A Peripheral Blood Diagnostic Test for Acute Rejection in Renal Transplantation

Name: Work Video:
Duration: 3 min 30 s
Li Li; Purvesh Khatri; Tara K. Sigdel; Tammy Tran; L.-H. Ying; Matthew J. Vitalone; A. Chen; Su Kim; Hong Dai; M. Zhang; Maarten Naesens; Valeriya Zarkhin; Poonam Sansanwal; R. Chen; Michael Mindrinos; Wenzhong Xiao; Mark R. Benfield; Robert B. Ettenger; Vikas R. Dharnidharka; Robert Mathias; Anthony A. Portale; Ruth A. McDonald; W. Harmon; David Kershaw; V. Matti Vehaskari; Elaine S. Kamil; H. Jorge Baluarte; Bradley A. Warady; Ronald W. Davis; Atul J. Butte; Oscar Salvatierra; Minnie Sarwal
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4714, 4896], '(PB)': [8, 206, 789], 'rather': [9, 207], 'than': [10, 208, 433, 2039, 2455, 3389, 4214, 4394, 5617], 'invasive': [11, 176, 209, 374, 1008, 4322, 5080], 'biopsy': [12, 77, 210, 275, 461, 493, 537, 553, 594, 613, 1169, 1324, 1331, 1350, 2414, 2570, 3913, 4338, 4359], 'is': [13, 211, 407, 510, 718, 1089, 1106, 1221, 2090, 3064, 3898, 4353, 4392, 4434, 4498, 4689, 4728, 4810, 5598], 'important': [14, 212, 3899, 4226, 4454], 'as': [15, 213, 631, 633, 926, 1320, 1322, 1454, 1462, 1487, 1934, 2665, 2667, 3295, 3309, 3461, 3562, 3564, 3708, 3834, 3836, 3909, 3916, 3926, 4105, 4184, 4272, 4411, 4597, 4910, 4964, 5047, 5102], 'it': [16, 214, 3109, 3934, 4077, 4412], 'will': [17, 215, 4151, 4623, 5085], 'lessen': [18, 216], 'the': [19, 28, 53, 99, 173, 182, 190, 217, 226, 251, 297, 371, 380, 388, 423, 440, 459, 490, 591, 637, 764, 770, 850, 875, 911, 937, 997, 1007, 1050, 1060, 1086, 1174, 1196, 1315, 1335, 1345, 1366, 1504, 1597, 1684, 1764, 1769, 1804, 1848, 1985, 2005, 2011, 2055, 2058, 2088, 2097, 2135, 2138, 2141, 2411, 2468, 2489, 2498, 2511, 2516, 2561, 2568, 2596, 2603, 2606, 2618, 2629, 2633, 2661, 2771, 2826, 2969, 2973, 3040, 3155, 3221, 3228, 3235, 3278, 3284, 3292, 3341, 3390, 3402, 3443, 3449, 3453, 3456, 3469, 3471, 3473, 3475, 3497, 3504, 3507, 3519, 3530, 3534, 3558, 3595, 3639, 3662, 3666, 3679, 3711, 3733, 3742, 3756, 3761, 3809, 3816, 3829, 3837, 3842, 3919, 3930, 3954, 3980, 3983, 4011, 4020, 4063, 4120, 4148, 4157, 4171, 4187, 4197, 4203, 4206, 4240, 4260, 4276, 4284, 4295, 4300, 4307, 4317, 4348, 4363, 4379, 4384, 4388, 4398, 4407, 4416, 4441, 4444, 4468, 4491, 4543, 4551, 4564, 4569, 4586, 4643, 4653, 4745, 4748, 4772, 4798, 4820, 4844, 4888, 4892, 4905, 5033, 5038, 5056, 5063, 5070, 5078, 5094, 5126, 5135, 5139, 5142, 5156, 5159, 5168, 5178, 5199, 5216, 5219, 5250, 5254, 5267, 5294, 5302, 5319, 5331, 5352, 5360, 5363, 5400, 5416, 5436, 5454, 5537, 5561, 5576, 5602, 5612, 5624, 5628], 'risk': [20, 218, 2662, 3463, 3559, 4527, 5051, 5075], 'infection': [22, 220, 1541, 4685], 'and': [23, 45, 48, 91, 115, 134, 149, 152, 162, 221, 243, 246, 289, 313, 332, 347, 350, 360, 398, 414, 451, 475, 504, 595, 687, 691, 772, 828, 836, 913, 946, 965, 1002, 1019, 1044, 1046, 1108, 1153, 1189, 1193, 1223, 1280, 1418, 1474, 1606, 1698, 1909, 1956, 1961, 1987, 2095, 2133, 2152, 2171, 2280, 2352, 2463, 2504, 2537, 2560, 2579, 2681, 2746, 2793, 2797, 2828, 2895, 2921, 2966, 3034, 3052, 3123, 3139, 3192, 3197, 3246, 3256, 3312, 3322, 3335, 3578, 3624, 3685, 3726, 3748, 3782, 3802, 3823, 3831, 3839, 3859, 3872, 3877, 3889, 3975, 4036, 4047, 4074, 4099, 4109, 4117, 4130, 4193, 4311, 4341, 4421, 4463, 4567, 4683, 4759, 4763, 4803, 4824, 4847, 4899, 4934, 4962, 5017, 5101, 5153, 5174, 5241, 5265, 5277, 5301, 5324, 5340, 5349, 5385, 5396, 5412, 5446, 5466, 5474, 5476, 5493, 5499, 5501, 5506, 5515, 5524, 5528, 5563, 5570, 5587], 'other': [24, 93, 156, 222, 291, 354, 432, 634, 971, 1476, 1543, 2581, 3804, 3886, 4741, 5059], 'stresses,': [25, 223], 'while': [26, 224, 3633], 'reducing': [27, 225, 590], 'costs': [29, 227], 'rejection': [31, 87, 229, 285, 405, 656, 717, 800, 827, 893, 2979, 3686, 3911, 4251, 4361, 4364, 4380, 4420, 4833, 4873, 5160, 5231], 'diagnosis.': [32, 230, 1329], 'Blood': [33, 231, 1551, 1558], 'gene': [34, 232, 806, 832, 1666, 1678, 1749, 1877, 1963, 1982, 2019, 2823, 3460, 3479, 4002, 4523, 4889], 'biomarker': [35, 233, 889], 'panels': [36, 234], 'were': [37, 83, 235, 281, 960, 1025, 1037, 1076, 1179, 1318, 1356, 1452, 1485, 1575, 1778, 1842, 1900, 2015, 2076, 2507, 2534, 2565, 2621, 2688, 2913, 2922, 2935, 3117, 3161, 3200, 3306, 3522, 3613, 3753, 3779, 3914, 4189, 4264, 4270, 5573, 5590], 'discovered': [38, 236], 'by': [39, 50, 103, 237, 248, 301, 497, 551, 658, 720, 831, 1150, 1334, 1359, 1665, 1732, 2104, 2109, 2119, 2129, 3814, 3918, 3968, 4039, 4347, 4563, 4768, 4988, 5077, 5134, 5429, 5611], 'microarrays': [40, 238, 1790, 1801, 2105], 'at': [41, 239, 1184, 1195, 1865, 1874, 2410, 2467, 2510, 2592, 2595, 2776, 3493, 3496, 3755, 4089, 5298], 'a': [42, 75, 108, 185, 240, 273, 306, 383, 455, 511, 575, 597, 863, 871, 930, 984, 1003, 1165, 1286, 1326, 1360, 1424, 1514, 1588, 1601, 1832, 1894, 1935, 2024, 2032, 2305, 2316, 2377, 2391, 2540, 2668, 2674, 2788, 3296, 3372, 3377, 3384, 3462, 3565, 3571, 3694, 3785, 3972, 3988, 3996, 4029, 4069, 4127, 4210, 4328, 4350, 4358, 4375, 4395, 4403, 4473, 4502, 4509, 4520, 4609, 4640, 4660, 4713, 4729, 4816, 4911, 5042, 5099, 5111, 5115, 5271], 'single': [43, 241, 1361, 2634, 4128], 'center': [44, 242, 1336, 2635], 'subsequently': [46, 244], 'validated': [47, 135, 245, 333, 2389, 3692, 4038, 4079, 4132], 'cross-validated': [49, 247], 'QPCR': [51, 249, 2110, 2130, 2908], 'in': [52, 250, 418, 621, 636, 652, 689, 776, 801, 870, 894, 956, 975, 1029, 1067, 1092, 1110, 1159, 1225, 1285, 1292, 1349, 1381, 1404, 1423, 1430, 1554, 1564, 1941, 2009, 2023, 2031, 2062, 2092, 2124, 2140, 2157, 2315, 2390, 2497, 2632, 2790, 2844, 2916, 2931, 2978, 3039, 3072, 3096, 3151, 3163, 3202, 3224, 3283, 3330, 3344, 3406, 3480, 3533, 3591, 3669, 3681, 3693, 3704, 3741, 3841, 3929, 3953, 3962, 4004, 4034, 4080, 4094, 4133, 4143, 4170, 4175, 4196, 4217, 4275, 4316, 4397, 4415, 4436, 4568, 4585, 4767, 4771, 4819, 4831, 4843, 4874, 4895, 4913, 4967, 5037, 5055, 5062, 5125, 5141, 5151, 5191, 5202, 5232, 5237, 5242, 5258, 5275, 5282, 5330, 5415, 5440, 5458, 5480, 5513, 5536, 5560], 'NIH': [54, 252, 5303, 5430], 'SNSO1': [55, 253, 2297, 2369, 2490, 3712, 3734, 4164, 4277, 5143, 5332, 5353], 'randomized': [56, 254, 1118, 1233, 1287, 1425, 5306], 'study': [57, 187, 255, 385, 1053, 1088, 1147, 1161, 1205, 1264, 2089, 2144, 3713, 4507, 5040, 5148, 5204, 5260, 5307, 5334], 'from': [58, 144, 154, 256, 342, 352, 874, 943, 950, 970, 1015, 1039, 1049, 1054, 1085, 1173, 1181, 1314, 2073, 2285, 2294, 2304, 2357, 2366, 2376, 2398, 2458, 3622, 3865, 3884, 3906, 4019, 4126, 4159, 4231, 4450, 4628, 4722, 4828, 5327, 5343, 5374, 5390, 5423, 5469, 5487, 5497, 5504, 5522, 5526], '12': [59, 257, 1055, 1188, 3705, 3795, 4090], 'US': [60, 258, 1056], 'pediatric': [61, 259, 1018, 1293, 1431, 5200], 'transplant': [62, 260, 420, 587, 826, 977, 1023, 1057, 4092, 5112, 5285, 5328], 'programs.': [63, 261], 'A': [64, 122, 262, 320, 539, 1115, 1230, 1479, 1629, 2018, 2084, 3399, 3419, 4023, 4839], 'total': [65, 263, 2705], '367': [67, 265, 1012], 'unique': [68, 266, 1017, 2287, 