Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1578765046', 'doi': 'https://doi.org/10.1016/s0074-7696(08)62384-0', 'title': 'Some Characteristics of Neoplastic Cell Transformation in Transgenic Mice', 'display_name': 'Some Characteristics of Neoplastic Cell Transformation in Transgenic Mice', 'publication_year': 1996, 'publication_date': '1996-01-01', 'ids': {'openalex': 'https://openalex.org/W1578765046', 'doi': 'https://doi.org/10.1016/s0074-7696(08)62384-0', 'mag': '1578765046', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8575893'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0074-7696(08)62384-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210191616', 'display_name': 'International review of cytology', 'issn_l': '0074-7696', 'issn': ['0074-7696', '2163-5854'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'book series'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'book-chapter', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020031909', 'display_name': 'I N Shvemberger', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210104940', 'display_name': 'Institute of Cytology', 'ror': 'https://ror.org/01p3q4q56', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I1313323035', 'https://openalex.org/I4210104940', 'https://openalex.org/I4210129690']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Irina N. Shvemberger', 'raw_affiliation_strings': ['Laboratory of Chromosome Stability and Cell Engineering, Institute of Cytology of Russian Academy of Sciences, St. Petersburg, Russia.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Chromosome Stability and Cell Engineering, Institute of Cytology of Russian Academy of Sciences, St. Petersburg, Russia.', 'institution_ids': ['https://openalex.org/I4210104940']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5102949056', 'display_name': 'А.Н. ЕРМИЛОВ', 'orcid': 'https://orcid.org/0000-0003-2046-9917'}, 'institutions': [{'id': 'https://openalex.org/I4210104940', 'display_name': 'Institute of Cytology', 'ror': 'https://ror.org/01p3q4q56', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I1313323035', 'https://openalex.org/I4210104940', 'https://openalex.org/I4210129690']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Alexander N. Ermilov', 'raw_affiliation_strings': ['Laboratory of Chromosome Stability and Cell Engineering, Institute of Cytology of Russian Academy of Sciences, 194064 St. Petersburg, Russia'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Chromosome Stability and Cell Engineering, Institute of Cytology of Russian Academy of Sciences, 194064 St. Petersburg, Russia', 'institution_ids': ['https://openalex.org/I4210104940']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.116444, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 62, 'max': 66}, 'biblio': {'volume': None, 'issue': None, 'first_page': '37', 'last_page': '90'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12929', 'display_name': 'Transgenic Animal Research', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12929', 'display_name': 'Transgenic Animal Research', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10613', 'display_name': 'Gene Therapy Techniques and Applications', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10878', 'display_name': 'Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins', 'score': 0.9952, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neoplastic-transformation', 'display_name': 'Neoplastic transformation', 'score': 0.64502275}, {'id': 'https://openalex.org/keywords/transgene-expression', 'display_name': 'Transgene Expression', 'score': 0.540742}, {'id': 'https://openalex.org/keywords/malignant-transformation', 'display_name': 'Malignant transformation', 'score': 0.4452756}], 'concepts': [{'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.8837421}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.66326374}, {'id': 'https://openalex.org/C204241405', 'wikidata': 'https://www.wikidata.org/wiki/Q461499', 'display_name': 'Transformation (genetics)', 'level': 3, 'score': 0.65461016}, {'id': 'https://openalex.org/C2993273003', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Neoplastic transformation', 'level': 4, 'score': 0.64502275}, {'id': 'https://openalex.org/C141035611', 'wikidata': 'https://www.wikidata.org/wiki/Q5532934', 'display_name': 'Genetically modified mouse', 'level': 4, 'score': 0.6104301}, {'id': 'https://openalex.org/C102230213', 'wikidata': 'https://www.wikidata.org/wiki/Q430117', 'display_name': 'Transgene', 'level': 3, 'score': 0.5748803}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.55767053}, {'id': 'https://openalex.org/C137858568', 'wikidata': 'https://www.wikidata.org/wiki/Q7239', 'display_name': 'Organism', 'level': 2, 'score': 0.49879527}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.45315835}, {'id': 'https://openalex.org/C31033888', 'wikidata': 'https://www.wikidata.org/wiki/Q752076', 'display_name': 'Malignant transformation', 'level': 