Title: Chapter 33. Pharmaceutics and Biopharmaceutics
Abstract: The pharmacological activity, efficacy, and toxicity of an administered medicament may be profoundly affected by the physico-chemical properties of the drug and the drug dosage form. Also, solutions of the drug (the emulsion and the soft elastic capsule) give superior absorption characteristics as measured by drug plasma levels than the solid drug forms (the suspension and the hard capsule). It would appear that indoxole represents another case where dissolution rate and/or drug availability is the rate determining process in the overall absorptive process. Thus parameters such as solubility, particle size, diffusional characteristics, availability, and rate of dissolution of the drug have been the areas emphasized in most biopharmaceutical studies. This chapter discusses the effect of these parameters on drug absorption. Basic investigations and developments in both pharmaceutics and biopharmaceutics area continued with increasing vigor. Although the bulk of published works still originates from academic institutions, an increasing proportion appears to be contributed by industrial organizations. The chapter summarizes recent general developments in these fields. Recently, the base induced degradation of 9-methylisoalloxazine under both aerobic and anaerobic conditions is studied. The initial product formed appears to be a carbinol amine. Researchers have continued their investigation of anaerobic hydrolytic degradations of ascorbic acid with a study on the effect of metallic ions on the overall rate. Although the reaction appears to be accelerated by doubly and triply charged species, the effect was small.
Publication Year: 1967
Publication Date: 1967-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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