2296, 2359, 2368], 'human': [69, 267, 1988, 2829, 3073], 'PB': [70, 268, 941, 957, 1013, 1157, 2163, 2508, 3670, 3751, 3973, 4005, 4035, 4474, 4666, 5557], 'samples,': [71, 269, 3833, 4076], 'each': [72, 270, 1323, 1339, 1721, 2063, 2275, 2347, 2627, 2657, 3339, 3447, 3528, 3554], 'paired': [73, 271, 1163], 'with': [74, 119, 146, 159, 272, 317, 344, 357, 523, 628, 888, 945, 962, 1112, 1121, 1164, 1227, 1236, 1768, 1831, 2450, 2473, 2544, 2623, 2660, 2925, 3066, 3216, 3376, 3427, 3524, 3557, 3594, 3616, 3638, 3674, 3723, 3789, 4010, 4044, 4096, 4367, 4508, 4649, 4671, 4677, 4692, 4897, 5207, 5212, 5321, 5548, 5579], 'for': [78, 175, 276, 373, 463, 578, 584, 593, 640, 891, 917, 996, 1042, 1078, 1261, 1338, 1507, 1567, 1578, 1604, 1782, 1825, 1844, 1937, 1959, 2078, 2102, 2149, 2165, 2274, 2310, 2346, 2382, 2611, 2656, 2673, 2907, 3113, 3234, 3272, 3424, 3465, 3512, 3553, 3570, 3648, 3654, 3979, 4057, 4068, 4283, 4339, 4360, 4378, 4406, 4426, 4447, 4455, 4458, 4483, 4486, 4501, 4515, 4545, 4553, 4593, 4614, 4735, 5052, 5110, 5226, 5345, 5359, 5377, 5393, 5424, 5555, 5568, 5601, 5627], 'centralized,': [79, 277, 5379], 'blinded': [80, 278, 5380], 'phenotype': [81, 279, 2485, 3729, 3952], 'classification,': [82, 280, 4737], 'analyzed': [84, 282], '(115': [85, 283], 'acute': [86, 284, 402, 653, 2254, 2326, 4110, 4246, 4250, 4850, 4870], '(AR),': [88, 286], '180': [89, 287], 'stable': [90, 288, 2474, 4160], '72': [92, 290], 'causes': [94, 292, 4639], 'injury).': [97, 295], 'Of': [98, 296], 'differentially': [100, 298, 1822, 2012, 2760, 2914, 3119], 'expressed': [101, 299, 1823, 2013, 2022, 2060, 2761, 2915, 3120, 4766], 'genes': [102, 300, 623, 887, 989, 1728, 1824, 2014, 2061, 2631, 2762, 2786, 2906, 2934, 3116, 3134, 3160, 3199, 3232, 3280, 3289, 3343, 3532, 3587, 3612, 4033, 4479, 4667, 4734, 4753, 4792, 4814, 4894], 'microarray,': [104, 302], 'Q-PCR': [105, 303, 1845, 2624, 3525, 3969, 5564], 'analysis': [106, 304, 1788, 1799, 3970], 'five': [109, 307, 3133, 3288, 3342], 'gene-set': [110, 308, 1603, 3445, 4446], '(DUSP1,': [111, 309], 'PBEF1,': [112, 310, 2948, 3180, 3334], 'PSEN1,': [113, 311, 2941, 3184], 'MAPK9': [114, 312], 'NKTR)': [116, 314], 'classified': [117, 315, 3908, 3915, 3925], 'AR': [118, 143, 153, 170, 316, 341, 351, 368, 434, 443, 464, 534, 855, 949, 969, 1001, 1473, 1826, 2115, 2252, 2324, 2416, 2525, 2664, 3122, 3164, 3203, 3481, 3561, 3617, 3673, 3770, 3830, 3838, 3864, 3882, 3917, 3951, 3956, 3963, 4013, 4073, 4116, 4169, 4198, 4235, 4273, 4288, 4297, 4310, 4314, 4325, 4513, 4522, 4531, 4549, 4572, 4617, 4633, 4654, 4736], 'high': [120, 318, 3675, 3947, 4385, 5048], 'accuracy.': [121, 319], 'logistic': [123, 321, 2116, 2654, 2670, 3214, 3273, 3373, 3407, 3425, 3548, 3567, 3607, 4024], 'regression': [124, 322, 2117, 2655, 2671, 3215, 3274, 3374, 3426, 3450, 3549, 3568, 3608, 4025], 'model': [125, 323, 2118, 2139, 2387, 2672, 3297, 3313, 3375, 3569, 3690, 3811, 3849, 3921, 4026, 4121, 4242, 4302, 4470, 4544, 4696, 4716, 5221], 'was': [126, 324, 990, 1148, 1162, 1332, 1470, 1552, 1585, 1594, 1891, 2020, 2037, 2066, 2388, 2482, 2494, 2518, 3110, 3357, 3368, 3383, 3550, 3635, 3691, 3738, 3763, 3812, 4066, 4078, 4122, 4131, 4303, 5149, 5427], 'built': [127, 325, 3276, 4027, 4123], 'on': [128, 136, 326, 334, 447, 535, 610, 1289, 1427, 1581, 1683, 1827, 1847, 2567, 2617, 2637, 2972, 3518, 3828, 3912, 4028, 4052, 4337, 4383, 4387, 4477, 4930, 5351], 'independent': [129, 137, 327, 335, 1079, 2126, 2393, 3346, 3696, 4082, 4135], 'training-set': [130, 328], '(n': [131, 139, 329, 337, 1489, 1510, 1548, 2168, 2174, 2182, 2185, 2188, 2191, 2194, 2197, 2417, 4266, 4290], '=': [132, 140, 330, 338, 1459, 1466, 1490, 1511, 1528, 1537, 1549, 2169, 2175, 2183, 2186, 2189, 2192, 2195, 2198, 2253, 2257, 2260, 2264, 2267, 2325, 2329, 2332, 2336, 2339, 2418, 2479, 2548, 2854, 2861, 2868, 2875, 2881, 2887, 2893, 2901, 3167, 3170, 3174, 3178, 3182, 3186, 3190, 3195, 3206, 3210, 3631, 3646, 3652, 3793, 4267, 4291], '47)': [133, 331], 'test-set': [138, 336], '198)samples,': [141, 339], 'discriminating': [142, 340, 4448, 4456], 'STA': [145, 343, 2256, 2328, 3124, 3832, 3866, 4075], '91%': [147, 160, 345, 358, 3851, 3873, 4045], 'sensitivity': [148, 161, 346, 359, 912, 4046], '94%': [150, 348, 3853], 'specificity': [151, 349, 914, 1647, 1697], 'all': [155, 353, 1182, 1354, 1828, 2046, 2677, 2812, 2917, 3574, 3585, 3610, 3885, 5235, 5556], 'non-AR': [157, 355, 3840], 'phenotypes': [158, 356, 3887], '90%': [163, 361, 3875, 3878, 4048], 'specificity.': [164, 362], 'The': [165, 363, 396, 472, 979, 1146, 1449, 1885, 2071, 2271, 2299, 2343, 2371, 2385, 2402, 2686, 3688, 3716, 3806, 3847, 3946, 4163, 4460, 4537, 4602, 4665, 4751, 4885, 5122, 5246, 5366], '5-gene': [166, 364, 2386, 2607, 3508, 3667, 3689, 3810, 3848, 3920, 4064, 4241, 4301, 4389, 4469, 4565, 4603, 4644, 5034, 5256], 'set': [167, 365, 987, 1735, 1766, 2128, 2301, 2373, 2404, 2492, 2608, 3348, 3509, 3536, 3668, 3718, 3736, 4003, 4030, 4308, 4731, 5128], 'can': [168, 366, 3671, 3935, 4243, 4558, 4718], 'diagnose': [169, 367, 742, 3672, 5230], 'potentially': [171, 369, 4560], 'avoiding': [172, 370], 'need': [174, 372, 592], 'biopsy.': [178, 376, 457, 1010], 'These': [179, 377, 2506, 2785, 2933, 3657, 3750], 'data': [180, 378, 1084, 1403, 1751, 2636, 2919, 3367, 3658, 4710], 'support': [181, 379, 5266, 5320, 5348, 5361, 5395], 'conduct': [183, 381], 'prospective': [186, 384, 1052, 1116, 1231, 5272], 'to': [188, 386, 409, 436, 530, 741, 763, 786, 854, 862, 866, 909, 935, 967, 992, 1006, 1365, 1595, 1607, 1626, 1762, 1780, 1803, 1820, 1902, 1924, 2003, 2052, 2778, 3148, 3220, 3226, 3370, 3401, 3862, 3880, 3900, 3994, 4161, 4221, 4227, 4237, 4253, 4280, 4305, 4355, 4439, 4517, 4579, 4612, 4625, 4634, 4663, 4711, 4740, 4756, 4779, 4984, 5015, 5044, 5166, 5229, 5287, 5318, 5370, 5386, 5398, 5407, 5623], 'validate': [189, 387], 'clinical': [191, 389, 1083, 1204, 1341, 2143, 2153, 2451, 2557, 2588, 2615, 2658, 2679, 3489, 3516, 3555, 3576, 4102, 4115, 4234, 4351, 4376, 5263, 5273, 5289], 'predictive': [192, 390, 3820, 3825, 4465, 4540], 'utility': [193, 391, 995, 5264], 'this': [195, 393, 1033, 1160, 2551, 4141, 4177, 4495, 4727, 5083, 5147, 5203, 5259, 5280, 5420, 5425, 5541], 'diagnostic': [196, 394, 460, 851, 1004, 5251], 'tool.': [197, 395], 'accurate': [397, 4183], 'timely': [399], 'diagnosis': [400, 426, 441, 477, 491, 639, 999, 1515, 2517, 3762, 4323, 4340, 4418], 'allograft': [404, 438, 479, 508, 612, 641, 655, 716, 743, 803, 876, 892, 1168, 1283, 1421, 1518, 2434, 3041, 3075, 4851, 4932], '(AR)': [406], 'necessary': [408, 3233], 'optimize': [410], 'immunosuppressive': [411, 5244], 'drug': [412], 'management': [413, 603, 4408, 5090], 'preserve': [415], 'function': [417, 527, 2476, 4848], 'kidney': [419, 456, 976, 1022, 1294, 1432, 4871], 'recipients.': [421], 'Unfortunately,': [422], 'methods': [424, 3394, 3423], 'remain': [427], 'imperfect.': [428], 'Since': [429], 'many': [430, 622, 2554], 'conditions': [431, 635, 973, 1862, 4155], 'lead': [435], 'dysfunction,': [439, 4590], 'cannot': [444], 