Title: Drug stereochemistry. analytical methods and pharmacology
Abstract: Part 1 Introduction: The early history of stereochemistry - from the discovery of molecular asymmetry and the first resolutionof a racemate by pasteur to the asymmetrical carbon of Van't Hoff and Le Bel, Dennis E. Drayer stereochemical terms and concepts - an overview, Irving W. Wainer and Alice A. Marcotte. Part 2 The separation and preparation of stereochemically pure drugs: enantiomer analysis by competitive binding methods, C. Edgar Cook indirect methods for the chromatographic resolution of drug enantiomers synthesis and separation of diastereomeric derivatives, Joseph Gal the direct resolution of enantiomeric drugs by chiral-phase gas chromatography, Wilfried A. Koenig HPLC chiral stationary phases for the stereochemical resolution of enantiomeric compounds - the current state of the art, Irving W. Wainer synthesis of enantiomerically pure drugs, John W. Scott enzymatic synthesis and resolution of enantiomerically pure compounds, David I. Stirling. Part 3 Pharmacokinetic and pharmacodynamic differences between drug stereoisomers: stereoselective biotransformation toxicological consequences and implications, Nico P.E. Vermeulen and Johan M. te Koppele stereoselective transport of drugs across epithelia, Ronda J. Ott and Kathleen M. Giacomini verapamil - a chiral challenge to the pharmacokinetic and pharmacodynamic assessment of bioavailability and bioequivalence, James A. Longstreth enantioselective binding of drugs to plasma proteins, Terence A.G. Noctor. Part 4 Perspectives on the use of stereochemically pure drugs: FDA perspective on the development of new stereoisomeric drugs - chemistry, manufacturing, and control issues, Wilson H. de Camp stereochemically pure drugs - an overview, Fakhreddin Jamali stereoisomeric drugs in therapeutics - clinical perspectives, Darrell R. Abernathy and Nabil S. Andrawis development of stereoisomeric drugs - an industrial perspective, Mitchell N. Cayen.
Publication Year: 1995
Publication Date: 1995-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 196
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