Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1607958791', 'doi': 'https://doi.org/10.18632/oncotarget.3089', 'title': 'Reduction of miR-29c enhances pancreatic cancer cell migration and stem cell-like phenotype', 'display_name': 'Reduction of miR-29c enhances pancreatic cancer cell migration and stem cell-like phenotype', 'publication_year': 2014, 'publication_date': '2014-12-30', 'ids': {'openalex': 'https://openalex.org/W1607958791', 'doi': 'https://doi.org/10.18632/oncotarget.3089', 'mag': '1607958791', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25605017', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4413616'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3089', 'pdf_url': 'https://www.oncotarget.com/article/3089/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/3089/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5023548042', 'display_name': 'Jianxin Jiang', 'orcid': 'https://orcid.org/0000-0001-7939-9082'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jianxin Jiang', 'raw_affiliation_strings': ['Department of Hepatobiliary Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Hepatobiliary Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056581550', 'display_name': 'Chao Yu', 'orcid': 'https://orcid.org/0000-0002-9244-9416'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chao Yu', 'raw_affiliation_strings': ['Department of Hepatobiliary Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Hepatobiliary Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101673078', 'display_name': 'Meiyuan Chen', 'orcid': None}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Meiyuan Chen', 'raw_affiliation_strings': ['Department of Hepatobiliary Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Hepatobiliary Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100397000', 'display_name': 'Hao Zhang', 'orcid': 'https://orcid.org/0000-0003-0613-3798'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hao Zhang', 'raw_affiliation_strings': ['Department of Hepatobiliary Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Hepatobiliary Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027454758', 'display_name': 'Se Tian', 'orcid': None}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Se Tian', 'raw_affiliation_strings': ['Department of Hepatobiliary Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Hepatobiliary Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou, China.', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101756414', 'display_name': 'Chengyi Sun', 'orcid': 'https://orcid.org/0000-0002-8603-3609'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chengyi Sun', 'raw_affiliation_strings': ['Department of Hepatobiliary Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Hepatobiliary Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou, China.', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.569, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 45, 'citation_normalized_percentile': {'value': 0.872394, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '6', 'issue': '5', 'first_page': '2767', 'last_page': '2778'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA Regulation in Cancer and Development', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA Regulation in Cancer and Development', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA Methylation and Modification in Gene Expression', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lrp6', 'display_name': 'LRP6', 'score': 0.58175844}, {'id': 'https://openalex.org/keywords/cancer', 'display_name': 'Cancer', 'score': 0.527068}], 'concepts': [{'id': 'https://openalex.org/C137620995', 'wikidata': 'https://www.wikidata.org/wiki/Q155769', 'display_name': 'Wnt signaling pathway', 'level': 3, 'score': 0.8547958}, {'id': 'https://openalex.org/C2780210213', 'wikidata': 'https://www.wikidata.org/wiki/Q212961', 'display_name': 'Pancreatic cancer', 'level': 3, 'score': 0.8179697}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.66483617}, {'id': 'https://openalex.org/C170320316', 'wikidata': 'https://www.wikidata.org/wiki/Q18028667', 'display_name': 'LRP6', 'level': 4, 'score': 0.58175844}, {'id': 'https://openalex.org/C107300179', 'wikidata': 'https://www.wikidata.org/wiki/Q41797887', 'display_name': 'Frizzled', 'level': 4, 'score': 0.5494496}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.5347127}, {'id': 'https://openalex.org/C55427017', 'wikidata': 'https://www.wikidata.org/wiki/Q1638475', 'display_name': 'Cancer stem cell', 'level': 3, 'score': 0.5265589}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.49604163}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.47034624}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3879152}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3353353}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.17952636}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.1490055}], 'mesh': [{'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010190', 'descriptor_name': 'Pancreatic Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009361', 'descriptor_name': 'Neoplasm Invasiveness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010190', 'descriptor_name': 'Pancreatic Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010190', 'descriptor_name': 'Pancreatic Neoplasms', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D010190', 'descriptor_name': 'Pancreatic Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D010190', 'descriptor_name': 'Pancreatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051900', 'descriptor_name': 'Smad3 Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051900', 'descriptor_name': 'Smad3 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060449', 'descriptor_name': 'Wnt Signaling Pathway', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3089', 'pdf_url': 'https://www.oncotarget.com/article/3089/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4413616', 'pdf_url': 'https://europepmc.org/articles/pmc4413616?