Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1589859980', 'doi': 'https://doi.org/10.1038/39355', 'title': 'Smad6 inhibits signalling by the TGF-β superfamily', 'display_name': 'Smad6 inhibits signalling by the TGF-β superfamily', 'publication_year': 1997, 'publication_date': '1997-10-01', 'ids': {'openalex': 'https://openalex.org/W1589859980', 'doi': 'https://doi.org/10.1038/39355', 'mag': '1589859980', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9335505'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/39355', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137773608', 'display_name': 'Nature', 'issn_l': '0028-0836', 'issn': ['0028-0836', '1476-4687'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101774377', 'display_name': 'Takeshi Imamura', 'orcid': 'https://orcid.org/0000-0001-5101-4304'}, 'institutions': [{'id': 'https://openalex.org/I205924995', 'display_name': 'Japan Society for the Promotion of Science', 'ror': 'https://ror.org/00hhkn466', 'country_code': 'JP', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1319490839', 'https://openalex.org/I205924995']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takeshi Imamura', 'raw_affiliation_strings': ['Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, and Research for the Future Program, Japan Society for the Promotion of Science, Toshima-ku, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, and Research for the Future Program, Japan Society for the Promotion of Science, Toshima-ku, Japan', 'institution_ids': ['https://openalex.org/I205924995']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054084420', 'display_name': 'Masao Takase', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I205924995', 'display_name': 'Japan Society for the Promotion of Science', 'ror': 'https://ror.org/00hhkn466', 'country_code': 'JP', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1319490839', 'https://openalex.org/I205924995']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masao Takase', 'raw_affiliation_strings': ['Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, and Research for the Future Program, Japan Society for the Promotion of Science, Toshima-ku, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, and Research for the Future Program, Japan Society for the Promotion of Science, Toshima-ku, Japan', 'institution_ids': ['https://openalex.org/I205924995']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082793540', 'display_name': 'Ayako Nishihara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I205924995', 'display_name': 'Japan Society for the Promotion of Science', 'ror': 'https://ror.org/00hhkn466', 'country_code': 'JP', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1319490839', 'https://openalex.org/I205924995']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ayako Nishihara', 'raw_affiliation_strings': ['Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, and Research for the Future Program, Japan Society for the Promotion of Science, Toshima-ku, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, and Research for the Future Program, Japan Society for the Promotion of Science, Toshima-ku, Japan', 'institution_ids': ['https://openalex.org/I205924995']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073869325', 'display_name': 'Eiichi Oeda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I205924995', 'display_name': 'Japan Society for the Promotion of Science', 'ror': 'https://ror.org/00hhkn466', 'country_code': 'JP', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1319490839', 'https://openalex.org/I205924995']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Eiichi Oeda', 'raw_affiliation_strings': ['Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, and Research for the Future Program, Japan Society for the Promotion of Science, Toshima-ku, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, and Research for the Future Program, Japan Society for the Promotion of Science, Toshima-ku, Japan', 'institution_ids': ['https://openalex.org/I205924995']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051341882', 'display_name': 'Jun‐ichi Hanai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I205924995', 'display_name': 'Japan Society for the Promotion of Science', 'ror': 'https://ror.org/00hhkn466', 'country_code': 'JP', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1319490839', 'https://openalex.org/I205924995']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Jun-ichi Hanai', 'raw_affiliation_strings': ['Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, and Research for the Future Program, Japan Society for the Promotion of Science, Toshima-ku, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, and Research for the Future Program, Japan Society for the Promotion of Science, Toshima-ku, Japan', 'institution_ids': ['https://openalex.org/I205924995']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090298420', 'display_name': 'Masahiro Kawabata', 'orcid': 'https://orcid.org/0009-0003-3362-3458'}, 'institutions': [{'id': 'https://openalex.org/I205924995', 'display_name': 'Japan Society for the Promotion of Science', 'ror': 'https://ror.org/00hhkn466', 'country_code': 'JP', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1319490839', 'https://openalex.org/I205924995']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masahiro Kawabata', 'raw_affiliation_strings': ['Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, and Research for the Future Program, Japan Society for the Promotion of Science, Toshima-ku, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, and Research for the Future Program, Japan Society for the Promotion of Science, Toshima-ku, Japan', 'institution_ids': ['https://openalex.org/I205924995']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5051009186', 'display_name': 'Kohei Miyazono', 'orcid': 'https://orcid.org/0000-0001-7341-0172'}, 'institutions': [{'id': 'https://openalex.org/I205924995', 'display_name': 'Japan Society for the Promotion of Science', 'ror': 'https://ror.org/00hhkn466', 'country_code': 'JP', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1319490839', 'https://openalex.org/I205924995']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kohei Miyazono', 'raw_affiliation_strings': ['Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, and Research for the