'be': [445, 582, 3149, 3936, 3943, 3966, 4225, 4327, 4402, 4481, 4559, 4577, 4591, 4626, 5067, 5120, 5162, 5223, 5534, 5621], 'made': [446], 'functional': [448], 'grounds': [449], 'alone': [450], 'requires': [452], 'confirmation': [453], 'using': [454, 492, 805, 1364, 1587, 1876, 1893, 1904, 2081, 2646, 3277, 3287, 3298, 3544, 4124, 5575, 5592], 'Although,': [458], 'criteria': [462, 1506, 3305], 'have': [465, 531, 615, 783, 856, 2601, 2773, 3144, 3291, 3502, 3923, 4180, 4574, 4624], 'been': [466, 784, 857, 2774, 3146, 3924, 4181], 'codified': [467, 2535, 3780], 'over': [468, 2045, 4331], 'time': [469, 2412, 2469, 2512, 2597, 3498, 3757, 4349, 5572], '(1Racusen': [470], 'LC': [471, 2421], 'Banff': [473, 1367, 1498, 1505, 2428, 2523, 3649, 3768, 4261], 'schema': [474], 'differential': [476, 638, 1687], 'dysfunction.Transpl': [480], 'Proc.': [481], '2004;': [482, 842, 1995, 2836, 4877], '36:': [483], '753-754Crossref': [484], 'PubMed': [485, 569, 668, 701, 728, 752, 814, 845, 902, 1306, 1394, 1444, 1642, 1672, 1711, 1757, 1815, 1970, 1998, 2445, 2839, 3016, 3047, 3081, 3104, 3413, 3437, 4857, 4880, 4957, 4994, 5025], 'Scopus': [486, 570, 669, 702, 729, 753, 815, 846, 903, 1142, 1257, 1307, 1395, 1445, 1643, 1673, 1712, 1758, 1816, 1971, 1999, 2446, 2840, 3017, 3048, 3082, 3105, 3266, 3414, 3438, 4858, 4881, 4958, 4995, 5026], '(20)': [487], 'Google': [488, 572, 671, 704, 731, 755, 817, 848, 905, 1144, 1259, 1309, 1397, 1447, 1645, 1675, 1714, 1760, 1818, 1973, 2001, 2448, 2842, 3019, 3050, 3084, 3107, 3268, 3416, 3440, 4860, 4883, 4940, 4960, 4997, 5028], 'Scholar),': [489, 849, 1646, 1676, 1715, 3108], 'process': [494, 2500, 3744, 4213], 'remains': [495], 'limited': [496], 'sampling': [498, 2599, 3500], 'error,': [499], 'assessment': [500, 4658, 5073], 'variability,': [501], 'procedural': [502], 'morbidity': [503], 'cost.': [505], 'Additionally,': [506, 2649, 5196], 'dysfunction': [509, 642, 1201, 2453, 2559, 4969], 'relatively': [512, 918], 'insensitive': [513], 'means': [514, 577, 600, 2249, 2321, 4611, 5043], 'detecting': [516], 'early': [517, 4424], 'AR;': [518], 'approximately': [519], '10%': [520, 2456], 'patients': [522, 627, 944, 1036, 1048, 1183, 3907, 4095, 4232, 4485, 4514, 4557, 4629, 5046, 5201, 5233, 5297, 5329], 'clinically': [524, 4256, 4453], 'normal': [525, 690, 2529, 3774], 'are': [528, 761, 1730, 2155, 2248, 2277, 2320, 2349, 2806, 4706, 4754, 4764, 5129, 5132, 5316, 5368, 5405], 'found': [529, 5535], 'evidence': [532, 684, 1496], 'surveillance': [536, 585], '(2Thierry': [538], 'Thervet': [540], 'E': [541, 1633], 'Vuiblet': [542], 'V': [543, 1101, 1216, 2983, 4841, 4864], 'et': [544, 649, 712, 796, 824, 883, 1094, 1102, 1209, 1217, 1268, 1277, 1374, 1406, 1415, 1656, 1952, 1980, 2426, 2821, 3026, 3060, 5004], 'al.Long-term': [545], 'impact': [546], 'subclinical': [548, 4245, 4312], 'inflammation': [549, 688, 1279, 1417], 'diagnosed': [550, 4042], 'protocol': [552, 2471, 4582], 'one': [554, 695, 2520, 2527, 3765, 3772], 'year': [555, 696, 1123, 1238], 'after': [556, 4618], 'transplantation.Am': [558, 1295, 1433], 'J': [559, 663, 723, 745, 809, 840, 1126, 1241, 1296, 1384, 1434, 1951, 2985, 3006, 3259, 4950, 5020], 'Transplant.': [560], '2011;': [561], '11:': [562], '2153-2161Abstract': [563], 'Full': [564, 566, 1137, 1139, 1252, 1254, 1301, 1303, 1389, 1391, 1439, 1441, 2440, 2442, 3011, 3013], 'Text': [565, 567, 1138, 1140, 1253, 1255, 1302, 1304, 1390, 1392, 1440, 1442, 2441, 2443, 3012, 3014], 'PDF': [568, 1141, 1256, 1305, 1393, 1443, 2444, 3015], '(49)': [571], 'Scholar).': [573, 756, 906, 1145, 3269, 3441, 5029], 'Ideally,': [574], 'less-invasive': [576], 'diagnosing': [579, 3466, 4059, 4546], 'AR,': [580, 630, 964, 1500, 1605, 2574, 2612, 3354, 3467, 3513, 3541, 3724, 3797, 4114, 4192, 4698], 'could': [581, 2600, 3501, 3941, 4480, 5189], 'used': [583, 966, 991, 1577, 1738, 1843, 1919, 1944, 2049, 2101, 2309, 2381, 2496, 3307, 3369, 3740, 3987, 4304], 'recipients,': [588], 'thereby': [589], 'providing': [596, 5098], 'more': [598, 3301, 3385, 4504, 4529, 5071, 5087, 5163, 5402], 'efficient': [599], 'immune': [602, 2929, 4218, 5193], 'injury.': [606], 'Transcriptional': [607], 'profiling': [608, 833, 3992], 'studies': [609, 782], 'specimens': [614], 'demonstrated': [616], 'substantial,': [617], 'coordinated': [618, 3663], 'expression': [619, 807, 1667, 1750, 1776, 1878, 1890, 2030, 2044, 2625, 2684, 3526, 3581, 3592, 3664, 4007], 'changes': [620, 760, 775, 852, 982, 4219], 'that': [624, 1729, 2493, 2912, 3282, 3459, 3478, 3661, 3737, 3902, 3938, 3959, 4084, 4248, 4293, 4335, 4391, 4472, 4717, 4812, 5069], 'uniquely': [625], 'identify': [626, 1821, 1925, 2004, 3995], 'established': [629], 'well': [632, 2666, 3563, 3835, 4009], '(3Sarwal': [643], 'M': [644, 676, 882, 1097, 1212, 1271, 1276, 1369, 1373, 1409, 1414, 1623, 3059, 3398, 5003], 'Chua': [645], 'MS': [646], 'Kambham': [647, 5373], 'N': [648, 1621, 4974], 'al.Molecular': [650], 'heterogeneity': [651], 'identified': [657, 1664, 2758, 3967], 'DNA': [659, 1624, 1704], 'microarray': [660, 953, 1579, 2166, 2918, 5562], 'profiling.N': [661], 'Engl': [662], 'Med.': [664, 3043, 3100, 3409, 3433], '2003;': [665], '349:': [666], '125-138Crossref': [667], '(629)': [670], 'Scholar,': [672, 705, 732], '4Park': [673], 'W': [674, 2991], 'Griffin': [675], 'Grande': [677], 'JP': [678], 'Cosio': [679], 'F': [680, 1617], 'Stegall': [681], 'MD': [682], 'Molecular': [683], 'injury': [686, 830, 1284, 1422, 1547, 3961, 4776, 4807, 4827, 4915], 'fibrotic': [692], 'allografts': [694, 2999], 'posttransplant.Transplantation.': [697], '2007;': [698, 1754, 3008, 3078, 5022], '83:': [699], '1466-1476Crossref': [700], '(35)': [703, 4859], '5Hoffmann': [706], 'SC': [707], 'Hale': [708], 'DA': [709, 1619], 'Kleiner': [710], 'DE': [711], 'al.Functionally': [713], 'significant': [714, 1926, 1939, 2068, 3589, 4329, 4404, 4690], 'defined': [719], 'transcriptional': [721, 774, 938, 958], 'criteria.Am': [722], 'Transpl.': [724, 810, 841, 1127, 1242, 1297, 1385, 1435, 4936, 5021], '2005;': [725], '5:': [726], '573-581Crossref': [727], '(117)': [730], '6Mannon': [733], 'RB': [734, 2425], 'Kirk': [735, 5389], 'AD': [736], 'Beyond': [737], 'histology:': [738], 'Novel': [739], 'tools': [740], 'dysfunction.Clin': [744], 'Am': [746, 4951], 'Soc': [747, 4952], 'Nephrol.': [748, 4953], '2006;': [749, 811, 3434, 4954], '1:': [750, 4955], '358-366Crossref': [751], '(29)': [754], 'In': [757, 907, 2550, 3442, 3982], 'general,': [758], 'these': [759, 781, 2532, 3130, 3777, 3939, 4478, 4813], 'related': [762, 853, 2269, 2341], 'inflammatory': [765], 'infiltrate': [766], 'resident': [767], 'cells': [768, 2851, 2858, 2865, 2872, 2890, 2898, 2996, 3038, 3095], 'within': [769, 921, 2488, 2997, 3732, 5435, 5453], 'kidney,': [771], 'associated': [773, 3065, 3615, 4670], 'tissue.': [778], 'However,': [779, 5114], 'when': [780], 'applied': [785, 1786, 1802, 3213], '(7Deng': [790], 'MC': [791], 'Eisen': [792, 1652], 'HJ': [793, 3243], 'Mehra': [794], 'MR': [795], 'al.Noninvasive': [797], 'discrimination': [798, 4493], 