://openalex.org/W2117697055', 'https://openalex.org/W2123058210', 'https://openalex.org/W2133147725', 'https://openalex.org/W2135317393', 'https://openalex.org/W2135487705', 'https://openalex.org/W2139829496', 'https://openalex.org/W2146560076', 'https://openalex.org/W2147351155', 'https://openalex.org/W2148961912', 'https://openalex.org/W2154062107', 'https://openalex.org/W2154632148', 'https://openalex.org/W2159356563', 'https://openalex.org/W2164017942', 'https://openalex.org/W2165018314', 'https://openalex.org/W2171252496', 'https://openalex.org/W2222948400', 'https://openalex.org/W2316336627', 'https://openalex.org/W26474220', 'https://openalex.org/W2764544710', 'https://openalex.org/W359303811', 'https://openalex.org/W4200263908', 'https://openalex.org/W4247377269', 'https://openalex.org/W4294307372'], 'related_works': ['https://openalex.org/W4319261673', 'https://openalex.org/W3048827759', 'https://openalex.org/W3038452322', 'https://openalex.org/W271422608', 'https://openalex.org/W2182844289', 'https://openalex.org/W2133805088', 'https://openalex.org/W2082814451', 'https://openalex.org/W2026422208', 'https://openalex.org/W2007842202', 'https://openalex.org/W1994310290'], 'abstract_inverted_index': {'The': [0, 39, 134, 260], 'first': [1, 164], 'two': [2], 'enzymatic': [3], 'steps': [4], 'of': [5, 37, 69, 137, 166, 174, 228, 242, 246, 267, 270], 'monoterpene': [6], 'indole': [7], 'alkaloid': [8], '(MIA)': [9], 'biosynthetic': [10], 'pathway': [11], 'are': [12, 57], 'catalysed': [13], 'by': [14, 27], 'strictosidine': [15, 25, 28, 102, 110, 129, 272], 'synthase': [16], '(STR)': [17], 'that': [18, 31, 100, 108, 155, 184], 'condensates': [19], 'tryptamine': [20], 'and': [21, 26, 67, 76, 107, 122, 157, 179, 190, 216, 223, 230, 248], 'secologanin': [22], 'to': [23, 63, 195, 205, 221, 224, 238, 250, 291, 298], 'form': [24], 'beta-D-glucosidase': [29], '(SGD)': [30], 'subsequently': [32], 'hydrolyses': [33], 'the': [34, 65, 92, 109, 147, 162, 196, 213, 226, 240, 243, 252, 264, 271, 292, 300], 'glucose': [35], 'moiety': [36], 'strictosidine.': [38], 'resulting': [40], 'unstable': [41], 'aglycon': [42], 'is': [43], 'rapidly': [44], 'converted': [45], 'into': [46], 'a': [47, 101, 125, 172, 284], 'highly': [48, 208], 'reactive': [49], 'dialdehyde,': [50], 'from': [51, 186, 200], 'which': [52], 'more': [53], 'than': [54], '2,000': [55], 'MIAs': [56, 72], 'derived.': [58], 'Many': [59], 'studies': [60, 153, 218], 'were': [61, 159, 193, 203], 'conducted': [62], 'elucidate': [64], 'biosynthesis': [66], 'regulation': [68], 'pharmacologically': [70], 'valuable': [71], 'such': [73, 138], 'as': [74, 207], 'vinblastine': [75], 'vincristine': [77], 'in': [78, 83, 105, 118, 131, 144, 150, 161, 289, 304], 'Catharanthus': [79], 'roseus': [80, 168, 189], 'or': [81], 'ajmaline': [82], 'Rauvolfia': [84], 'serpentina.': [85], 'However,': [86, 171], 'very': [87], 'few': [88], 'reports': [89], 'focused': [90], 'on': [91], 'MIA': [93, 253], 'physiological': [94, 258], 'functions.In': [95], 'this': [96], 'study': [97], 'we': [98], 'showed': [99, 154], 'pool': [103, 274], 'existed': [104], 'planta': [106], 'deglucosylation': [111], 'product(s)': [112], 'was': [113, 142, 236], '(were)': [114], 'specifically': [115], 'responsible': [116], 'for': [117, 128], 'vitro': [119], 'protein': [120], 'cross-linking': [121], 'precipitation': [123], 'suggesting': [124], 'potential': [126, 280], 'role': [127, 241], 'activation': [130, 140, 269], 'plant': [132], 'defence.': [133], 'spatial': [135, 234], 'feasibility': [136], 'an': [139], 'process': [141], 'evaluated': [143], 'planta.': [145], 'On': [146], 'one': [148], 'hand,': [149], 'situ': [151], 'hybridisation': [152], 'CrSTR': [156, 229], 'CrSGD': [158, 231], 'coexpressed': [160], 'epidermal': [163], 'barrier': [165], 'C.': [167, 188], 'aerial': [169], 'organs.': [170], 'combination': [173], 'GFP-imaging,': [175], 'bimolecular': [176], 'fluorescence': [177], 'complementation': [178], 'electromobility': [180], 'shift-zymogram': [181], 'experiments': [182], 'revealed': [183], 'STR': [185, 247], 'both': [187, 201], 'R.': [191], 'serpentina': [192], 'localised': [194], 'vacuole': [197], 'whereas': [198], 'SGD': [199, 249], 'species': [202], 'shown': [204], 'accumulate': [206], 'stable': [209], 'supramolecular': [210], 'aggregates': [211], 'within': [212], 'nucleus.': [214], 'Deletion': [215], 'fusion': [217], 'allowed': [219], 'us': [220], 'identify': [222], 'demonstrate': [225], 'functionality': [227], 'targeting': [232], 'sequences.A': [233], 'model': [235, 261], 'drawn': [237], 'explain': [239], 'subcellular': [244], 'sequestration': [245], 'control': [251], 'metabolic': [254], 'flux': [255], 'under': [256], 'normal': [257], 'conditions.': [259], 'also': [262], 'illustrates': [263], 'possible': [265], 'mechanism': [266], 'massive': [268], 'vacuolar': [273], 'upon': [275], 'enzyme-substrate': [276], 'reunion': [277], 'occurring': [278], 'during': [279], 'herbivore': [281], 'feeding': [282], 'constituting': [283], 'so-called': [285], '"nuclear': [286], 'time': [287], 'bomb"': [288, 295], 'reference': [290], '"mustard': [293], 'oil': [294], 'commonly': [296], 'used': [297], 'describe': [299], 'myrosinase-glucosinolate': [301], 'defence': [302], 'system': [303], 'Brassicaceae.': [305]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1619637593', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 14}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 16}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 16}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-09-01T01:18:41.965011', 'created_date': '2016-06-24'}