Publication Information

{'id': 'https://openalex.org/W1593421540', 'doi': 'https://doi.org/10.1016/s0021-9258(19)85987-2', 'title': 'Mechanism of porphobilinogen synthase. Requirement of Zn2+ for enzyme activity.', 'display_name': 'Mechanism of porphobilinogen synthase. Requirement of Zn2+ for enzyme activity.', 'publication_year': 1980, 'publication_date': '1980-03-01', 'ids': {'openalex': 'https://openalex.org/W1593421540', 'doi': 'https://doi.org/10.1016/s0021-9258(19)85987-2', 'mag': '1593421540', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7354072'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(19)85987-2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/s0021-9258(19)85987-2', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5049055647', 'display_name': 'David R. Bevan', 'orcid': 'https://orcid.org/0000-0001-9974-1105'}, 'institutions': [{'id': 'https://openalex.org/I4210146067', 'display_name': 'BioScience Laboratories (United States)', 'ror': 'https://ror.org/03vsr5p38', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210146067']}, {'id': 'https://openalex.org/I111979921', 'display_name': 'Northwestern University', 'ror': 'https://ror.org/000e0be47', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111979921']}, {'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'D.R. Bevan', 'raw_affiliation_strings': [' Present address, Bio Science Laboratories, New Orleans Branch, New Orleans, La. 70112.', 'Department of Biochemistry and Molecular Biology, Northwestern University, Evanston, Illinois 60201', 'Freshwater Biological Institute, University of Minnesota, Navarre, Minn. 55392.', 'Northwestern University.'], 'affiliations': [{'raw_affiliation_string': ' Present address, Bio Science Laboratories, New Orleans Branch, New Orleans, La. 70112.', 'institution_ids': ['https://openalex.org/I4210146067']}, {'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Northwestern University, Evanston, Illinois 60201', 'institution_ids': ['https://openalex.org/I111979921']}, {'raw_affiliation_string': 'Freshwater Biological Institute, University of Minnesota, Navarre, Minn. 55392.', 'institution_ids': ['https://openalex.org/I130238516']}, {'raw_affiliation_string': 'Northwestern University.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081030769', 'display_name': 'Peter Bodlaender', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I111979921', 'display_name': 'Northwestern University', 'ror': 'https://ror.org/000e0be47', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111979921']}, {'id': 'https://openalex.org/I4210146067', 'display_name': 'BioScience Laboratories (United States)', 'ror': 'https://ror.org/03vsr5p38', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210146067']}, {'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'P. Bodlaender', 'raw_affiliation_strings': [' Present address, Bio Science Laboratories, New Orleans Branch, New Orleans, La. 70112.', 'Department of Biochemistry and Molecular Biology, Northwestern University, Evanston, Illinois 60201', 'Freshwater Biological Institute, University of Minnesota, Navarre, Minn. 55392.', 'Northwestern University.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Northwestern University, Evanston, Illinois 60201', 'institution_ids': ['https://openalex.org/I111979921']}, {'raw_affiliation_string': ' Present address, Bio Science Laboratories, New Orleans Branch, New Orleans, La. 70112.', 'institution_ids': ['https://openalex.org/I4210146067']}, {'raw_affiliation_string': 'Freshwater Biological Institute, University of Minnesota, Navarre, Minn. 55392.', 'institution_ids': ['https://openalex.org/I130238516']}, {'raw_affiliation_string': 'Northwestern University.', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5035110674', 'display_name': 'David Shemin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210146067', 'display_name': 'BioScience Laboratories (United States)', 'ror': 'https://ror.org/03vsr5p38', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210146067']}, {'id': 'https://openalex.org/I111979921', 'display_name': 'Northwestern University', 'ror': 'https://ror.org/000e0be47', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111979921']}, {'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'D. Shemin', 'raw_affiliation_strings': [' Present address, Bio Science