'cardiac': [802], 'recipients': [804, 1024, 5286], 'profiling.Am': [808], '6:': [812], '150-160Crossref': [813], '(422)': [816], 'Scholar,8Flechner': [818], 'SM': [819, 821], 'Kurian': [820], 'Head': [822], 'SR': [823], 'al.Kidney': [825], 'tissue': [829], 'biopsies': [835, 1178, 1355, 2472, 2514, 3759, 4017, 4274, 4315, 4583], 'lymphocytes.Am': [839], '4:': [843, 1755], '1475-1489Crossref': [844], '(245)': [847], 'less': [858], 'evident,': [859], 'presumably': [860], 'due': [861, 5165], 'reduced': [864, 4575], 'signal': [865], 'noise': [867, 3257], 'ratio': [868], 'inherent': [869], 'site': [872], 'remote': [873], '(9Li': [877], 'L': [878, 880, 1744, 3086, 4917], 'Ying': [879], 'Naesens': [881, 1267, 1405], 'al.Interference': [884], 'globin': [886, 1677], 'discovery': [890, 1043, 1580, 1835, 2103, 2503, 2764, 3747, 5127, 5140], 'samples.Physiol': [897], 'Genom.': [898], '2008;': [899, 4937], '32:': [900], '190-197Crossref': [901], '(37)': [904], 'order': [908, 3225], 'increase': [910, 2457], 'detection': [916], 'rare': [919], 'biomarkers': [920], 'molecularly': [922], 'heterogeneous': [923, 4153], 'samples': [924, 942, 1014, 1521, 1574, 2100, 2164, 2283, 2292, 2302, 2308, 2355, 2364, 2374, 2380, 2397, 2408, 2465, 2487, 2533, 2543, 2555, 2620, 2639, 2772, 3352, 3521, 3539, 3700, 3731, 3752, 3778, 3788, 3867, 3883, 3905, 3940, 3957, 4087, 4125, 4230, 4622, 5558], 'such': [925, 3308, 4104, 4596], 'PB,': [927, 2756], 'we': [928, 1737, 2650, 2757, 3986], 'employed': [929], 'carefully': [931], 'designed': [932], 'methodological': [933], 'approach': [934, 3993], 'integrate': [936], 'profiles': [939, 959], 'without': [947], 'biopsy-proven': [948, 963], 'three': [951], 'different': [952, 1725, 1733, 2545, 2562, 2614, 2845, 3360, 3515, 3706, 3790, 4091, 5243], 'platforms.': [954], 'Changes': [955], 'correlated': [961, 2622, 3523], 'distinguish': [968, 4720], 'common': [972], 'arising': [974], 'patients.': [978, 2298, 2370, 4022], 'examination': [980, 4925], 'across': [983, 1352, 2811, 4100], 'highly': [985, 2016, 2021, 2059, 3997], 'regulated': [986], 'assess': [993], 'their': [994, 4194, 5346], 'noninvasive': [998], 'alternative': [1005, 4594], 'And': [1011], '236': [1016], 'young': [1020, 5154], 'adult': [1021, 5283], 'enrolled': [1026, 1038, 1077], '(as': [1027], 'shown': [1028, 3147], 'Figure': [1030, 2093, 3870, 3891, 3895], '1).': [1031], 'Within': [1032], 'cohort,': [1034, 3932, 4137], '137': [1035, 2286, 2358], 'Stanford': [1040, 2288, 2360, 3351, 5299, 5375], 'University': [1041, 5300, 5376, 5392], 'validation,': [1045], '99': [1047, 2295, 2367], 'NIH/NIAID': [1051, 5344], 'centers,': [1058, 1353, 4093], '"Suppressing': [1059], 'Immune': [1061], 'System': [1062, 1853], 'With': [1063], 'or': [1064, 1461, 1530, 1539, 1542, 1563, 2069, 2526, 2589, 2594, 2734, 2744, 2752, 3300, 3429, 3490, 3495, 3642, 3771, 4371, 4532, 4600, 4702, 5049, 5177, 5211, 5604], 'Without': [1065], 'Steroids': [1066], 'Children': [1068], 'Who': [1069], 'Have': [1070], 'Received': [1071], 'Kidney': [1072], 'Transplants"(SNS01;': [1073], 'NCT00141037;': [1074], 'ClinicalTrials.gov)': [1075], 'external': [1080], 'validation': [1081, 2173, 4278, 5417], '(complete': [1082, 1400], 'SNS': [1087, 1203, 1262, 1401, 2142], 'discussed': [1090], 'elsewhere': [1091], 'Sarwal': [1093, 1208, 5463], 'al.': [1095, 1210, 1269, 1407], '(10Sarwal': [1096], 'Ettenger': [1098, 1213], 'R': [1099, 1214, 1742, 1795, 2987], 'Dharnidharka': [1100, 1215], 'al.Complete': [1103, 1218], 'steroid': [1104, 1219, 1290, 1428, 2261, 2333, 5584], 'avoidance': [1105, 1220, 1291, 1429], 'effective': [1107, 1222], 'safe': [1109, 1224], 'children': [1111, 1226, 5152, 5276], 'transplants:': [1114, 1229], 'multicenter': [1117, 1232, 4136, 5144, 5305, 5333], 'controlled': [1119, 1234], 'trial': [1120, 1235, 1288, 1426, 4165, 5274], '3': [1122, 1237, 1829], 'follow': [1124, 1239], 'up.Am': [1125, 1240], '2012;': [1128, 1243, 1298, 1386, 1436], '(June': [1129, 1244], '13,': [1130, 1245], 'PMID:': [1131, 1246], '22694755': [1132, 1247], '[Epub': [1133, 1248], 'ahead': [1134, 1249], 'print].)Abstract': [1136, 1251], '(108)': [1143, 1258], 'governed': [1149], 'IRB': [1151], 'approval': [1152], 'informed': [1154], 'consent.': [1155], 'Each': [1156, 1330], 'sample': [1158, 2127, 2272, 2344, 2491, 3735, 3974, 4279, 5123, 5239, 5325], 'contemporary': [1166], '(within': [1170], '48': [1171], 'hours)': [1172], 'same': [1175, 1316, 3293, 4021], 'patient.': [1176, 3981, 5113], 'Surveillance': [1177], 'obtained': [1180, 4088], 'engraftment,': [1185], '3,': [1186], '6,': [1187], '24': [1190, 3355, 3542], 'months': [1191], 'posttransplantation': [1192], 'additionally': [1194], 'times': [1197, 2041], 'suspected': [1199], '(for': [1202], 'details': [1206, 1265], 'see': [1207, 1266], '[10Sarwal': [1211], 'Scholar];': [1260], 'histology': [1263, 1402, 3640], '[11Naesens': [1270, 1408], 'Salvatierra': [1272, 1410], 'Jr,': [1273, 1411], 'O': [1274, 1412, 3055, 4837, 4862], 'Benfield': [1275, 1413], 'al.Subclinical': [1278, 1416], 'chronic': [1281, 1419, 1517, 1531, 1545], '12:': [1299, 1387, 1437], '2730-2743Abstract': [1300, 1438], '(36)': [1308, 1446], 'Scholar]).': [1310, 1448], 'Multiple': [1311], 'PB-biopsy': [1312, 1450, 1483, 3721], 'pairs': [1313, 1451, 1484, 3722], 'patient': [1317, 2150, 3682, 4149, 5322], 'utilized': [1319], 'long': [1321], 'had': [1325, 1513, 1522, 2556, 3588], 'conclusive': [1327], 'phenotypic': [1328], 'scored': [1333, 4271], 'pathologist': [1337, 1363], 'enrolling': [1340], 'site;': [1342], 'but': [1343, 1501, 3933, 4174, 4269, 5131], 'given': [1344, 2033], 'possibility': [1346], 'discordance': [1348], 'reads': [1351, 5381], 'blindly': [1357], 'rescored': [1358], 'central': [1362, 4755], '(12Mengel': [1368], 'Sis': [1370], 'B': [1371, 2798, 2897, 4835, 4866], 'Haas': [1372], 'al.Banff': [1375], '2011': [1376], 'Meeting': [1377], 'Report:': [1378], 'New': [1379], 'concepts': [1380], 'antibody-mediated': [1382], 'rejection.Am': [1383, 3005], '563-570Abstract': [1388], '(337)': [1396], 'Scholar)': [1398, 1761, 1819, 2002, 2843, 3051, 4884, 4961], 'classification': [1399, 1509, 2431, 3237], 'categorized': [1453], '"acute': [1455], 'rejection"': [1456], '(AR;': [1457], 'n': [1458, 1465, 1527, 1536, 2478, 2547, 3792], '115),': [1460], '"stable"': [1463], '(STA,': [1464], '180),': [1467], 'if': [1468, 1492, 2028, 2585, 3486, 4239, 4431, 4519, 4636], 'there': [1469, 3634, 4497, 4688], 'absence': [1471, 4487, 4547, 4570], 'any': [1475, 2586, 3487, 4053, 5607], 'substantial': [1477], 'pathology.': [1478, 3805], 'third': [1480], 'category': [1481], 'characterized': [1486], '"non-AR/non-STA"': [1488], '72)': [1491], 'they': [1493], 'exhibited': [1494], 'no': [1495, 3636], 'graded': [1499, 2524, 3769, 4262], 'either': [1502, 2522, 3767, 5167], 'met': [1503, 4294], '"borderline"': [1508], '12),': [1512], 'nephropathy': [1519], '(CAN;': [1520], 'IFTA': [1523], 'grade': [1524, 3641], '≥': [1525], '1;': [1526], '37),': [1529], 'calcineurin': [1532, 2741], 'inhibitor': [1533], 'toxicity': [1534], '(CNIT;': [1535], '16),': [1538], 