Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1595298938', 'doi': 'https://doi.org/10.1111/cei.12465', 'title': 'Generation of β cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice', 'display_name': 'Generation of β cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice', 'publication_year': 2014, 'publication_date': '2014-10-10', 'ids': {'openalex': 'https://openalex.org/W1595298938', 'doi': 'https://doi.org/10.1111/cei.12465', 'mag': '1595298938', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25302633', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4337673'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/cei.12465', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cei.12465', 'source': {'id': 'https://openalex.org/S11896317', 'display_name': 'Clinical & Experimental Immunology', 'issn_l': '0009-9104', 'issn': ['0009-9104', '1365-2249'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cei.12465', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5006140704', 'display_name': 'Jeffrey Babad', 'orcid': 'https://orcid.org/0000-0002-2586-1371'}, 'institutions': [{'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J Babad', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA', 'institution_ids': ['https://openalex.org/I129975664']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053705639', 'display_name': 'Gayatri Mukherjee', 'orcid': 'https://orcid.org/0000-0003-3199-7213'}, 'institutions': [{'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'G Mukherjee', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA', 'institution_ids': ['https://openalex.org/I129975664']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069266337', 'display_name': 'Antonia Follenzi', 'orcid': 'https://orcid.org/0000-0001-9780-300X'}, 'institutions': [{'id': 'https://openalex.org/I123338534', 'display_name': 'Università degli Studi del Piemonte Orientale “Amedeo Avogadro”', 'ror': 'https://ror.org/04387x656', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I123338534']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'A Follenzi', 'raw_affiliation_strings': ['Department of Health Sciences, University of Piemonte Orientale ‘A. Avogadro’, Novara, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Health Sciences, University of Piemonte Orientale ‘A. Avogadro’, Novara, Italy', 'institution_ids': ['https://openalex.org/I123338534']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060535758', 'display_name': 'Riyasat Ali', 'orcid': 'https://orcid.org/0000-0003-4022-276X'}, 'institutions': [{'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R Ali', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA', 'institution_ids': ['https://openalex.org/I129975664']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038398583', 'display_name': 'Bart O. Roep', 'orcid': 'https://orcid.org/0000-0002-3110-7391'}, 'institutions': [{'id': 'https://openalex.org/I2800006345', 'display_name': 'Leiden University Medical Center', 'ror': 'https://ror.org/05xvt9f17', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800006345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'B O Roep', 'raw_affiliation_strings': ['Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands', 'institution_ids': ['https://openalex.org/I2800006345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112814700', 'display_name': 'L D Shultz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210115256', 'display_name': 'Jackson Laboratory', 'ror': 'https://ror.org/021sy4w91', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210115256']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'L D Shultz', 'raw_affiliation_strings': ['The Jackson Laboratory, Bar Harbor, ME, USA'], 'affiliations': [{'raw_affiliation_string': 'The Jackson Laboratory, Bar Harbor, ME, USA', 'institution_ids': ['https://openalex.org/I4210115256']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024832913', 'display_name': 'Pere Santamaría', 'orcid': 'https://orcid.org/0000-0003-3469-1586'}, 'institutions': [{'id': 'https://openalex.org/I168635309', 'display_name': 'University of Calgary', 'ror': 'https://ror.org/03yjb2x39', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I168635309']}, {'id': 'https://openalex.org/I4210160192', 'display_name': "Consorci Institut D'Investigacions Biomediques August Pi I Sunyer", 'ror': 