2, 'score': 0.4452756}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.42635518}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.40030926}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.34440342}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.31935126}], 'mesh': [{'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009857', 'descriptor_name': 'Oncogenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0074-7696(08)62384-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210191616', 'display_name': 'International review of cytology', 'issn_l': '0074-7696', 'issn': ['0074-7696', '2163-5854'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'book series'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8575893', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 196, 'referenced_works': ['https://openalex.org/W1031582328', 'https://openalex.org/W105353919', 'https://openalex.org/W1209009237', 'https://openalex.org/W131646415', 'https://openalex.org/W139001595', 'https://openalex.org/W1439558430', 'https://openalex.org/W1483574195', 'https://openalex.org/W1517525947', 'https://openalex.org/W1522994879', 'https://openalex.org/W1532038504', 'https://openalex.org/W1561293635', 'https://openalex.org/W1563045893', 'https://openalex.org/W1565233301', 'https://openalex.org/W1585381368', 'https://openalex.org/W1589525182', 'https://openalex.org/W1655943345', 'https://openalex.org/W173611128', 'https://openalex.org/W1778381175', 'https://openalex.org/W1803151097', 'https://openalex.org/W1816453354', 'https://openalex.org/W1830988894', 'https://openalex.org/W1850159583', 'https://openalex.org/W1865131886', 'https://openalex.org/W1924015987', 'https://openalex.org/W1951553828', 'https://openalex.org/W1961851796', 'https://openalex.org/W1963534980', 'https://openalex.org/W1964166323', 'https://openalex.org/W1966683022', 'https://openalex.org/W1968075576', 'https://openalex.org/W1968283357', 'https://openalex.org/W1968555245', 'https://openalex.org/W1972356270', 'https://openalex.org/W1972804480', 'https://openalex.org/W1972932855', 'https://openalex.org/W1973862215', 'https://openalex.org/W1977289089', 'https://openalex.org/W1977895957', 'https://openalex.org/W1978084824', 'https://openalex.org/W1978376213', 'https://openalex.org/W1978580469', 'https://openalex.org/W1980561309', 'https://openalex.org/W1981634986', 'https://openalex.org/W1981836564', 'https://openalex.org/W1982093899', 'https://openalex.org/W1982882974', 'https://openalex.org/W1982928787', 'https://openalex.org/W1983572433', 'https://openalex.org/W19851800', 'https://openalex.org/W1985634042', 'https://openalex.org/W1985709940', 'https://openalex.org/W1985856981', 'https://openalex.org/W1986150533', 'https://openalex.org/W1987905586', 'https://openalex.org/W1988365075', 'https://openalex.org/W1989193912', 'https://openalex.org/W1990367849', 'https://openalex.org/W1992183658', 'https://openalex.org/W1993516011', 'https://openalex.org/W1994993938', 'https://openalex.org/W1995545281', 'https://openalex.org/W1998991519', 'https://openalex.org/W1999083651', 'https://openalex.org/W1999682892', 'https://openalex.org/W2000970779', 'https://openalex.org/W2002085824', 'https://openalex.org/W2003785972', 'https://openalex.org/W2005363350', 'https://openalex.org/W2005472812', 'https://openalex.org/W2005755068', 'https://openalex.org/W2006673918', 'https://openalex.org/W2006941348', 'https://openalex.org/W2008693734', 'https://openalex.org/W2008972719', 'https://openalex.org/W2009155017', 'https://openalex.org/W2009629494', 'https://openalex.org/W2014897341', 'https://openalex.org/W2016659849', 'https://openalex.org/W2017094771', 'https://openalex.org/W2017779355', 'https://openalex.org/W2020002174', 'https://openalex.org/W2020022390', 'https://openalex.org/W2022329296', 'https://openalex.org/W2024180247', 'https://openalex.org/W2024747785', 'https://openalex.org/W2024852592', 'https://openalex.org/W2027550076', 'https://openalex.org/W2027873572', 'https://openalex.org/W2028120902', 'https://openalex.org/W2031781918', 'https://openalex.org/W2033618020', 'https://openalex.org/W2034442000', 'https://openalex.org/W2034841844', 'https://openalex.org/W2036042116', 'https://openalex.org/W2037586575', 'https://openalex.org/W2037755687', 'https://openalex.org/W2039050546', 'https://openalex.org/W2040808729', 'https://openalex.org/W2041354540', 'https://openalex.org/W2042721662', 'https://openalex.org/W2049150304', 'https://openalex.org/W2049395473', 'https://openalex.org/W2052014900', 'https://openalex.org/W2052640094', 'https://openalex.org/W2053275898', 'https://openalex.org/W2054778208', 'https://openalex.org/W2056347188', 'https://openalex.org/W2056441922', 'https://openalex.org/W2058704935', 'https://openalex.org/W2063810681', 'https://openalex.org/W2065766428', 'https://openalex.org/W2068901208', 'https://openalex.org/W2069592391', 'https://openalex.org/W2070458593', 'https://openalex.org/W2071607446', 'https://openalex.org/W2072798501', 