'bacterial/viral': [1540, 4684], 'undefined': [1544], '7).': [1550], 'collected': [1553, 2409, 2466, 2509, 3703, 3754, 4018], '2.5': [1555], 'mL': [1556], 'PAXgene™': [1557], 'RNA': [1559, 1584, 1889, 1906, 1911], 'Tubes': [1560], '(PreAnalytiX,': [1561], 'Qiagen)': [1562], 'Ficoll': [1565], 'tubes': [1566], '(PBL)': [1570], 'isolation': [1571], '(the': [1572], 'latter': [1573, 2552], 'only': [1576, 3593], 'Affymetrix).': [1582], 'Total': [1583], 'extracted': [1586], 'previously': [1589, 3145, 4215], 'published': [1590], 'protocol9.': [1591], 'Our': [1592], 'goal': [1593], 'maximize': [1596], 'power': [1598, 5136], 'discovering': [1600], 'robust': [1602, 3386], 'minimize': [1608], 'platform': [1609, 1716, 1723], 'specific': [1610, 1717, 3599], 'artifacts': [1611], '(e.g.,': [1612], 'issues': [1613], 'cross-hybridization': [1615], '(13Naef': [1616], 'Lim': [1618], 'Patil': [1620], 'Magnasco': [1622], 'hybridization': [1625, 1649], 'mismatched': [1627], 'templates:': [1628], 'chip': [1630], 'study.Phys': [1631], 'Rev': [1632], 'Stat': [1634, 3261], 'Nonlin': [1635], 'Soft': [1636], 'Matter': [1637], 'Phys.': [1638], '2002;': [1639, 3101, 3410], '65:': [1640], '040902Crossref': [1641], '(1)': [1644], '(14Alizadeh': [1650], 'AA': [1651], 'MB': [1653], 'Davis': [1654, 5509], 'RE': [1655], 'al.Distinct': [1657], 'types': [1658, 2008], 'diffuse': [1660], 'large': [1661], 'B-cell': [1662], 'lymphoma': [1663], 'profiling.Nature.': [1668], '2000;': [1669], '403:': [1670], '503-511Crossref': [1671], '(8032)': [1674], 'effect9': [1679], 'whole': [1681], 'Affymetrix': [1685, 5514], 'platform,': [1686], 'stability': [1688], 'Cy': [1690], 'dyes': [1691], '(15Randolph': [1692], 'JB': [1693], 'Waggoner': [1694], 'AS': [1695], 'Stability,': [1696], 'fluorescence': [1699], 'brightness': [1700], 'multiply-labeled': [1702], 'fluorescent': [1703], 'probes.Nucleic': [1705], 'Acids': [1706], 'Res.': [1707], '1997;': [1708], '25:': [1709, 3435], '2923-2929Crossref': [1710], '(143)': [1713], 'bias).': [1718], 'Furthermore,': [1719], 'because': [1720], 'array': [1722], 'uses': [1724], 'sets': [1726], 'represented': [1731], 'probe': [1734, 1765], 'IDs,': [1736], 'AILUN': [1739], '(http://ailun.stanford.edu)': [1740], '(16Chen': [1741], 'Li': [1743], 'Butte': [1745, 5483], 'AJ': [1746], 'AILUN:': [1747], 'Reannotating': [1748], 'automatically.Nat': [1752], 'Methods.': [1753], '879Crossref': [1756], '(86)': [1759], 're-annotate': [1763], 'IDs': [1767], 'current': [1770, 3984, 4054, 4332, 5039], 'Entrez': [1771], 'Gene': [1772, 1775, 2780], 'IDs.': [1773], 'All': [1774, 2769], 'values': [1777, 1899, 4466, 5567], 'transformed': [1779], 'log2': [1781], 'further': [1783, 4201, 4707, 4719, 5224], 'analysis.': [1784, 5594], 'We': [1785, 1918, 1929, 1943, 2048, 2903, 3212, 4705, 5291, 5314, 5336, 5355, 5404], 'significance': [1787, 3317], '(SAM)': [1791], '(17Tusher': [1792], 'VG': [1793], 'Tibshirani': [1794], 'Chu': [1796], 'G': [1797, 3396], 'Significance': [1798], 'ionizing': [1805], 'radiation': [1806], 'response.Proc': [1807], 'Natl': [1808, 1991, 2832], 'Acad': [1809, 1992, 2833], 'Sci': [1810, 1993, 2834], 'USA.': [1811, 1994, 2835], '2001;': [1812, 4854], '98:': [1813], '5116-5121Crossref': [1814], '(9775)': [1817], 'platforms,': [1830], 'threshold': [1833, 1936], 'false': [1834], 'rate': [1836, 5180], '(FDR)': [1837], '<': [1838, 2767, 3126, 3142, 3320, 3362, 3603, 3619, 3628], '5%.': [1839], 'Standard': [1840], 'protocols': [1841], 'reactions': [1846], 'ABI': [1849], '7900': [1850], 'Sequence': [1851], 'Detection': [1852], '(Applied': [1854, 1880], 'Biosystems,': [1855, 1881], 'Foster': [1856, 1882], 'City,': [1857, 1883], 'CA)': [1858], 'under': [1859], 'standard': [1860, 3324], 'cycle': [1861], '(10': [1863], 'min': [1864], '95°C,': [1866, 1871], '40': [1867], 'cycles': [1868], '15s': [1870], '30': [1872], 's': [1873], '60°C),': [1875], 'assays': [1879], 'CA).': [1884], 'relative': [1886], 'amount': [1887], 'calculated': [1892, 5574, 5591], 'comparative': [1895, 3420], 'CT': [1896], 'method.': [1897], 'Expression': [1898, 2781, 3337], 'normalized': [1901], '18S': [1903], 'ribosomal': [1905], 'endogenous': [1907], 'reference': [1908], 'universal': [1910], '(Agilent': [1912], 'Inc.,': [1913], 'Santa': [1914], 'Clara;': [1915], 'Cat': [1916], '#740000).': [1917], 'Ingenuity': [1920], 'Pathway': [1921], 'Analysis': [1922], '(IPA)': [1923], 'signaling': [1927, 2801], 'pathways.': [1928], 'chose': [1930, 2904], '-log10P': [1931], '>': [1932], '1.3': [1933], 'identifying': [1938], 'pathways': [1940], 'IPA.': [1942], 'BioGPS': [1945], '(18Wu': [1946], 'C': [1947, 1949], 'Orozco': [1948], 'Boyer': [1950], 'al.BioGPS:': [1953], 'An': [1954, 4981], 'extensible': [1955], 'customizable': [1957], 'portal': [1958], 'querying': [1960], 'organizing': [1962], 'annotation': [1964], 'resources..Genome': [1965], 'Biol.': [1966], '2009;': [1967, 4991], '10:': [1968], 'R130Crossref': [1969], '(1097)': [1972], 'Scholar,19Su': [1974], 'AI': [1975, 2816], 'Wiltshire': [1976, 2817], 'T': [1977, 2735, 2795, 2818, 2850, 2857, 2995, 3037, 3069, 3094, 4999, 5577], 'Batalov': [1978, 2819], 'S': [1979, 2820, 3241], 'al.A': [1981, 2822], 'atlas': [1983, 2824], 'mouse': [1986, 2827], 'protein-encoding': [1989, 2830], 'transcriptomes.Proc': [1990, 2831], '101:': [1996, 2837], '6062-6067Crossref': [1997, 2838], '(2852)': [2000, 2841], 'cell': [2007, 2026, 2035, 2064, 2708, 2736, 2796, 2799, 3070, 4761, 4795], 'which': [2010, 3382, 5091, 5188], 'expressed.': [2017], 'type': [2027, 2036, 2065], 'its': [2029, 2042, 4254, 4368, 5227], 'greater': [2038, 3474], '10': [2040, 3157, 3279, 3318, 4749], 'median': [2043, 2809], 'tissues.': [2047], 'hypergeometric': [2050, 2074], 'test': [2051, 2075, 3717, 4065, 4142, 4475, 4605, 4645, 5035, 5578], 'determine': [2053], 'whether': [2054], 'proportion': [2056], 'statistically': [2067], 'not.': [2070], 'p-values': [2072], 'corrected': [2077], 'multiple': [2079, 4101, 4678], 'hypotheses': [2080], 'Benjamini–Hochberg': [2082], 'correction.': [2083], 'schematic': [2085], 'outline': [2086], 'presented': [2091], '1': [2094], 'shows': [2096, 3000], 'number': [2098, 3230, 4286, 4511], '(122': [2106], 'PB),': [2107, 2112], 'verification': [2108, 2909], '(34': [2111, 2640], 'building': [2113], 'an': [2114, 2125, 2483, 3345, 3727, 3950, 4081, 4134, 4423, 4428], 'penalized': [2120, 3378], 'maximum': [2121, 3379, 3392], 'likelihood': [2122, 3380, 3393], 'method,': [2123, 3381], '(47': [2131], 'PB)': [2132], 'testing': [2134], 'performance': [2136, 3294, 3314, 4442, 5031, 5217], '(198': [2145], 'PB).': [2146], 'Summary': [2147], 'statistics': [2148], 'demographic': [2151], 'variables': [2154], 'provided': [2156], 'Table': [2158, 5551], '1.Table': [2159], '1:Demographic': [2160], 'information': [2161], 'experiments': [2167], '122)': [2170], 'PCR': [2172], '106)*Clinical': [2176], 'characteristicsMicroarray': [2177], 'discoveryPCR': [2178], 'validationTraining': [2179], 'setTest': [2180], 