Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1580117864', 'doi': 'https://doi.org/10.5772/33757', 'title': 'Heme Proteins, Heme Oxygenase-1 and Oxidative Stress', 'display_name': 'Heme Proteins, Heme Oxygenase-1 and Oxidative Stress', 'publication_year': 2012, 'publication_date': '2012-04-25', 'ids': {'openalex': 'https://openalex.org/W1580117864', 'doi': 'https://doi.org/10.5772/33757', 'mag': '1580117864'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.5772/33757', 'pdf_url': 'https://www.intechopen.com/citation-pdf-url/35985', 'source': {'id': 'https://openalex.org/S4306463447', 'display_name': 'InTech eBooks', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'ebook platform'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'book-chapter', 'type_crossref': 'book-chapter', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://www.intechopen.com/citation-pdf-url/35985', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5079580258', 'display_name': 'Hiroshi Morimatsu', 'orcid': 'https://orcid.org/0000-0002-6744-0508'}, 'institutions': [{'id': 'https://openalex.org/I4210100185', 'display_name': 'Okayama University Hospital', 'ror': 'https://ror.org/019tepx80', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210100185']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroshi Morimatsu', 'raw_affiliation_strings': ['Department of Anesthesiology and Resuscitology, Okayama University Hospital, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology and Resuscitology, Okayama University Hospital, Japan', 'institution_ids': ['https://openalex.org/I4210100185']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101799446', 'display_name': 'Toru Takahashi', 'orcid': 'https://orcid.org/0000-0003-2665-3520'}, 'institutions': [{'id': 'https://openalex.org/I4210100185', 'display_name': 'Okayama University Hospital', 'ror': 'https://ror.org/019tepx80', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210100185']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toru Takahashi', 'raw_affiliation_strings': ['Department of Anesthesiology and Resuscitology, Okayama University Hospital, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology and Resuscitology, Okayama University Hospital, Japan', 'institution_ids': ['https://openalex.org/I4210100185']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009787554', 'display_name': 'Hiroko Shimizu', 'orcid': 'https://orcid.org/0000-0002-4318-4036'}, 'institutions': [{'id': 'https://openalex.org/I4210100185', 'display_name': 'Okayama University Hospital', 'ror': 'https://ror.org/019tepx80', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210100185']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroko Shimizu', 'raw_affiliation_strings': ['Department of Anesthesiology and Resuscitology, Okayama University Hospital, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology and Resuscitology, Okayama University Hospital, Japan', 'institution_ids': ['https://openalex.org/I4210100185']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060468241', 'display_name': 'J Matsumi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210100185', 'display_name': 'Okayama University Hospital', 'ror': 'https://ror.org/019tepx80', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210100185']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Junya Matsumi', 'raw_affiliation_strings': ['Department of Anesthesiology and Resuscitology, Okayama University Hospital, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology and Resuscitology, Okayama University Hospital, Japan', 'institution_ids': ['https://openalex.org/I4210100185']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010326688', 'display_name': 'Junko Kosaka', 'orcid': 'https://orcid.org/0000-0001-5090-5316'}, 'institutions': [{'id': 'https://openalex.org/I4210100185', 'display_name': 'Okayama University Hospital', 'ror': 