Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1598785982', 'doi': 'https://doi.org/10.1016/0014-4800(78)90067-9', 'title': 'Antagonism by chloramphenicol of carbon tetrachloride hepatotoxicity', 'display_name': 'Antagonism by chloramphenicol of carbon tetrachloride hepatotoxicity', 'publication_year': 1978, 'publication_date': '1978-02-01', 'ids': {'openalex': 'https://openalex.org/W1598785982', 'doi': 'https://doi.org/10.1016/0014-4800(78)90067-9', 'mag': '1598785982', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/620763'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0014-4800(78)90067-9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S111757857', 'display_name': 'Experimental and Molecular Pathology', 'issn_l': '0014-4800', 'issn': ['0014-4800', '1096-0945'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'http://deepblue.lib.umich.edu/bitstream/2027.42/22664/1/0000217.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5066192218', 'display_name': 'Elizabeth D. Dolci', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elizabeth D. Dolci', 'raw_affiliation_strings': ['Department of Environmental and Industrial Health, School of Public Health, The University of Michigan, Ann Arbor, Michigan 48109, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Environmental and Industrial Health, School of Public Health, The University of Michigan, Ann Arbor, Michigan 48109, USA', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5077102408', 'display_name': 'Michael J. Brabec', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael J. Brabec', 'raw_affiliation_strings': ['Department of Environmental and Industrial Health, School of Public Health, The University of Michigan, Ann Arbor, Michigan 48109, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Environmental and Industrial Health, School of Public Health, The University of Michigan, Ann Arbor, Michigan 48109, USA', 'institution_ids': ['https://openalex.org/I27837315']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1900, 'currency': 'USD', 'value_usd': 1900, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 5, 'citation_normalized_percentile': {'value': 0.554241, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 73, 'max': 75}, 'biblio': {'volume': '28', 'issue': '1', 'first_page': '96', 'last_page': '106'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11465', 'display_name': 'Mechanisms of Drug-Induced Hepatotoxicity', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11465', 'display_name': 'Mechanisms of Drug-Induced Hepatotoxicity', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10375', 'display_name': 'Drug Metabolism and Pharmacogenomics', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11036', 'display_name': 'Pharmacokinetics of Antibiotics in Critically Ill Patients', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ccl4', 'display_name': 'CCL4', 'score': 0.49657637}, {'id': 'https://openalex.org/keywords/cytochrome-p450', 'display_name': 'Cytochrome P450', 'score': 0.472541}], 'concepts': [{'id': 'https://openalex.org/C2778473333', 'wikidata': 'https://www.wikidata.org/wiki/Q274515', 'display_name': 'Chloramphenicol', 'level': 3, 'score': 0.88687027}, {'id': 'https://openalex.org/C2780829032', 'wikidata': 'https://www.wikidata.org/wiki/Q898539', 'display_name': 'Lipid peroxidation', 'level': 3, 'score': 0.8492396}, {'id': 'https://openalex.org/C2777359374', 'wikidata': 'https://www.wikidata.org/wiki/Q225045', 'display_name': 'Carbon tetrachloride', 'level': 2, 'score': 0.82511604}, {'id': 'https://openalex.org/C2780768313', 'wikidata': 'https://www.wikidata.org/wiki/Q408068', 'display_name': 'Cytochrome', 'level': 3, 'score': 0.73162484}, {'id': 'https://openalex.org/C87644729', 'wikidata': 'https://www.wikidata.org/wiki/Q547502', 'display_name': 'Microsome', 'level': 3, 'score': 0.6420659}, {'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.61987877}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5711136}, {'id': 'https://openalex.org/C102124568', 'wikidata': 'https://www.wikidata.org/wiki/Q5009626', 'display_name': 'CCL4', 'level': 3, 'score': 0.49657637}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.49085099}, {'id': 'https://openalex.org/C2777383412', 'wikidata': 'https://www.wikidata.org/wiki/Q4770891', 'display_name': 'Antagonism', 'level': 3, 'score': 0.48681256}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4786169}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.4081185}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2936232}, {'id': 'https://openalex.org/C2778004101', 'wikidata': 'https://www.wikidata.org/wiki/Q133948', 'display_name': 'Antioxidant', 'level': 2, 'score': 0.21368486}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.19500864}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.14140815}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.058815897}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002252', 'descriptor_name': 'Carbon Tetrachloride Poisoning', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002701', 'descriptor_name': 'Chloramphenicol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D003577', 'descriptor_name': 'Cytochrome P-450 Enzyme System', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D050356', 'descriptor_name': 'Lipid Metabolism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008862', 