Future Program, Japan Society for the Promotion of Science, Toshima-ku, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, and Research for the Future Program, Japan Society for the Promotion of Science, Toshima-ku, Japan', 'institution_ids': ['https://openalex.org/I205924995']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9750, 'currency': 'EUR', 'value_usd': 11690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 24.189, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 1022, 'citation_normalized_percentile': {'value': 0.99997, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '389', 'issue': '6651', 'first_page': '622', 'last_page': '626'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11501', 'display_name': 'Transforming Growth Factor Beta Signaling Pathway', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11501', 'display_name': 'Transforming Growth Factor Beta Signaling Pathway', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11369', 'display_name': 'Molecular Characterization of Colorectal Cancer', 'score': 0.9894, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10231', 'display_name': 'Pancreatic Cancer Research and Treatment', 'score': 0.9685, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bmpr2', 'display_name': 'BMPR2', 'score': 0.5929762}, {'id': 'https://openalex.org/keywords/smad2-protein', 'display_name': 'Smad2 Protein', 'score': 0.5904393}, {'id': 'https://openalex.org/keywords/r-smad', 'display_name': 'R-SMAD', 'score': 0.57512784}, {'id': 'https://openalex.org/keywords/smad-dependent-pathways', 'display_name': 'Smad-dependent pathways', 'score': 0.513683}], 'concepts': [{'id': 'https://openalex.org/C2781080636', 'wikidata': 'https://www.wikidata.org/wiki/Q700000', 'display_name': 'SMAD', 'level': 3, 'score': 0.8986269}, {'id': 'https://openalex.org/C31507581', 'wikidata': 'https://www.wikidata.org/wiki/Q425383', 'display_name': 'Bone morphogenetic protein', 'level': 3, 'score': 0.78615534}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6616498}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.6374254}, {'id': 'https://openalex.org/C73834784', 'wikidata': 'https://www.wikidata.org/wiki/Q17849752', 'display_name': 'BMPR2', 'level': 4, 'score': 0.5929762}, {'id': 'https://openalex.org/C2909521502', 'wikidata': 'https://www.wikidata.org/wiki/Q14903945', 'display_name': 'Smad2 Protein', 'level': 4, 'score': 0.5904393}, {'id': 'https://openalex.org/C73568257', 'wikidata': 'https://www.wikidata.org/wiki/Q7273271', 'display_name': 'R-SMAD', 'level': 5, 'score': 0.57512784}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.5372116}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5120056}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.48738128}, {'id': 'https://openalex.org/C111001777', 'wikidata': 'https://www.wikidata.org/wiki/Q3562192', 'display_name': 'TGF beta signaling pathway', 'level': 3, 'score': 0.43016607}, {'id': 'https://openalex.org/C2778229498', 'wikidata': 'https://www.wikidata.org/wiki/Q24785672', 'display_name': 'Transforming growth factor beta', 'level': 3, 'score': 0.41046062}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34521824}, {'id': 'https://openalex.org/C118131993', 'wikidata': 'https://www.wikidata.org/wiki/Q423671', 'display_name': 'Transforming growth factor', 'level': 2, 'score': 0.29611748}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1688844}, {'id': 'https://openalex.org/C2775960820', 'wikidata': 'https://www.wikidata.org/wiki/Q408378', 'display_name': 'Growth factor', 'level': 3, 'score': 0.092720985}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.07443035}, {'id': 'https://openalex.org/C125555471', 'wikidata': 'https://www.wikidata.org/wiki/Q14908037', 'display_name': 'TGF alpha', 'level': 4, 'score': 0.059361756}], 'mesh': [{'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019556', 'descriptor_name': 'COS Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003001', 'descriptor_name': 'Cloning, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018125', 'descriptor_name': 'Receptors, Transforming Growth Factor beta', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018125', 'descriptor_name': 'Receptors, Transforming Growth Factor beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051899', 'descriptor_name': 'Smad2 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051905', 'descriptor_name': 'Smad6 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/39355', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137773608', 'display_name': 'Nature', 'issn_l': '0028-0836', 'issn': ['0028-0836', '1476-4687'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9335505', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 18, 'referenced_works': ['https://openalex.org/W1964269746', 'https://openalex.org/W1976420978', 'https://openalex.org/W1986407289', 'https://openalex.org/W1988942273', 'https://openalex.org/W1989722096', 'https://openalex.org/W1992468405', 'https://openalex.org/W2019303375', 'https://openalex.org/W2036734848', 'https://openalex.org/W2043423071', 'https://openalex.org/W2052562309', 'https://openalex.org/W2057161685', 'https://openalex.org/W2068207017', 'https://openalex.org/W2082466352', 'https://openalex.org/W2093417867', 'https://openalex.org/W210896705', 'https://openalex.org/W2150073419', 'https://openalex.org/W4211166816', 'https://openalex.org/W4252562012'], 'related_works': ['https://openalex.org/W2128603782', 'https://openalex.org/W2084985493', 'https://openalex.org/W2071788329', 'https://openalex.org/W2052096221', 'https://openalex.org/W2036292706', 'https://openalex.org/W2036018577', 'https://openalex.org/W2022417756', 'https://openalex.org/W2022047268', 'https://openalex.org/W1981191750', 'https://openalex.org/W1840163537'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1589859980', 'counts_by_year': [{'year': 2024, 'cited_by_count': 18}, {'year': 2023, 'cited_by_count': 14}, {'year': 2022, 'cited_by_count': 21}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 20}, {'year': 2019, 'cited_by_count': 19}, {'year': 2018, 'cited_by_count': 21}, {'year': 2017, 'cited_by_count': 18}, {'year': 2016, 'cited_by_count': 25}, {'year': 2015, 'cited_by_count': 20}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 38}, {'year': 2012, 'cited_by_count': 35}], 'updated_date': '2024-09-12T18:49:28.580190', 'created_date': '2016-06-24'}