'https://ror.org/054vayn55', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210160192', 'https://openalex.org/I4387153040']}], 'countries': ['CA', 'ES'], 'is_corresponding': False, 'raw_author_name': 'P Santamaria', 'raw_affiliation_strings': ['Department of Microbiology, Immunology, and Infectious Diseases, Faculty of Medicine, University of Calgary, Calgary, Canada', "Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain", 'Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary, Calgary, Canada'], 'affiliations': [{'raw_affiliation_string': 'Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary, Calgary, Canada', 'institution_ids': ['https://openalex.org/I168635309']}, {'raw_affiliation_string': 'Department of Microbiology, Immunology, and Infectious Diseases, Faculty of Medicine, University of Calgary, Calgary, Canada', 'institution_ids': ['https://openalex.org/I168635309']}, {'raw_affiliation_string': "Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain", 'institution_ids': ['https://openalex.org/I4210160192']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062526829', 'display_name': 'Otto O. Yang', 'orcid': 'https://orcid.org/0000-0003-1970-8992'}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}, {'id': 'https://openalex.org/I1305519073', 'display_name': 'AIDS Healthcare Foundation', 'ror': 'https://ror.org/05n8mee18', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1305519073']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'O O Yang', 'raw_affiliation_strings': ['AIDS Healthcare Foundation, Los Angeles, CA, USA', 'Department of Microbiology, Immunology, and Molecular Genetics, Geffen School of Medicine, University of California, Los Angeles, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Immunology, and Molecular Genetics, Geffen School of Medicine, University of California, Los Angeles, CA, USA', 'institution_ids': ['https://openalex.org/I161318765', 'https://openalex.org/I161318765']}, {'raw_affiliation_string': 'AIDS Healthcare Foundation, Los Angeles, CA, USA', 'institution_ids': ['https://openalex.org/I1305519073']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089011676', 'display_name': 'Harris Goldstein', 'orcid': 'https://orcid.org/0000-0003-0543-6025'}, 'institutions': [{'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'H Goldstein', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA', 'Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA', 'institution_ids': ['https://openalex.org/I129975664']}, {'raw_affiliation_string': 'Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA', 'institution_ids': ['https://openalex.org/I129975664']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022634163', 'display_name': 'Dale L. Greiner', 'orcid': 'https://orcid.org/0000-0002-5923-339X'}, 'institutions': [{'id': 'https://openalex.org/I166722992', 'display_name': 'University of Massachusetts Chan Medical School', 'ror': 'https://ror.org/0464eyp60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I166722992']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'D L Greiner', 'raw_affiliation_strings': ['Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA', 'institution_ids': ['https://openalex.org/I166722992']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5085145316', 'display_name': 'Teresa P. DiLorenzo', 'orcid': 'https://orcid.org/0000-0003-4337-3598'}, 'institutions': [{'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'T P DiLorenzo', 'raw_affiliation_strings': ['Department of Medicine (Division of Endocrinology), Albert Einstein College of Medicine, Bronx, NY, USA', 'Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA', 'institution_ids': ['https://openalex.org/I129975664']}, {'raw_affiliation_string': 'Department of Medicine (Division of Endocrinology), Albert Einstein College of Medicine, Bronx, NY, USA', 'institution_ids': ['https://openalex.org/I129975664']}]}], 'institution_assertions': [], 'countries_distinct_count': 5, 'institutions_distinct_count': 9, 'corresponding_author_ids': ['https://openalex.org/A5085145316'], 'corresponding_institution_ids': ['https://openalex.org/I129975664'], 'apc_list': {'value': 2650, 'currency': 'GBP', 'value_usd': 3250, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.898, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 22, 'citation_normalized_percentile': {'value': 0.840998, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '179', 