'setAR': [2181], '60)STA': [2184], '62)p-ValueAR': [2187], '23)STA': [2190], '24)p-ValueAR': [2193], '32)Non-AR': [2196], '166)p-ValueRecipientsGender,': [2199], '%': [2200, 2232], 'females31.91%44.64%0.1920.00%47.37%0.0952.00%36.49%0.41Mean': [2201], 'age,': [2202, 2234, 2692, 2700], 'year12.49': [2203], '±': [2204, 2206, 2208, 2210, 2212, 2214, 2218, 2220, 2222, 2224, 2226, 2228, 2236, 2238, 2240, 2242, 2244, 2246, 2250, 2322], '5.0410.94': [2205], '6.010.1710.31': [2207], '5.2414.24': [2209], '5.870.0511.91': [2211], '5.5711.85': [2213], '5.690.78Immunosuppression,': [2215], '%SF51.06%57.14%0.5466.67%73.68%0.6744%44.6%1.00HLA': [2216], 'match2.45': [2217], '1.362.41': [2219], '1.410.903.13': [2221], '1.412.59': [2223], '1.430.271.22': [2225], '1.191.39': [2227], '1.230.09DonorsDonor': [2229], 'source': [2230, 5589], '%LRD63.64%75.51%0.2180.00%84.21%0.7624.00%41.89%0.36Gender,': [2231], 'females53.49%48.00%0.6046.67%63.16%0.3540.00%41.89%1.00Mean': [2233], 'year33.26': [2235], '13.1032.72': [2237], '11.030.8332.41': [2239], '13.8739.17': [2241], '10.310.1327.79': [2243], '9.6928.50': [2245], '10.080.59Values': [2247], 'SD.': [2251, 2323], 'rejection;': [2255, 2327], 'stable;': [2258, 2330], 'SF': [2259, 2331], 'free;': [2262, 2334], 'txp': [2263, 2335], 'transplant;': [2265, 2337], 'LRD': [2266, 2338], 'living': [2268, 2340], 'donor.': [2270, 2342], 'numbers': [2273, 2345, 5124], 'dataset': [2276, 2348], 'shown.': [2278, 2350], 'Discovery,': [2279, 2351], 'Training': [2281, 2353, 2644, 3347, 3535], 'Set': [2282, 2291, 2354, 2363, 3223, 3844], 'came': [2284, 2293, 2303, 2356, 2365, 2375], 'patients;': [2289, 2361], 'Test': [2290, 2362, 2403, 3843], 'Verification': [2300, 2372, 2641, 3222], 'subset': [2306, 2378, 3218, 3249], 'Microarray': [2311, 2383], 'Discovery.': [2312, 2384], 'Open': [2313], 'table': [2314], 'new': [2317, 4610, 5105], 'tab': [2318], 'Values': [2319], 'second': [2392, 3695], 'cohort': [2394, 3697, 4083], '198': [2396, 3699], 'SNS01': [2399, 4318], '(Test': [2400, 3701], 'Set).': [2401], 'consisted': [2405, 2538, 3719, 3783], 'confirmed': [2415], '32;': [2419], '[20Racusen': [2420], 'Solez': [2422], 'K': [2423, 2981, 4944], 'Colvin': [2424], 'al.The': [2427, 5005], '97': [2429], 'working': [2430], 'pathology.Kidney': [2435], 'Int.': [2436], '1999;': [2437], '55:': [2438], '713-723Abstract': [2439], '(2773)': [2447], 'Scholar])': [2449], '(greater': [2454], 'baseline': [2459, 2593, 3494], 'serum': [2460, 4399], 'creatinine': [2461], 'values),': [2462], '(STA;': [2477], '94).': [2480], 'There': [2481], 'additional': [2484, 3728], 'not': [2495, 2519, 3739, 3764, 4179, 4675, 5599], 'earlier': [2499, 3743, 3977, 4393, 4417], 'single–center': [2502, 3746], 'validation.': [2505, 3749], 'where': [2515, 3468, 3760, 4147, 4556], 'histology;': [2531, 3776], 'nonAR/nonSTA,': [2536, 3781], 'collection': [2541, 3786], 'pathologies;': [2546, 3791], '72).': [2549], 'category,': [2553, 4173], 'pathological': [2563], 'categories': [2564], 'based': [2566, 4382, 4476], 'centralized': [2569], 'read-outs': [2571], '(12': [2572], 'borderline': [2573, 3796, 3910, 3955, 4168, 4191, 4265, 4313], '37': [2575, 3798], 'CAN,': [2576, 3799, 4106], '16': [2577, 3800], 'CNIT': [2578, 3801], '7': [2580, 3803], 'pathology).': [2582], 'To': [2583, 3484], 'examine': [2584, 3485, 4238, 4635], 'demographic,': [2587, 3488, 4679], 'immunosuppression': [2590, 3491, 3684, 4637, 5108, 5312], 'confounders': [2591, 2616, 2680, 2687, 3492, 3517, 3577], 'driven': [2602, 3503], 'segregation': [2604, 3505], 'prediction': [2609, 3510, 3948, 4646], 'score': [2610, 3271, 3511, 4386, 4524], '18': [2613, 2678, 3514, 3575], 'single-center': [2619, 3520], '5': [2630, 2682, 3444, 3531, 3579, 3586, 3611, 4032, 4733, 4752], '81': [2638], '+': [2642], '47': [2643, 3350, 3538], 'Set)': [2645, 3702], 'Pearson': [2647, 3545], 'correlation.': [2648, 3546], 'also': [2651, 3111, 3358, 3551, 3942, 3965, 4607, 5315], 'performed': [2652, 5150], 'univariate': [2653, 3606], 'confounder': [2659, 3556], 'multivariate': [2669, 3566], 'combination': [2675, 3572], "genes'": [2683, 3580], 'values.': [2685, 3582], 'posttransplant': [2689, 5571], 'time,': [2690], 'recipient': [2691, 2693], 'gender,': [2694, 2696], 'donor': [2695, 2697, 2699, 3598, 5588], 'source,': [2698], 'steroid-free': [2701], 'vs.': [2702], 'steroid-based': [2703, 5311], 'immunosuppression,': [2704], 'white': [2706], 'count,': [2709], 'hematocrit,': [2710], 'CMV': [2711], 'status,': [2712, 2714], 'EBV': [2713], 'BK': [2715], 'virus': [2716], 'infection,': [2717, 4108, 4598], 'bacterial': [2718], 'Infection,': [2719], 'presence': [2720, 3596, 4587, 5057], 'donor-specific': [2722, 3062], 'antibodies': [2723], '(DSA),': [2724], 'panel': [2725, 5257], 'reactive': [2726], 'antibodies,': [2727], 'use': [2728, 2739, 2747], 'induction': [2730, 5206], 'therapy': [2731, 5210], '(either': [2732], 'Daclizumab': [2733], 'depleting': [2737], 'antibodies),': [2738], 'inhibitors': [2742], '(tacrolimus': [2743], 'cyclosporine),': [2745], 'anti-metabolites': [2749], '(mycophenolate': [2750], 'mofetil': [2751], 'azathioprine).': [2753], 'From': [2754], '122': [2755], '2382': [2759], '(false': [2763], 'rate;': [2765], 'FDR': [2766], '5%).': [2768], 'deposited': [2775], 'GSE14067': [2777], 'NCBI': [2779], 'Omnibus': [2782], '(GEO)': [2783], 'database.': [2784], 'play': [2787, 4815], 'role': [2789, 2975, 4818], 'leukocyte': [2791, 4757], 'extravasation,': [2792], 'chemokine,': [2794], 'receptor': [2800], '(-log10P>1.3;': [2802], 'IPA®;': [2803], 'http://www.ingenuity.com).': [2804], 'They': [2805], 'enriched': [2807], '(10x': [2808], 'intensity': [2810], 'tissues;': [2813], 'http://www.BioGPS.org)': [2814], '(19Su': [2815], 'cells,': [2847], 'namely': [2848], 'CD8+': [2849], '(126,': [2852], 'p': [2853, 2860, 2867, 2874, 2880, 2886, 2892, 2900, 3141, 3166, 3173, 3177, 3181, 3185, 3189, 3194, 3205, 3209, 3602, 3651], '3.80e-16),': [2855], 'CD4+': [2856], '(118,': [2859], '5e-13),': [2862], 'CD56+': [2863], 'NK': [2864], '(149,': [2866], '1.3e-9),': [2869], 'CD33+': [2870], 'Myeloid': [2871], '(150,': [2873], '1.7e-8),': [2876], 'Dendritic': [2877], 'Cells': [2878], '(130,': [2879], '8.8e-8),': [2882], 'CD14+': [2883], 'Monocytes': [2884, 4842], '(111,': [2885], '1.1e-4),': [2888], 'CD34+': [2889], '(119,': [2891], '4.8e-6)': [2894], 'CD19+': [2896], '(91,': [2899], '1.6e-3).': [2902], '32': [2905], '(Figure': [2910, 3364, 3714, 3845], '1A)': [2911], 'sets,': [2920], 'biologically': [2923, 3999, 4182], 'relevant': [2924], 'enrichment': [2926], 'cell–specific': [2928], 'responses': [2930, 4783], 'AR.': [2932, 3152, 4060, 4162, 4459, 4489, 4536, 4704], 'DUSP1,': [2936, 3331], 'IL1RAP,': [2937], 'MCM7,': [2938], 'NKTR,': [2939, 3208, 3333], 'MAPK9,': [2940, 3332], 'PTPRC,': [2942], 'SLPI,': [2943], 'STAT1,': [2944, 3136], 'STAT3,': [2945], 'CFLAR,': [2946], 'IL32,': [2947], 'PHLDA1,': [2949], 'IFNGR1,': [2950, 3172], 'IL8RA,': [2951], 'ITGAX,': [2952, 3176], 'PLCG1,': [2953], 'PTPN11,': [2954], 'TNFAIP6,': [2955], 'ZAP70,': [2956], 'GOLGA8A,': [2957], 'RYBP,': [2958, 3193], 'TLR8,': [2959], 'RNF130,': [2960, 3188], 'F2RL1,': [2961], 