'descriptor_name': 'Microsomes, Liver', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002252', 'descriptor_name': 'Carbon Tetrachloride Poisoning', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002701', 'descriptor_name': 'Chloramphenicol', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D002701', 'descriptor_name': 'Chloramphenicol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003577', 'descriptor_name': 'Cytochrome P-450 Enzyme System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003579', 'descriptor_name': 'Cytochrome Reductases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003579', 'descriptor_name': 'Cytochrome Reductases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006591', 'descriptor_name': 'Hexobarbital', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006591', 'descriptor_name': 'Hexobarbital', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008862', 'descriptor_name': 'Microsomes, Liver', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008862', 'descriptor_name': 'Microsomes, Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0014-4800(78)90067-9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S111757857', 'display_name': 'Experimental and Molecular Pathology', 'issn_l': '0014-4800', 'issn': ['0014-4800', '1096-0945'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/2027.42/22664', 'pdf_url': 'http://deepblue.lib.umich.edu/bitstream/2027.42/22664/1/0000217.pdf', 'source': {'id': 'https://openalex.org/S4306400393', 'display_name': 'Deep Blue (University of Michigan)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I27837315', 'host_organization_name': 'University of Michigan–Ann Arbor', 'host_organization_lineage': ['https://openalex.org/I27837315'], 'host_organization_lineage_names': ['University of Michigan–Ann Arbor'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/620763', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/2027.42/22664', 'pdf_url': 'http://deepblue.lib.umich.edu/bitstream/2027.42/22664/1/0000217.pdf', 'source': {'id': 'https://openalex.org/S4306400393', 'display_name': 'Deep Blue (University of Michigan)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I27837315', 'host_organization_name': 'University of Michigan–Ann Arbor', 'host_organization_lineage': ['https://openalex.org/I27837315'], 'host_organization_lineage_names': ['University of Michigan–Ann Arbor'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6', 'score': 0.52}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W126145571', 'https://openalex.org/W1506043065', 'https://openalex.org/W1553482361', 'https://openalex.org/W1899938340', 'https://openalex.org/W1920512451', 'https://openalex.org/W1951469402', 'https://openalex.org/W1970966680', 'https://openalex.org/W1981389278', 'https://openalex.org/W1987338126', 'https://openalex.org/W2003049927', 'https://openalex.org/W2007984332', 'https://openalex.org/W2008267946', 'https://openalex.org/W2012757283', 'https://openalex.org/W2012928272', 'https://openalex.org/W2023134637', 'https://openalex.org/W2024940329', 'https://openalex.org/W2062442749', 'https://openalex.org/W2069687969', 'https://openalex.org/W2098278399', 'https://openalex.org/W2141734850', 'https://openalex.org/W2158964684', 'https://openalex.org/W2171473267', 'https://openalex.org/W2176956421', 'https://openalex.org/W2282054059', 'https://openalex.org/W2313835802', 'https://openalex.org/W2406377496', 'https://openalex.org/W2415371752', 'https://openalex.org/W2473281750', 'https://openalex.org/W4246724958'], 'related_works': ['https://openalex.org/W4387646365', 'https://openalex.org/W2917795919', 'https://openalex.org/W2508012606', 'https://openalex.org/W2419131078', 'https://openalex.org/W2359831249', 'https://openalex.org/W2355939533', 'https://openalex.org/W2347377923', 'https://openalex.org/W2288620160', 'https://openalex.org/W2042520936', 'https://openalex.org/W1988454503'], 'abstract_inverted_index': {'Administration': [0], 'of': [1, 10], 'chloramphenicol': [2, 33, 75], 'early': [3], 'in': [4, 21, 27, 29, 67], 'CCl4': [5, 58, 83], 'intoxication': [6], 'prevents': [7], 'lipid': [8, 36, 78], 'peroxidation': [9, 37, 79], 'endoplasmic': [11], 'reticulum': [12], 'membranes.': [13], 'Conversely,': [14], 'a': [15, 35, 89], 'sulfamoyl': [16], 'analog,': [17], 'Tevenel,': [18], 'was': [19], 'ineffective': [20], 'preventing': [22], 'the': [23], 'lipoperoxidative': [24], 'process.': [25], 'Likewise,': [26], 'an': [28], 'vitro': [30], 'microsomal': [31], 'system': [32], 'inhibited': [34], 'process': [38], 'and': [39], 'Tevenel': [40], 'did': [41, 51, 61], 'not.': [42], 'However,': [43], 'both': [44], 'compounds': [45], 'bind': [46], 'to': [47], 'cytochrome': [48, 54, 64], 'P-450.': [49], 'Chloramphenicol': [50], 'not': [52], 'maintain': [53], 'P-450': [55, 65], 'levels': [56, 66], 'after': [57], 'administration': [59], 'nor': [60], 'it': [62], 'depress': [63], 'untreated': [68], 'animals.': [69], 'The': [70], 'data': [71], 'obtained': [72], 'indicate': [73], 'that': [74], 'may': [76], 'prevent': [77], 'either': [80], 'by': [81, 86], 'inhibiting': [82], 'metabolism': [84], 'or': [85], 'acting': [87], 'as': [88], 'free': [90], 'radical': [91], 'sequestering': [92], 'agent.': [93]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1598785982', 'counts_by_year': [], 'updated_date': '2024-08-21T09:01:37.287628', 'created_date': '2016-06-24'}