'issue': '3', 'first_page': '398', 'last_page': '413'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11491', 'display_name': 'CAR-T cell therapy research', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11491', 'display_name': 'CAR-T cell therapy research', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9929, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11171', 'display_name': 'Diabetes and associated disorders', 'score': 0.9917, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.7715429}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6618663}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.5530501}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.5227259}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.5089233}, {'id': 'https://openalex.org/C167672396', 'wikidata': 'https://www.wikidata.org/wiki/Q417800', 'display_name': 'CD8', 'level': 3, 'score': 0.5063487}, {'id': 'https://openalex.org/C207936829', 'wikidata': 'https://www.wikidata.org/wiki/Q423163', 'display_name': 'Major histocompatibility complex', 'level': 3, 'score': 0.48380154}, {'id': 'https://openalex.org/C67662055', 'wikidata': 'https://www.wikidata.org/wiki/Q1047791', 'display_name': 'Antigen-presenting cell', 'level': 4, 'score': 0.48251057}, {'id': 'https://openalex.org/C19317047', 'wikidata': 'https://www.wikidata.org/wiki/Q412037', 'display_name': 'T-cell receptor', 'level': 4, 'score': 0.47203365}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3292321}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.2615578}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.089606136}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018414', 'descriptor_name': 'CD8-Positive T-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D003922', 'descriptor_name': 'Diabetes Mellitus, Type 1', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D005822', 'descriptor_name': 'Genetic Vectors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D016219', 'descriptor_name': 'Immunotherapy, Adoptive', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D050417', 'descriptor_name': 'Insulin-Secreting Cells', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D016086', 'descriptor_name': 'Lentivirus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D013602', 'descriptor_name': 'T-Lymphocytes, Cytotoxic', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018414', 'descriptor_name': 'CD8-Positive T-Lymphocytes', 'qualifier_ui': 'Q000637', 'qualifier_name': 'transplantation', 'is_major_topic': False}, {'descriptor_ui': 'D018414', 'descriptor_name': 'CD8-Positive T-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003922', 'descriptor_name': 'Diabetes Mellitus, Type 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005822', 'descriptor_name': 'Genetic Vectors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005952', 'descriptor_name': 'Glucose-6-Phosphatase', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D005952', 'descriptor_name': 'Glucose-6-Phosphatase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015789', 'descriptor_name': 'HLA-A2 Antigen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015789', 'descriptor_name': 'HLA-A2 Antigen', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015789', 'descriptor_name': 'HLA-A2 Antigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016219', 'descriptor_name': 'Immunotherapy, Adoptive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050417', 'descriptor_name': 'Insulin-Secreting Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019169', 'descriptor_name': 'Jurkat Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016086', 'descriptor_name': 'Lentivirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016688', 'descriptor_name': 'Mice, Inbred NOD', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011948', 'descriptor_name': 'Receptors, Antigen, T-Cell', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011948', 'descriptor_name': 'Receptors, Antigen, T-Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015375', 'descriptor_name': 'Receptors, Interleukin-2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015375', 'descriptor_name': 'Receptors, Interleukin-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013602', 'descriptor_name': 'T-Lymphocytes, Cytotoxic', 'qualifier_ui': 'Q000637', 'qualifier_name': 