Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1581747141', 'doi': 'https://doi.org/10.1023/a:1011036428972', 'title': 'HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein.', 'display_name': 'HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein.', 'publication_year': 2001, 'publication_date': '2001-01-01', 'ids': {'openalex': 'https://openalex.org/W1581747141', 'doi': 'https://doi.org/10.1023/a:1011036428972', 'mag': '1581747141', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11474784'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1023/a:1011036428972', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S103865650', 'display_name': 'Pharmaceutical Research', 'issn_l': '0724-8741', 'issn': ['0724-8741', '1573-904X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5037931678', 'display_name': 'Er‐jia Wang', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'E Wang', 'raw_affiliation_strings': ['Drug Metabolism and Pharmacokinetics, Schering-Plough Research Institute, Lafayette, New Jersey 07848, USA.'], 'affiliations': [{'raw_affiliation_string': 'Drug Metabolism and Pharmacokinetics, Schering-Plough Research Institute, Lafayette, New Jersey 07848, USA.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001680116', 'display_name': 'Christopher N. Casciano', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C N Casciano', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009330366', 'display_name': 'Robert P. Clement', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'R P Clement', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5019786358', 'display_name': 'William W. Johnson', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'W W Johnson', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3490, 'currency': 'EUR', 'value_usd': 4590, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 5.305, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 172, 'citation_normalized_percentile': {'value': 0.999901, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '18', 'issue': '6', 'first_page': '800', 'last_page': '806'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10570', 'display_name': 'Mechanisms of Multidrug Resistance in Cancer', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10570', 'display_name': 'Mechanisms of Multidrug Resistance in Cancer', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10375', 'display_name': 'Drug Metabolism and Pharmacogenomics', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10678', 'display_name': 'Cyclooxygenase-2 Inhibitors in Inflammation and Cancer', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lovastatin', 'display_name': 'Lovastatin', 'score': 0.66785824}, {'id': 'https://openalex.org/keywords/fluvastatin', 'display_name': 'Fluvastatin', 'score': 0.57608557}, {'id': 'https://openalex.org/keywords/pitavastatin', 'display_name': 'Pitavastatin', 'score': 0.5727183}, {'id': 'https://openalex.org/keywords/drug-metabolism', 'display_name': 'Drug Metabolism', 'score': 0.515811}, {'id': 'https://openalex.org/keywords/hydroxymethylglutaryl-coa-reductase', 'display_name': 'Hydroxymethylglutaryl-CoA reductase', 'score': 0.4853979}, {'id': 'https://openalex.org/keywords/p-glycoprotein', 'display_name': 'P-glycoprotein', 'score': 0.4631049}, {'id': 'https://openalex.org/keywords/ic50', 'display_name': 'IC50', 'score': 0.41934234}], 'concepts': [{'id': 'https://openalex.org/C2777482532', 'wikidata': 'https://www.wikidata.org/wiki/Q668093', 'display_name': 'Atorvastatin', 'level': 2, 'score': 0.8374895}, {'id': 'https://openalex.org/C2779519902', 'wikidata': 'https://www.wikidata.org/wiki/Q1240093', 'display_name': 'Pravastatin', 'level': 3, 'score': 0.8349571}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.7546165}, {'id': 'https://openalex.org/C2776329913', 'wikidata': 'https://www.wikidata.org/wiki/Q670131', 'display_name': 'Simvastatin', 'level': 2, 'score': 0.72266024}, {'id': 'https://openalex.org/C2780499067', 'wikidata': 'https://www.wikidata.org/wiki/Q415159', 'display_name': 'Rosuvastatin', 'level': 2, 'score': 0.6751518}, {'id': 'https://openalex.org/C104950815', 'wikidata': 'https://www.wikidata.org/wiki/Q415607', 'display_name': 'HMG-CoA reductase', 'level': 4, 'score': 0.6737669}, {'id': 'https://openalex.org/C2780940807', 'wikidata': 'https://www.wikidata.org/wiki/Q417740', 'display_name': 'Lovastatin', 'level': 3, 'score': 0.66785824}, {'id': 'https://openalex.org/C2776839432', 'wikidata': 'https://www.wikidata.org/wiki/Q954845', 'display_name': 'Statin', 'level': 2, 'score': 0.6606568}, {'id': 'https://openalex.org/C109650736', 'wikidata': 'https://www.wikidata.org/wiki/Q424440', 'display_name': 'CYP3A4', 'level': 4, 'score': 0.6342062}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5791066}, {'id': 'https://openalex.org/C2778417548', 'wikidata': 'https://www.wikidata.org/wiki/Q417942', 'display_name': 'Fluvastatin', 'level': 3, 'score': 0.57608557}, {'id': 'https://openalex.org/C2776692505', 'wikidata': 'https://www.wikidata.org/wiki/Q412677', 'display_name': 'Pitavastatin', 'level': 3, 'score': 0.5727183}, {'id': 'https://openalex.org/C134651460', 'wikidata': 'https://www.wikidata.org/wiki/Q3100717', 'display_name': 'Reductase', 'level': 3, 'score': 0.5351912}, {'id': 'https://openalex.org/C97320921', 'wikidata': 'https://www.wikidata.org/wiki/Q718753', 'display_name': 'Drug interaction', 'level': 3, 'score': 0.5333422}, {'id': 'https://openalex.org/C149011108', 'wikidata': 'https://www.wikidata.org/wiki/Q652985', 'display_name': 'Transporter', 'level': 3, 'score': 0.4925345}, {'id': 'https://openalex.org/C2777320049', 'wikidata': 