Title: Altered regulation of the transport of RNA from nucleus to cytoplasm in rat hepatoma cells.
Abstract: Summary RNA base sequences that are restricted to the nucleus in normal rat liver are found in the cytoplasm in azo dye-induced primary hepatomas. Some of these RNA9s are present in the cytoplasm of 19-day fetal liver and of liver regenerating 2.5 hr after 30% hepatectomy. No RNA9s were found to be restricted to the nucleus in the tumor cells, suggesting that the mechanism of selective transport of RNA between nucleus and cytoplasm may be lost during malignant transformation. This migration of RNA out of the tumor cell nucleus is an early effect of the carcinogen, appearing in a significant fraction of the liver cells after the animals were fed a diet containing 0.06% 3′-methyl-4-dimethylaminoazobenzene for only 6 days. Liver cells of rats fed the noncarcinogenic analog aminoazobenzene have nucleus-restricted RNA equivalent to that of normal liver.
Publication Year: 1972
Publication Date: 1972-02-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 77
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