'https://ror.org/019tepx80', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210100185']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Junko Kosaka', 'raw_affiliation_strings': ['Department of Anesthesiology and Resuscitology, Okayama University Hospital, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology and Resuscitology, Okayama University Hospital, Japan', 'institution_ids': ['https://openalex.org/I4210100185']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5037403502', 'display_name': 'Kiyoshi Morit', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210100185', 'display_name': 'Okayama University Hospital', 'ror': 'https://ror.org/019tepx80', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210100185']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kiyoshi Morit', 'raw_affiliation_strings': ['Department of Anesthesiology and Resuscitology, Okayama University Hospital, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology and Resuscitology, Okayama University Hospital, Japan', 'institution_ids': ['https://openalex.org/I4210100185']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.955, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.926357, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 82, 'max': 83}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11848', 'display_name': 'Heme Oxygenase-1 and Carbon Monoxide', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11848', 'display_name': 'Heme Oxygenase-1 and Carbon Monoxide', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12094', 'display_name': 'Hemoglobin structure and function', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12068', 'display_name': 'Neonatal Health and Biochemistry', 'score': 0.9943, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hemeprotein', 'display_name': 'Hemeprotein', 'score': 0.85292894}, {'id': 'https://openalex.org/keywords/hemin', 'display_name': 'Hemin', 'score': 0.5091683}, {'id': 'https://openalex.org/keywords/protoporphyrin-ix', 'display_name': 'Protoporphyrin IX', 'score': 0.4700386}], 'concepts': [{'id': 'https://openalex.org/C2776217839', 'wikidata': 'https://www.wikidata.org/wiki/Q189621', 'display_name': 'Heme', 'level': 3, 'score': 0.9118079}, {'id': 'https://openalex.org/C20705724', 'wikidata': 'https://www.wikidata.org/wiki/Q902628', 'display_name': 'Hemeprotein', 'level': 4, 'score': 0.85292894}, {'id': 'https://openalex.org/C2778063876', 'wikidata': 'https://www.wikidata.org/wiki/Q192642', 'display_name': 'Myoglobin', 'level': 2, 'score': 0.8476675}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.69762397}, {'id': 'https://openalex.org/C2778917026', 'wikidata': 'https://www.wikidata.org/wiki/Q43041', 'display_name': 'Hemoglobin', 'level': 2, 'score': 0.63386214}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.6090787}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.597181}, {'id': 'https://openalex.org/C2777723881', 'wikidata': 'https://www.wikidata.org/wiki/Q107315604', 'display_name': 'Hemin', 'level': 4, 'score': 0.5091683}, {'id': 'https://openalex.org/C197957613', 'wikidata': 'https://www.wikidata.org/wiki/Q407280', 'display_name': 'Cofactor', 'level': 3, 'score': 0.509098}, {'id': 'https://openalex.org/C57600042', 'wikidata': 'https://www.wikidata.org/wiki/Q227564', 'display_name': 'Oxidative phosphorylation', 'level': 2, 'score': 0.503545}, {'id': 'https://openalex.org/C2779219270', 'wikidata': 'https://www.wikidata.org/wiki/Q419972', 'display_name': 'Heme oxygenase', 'level': 4, 'score': 0.4732048}, {'id': 'https://openalex.org/C2779671804', 'wikidata': 'https://www.wikidata.org/wiki/Q619815', 'display_name': 'Protoporphyrin IX', 'level': 3, 'score': 0.4700386}, {'id': 'https://openalex.org/C2775832776', 'wikidata': 'https://www.wikidata.org/wiki/Q65122087', 'display_name': 'Ferrous', 'level': 2, 'score': 