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413616', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25605017', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3089', 'pdf_url': 'https://www.oncotarget.com/article/3089/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.56}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1480706413', 'https://openalex.org/W1496143836', 'https://openalex.org/W155227606', 'https://openalex.org/W1631692643', 'https://openalex.org/W1648301895', 'https://openalex.org/W1958542839', 'https://openalex.org/W1969669359', 'https://openalex.org/W1978502285', 'https://openalex.org/W1987708512', 'https://openalex.org/W1989281114', 'https://openalex.org/W1990563353', 'https://openalex.org/W1999356404', 'https://openalex.org/W2002404925', 'https://openalex.org/W2013468181', 'https://openalex.org/W2019264784', 'https://openalex.org/W2028574954', 'https://openalex.org/W2029443168', 'https://openalex.org/W2030621485', 'https://openalex.org/W2043965273', 'https://openalex.org/W2056942951', 'https://openalex.org/W2059022111', 'https://openalex.org/W2062290101', 'https://openalex.org/W2062537719', 'https://openalex.org/W2074605890', 'https://openalex.org/W2075329854', 'https://openalex.org/W2076872714', 'https://openalex.org/W2093453499', 'https://openalex.org/W2102085111', 'https://openalex.org/W2103177465', 'https://openalex.org/W2103288147', 'https://openalex.org/W2113281755', 'https://openalex.org/W2118453722', 'https://openalex.org/W2125523949', 'https://openalex.org/W2129355962', 'https://openalex.org/W2130410032', 'https://openalex.org/W2131170195', 'https://openalex.org/W2131717731', 'https://openalex.org/W2135580384', 'https://openalex.org/W2136754349', 'https://openalex.org/W2146684369', 'https://openalex.org/W2149385948', 'https://openalex.org/W2153056550', 'https://openalex.org/W2155507705', 'https://openalex.org/W2157452165', 'https://openalex.org/W2157852151', 'https://openalex.org/W2161025693', 'https://openalex.org/W2165685789', 'https://openalex.org/W2165801731', 'https://openalex.org/W2169752217', 'https://openalex.org/W2170685293', 'https://openalex.org/W2404048289'], 'related_works': ['https://openalex.org/W4307544679', 'https://openalex.org/W4206653363', 'https://openalex.org/W2913541467', 'https://openalex.org/W2187739293', 'https://openalex.org/W2155308439', 'https://openalex.org/W2080509277', 'https://openalex.org/W2017632960', 'https://openalex.org/W1972875962', 'https://openalex.org/W1964589725', 'https://openalex.org/W1543862028'], 'abstract_inverted_index': {'//': [0, 42], 'Jianxin': [1], 'Jiang': [2], '1': [3, 7, 11, 15, 19, 23, 24], ',': [4, 8, 12, 16], 'Chao': [5], 'Yu': [6], 'Meiyuan': [9], 'Chen': [10], 'Hao': [13], 'Zhang': [14], 'Se': [17], 'Tian': [18], 'and': [20, 81, 119, 161, 188, 191, 213], 'Chengyi': [21, 39], 'Sun': [22], 'Department': [25], 'of': [26, 31, 69, 108], 'Hepatobiliary': [27], 'Surgery,': [28], 'Affiliated': [29], 'Hospital': [30], 'Guiyang': [32], 'Medical': [33], 'College,': [34], 'Guiyang,': [35], 'Guizhou,': [36], 'China': [37], 'Correspondence:': [38], 'Sun,': [40], 'email:': [41], 'Keywords': [43], ':': [44, 52, 57, 62], 'Pancreatic': [45], 'cancer,': [46], 'miR-29c,': [47], 'Wnt,': [48], 'FRAT2,': [49], 'LRP6': [50], 'Received': [51], 'October': [53], '30,': [54, 64], '2014': [55, 60, 65], 'Accepted': [56], 'December': [58, 63], '25,': [59], 'Published': [61], 'Abstract': [66], 'The': [67], 'hallmarks': [68], 'pancreatic': [70, 116, 121, 125, 198, 211, 223], 'cancer': [71, 117, 126, 199, 212], 'are': [72], 'limitless': [73], 'replicative': [74], 'potential': [75], 'as': [76, 78], 'well': [77], 'tissue': [79], 'invasion': [80], 'metastasis,': [82], 'leading': [83, 172], 'to': [84, 173], 'an': [85, 182], 'extremely': [86], 'aggressive': [87], 'disease': [88], 'with': [89, 132, 181], 'shockingly': [90], 'high': [91], 'lethality.': [92], 'However,': [93], 'the': [94, 106, 124, 140, 192], 'molecular': [95], 'mechanisms': [96], 'underlying': [97], 'these': [98], 'characteristics': [99], 'remain': [100], 'largely': [101], 'unclear.': [102], 'Herein,': [103], 'we': [104], 'report': [105], 'results': [107, 178], 'a': [109, 204, 216], 'differential': [110], 'miRNA': [111], 'expression': [112], 'screen': [113], 'that': [114], 'compared': [115], 'tissues': [118, 127], 'normal': [120], 'tissues,': [122], 'where': [123], 'had': [128], 'highly': [129], 'downregulated': [130], 'miR-29c': [131, 170, 186], 'relative': [133], 'Wnt': [134, 142, 174, 194, 208], 'cascade': [135, 195], 'hyperactivation.': [136], 'MiR-29c': [137], 'directly': [138], 'suppressed': [139], 'following': [141], 'upstream': [143], 'regulators:': [144], 'frequently': [145], 'rearranged': [146], 'in': [147, 196, 210, 222], 'advanced': [148], 'T-cell': [149], 'lymphomas': [150], '2': [151], '(FRAT2),': [152], 'low-density': [153], 'lipoprotein': [154], 'receptor–related': [155], 'protein': [156], '6': [157], '(LRP6),': [158], 'Frizzled-4': [159], '(FZD4)': [160], 'Frizzled-5': [162], '(FZD5).': [163], 'Furthermore,': [164], 'transforming': [165], 'growth': [166], 'factor-β': [167], '(TGF-β)': [168], 'inhibited': [169], 'expression,': [171], 'activation.': [175], 'Significantly,': [176], 'our': [177], 'were': [179], 'consistent': [180], 'important': [183], 'correlation': [184], 'between': [185], 'levels': [187], 'TGF-β': [189], 'hyperactivation': [190, 209], 'activated': [193], 'human': [197], 'specimens.': [200], 'These': [201], 'findings': [202], 'reveal': [203], 'novel': [205], 'mechanism': [206], 'for': [207, 219], 'may': [214], 'suggest': [215], 'new': [217], 'target': [218], 'clinical': [220], 'intervention': [221], 'cancer.': [224]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1607958791', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 2}], 'updated_date': '2024-09-18T23:42:55.078999', 'created_date': '2016-06-24'}