Title: Computational Modeling of Selective Pharmacophores at the α <sub>1</sub> ‐Adrenergic Receptors
Abstract: This chapter contains sections titled: Introduction Ligand-Based and Receptor-Based Pharmacophore Modeling and QSAR Analysis The General α1-AR Pharmacophore Ligand-Based Pharmacophore and Virtual Screening Prazosin Analogues (2,4-Diamino-6,7-dimethoxyquinazoline Derivatives) 1,4-Benzodioxan (WB-4101) Related Compounds Arylpiperazine Derivatives Target and Antitarget Pharmacophore Modeling Modeling the α1-AR Subtype Selectivities of Different Classes of Antagonists Supermolecule-Based Subtype Pharmacophore and QSAR Models Ligand-Based Subtype Pharmacophores Receptor-Based Subtype Pharmacophore and Ligand–Target/Antitarget Interaction-Based QSAR Antitarget Modeling of Biogenic Amine-Binding GPCRs: Common Features and Subtle Differences Conclusions From Molecules to Pharmacophores to Descriptors to Models Perspectives Pharmacophore Combination Approach: From Lock and Key to Passe–Partout Model References
Publication Year: 2008
Publication Date: 2008-01-23
Language: en
Type: other
Indexed In: ['crossref']
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Cited By Count: 2
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