0.43853322}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.42782527}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.18592584}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.10139498}, {'id': 'https://openalex.org/C2781323092', 'wikidata': 'https://www.wikidata.org/wiki/Q1428072', 'display_name': 'Photodynamic therapy', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.5772/33757', 'pdf_url': 'https://www.intechopen.com/citation-pdf-url/35985', 'source': {'id': 'https://openalex.org/S4306463447', 'display_name': 'InTech eBooks', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'ebook platform'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.5772/33757', 'pdf_url': 'https://www.intechopen.com/citation-pdf-url/35985', 'source': {'id': 'https://openalex.org/S4306463447', 'display_name': 'InTech eBooks', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'ebook platform'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 71, 'referenced_works': ['https://openalex.org/W1527015104', 'https://openalex.org/W1586487499', 'https://openalex.org/W1591909631', 'https://openalex.org/W1734082729', 'https://openalex.org/W1862027433', 'https://openalex.org/W1922292712', 'https://openalex.org/W1966582616', 'https://openalex.org/W1968791438', 'https://openalex.org/W1969234034', 'https://openalex.org/W1969833190', 'https://openalex.org/W1971631056', 'https://openalex.org/W1973664534', 'https://openalex.org/W1986333802', 'https://openalex.org/W1987637787', 'https://openalex.org/W1987777210', 'https://openalex.org/W1988787425', 'https://openalex.org/W1991659435', 'https://openalex.org/W1996227024', 'https://openalex.org/W1999140237', 'https://openalex.org/W2001019228', 'https://openalex.org/W2001230995', 'https://openalex.org/W2001761805', 'https://openalex.org/W2002072388', 'https://openalex.org/W2006754144', 'https://openalex.org/W2010307719', 'https://openalex.org/W2016603646', 'https://openalex.org/W2022776454', 'https://openalex.org/W202297633', 'https://openalex.org/W2023644648', 'https://openalex.org/W2026458071', 'https://openalex.org/W2027666635', 'https://openalex.org/W2028778467', 'https://openalex.org/W2041553103', 'https://openalex.org/W2057467676', 'https://openalex.org/W2058882776', 'https://openalex.org/W2062013217', 'https://openalex.org/W2066684838', 'https://openalex.org/W2070963340', 'https://openalex.org/W2071307185', 'https://openalex.org/W2073561269', 'https://openalex.org/W2078177166', 'https://openalex.org/W2082942431', 'https://openalex.org/W2084224237', 'https://openalex.org/W2085304303', 'https://openalex.org/W2091593115', 'https://openalex.org/W2092631285', 'https://openalex.org/W2095045934', 'https://openalex.org/W2099367350', 'https://openalex.org/W2102446851', 'https://openalex.org/W2108881007', 'https://openalex.org/W2117960203', 'https://openalex.org/W2123008059', 'https://openalex.org/W2124089349', 'https://openalex.org/W2127798432', 'https://openalex.org/W2129341618', 'https://openalex.org/W2130236290', 'https://openalex.org/W2130660809', 'https://openalex.org/W2131798031', 'https://openalex.org/W2135080743', 'https://openalex.org/W2152627231', 'https://openalex.org/W2153251153', 'https://openalex.org/W2158040122', 'https://openalex.org/W2162356875', 'https://openalex.org/W2165847344', 'https://openalex.org/W2169952241', 'https://openalex.org/W2287545218', 'https://openalex.org/W2317894387', 'https://openalex.org/W3025805620', 'https://openalex.org/W3139744916', 'https://openalex.org/W4252145143', 'https://openalex.org/W77625167'], 'related_works': ['https://openalex.org/W4378217045', 'https://openalex.org/W2515712478', 'https://openalex.org/W2474367489', 'https://openalex.org/W2406106111', 'https://openalex.org/W2362645096', 'https://openalex.org/W2112907618', 'https://openalex.org/W2083785147', 'https://openalex.org/W1987582475', 'https://openalex.org/W1979190686', 'https://openalex.org/W1832224497'], 'abstract_inverted_index': {'IntroductionHeme': [0], 'is': [1, 5, 29, 