'https://openalex.org/W2074402178', 'https://openalex.org/W2074736235', 'https://openalex.org/W2076150691', 'https://openalex.org/W2076684492', 'https://openalex.org/W2079160565', 'https://openalex.org/W2079816467', 'https://openalex.org/W2086029972', 'https://openalex.org/W2086969004', 'https://openalex.org/W2087958909', 'https://openalex.org/W2089373281', 'https://openalex.org/W2089723533', 'https://openalex.org/W2090914751', 'https://openalex.org/W2091400806', 'https://openalex.org/W2091898459', 'https://openalex.org/W2098351981', 'https://openalex.org/W2102070943', 'https://openalex.org/W2102957784', 'https://openalex.org/W2103320400', 'https://openalex.org/W2106448791', 'https://openalex.org/W2110722896', 'https://openalex.org/W2112732129', 'https://openalex.org/W2113100827', 'https://openalex.org/W2115073960', 'https://openalex.org/W2117237148', 'https://openalex.org/W2117854673', 'https://openalex.org/W2119318224', 'https://openalex.org/W2132078790', 'https://openalex.org/W2132638279', 'https://openalex.org/W2135025955', 'https://openalex.org/W2136286807', 'https://openalex.org/W2138009608', 'https://openalex.org/W2139397808', 'https://openalex.org/W2140672059', 'https://openalex.org/W2144663706', 'https://openalex.org/W2146298882', 'https://openalex.org/W21482037', 'https://openalex.org/W2157726442', 'https://openalex.org/W2158773962', 'https://openalex.org/W2160399392', 'https://openalex.org/W2160721176', 'https://openalex.org/W2162037462', 'https://openalex.org/W2163463494', 'https://openalex.org/W2169108062', 'https://openalex.org/W2170051465', 'https://openalex.org/W2171759834', 'https://openalex.org/W21751534', 'https://openalex.org/W2177441133', 'https://openalex.org/W2196738014', 'https://openalex.org/W2239075511', 'https://openalex.org/W2275016260', 'https://openalex.org/W2318463652', 'https://openalex.org/W2327401110', 'https://openalex.org/W2396714777', 'https://openalex.org/W2401638348', 'https://openalex.org/W2413516058', 'https://openalex.org/W2416133419', 'https://openalex.org/W2416228609', 'https://openalex.org/W2417039327', 'https://openalex.org/W2418896639', 'https://openalex.org/W2436361950', 'https://openalex.org/W2437030891', 'https://openalex.org/W2437382832', 'https://openalex.org/W2462847194', 'https://openalex.org/W2465981349', 'https://openalex.org/W2467860489', 'https://openalex.org/W2468063275', 'https://openalex.org/W2470503938', 'https://openalex.org/W2474009778', 'https://openalex.org/W2738128030', 'https://openalex.org/W283628008', 'https://openalex.org/W334309946', 'https://openalex.org/W4236681559', 'https://openalex.org/W4248369960', 'https://openalex.org/W4249149547', 'https://openalex.org/W4252180902', 'https://openalex.org/W4253274927', 'https://openalex.org/W4253663860', 'https://openalex.org/W569786247', 'https://openalex.org/W62587231', 'https://openalex.org/W69362276'], 'related_works': ['https://openalex.org/W2413400652', 'https://openalex.org/W2407241705', 'https://openalex.org/W2398991683', 'https://openalex.org/W2158124286', 'https://openalex.org/W2070974215', 'https://openalex.org/W2064668712', 'https://openalex.org/W2057436807', 'https://openalex.org/W2030084515', 'https://openalex.org/W1973459962', 'https://openalex.org/W1536426327'], 'abstract_inverted_index': {'The': [0, 104], 'role': [1, 24], 'of': [2, 5, 25, 50, 59, 68, 87, 119], 'the': [3, 23, 26, 42, 72, 85, 93, 123, 126], 'expression': [4], 'different': [6], 'cellular': [7], 'genes': [8, 27, 36], 'and': [9, 31, 34, 44, 71, 98, 128], 'viral': [10], 'oncogenes': [11], 'in': [12, 37, 53, 75, 91, 101], 'malignant': [13, 120], 'cell': [14], 'transformation': [15, 121], 'is': [16], 'discussed.': [17, 57], 'We': [18, 78], 'pay': [19], 'special': [20], 'attention': [21], 'to': [22, 64, 125], 'for': [28, 115], 'growth': [29], 'factors': [30], 'their': [32], 'receptors': [33], 'homeobox': [35], 'oncogenesis.': [38], 'Based': [39], 'on': [40], 'both': [41], 'literature': [43], 'our': [45], 'own': [46], 'data,': [47], 'specific': [48], 'features': [49], 'tumors': [51], 'developed': [52], 'transgenic': [54, 108], 'mice': [55, 109], 'are': [56, 62, 110], 'All': [58], 'these': [60], 'data': [61], 'used': [63, 90], 'analyze': [65], 'current': [66], 'theories': [67], 'multistep': [69], 'oncogenesis': [70, 88], 'stochastic': [73], 'component': [74], 'this': [76], 'process.': [77], 'suggest': [79], 'that': [80, 107], 'all': [81], 'known': [82], 'evidence': [83], 'about': [84], 'mechanisms': [86], 'be': [89], 'studying': [92, 116], 'problem': [94], 'at': [95], 'various': [96, 117], 'structural': [97], 'functional': [99], 'levels': [100], 'an': [102], 'organism.': [103], 'chapter': [105], 'shows': [106], 'a': [111], 'most': [112], 'suitable': [113], 'model': [114], 'aspects': [118], 'from': [122], 'molecular': [124], 'organismal': [127], 'populational': [129], 'levels.': [130]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1578765046', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-09-08T01:08:48.667352', 'created_date': '2016-06-24'}