Laboratories, New Orleans Branch, New Orleans, La. 70112.', 'Department of Biochemistry and Molecular Biology, Northwestern University, Evanston, Illinois 60201', 'Freshwater Biological Institute, University of Minnesota, Navarre, Minn. 55392.', 'Northwestern University.'], 'affiliations': [{'raw_affiliation_string': ' Present address, Bio Science Laboratories, New Orleans Branch, New Orleans, La. 70112.', 'institution_ids': ['https://openalex.org/I4210146067']}, {'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Northwestern University, Evanston, Illinois 60201', 'institution_ids': ['https://openalex.org/I111979921']}, {'raw_affiliation_string': 'Freshwater Biological Institute, University of Minnesota, Navarre, Minn. 55392.', 'institution_ids': ['https://openalex.org/I130238516']}, {'raw_affiliation_string': 'Northwestern University.', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 2.829, 'has_fulltext': False, 'cited_by_count': 122, 'citation_normalized_percentile': {'value': 0.96793, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '255', 'issue': '5', 'first_page': '2030', 'last_page': '2035'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12441', 'display_name': 'Porphyrin Metabolism and Disorders', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12441', 'display_name': 'Porphyrin Metabolism and Disorders', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10499', 'display_name': 'Folate and B Vitamins Research', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12827', 'display_name': 'Biochemical and Molecular Research', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/porphobilinogen', 'display_name': 'Porphobilinogen', 'score': 0.8617274}, {'id': 'https://openalex.org/keywords/porphobilinogen-synthase', 'display_name': 'Porphobilinogen synthase', 'score': 0.73619616}], 'concepts': [{'id': 'https://openalex.org/C2776682811', 'wikidata': 'https://www.wikidata.org/wiki/Q421178', 'display_name': 'Porphobilinogen', 'level': 3, 'score': 0.8617274}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.79420143}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.79039586}, {'id': 'https://openalex.org/C44538786', 'wikidata': 'https://www.wikidata.org/wiki/Q17816567', 'display_name': 'Porphobilinogen synthase', 'level': 4, 'score': 0.73619616}, {'id': 'https://openalex.org/C28212737', 'wikidata': 'https://www.wikidata.org/wiki/Q5381543', 'display_name': 'Enzyme assay', 'level': 3, 'score': 0.63922155}, {'id': 'https://openalex.org/C41183919', 'wikidata': 'https://www.wikidata.org/wiki/Q423026', 'display_name': 'Active site', 'level': 3, 'score': 0.49137107}, {'id': 'https://openalex.org/C199164860', 'wikidata': 'https://www.wikidata.org/wiki/Q6822745', 'display_name': 'Metal ions in aqueous solution', 'level': 3, 'score': 0.48959428}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.48844996}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.4644672}, {'id': 'https://openalex.org/C112243037', 'wikidata': 'https://www.wikidata.org/wiki/Q22327117', 'display_name': 'ATP synthase', 'level': 3, 'score': 0.4190426}, {'id': 'https://openalex.org/C197404232', 'wikidata': 'https://www.wikidata.org/wiki/Q319827', 'display_name': 'Chelation', 'level': 2, 'score': 0.41625154}, {'id': 'https://openalex.org/C544153396', 'wikidata': 'https://www.wikidata.org/wiki/Q11426', 'display_name': 'Metal', 'level': 2, 'score': 0.38336262}, {'id': 'https://openalex.org/C2781374117', 'wikidata': 'https://www.wikidata.org/wiki/Q5252382', 'display_name': 'Dehydratase', 'level': 3, 'score': 0.2881769}, {'id': 'https://openalex.org/C179104552', 'wikidata': 'https://www.wikidata.org/wiki/Q11165', 'display_name': 'Inorganic chemistry', 'level': 1, 'score': 0.11448169}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.089517355}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(19)85987-2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(19)85987-2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.63, 'id': 'https://metadata.un.org/sdg/6', 'display_name': 'Clean water and sanitation'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W122598559', 'https://openalex.org/W1511370992', 'https://openalex.org/W1552473798', 'https://openalex.org/W1554023844', 'https://openalex.org/W1581651912', 'https://openalex.org/W1582222047', 'https://openalex.org/W1603139379', 