'https://www.wikidata.org/wiki/Q2989497', 'display_name': 'Hydroxymethylglutaryl-CoA reductase', 'level': 5, 'score': 0.4853979}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.47875208}, {'id': 'https://openalex.org/C2778707650', 'wikidata': 'https://www.wikidata.org/wiki/Q412902', 'display_name': 'P-glycoprotein', 'level': 4, 'score': 0.4631049}, {'id': 'https://openalex.org/C2776980637', 'wikidata': 'https://www.wikidata.org/wiki/Q427492', 'display_name': 'Enzyme inhibitor', 'level': 3, 'score': 0.43527105}, {'id': 'https://openalex.org/C2777752497', 'wikidata': 'https://www.wikidata.org/wiki/Q286779', 'display_name': 'IC50', 'level': 3, 'score': 0.41934234}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.35032415}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.30664322}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.30182004}, {'id': 'https://openalex.org/C2778163477', 'wikidata': 'https://www.wikidata.org/wiki/Q43656', 'display_name': 'Cholesterol', 'level': 2, 'score': 0.25857657}, {'id': 'https://openalex.org/C526171541', 'wikidata': 'https://www.wikidata.org/wiki/Q407693', 'display_name': 'Cytochrome P450', 'level': 3, 'score': 0.18539062}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.17245066}, {'id': 'https://openalex.org/C133936738', 'wikidata': 'https://www.wikidata.org/wiki/Q643839', 'display_name': 'Multiple drug resistance', 'level': 3, 'score': 0.064572215}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D020168', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily B, Member 1', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000924', 'descriptor_name': 'Anticholesteremic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D019161', 'descriptor_name': 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D016475', 'descriptor_name': '3T3 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020168', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily B, Member 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020168', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily B, Member 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000924', 'descriptor_name': 'Anticholesteremic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069059', 'descriptor_name': 'Atorvastatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006538', 'descriptor_name': 'Heptanoic Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006538', 'descriptor_name': 'Heptanoic Acids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019161', 'descriptor_name': 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008148', 'descriptor_name': 'Lovastatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008148', 'descriptor_name': 'Lovastatin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017035', 'descriptor_name': 'Pravastatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017035', 'descriptor_name': 'Pravastatin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011758', 'descriptor_name': 'Pyrroles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011758', 'descriptor_name': 'Pyrroles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019821', 'descriptor_name': 'Simvastatin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D019821', 'descriptor_name': 'Simvastatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1023/a:1011036428972', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S103865650', 'display_name': 'Pharmaceutical Research', 'issn_l': '0724-8741', 'issn': ['0724-8741', '1573-904X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11474784', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.52, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W138462898', 'https://openalex.org/W158929996', 'https://openalex.org/W1601678499', 'https://openalex.org/W1649842740', 'https://openalex.org/W1826954337', 'https://openalex.org/W1966512701', 'https://openalex.org/W1968769447', 'https://openalex.org/W1976131092', 'https://openalex.org/W1978530024', 'https://openalex.org/W1989023531', 'https://openalex.org/W1990043592', 'https://openalex.org/W2000790999', 'https://openalex.org/W2008888925', 'https://openalex.org/W2012334764', 'https://openalex.org/W2039956653', 'https://openalex.org/W2057004544', 'https://openalex.org/W2061864878', 'https://openalex.org/W2065734483', 'https://openalex.org/W2068941476', 'https://openalex.org/W2076672515', 'https://openalex.org/W2077732105', 'https://openalex.org/W2078883566', 'https://openalex.org/W2087015670', 'https://openalex.org/W2093105444', 'https://openalex.org/W2102744264', 'https://openalex.org/W2106109834', 'https://openalex.org/W2118234018', 'https://openalex.org/W2158950656', 'https://openalex.org/W2162438271', 'https://openalex.org/W2169050770', 'https://openalex.org/W2171475781', 'https://openalex.org/W2338977280', 'https://openalex.org/W2403066849', 'https://openalex.org/W2411964537', 'https://openalex.org/W2412360598', 'https://openalex.org/W2460926622', 'https://openalex.org/W2464789542', 'https://openalex.org/W2465382919', 'https://openalex.org/W2469439410', 'https://openalex.org/W2615953705', 'https://openalex.org/W2999477698'], 'related_works': ['https://openalex.org/W2606534589', 'https://openalex.org/W2469335792', 'https://openalex.org/W2418153705', 'https://openalex.org/W2415531687', 'https://openalex.org/W2326218968', 'https://openalex.org/W2323501455', 'https://openalex.org/W2063521571', 'https://openalex.org/W2042709174', 'https://openalex.org/W2032022098', 'https://openalex.org/W1987820165'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1581747141', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-09-14T01:34:31.890057', 'created_date': '2016-06-24'}