'GRZYB,': [2962], 'PFN1,': [2963], 'FCGR1A,': [2964], 'NFATC3': [2965], 'IL6R.': [2967], 'Given': [2968, 4490], 'recent': [2970], 'research': [2971], 'dual': [2974], 'FOXP3': [2977], '(21Brown': [2980], 'Moxham': [2982], 'Karegli': [2984], 'Phillips': [2986], 'Sacks': [2988], 'SH': [2989], 'Wong': [2990], 'Ultra-localization': [2992], 'Foxp3+': [2994], 'infiltration': [3001], 'tubules': [3003], 'mimicking': [3004], 'Pathol.': [3007], '171:': [3009], '1915-1922Abstract': [3010], '(33)': [3018], 'Scholar,22Fan': [3020], 'Z': [3021], 'Spencer': [3022], 'JA': [3023], 'Lu': [3024], 'Y': [3025], 'al.In': [3027], 'vivo': [3028], 'tracking': [3029], "'color-coded'": [3031], 'effector,': [3032], 'natural': [3033], 'induced': [3035], 'regulatory': [3036, 3068, 3093], 'response.Nat': [3042], '2010;': [3044], '16:': [3045, 4878], '718-722Crossref': [3046], '(130)': [3049], 'tolerance': [3053], '(23Bestard': [3054], 'Cruzado': [3056], 'JM': [3057], 'Mestre': [3058], 'al.Achieving': [3061], 'hyporesponsiveness': [3063], 'FOXP3+': [3067], 'recruitment': [3071, 5012, 5323], 'infiltrates.J': [3076], 'Immunol.': [3077, 4876, 4990], '179:': [3079], '4901-4909Crossref': [3080], '(141)': [3083], 'Scholar,24Graca': [3085], 'Cobbold': [3087], 'SP': [3088], 'Waldmann': [3089], 'H': [3090], 'Identification': [3091], 'tolerated': [3097], 'allografts.J': [3098], 'Exp': [3099], '195:': [3102], '1641-1646Crossref': [3103], '(487)': [3106], 'selected': [3112, 4893, 5255], 'verification.': [3114], '15': [3115, 3131], 'significantly': [3118, 3359, 3614], 'between': [3121], '(p-value': [3125, 3361], '0.05).': [3127, 3604], 'Out': [3128, 3153], 'genes,': [3132, 3158], '(F2RL1,': [3135], 'FOXP3,': [3137], 'PTPRC': [3138], 'IL6R;': [3140], '0.05)': [3143, 3363], 'involved': [3150], 'remaining': [3156], '8': [3159], 'over-expressed': [3162], '(CFLAR,': [3165], '0.0016;': [3168], 'DUSP1,p': [3169], '0.0013;': [3171], '0.0062;': [3175], '0.0011;': [3179], '0.00008;': [3183], '0.00007;': [3187], '0.0459;': [3191], '0.0012),': [3196], '2': [3198], 'under-expressed': [3201], '(MAPK9,': [3204], '0.0006;': [3207], '0.0016).': [3211], 'best': [3217], 'selection': [3219, 3250, 3304], 'find': [3227], 'minimum': [3229], 'proper': [3236], 'biopsy-confirmed': [3239], 'AR(25Derksen': [3240], 'Keselman': [3242], 'Backward,': [3244], 'forward': [3245], 'stepwise': [3247], 'automated': [3248], 'algorithms:': [3251], 'Frequency': [3252], 'obtaining': [3254], 'authentic': [3255], 'variables.Br': [3258], 'Math': [3260], 'Psychol.': [3262], '1992;': [3263], '45:': [3264], '265-282Crossref': [3265], '(503)': [3267], 'Chi-square': [3270], 'models': [3275], 'showed': [3281], 'data-set': [3285], 'used,': [3286], 'would': [3290, 4200, 4224, 4326, 4401, 4413], 'six': [3299], 'genes.': [3302], 'Additional': [3303, 4621, 5530], 'biological': [3310], 'relevance': [3311], '(high': [3315], 'statistical': [3316], 'p-value': [3319], '0.005': [3321], 'low': [3323, 5050], 'error': [3325], 'mean': [3327], '[SEM]),': [3328], 'resulting': [3329], 'PSEN1.': [3336], '(23': [3353, 3540], 'STA)': [3356, 3543], '2A).': [3365], 'This': [3366, 4208], 'develop': [3371, 4712], 'estimation': [3387], 'procedure': [3388], 'usual': [3391], '(26Heinze': [3395], 'Schemper': [3397], 'solution': [3400], 'problem': [3403], 'separation': [3405], 'regression.Stat': [3408], '21:': [3411], '2409-2419Crossref': [3412], '(1228)': [3415], 'Scholar,27Heinze': [3417], 'G.': [3418], 'investigation': [3421], 'separated': [3428, 3431], 'nearly': [3430], 'data.Stat': [3432], '4216-4226Crossref': [3436], '(264)': [3439], 'model,': [3446, 3609], 'coefficients': [3451], 'describes': [3452], 'size': [3454, 5169], 'contribution': [3457], 'factor': [3464], 'larger': [3470, 4445, 4510, 5238], 'coefficient,': [3472], 'influence': [3476], '(Table': [3482], 'S1).': [3483], 'Univariate': [3547], 'done': [3552], 'By': [3583, 3605], 't-test,': [3584], 'change': [3590], 'antibody': [3600, 4928], '(DSA;': [3601], '(p': [3618, 3627, 3645], '0.0001;': [3620, 3629], 'AUC': [3621, 3630, 3893], '0.829-0.938)': [3623], 'DSA': [3625, 4693, 4898, 4909], 'positivity': [3626, 3644], '0.828)': [3632], 'association': [3637, 4886], 'C4d': [3643, 3655], '0.80': [3647], 'score;': [3650], '0.79': [3653], 'positivity).': [3656], 'thus': [3659], 'underscore': [3660], 'confidence,': [3676], 'irrespective': [3677, 4699], 'differences': [3680], 'characteristics,': [3683], 'timing.': [3687], 'centers': [3707], 'part': [3709], '2B).': [3715], 'STA,': [3725], '72;': [3794], 'accuracy': [3807, 3879], 'assessed': [3813], 'evaluating': [3815], 'sensitivity,': [3817, 3852, 3874], 'specificity,': [3818, 3854, 3876, 4049], 'positive': [3819, 4462], 'value': [3821, 3826, 4541], '(PPV)': [3822], 'negative': [3824, 4464, 4539], '(NPV)': [3827], '3A).': [3846], 'has': [3850, 4365, 5477, 5510, 5518], '83%': [3855], 'PPV,': [3856], '97%': [3857], 'NPV': [3858], '92%': [3860], 'accuracy,': [3861], 'separate': [3863, 3881], '(AUC': [3868], '0.955;': [3869], '3B);': [3871], '(STA': [3888], 'non-AR/non-STA;': [3890], '3C;': [3892], '0.937,': [3894], '3D).': [3896], 'It': [3897, 4223, 4809, 5065], 'note': [3901], '8/12': [3903], '(these': [3922], 'true': [3927, 3944], 'negatives': [3928], 'non-AR/non-STA': [3931], 'argued': [3937], 'positives).': [3945], 'suggests': [3958, 4209, 5041], 'preclinical': [3960], 'may': [3964, 4606, 4743, 5066, 5092, 5161, 5533], 'suggest': [3976, 4471, 5261], 'treatment': [3978, 4457, 4619, 4631, 4681, 5182], 'study,': [3985, 4516], 'cross-platform,': [3989], 'high-throughput,': [3990], 'transcript': [3991], 'specific,': [3998], 'meaningful,': [4000], 'concise': [4001], 'whose': [4006], 'correlates': [4008], 'AR/no': [4012], 'contemporaneous': [4016], 'extensively': [4037], 'Q-PCR,': [4040], 'accurately': [4041], 'rejection,': [4043, 4247, 4452, 4673, 5097], 'substantially': [4050], 'improving': [4051], 'available': [4055, 4354], 'method': [4056], 'specifically': [4058], 'Importantly,': [4061], 'though': [4062, 4726], 'developed': [4067], 'binary': [4070], 'comparison': [4071], 'comprised': [4085], 'varying': [4097], 'demographics': [4098], 'phenotypes,': [4103], 'CNIT,': [4107], 'tubular': [4111], 'necrosis,': [4112], 'sub-clinical': [4113], 'STA.': [4118], 'As': [4119, 5146], 'center,': [4129], 'general': [4138], 'applicability': [4139], 'real-world': [4144], 'appears': [4145], 'feasible': [4146], 'population': [4150], 'contain': [4152], 'along': [4156], 'continuum': [4158], 'arbitrarily': [4166], 'assigned': [4167], 'nonAR/nonSTA': [4172], 'retrospect,': [4176], 'might': [4178], 'most': [4185, 4668], '"misclassifications"': [4188], 'actually': [4190], 'inclusion': [4195, 4746], 'group': [4199, 4438], 'enhance': [4202], 'PPV': [4204], 'test.': [4207], 'longer': [4211], 'biologic': [4212], 'thought': [4216], 'leading': [4220], 'rejection.': [4222, 4724], 'evaluate': [4228, 4518], 'serial': [4229], 'developing': [4233], 'episodes': [4236], 'detect': [4244], 'is,': [4249], 'prior': [4252], 'becoming': [4255], 'evident.': [4257], 'Some': [4258], 'ARs': [4263], '12)': [4268], 