'transplantation', 'is_major_topic': False}, {'descriptor_ui': 'D013602', 'descriptor_name': 'T-Lymphocytes, Cytotoxic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/cei.12465', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cei.12465', 'source': {'id': 'https://openalex.org/S11896317', 'display_name': 'Clinical & Experimental Immunology', 'issn_l': '0009-9104', 'issn': ['0009-9104', '1365-2249'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337673', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25302633', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/cei.12465', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cei.12465', 'source': {'id': 'https://openalex.org/S11896317', 'display_name': 'Clinical & Experimental Immunology', 'issn_l': '0009-9104', 'issn': ['0009-9104', '1365-2249'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.83, 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320309446', 'funder_display_name': 'Leona M. and Harry B. Helmsley Charitable Trust', 'award_id': '2012PG-T1D018'}, {'funder': 'https://openalex.org/F4320309829', 'funder_display_name': 'Canadian Diabetes Association', 'award_id': None}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01 DK064315'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'P60 DK020541'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01 AI043203'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01 DA033788'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'U01 DK089572'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01 DK094327'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'P01 AI046629'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'P30 AI051519'}, {'funder': 'https://openalex.org/F4320332606', 'funder_display_name': 'University of Massachusetts Medical School', 'award_id': None}, {'funder': 'https://openalex.org/F4320334506', 'funder_display_name': 'Canadian Institutes of Health Research', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 78, 'referenced_works': ['https://openalex.org/W1514822796', 'https://openalex.org/W1530958543', 'https://openalex.org/W1549484347', 'https://openalex.org/W1567111707', 'https://openalex.org/W1577058011', 'https://openalex.org/W1581592894', 'https://openalex.org/W1601328537', 'https://openalex.org/W1810825740', 'https://openalex.org/W186924384', 'https://openalex.org/W1896681525', 'https://openalex.org/W1964115378', 'https://openalex.org/W1964885806', 'https://openalex.org/W1978670809', 'https://openalex.org/W1979812429', 'https://openalex.org/W1982947765', 'https://openalex.org/W1984817631', 'https://openalex.org/W1987528256', 'https://openalex.org/W1994534621', 'https://openalex.org/W2000734326', 'https://openalex.org/W2006919974', 'https://openalex.org/W2008284182', 'https://openalex.org/W2008927380', 'https://openalex.org/W2014383130', 'https://openalex.org/W2017502093', 'https://openalex.org/W2018027744', 'https://openalex.org/W2020846586', 'https://openalex.org/W2021436834', 'https://openalex.org/W2025835234', 'https://openalex.org/W2031442174', 'https://openalex.org/W2038363431', 'https://openalex.org/W2038566729', 'https://openalex.org/W2044481899', 'https://openalex.org/W2059980572', 'https://openalex.org/W2062451762', 'https://openalex.org/W2066035076', 'https://openalex.org/W2066592806', 'https://openalex.org/W2070530924', 'https://openalex.org/W2071492067', 'https://openalex.org/W2073316548', 'https://openalex.org/W2074545819', 'https://openalex.org/W2081048670', 'https://openalex.org/W2082331163', 'https://openalex.org/W2085213267', 'https://openalex.org/W2094652659', 'https://openalex.org/W2096089121', 'https://openalex.org/W2098822919', 'https://openalex.org/W2100950956', 'https://openalex.org/W2103006735', 'https://openalex.org/W2104259070', 'https://openalex.org/W2106074514', 'https://openalex.org/W2107644576', 'https://openalex.org/W2110776768', 'https://openalex.org/W2111339507', 'https://openalex.org/W2112604002', 'https://openalex.org/W2114306477', 'https://openalex.org/W2115898840', 'https://openalex.org/W2116062123', 'https://openalex.org/W2120766171', 'https://openalex.org/W2128367413', 'https://openalex.org/W2132051812', 'https://openalex.org/W2133518630', 'https://openalex.org/W2135847337', 'https://openalex.org/W2136000231', 'https://openalex.org/W2136553172', 'https://openalex.org/W2145254159', 'https://openalex.org/W2146776232', 