Title: EFFECTS OF DANCHI DECOCTION ON P450AROM, SURVIVIN OF EUTOPIC ENDOMETRIUM OF PATIENTSWITH ENDOMETRIOSIS AFTER CONSERVATIVE SURGERY
Abstract: Background: Endometriosis is a common gynecological disease, which can seriously affect the physical and mental health of patients. However,
 there is not a satisfactory way to treat endometriosis with a low recurrence rate.
 Materials and Methods: Including twenty patients with endometriosis given conservative surgery, a prospective clinical study was performed
 with randomly grouping and positive control. The traditional Chinese medicine (TCM) and western medicine (WM) groups were given Danchi
 decoction and GnRH-a or gestrinone respectively. Treatment was given in 1–5 days during the first menstruation. The eutopic endometriums
 were collected before and 3 months after the treatment, respectively. Then immunohistochemistry was performed to obtain the expressions of
 P450arom and survivin. In the normal control (NC) group no drugs were administered.
 Results: Before the treatment, the expressions of P450arom and survivin in both TCM and WM groups were much higher than the NC group
 (P0.05). The expressions of the two groups were remarkably decreased after
 the treatment (P0.05).
 Conclusion: Danchi decoction can control the recurrence of endometriosis by restraining abnormal secretion of aromatizing enzyme and
 regulating cell apoptosis in eutopic endometrium. Excessive expressions of aromatizing enzyme and decreased apoptosis are a possible
 mechanism of endometriosis recurrence.