'help': [4281], 'compensate': [4282], 'small': [4285], 'events': [4289], '32)': [4292], 'conventional': [4296], 'criteria.': [4298], 'Thus': [4299], 'predict': [4306], 'subjects.': [4319], 'Early': [4320], 'minimally': [4321, 5079], 'advance': [4330, 4405], 'practice': [4333], 'standards': [4334], 'depend': [4336], 'initiation': [4342], 'treatment.': [4344], 'At': [4345], 'present,': [4346], 'trigger': [4352, 4425], 'warrant': [4356], 'doing': [4357], 'diagnosis,': [4362], 'evolved': [4366], 'full': [4369], 'humoral': [4370, 4451, 4533, 4703, 4721, 5009], 'cellular': [4372, 4449, 4535, 4701, 4723, 4781, 5006], 'mechanisms.': [4373], 'Having': [4374], 'indication': [4377], 'episode,': [4381, 4655], 'test,': [4390, 4496, 4566], 'rise': [4396], 'creatinine,': [4400], 'patients,': [4410], 'result': [4414, 5190], 'provide': [4422, 4608], 'performing': [4427], 'indicated': [4429], 'biopsy,': [4430], 'warranted.': [4432], 'Work': [4433], 'underway': [4435], 'our': [4437, 4695, 4709], 'refine': [4440], 'excellent': [4461, 4492], 'useful': [4482], 'screening': [4484], 'strong': [4499, 4538], 'justification': [4500], 'larger,': [4503], 'definitive': [4505], 'follow-up': [4506], 'higher': [4521, 5179], 'translates': [4525], 'into': [4526], 'aggressive': [4530, 5164], 'versus': [4534, 5310], 'opens': [4550], 'door': [4552], 'personalized': [4554], 'therapy,': [4555], 'screened': [4561], 'serially': [4562], 'risk,': [4573], 'follow-up,': [4576], 'candidates': [4578], 'avoid': [4580], 'unnecessary': [4581], 'and,': [4584], 'evaluated': [4592, 4627], 'etiologies,': [4595], 'obstruction': [4599], 'toxicity.': [4601], 'monitor': [4613], 'resolution': [4615, 4651], 'intensification.': [4620], 'undergoing': [4630], 'intensification': [4638], 'decrement': [4641], 'score,': [4647], 'commensurate': [4648], 'histological': [4650, 5060], 'perhaps': [4656], 'guiding': [4657], "patient's": [4661], 'response': [4662, 4983, 5194], 'therapy.': [4664], 'strongly': [4669], 'do': [4674], 'correlate': [4676], 'clinical,': [4680], 'modality': [4682], 'parameters.': [4686], 'Although': [4687], 'correlation': [4691], 'positivity,': [4694], 'predicts': [4697], 'analyzing': [4708], 'gene-based': [4715], 'Even': [4725], 'minimal': [4730], 'expanding': [4738], 'out': [4739], 'populations': [4742], 'require': [4744], 'gene-set.': [4750], 'trafficking': [4758, 4901], 'T/B': [4760], 'activation,': [4762], 'mostly': [4765], 'activated': [4769, 4829], 'monocytes': [4770, 4830, 4903, 4963, 5014], 'circulation,': [4774], 'reflecting': [4775], 'mechanisms': [4777], 'relating': [4778], 'oxidative': [4780], 'stress': [4782], '(DUSP1),': [4784], 'apoptosis': [4785], '(MAPK9),': [4786], 'IL2': [4787], 'dependant': [4788], 'activation': [4789], 'cytolytic': [4791], '(NKTR),': [4793], 'increased': [4794], 'adhesion': [4796], 'via': [4797], 'e-cadherin/': [4799], 'catenin': [4800], 'complex': [4801], '(PSEN1),': [4802], 'vascular': [4804], 'smooth': [4805], 'muscle': [4806], '(PBEF1).': [4808], 'likely': [4811], 'pivotal': [4817], 'mechanism': [4821], 'cytolysis': [4823], 'microvasculature': [4826], '(28Steiniger': [4834], 'Stehling': [4836], 'Scriba': [4838], 'Grau': [4840, 4863], 'rat:': [4845], 'Phenotype': [4846], 'during': [4849, 4869], 'rejection.Immunol': [4852], 'Rev.': [4853], '184:': [4855], '38-44Crossref': [4856], 'Scholar,29Stehling': [4861], 'Steiniger': [4865], 'Monocyte': [4867], 'cytotoxicity': [4868], 'rats.Int': [4875], '101-110Crossref': [4879], '(15)': [4882], 'profile': [4890], 'supports': [4904], 'growing': [4906], 'recognition': [4907], 'culprit': [4912], '(30Zhu': [4916], 'Lee': [4918], 'PC': [4919], 'Everly': [4920], 'MJ': [4921], 'Terasaki': [4922], 'PI': [4923], 'Detailed': [4924], 'HLA': [4927], 'development': [4929, 5269], 'failure': [4933], 'function.Clin': [4935], ':': [4938], '171-187PubMed': [4939], 'Scholar,31Terasaki': [4941], 'P': [4942, 5566], 'Mizutani': [4943], 'Antibody': [4945], 'mediated': [4946, 4987], 'rejection:': [4947, 5010], 'Update': [4948], '2006.Clin': [4949], '400-403Crossref': [4956], '(40)': [4959], 'primary': [4965], 'culprits': [4966], '(32Zecher': [4970], 'D': [4971], 'van': [4972], 'Rooijen': [4973], 'Rothstein': [4975], 'DM': [4976], 'Shlomchik': [4977], 'WD': [4978], 'Lakkis': [4979], 'FG': [4980], 'innate': [4982], 'allogeneic': [4985], 'nonself': [4986], 'monocytes.J': [4989], '183:': [4992], '7810-7816Crossref': [4993], '(80)': [4996], 'Scholar,33Fahim': [4998], 'Bohmig': [5000], 'GA': [5001], 'Exner': [5002], 'lesion': [5007], 'Predominant': [5011], 'peritubular': [5016], 'glomerular': [5018], 'capillaries.Am': [5019], '7:': [5023], '385-393Crossref': [5024], '(84)': [5027], 'Serial': [5030], 'proposed': [5036], 'stratify': [5045], 'rejections,': [5053], 'even': [5054], 'injuries': [5061], 'graft.': [5064], 'anticipated': [5068], 'frequent': [5072], 'afforded': [5076], 'nature': [5081, 5157], 'assay': [5084], 'facilitate': [5086], 'prompt': [5088], 'therapeutic': [5089], 'alter': [5093], 'course': [5095], 'critical,': [5100], 'yet': [5103], 'unavailable,': [5104], 'dimension': [5106], 'customization': [5109], 'couple': [5116], 'caveats': [5118], 'should': [5119, 5222, 5620], 'noted.': [5121], 'limited,': [5130], 'offset': [5133], 'validating': [5138], 'study.': [5145, 5354], 'adults,': [5155], 'mismatch': [5170], 'adult-sized': [5172], 'organ': [5173], 'infant': [5175], 'recipient,': [5176, 5185], 'nonadherence': [5183], 'adolescent': [5184], 'both': [5186], 'stronger': [5192], 'signal.': [5195], 'none': [5197], 'received': [5205, 5519], 'anti-CD52': [5208], 'depletion': [5209], 'co-stimulatory': [5213], 'blockade.': [5214], 'Therefore,': [5215], '5-genes': [5220], 'studied': [5225], 'potential': [5228, 5252, 5262], 'ages,': [5236], 'cohorts': [5240], 'regimens.': [5245], 'empirical': [5247], 'results': [5248], 'future': [5268], 'extension': [5278], 'work': [5281], 'confirm': [5288], 'application.': [5290], 'deeply': [5292], 'appreciate': [5293], 'participation': [5295], 'funded': [5304, 5428], 'steroid-avoidance': [5309], '(SNSO1).': [5313], 'indebted': [5317], 'collections': [5326], 'centers.': [5335], 'thank': [5337, 5356], 'Nancy': [5338], 'Bridges': [5339], 'Daniel': [5341], 'Rotrosen': [5342], 'continuous': [5347], 'advice': [5350], 'Nikki': [5357], 'Williams': [5358], 'throughout': [5362], 'manuscript': [5364, 5401], 'preparation.': [5365], 'authors': [5367], 'grateful': [5369], 'Dr.': [5371, 5387, 5462, 5482, 5508], 'Neeraja': [5372], 'her': [5378], 'pathology': [5384], 'Allan': [5388], 'Emory': [5391], 'his': [5394], 'suggestions': [5397], 'make': [5399], 'meaningful.': [5403], 'thankful': [5406], 'David': [5408], 'Ikle,': [5409], 'Michael': [5410], 'Riggs,': [5411], 'Katie': [5413], 'Poole': [5414], 'phase': [5418], 'project.': [5421], 'Support': [5422], 'project': [5426], 'grants': [5431], 'UO1AI055795': [5432], '(OS': [5433], 'awarded': [5434, 5452], 'Cooperative': [5437, 5455], 'Clinical': [5438, 5456], 'Trials': [5439, 5457], 'Pediatric': [5441, 5459], 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