'https://openalex.org/W1775749144', 'https://openalex.org/W1878915947', 'https://openalex.org/W1973956782', 'https://openalex.org/W1978844031', 'https://openalex.org/W1981163897', 'https://openalex.org/W1983649348', 'https://openalex.org/W1999903569', 'https://openalex.org/W2001360032', 'https://openalex.org/W2002116889', 'https://openalex.org/W2002310840', 'https://openalex.org/W2003077115', 'https://openalex.org/W2015581577', 'https://openalex.org/W2017774801', 'https://openalex.org/W2022781009', 'https://openalex.org/W2024377978', 'https://openalex.org/W2025100393', 'https://openalex.org/W2025559230', 'https://openalex.org/W2050511169', 'https://openalex.org/W2052696170', 'https://openalex.org/W2053613947', 'https://openalex.org/W2054079250', 'https://openalex.org/W2059401358', 'https://openalex.org/W2067213562', 'https://openalex.org/W2072914806', 'https://openalex.org/W2073134219', 'https://openalex.org/W2074364708', 'https://openalex.org/W2165766524', 'https://openalex.org/W2214193846', 'https://openalex.org/W2249210423', 'https://openalex.org/W2346770505', 'https://openalex.org/W2404284841', 'https://openalex.org/W91026939'], 'related_works': ['https://openalex.org/W998537933', 'https://openalex.org/W2414789786', 'https://openalex.org/W2318516048', 'https://openalex.org/W2048139771', 'https://openalex.org/W2034594351', 'https://openalex.org/W2015273843', 'https://openalex.org/W2011841810', 'https://openalex.org/W2000481103', 'https://openalex.org/W1981862881', 'https://openalex.org/W1796692443'], 'abstract_inverted_index': {'The': [0, 46], 'role': [1], 'of': [2, 8, 10, 26, 35, 61, 134, 145, 156, 171, 200, 204], 'metal': [3, 27, 58], 'ions': [4, 28, 174], 'in': [5, 43, 50, 101, 149, 153, 193, 197, 212], 'the': [6, 33, 44, 64, 71, 76, 102, 114, 117, 127, 146, 154, 159, 166, 169, 172, 176, 183, 198, 201, 205, 224, 233], 'mechanism': [7], 'action': [9], 'bovine': [11], 'liver': [12], 'porphobilinogen': [13, 213], 'synthase': [14, 53, 214], 'was': [15, 41, 54, 223], 'investigated.': [16], 'Studies': [17], 'with': [18, 23, 81, 97, 165, 175, 179], 'chelating': [19], 'agents': [20], 'were': [21, 78, 121], 'consistent': [22, 164], 'a': [24, 95, 98, 150], 'requirement': [25], 'for': [29, 210], 'enzyme': [30, 68, 77, 115, 129, 138, 147, 177], 'activity,': [31], 'and': [32, 141], 'use': [34], '8-hydroxyquinoline-5-sulfonic': [36], 'acid': [37], 'suggested': [38], 'that': [39, 92, 108, 126, 168, 188, 221], 'Zn2+': [40, 62, 93, 109, 157, 173, 189, 211], 'present': [42], 'enzyme.': [45, 103, 160, 206], 'low': [47], 'activity': [48, 69, 139, 231], 'detected': [49], 'metal-free': [51], 'apoporphobilinogen': [52], 'attributed': [55], 'to': [56, 63, 113, 158, 232], 'adventitious': [57], 'ions.': [59], 'Addition': [60], 'apoenzyme': [65], 'completely': [66], 'restored': [67, 230], 'if': [70], 'essential': [72, 118], 'sulfhydryl': [73, 82, 99, 180], 'groups': [74, 181], 'on': [75], 'first': [79], 'reduced': [80], 'reagents.': [83], 'It': [84, 186, 217], 'does': [85, 190], 'not': [86, 111, 191], 'follow': [87], 'necessarily': [88], 'from': [89, 136], 'this': [90], 'observation': [91], 'forms': [94], 'bond': [96], 'group': [100], 'However,': [104], 'we': [105], 'also': [106], 'observed': [107], 'did': [110], 'bind': [112], 'unless': [116], 'cysteinyl': [119], 'residues': [120], 'reduced.': [122], 'We': [123], 'have': [124], 'concluded': [125], 'octameric': [128], 'contains': [130], '4': [131], 'g': [132], 'atoms': [133], 'Zn2+/mol': [135], 'our': [137], 'measurements': [140], 'binding': [142, 155, 195], 'studies.': [143], 'Alkylation': [144], 'resulted': [148], 'marked': [151], 'reduction': [152], 'These': [161], 'observations': [162], 'are': [163, 215], 'suggestion': [167], 'interaction': [170], 'occurs': [178], 'at': [182], 'active': [184], 'site.': [185], 'appears': [187], 'participate': [192], 'substrate': [194], 'nor': [196], 'maintenance': [199], 'quaternary': [202], 'structure': [203], 'Possible': [207], 'mechanistic': [208], 'roles': [209], 'discussed.': [216], 'should': [218], 'be': [219], 'noted': [220], 'Cd2+': [222], 'only': [225], 'other': [226], 'element': [227], 'found': [228], 'which': [229], 'apoenzyme.': [234]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1593421540', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2025-01-17T20:22:10.962114', 'created_date': '2016-06-24'}