'https://openalex.org/W2149569047', 'https://openalex.org/W2149911790', 'https://openalex.org/W2153584840', 'https://openalex.org/W2157384708', 'https://openalex.org/W2159465679', 'https://openalex.org/W2161382076', 'https://openalex.org/W2162577886', 'https://openalex.org/W2164707000', 'https://openalex.org/W2165738704', 'https://openalex.org/W2166582246', 'https://openalex.org/W2278485465', 'https://openalex.org/W4237567990'], 'related_works': ['https://openalex.org/W3032468696', 'https://openalex.org/W2176905394', 'https://openalex.org/W2136036540', 'https://openalex.org/W2113488569', 'https://openalex.org/W2089872551', 'https://openalex.org/W2075125040', 'https://openalex.org/W2038509173', 'https://openalex.org/W2029863221', 'https://openalex.org/W2011835836', 'https://openalex.org/W1973836350'], 'abstract_inverted_index': {'Several': [0], 'β': [1, 57, 128, 186], 'cell': [2, 23, 118, 129], 'antigens': [3], 'recognized': [4, 139], 'by': [5, 79, 103, 193], 'T': [6, 22, 59, 75, 92, 112, 117, 190, 249, 256], 'cells': [7, 60, 76, 93, 113, 191, 217], 'in': [8, 25, 35, 83, 89, 140, 204, 219, 228], 'the': [9, 26, 87, 127, 141, 144, 174, 199, 229, 240, 246], 'non-obese': [10], 'diabetic': [11], '(NOD)': [12], 'mouse': [13, 53], 'model': [14, 54], 'of': [15, 40, 143, 162, 198, 242, 248], 'type': [16], '1': [17], 'diabetes': [18, 34], '(T1D)': [19], 'are': [20], 'also': [21], 'targets': [24], 'human': [27, 49, 56, 110, 145, 188], 'disease.': [28], 'While': [29], 'numerous': [30], 'antigen-specific': [31, 68], 'therapies': [32, 251], 'prevent': [33], 'NOD': [36], 'mice,': [37], 'successful': [38], 'translation': [39], 'rodent': [41], 'findings': [42], 'to': [43, 72, 99, 107, 114, 206, 235], 'patients': [44], 'has': [45], 'been': [46], 'difficult.': [47], 'A': [48], 'leucocyte': [50], 'antigen': [51, 130, 207], '(HLA)-transgenic': [52], 'incorporating': [55], 'cell-specific': [58, 187], 'might': [61], 'provide': [62], 'a': [63, 123, 160], 'better': [64], 'platform': [65], 'for': [66, 122, 178, 245, 252], 'evaluating': [67], 'therapies.': [69], 'The': [70, 154, 185, 216], 'ability': [71], 'study': [73], 'such': [74], 'is': [77], 'limited': [78], 'their': [80], 'low': [81], 'frequency': [82], 'peripheral': [84], 'blood': [85], 'and': [86, 138, 208, 224, 232, 254], 'difficulty': [88], 'obtaining': [90], 'islet-infiltrating': [91], 'from': [94, 126], 'patients.': [95], 'We': [96], 'have': [97], 'worked': [98], 'overcome': [100], 'this': [101, 243], 'limitation': [102], 'using': [104], 'lentiviral': [105, 194], 'transduction': [106, 195], "'reprogram'": [108], 'primary': [109], 'CD8': [111, 189], 'express': [115], 'three': [116], 'receptors': [119], '(TCRs)': [120], 'specific': [121], 'peptide': [124], 'derived': [125], 'islet-specific': [131], 'glucose-6-phosphatase': [132], 'catalytic': [133], 'subunit-related': [134], 'protein': [135], '(IGRP265-273': [136], ')': [137], 'context': [142], 'class': [146], 'I': [147], 'major': [148], 'histocompatibility': [149], 'complex': [150], '(MHC)': [151], 'molecule': [152], 'HLA-A2.': [153], 'TCRs': [155, 200], 'bound': [156, 166], 'peptide/MHC': [157], 'multimers': [158], 'with': [159, 167, 196], 'range': [161], 'avidities,': [163], 'but': [164], 'all': [165], 'at': [168], 'least': [169], '10-fold': [170], 'lower': [171], 'avidity': [172], 'than': [173], 'anti-viral': [175], 'TCR': [176], 'used': [177], 'comparison.': [179], 'One': [180], 'exhibited': [181, 209], 'antigenic': [182], 'recognition': [183], 'promiscuity.': [184], 'generated': [192], 'one': [197], 'released': [201], 'interferon': [202], '(IFN)-γ': [203], 'response': [205], 'cytotoxic': [210], 'activity': [211], 'against': [212], 'peptide-pulsed': [213], 'target': [214], 'cells.': [215], 'engrafted': [218], 'HLA-A2-transgenic': [220], 'NOD-scid': [221], 'IL2rγ(null)': [222], 'mice': [223], 'could': [225], 'be': [226], 'detected': [227], 'blood,': [230], 'spleen': [231], 'pancreas': [233], 'up': [234], '5': [236], 'weeks': [237], 'post-transfer,': [238], 'suggesting': [239], 'utility': [241], 'approach': [244], 'evaluation': [247], 'cell-modulatory': [250], 'T1D': [253], 'other': [255], 'cell-mediated': [257], 'autoimmune': [258], 'diseases.': [259]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1595298938', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2025-01-07T23:51:36.338725', 'created_date': '2016-06-24'}