41, 48, 81, 97, 126, 162, 224, 248], 'ferrous': [2], 'protoporphyrin-IX': [3], 'that': [4, 17, 28, 40], 'the': [6, 54, 79, 100, 104, 113, 151, 208, 225, 289], 'prosthetic': [7, 226], 'group': [8, 227], 'of': [9, 19, 56, 91, 99, 153, 173, 220, 228, 291], 'hemoproteins,': [10, 38], 'such': [11, 186, 232], 'as': [12, 187, 233, 267, 269], 'hemoglobin,': [13, 234], 'myoglobin': [14], 'and': [15, 63, 107, 158, 183, 191, 199, 214, 218, 244, 256, 264, 272, 295], 'cytochromes': [16], 'are': [18], 'vital': [20], 'importance.In': [21], 'contrast,': [22], '"free': [23, 92], 'heme",': [24], 'a': [25, 109, 258], 'protein-unbound': [26, 278], 'heme,': [27, 276, 279], 'either': [30], 'just': [31], 'synthesized': [32], 'but': [33, 134], 'yet': [34], 'not': [35, 129], 'incorporated': [36], 'into': [37], 'or': [39], 'released': [42], 'from': [43, 139], 'hemoprotein': [44], 'under': [45], 'oxidative': [46, 71, 116, 136, 215], 'conditions,': [47], 'highly': [49], 'toxic,': [50], 'since': [51], 'it': [52, 286], 'catalyzes': [53], 'production': [55, 152, 290], 'reactive': [57, 292], 'oxygen': [58, 293], 'species': [59, 294], '(ROS).Thus,': [60], 'heme': [61, 65, 121, 123, 133, 147, 180, 211, 221, 230], 'proteins': [62, 231], 'free': [64, 275], 'have': [66, 177], 'an': [67, 88, 249], 'important': [68, 195], 'relationship': [69, 209], 'with': [70, 76, 83], 'stress.In': [72], 'order': [73], 'to': [74, 145, 165, 206, 283], 'cope': [75], 'this': [77], 'problem,': [78], 'body': [80], 'equipped': [82], 'various': [84], 'defense': [85, 105], 'mechanism(s)': [86], 'against': [87, 112], 'excessive': [89], 'amount': [90], 'heme"': [93], 'concentrations.Heme': [94], 'oxygenase': [95], '(HO)': [96], 'one': [98], 'key': [101], 'players': [102], 'in': [103, 120, 150, 197, 252, 261, 288], 'mechanism,': [106], 'plays': [108, 257], 'fundamental': [110], 'role': [111, 260], 'freeheme': [114], 'mediated': [115], 'process.The': [117], 'rate-limiting': [118], 'enzyme': [119], 'catabolism,': [122], 'oxygenase-1': [124, 142], '(HO-1),': [125], 'induced': [127], 'by': [128, 168], 'only': [130], 'its': [131, 184], 'substrate': [132], 'also': [135], 'stress': [137], 'resulting': [138, 149], 'I/R': [140], 'injury.Heme': [141], 'induction': [143], 'leads': [144], 'increased': [146], 'breakdown,': [148], 'iron,': [154], 'carbon': [155], 'monoxide': [156], '(CO),': [157], 'biliverdin': [159, 169, 189], 'IXα,': [160, 190], 'which': [161], 'subsequently': [163], 'reduced': [164], 'bilirubin': [166, 192], 'IXα': [167, 193], 'reductase.Recently,': [170], 'large': [171], 'numbers': [172], 'reports': [174], 'including': [175], 'ours': [176], 'emerged': [178], 'suggesting': [179], 'proteins,': [181, 212], 'HO,': [182], 'substrates': [185], 'CO,': [188], 'play': [194], 'roles': [196], 'pathophysiology': [198], 'therapeutic': [200], 'implications.Here': [201], 'we': [202], 'summurize': [203], 'these': [204], 'evidences': [205], 'clarify': [207], 'among': [210], 'HO-1,': [213], 'stress.': [216], 'Synthesis': [217], 'degradation': [219], 'protein': [222], '1Heme': [223], 'all': [229, 253], 'myoglobin,': [235], 'cytochrome,': [236], 'catalase,': [237], 'peroxidases,': [238], 'nitric': [239], 'oxide': [240], 'synthase,': [241, 243], 'prostaglandin': [242], 'certain': [245], 'transcription': [246], 'factors.Heme': [247], 'essential': [250], 'molecule': [251], 'aerobic': [254], 'cells': [255, 284], 'crucial': [259], 'physiological,': [262], 'pharmacological,': [263], 'toxicological': [265], 'reactions,': [266], 'well': [268], 'cell': [270], 'differentiation': [271], 'other': [273], 'functions.However,': [274], 'namely': [277], 'can': [280], 'be': [281], 'toxic': [282], 'because': [285], 'results': [287], 'www.intechopen.': [296]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1580117864', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}], 'updated_date': '2024-12-17T14:51:59.636050', 'created_date': '2016-06-24'}