Publication Information

{'id': 'https://openalex.org/W1577601626', 'doi': 'https://doi.org/10.1016/s0021-9258(17)37371-4', 'title': 'Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core.', 'display_name': 'Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core.', 'publication_year': 1994, 'publication_date': '1994-03-01', 'ids': {'openalex': 'https://openalex.org/W1577601626', 'doi': 'https://doi.org/10.1016/s0021-9258(17)37371-4', 'mag': '1577601626', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8119978'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(17)37371-4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/s0021-9258(17)37371-4', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5038727529', 'display_name': 'Dov Barak', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I104146711', 'display_name': 'Israel Institute for Biological Research', 'ror': 'https://ror.org/05atez085', 'country_code': 'IL', 'type': 'facility', 'lineage': ['https://openalex.org/I104146711']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'D. Barak', 'raw_affiliation_strings': ['Department of Biochemistry, Israel Institute for Biological Research, Ness-Ziona.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Israel Institute for Biological Research, Ness-Ziona.', 'institution_ids': ['https://openalex.org/I104146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109840630', 'display_name': 'C. Kronman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I104146711', 'display_name': 'Israel Institute for Biological Research', 'ror': 'https://ror.org/05atez085', 'country_code': 'IL', 'type': 'facility', 'lineage': ['https://openalex.org/I104146711']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'C. Kronman', 'raw_affiliation_strings': ['Department of Biochemistry, Israel Institute for Biological Research, Ness-Ziona.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Israel Institute for Biological Research, Ness-Ziona.', 'institution_ids': ['https://openalex.org/I104146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050309650', 'display_name': 'Arie Ordentlich', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I104146711', 'display_name': 'Israel Institute for Biological Research', 'ror': 'https://ror.org/05atez085', 'country_code': 'IL', 'type': 'facility', 'lineage': ['https://openalex.org/I104146711']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'A. Ordentlich', 'raw_affiliation_strings': ['Department of Biochemistry, Israel Institute for Biological Research, Ness-Ziona.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Israel Institute for Biological Research, Ness-Ziona.', 'institution_ids': ['https://openalex.org/I104146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049207667', 'display_name': 'Naomi Ariel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I104146711', 'display_name': 'Israel Institute for Biological Research', 'ror': 'https://ror.org/05atez085', 'country_code': 'IL', 'type': 'facility', 'lineage': ['https://openalex.org/I104146711']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'N. Ariel', 'raw_affiliation_strings': ['Department of Biochemistry, Israel Institute for Biological Research, Ness-Ziona.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Israel Institute for Biological Research, Ness-Ziona.', 'institution_ids': ['https://openalex.org/I104146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002465977', 'display_name': 'A. Bromberg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I104146711', 'display_name': 'Israel Institute for Biological Research', 'ror': 'https://ror.org/05atez085', 'country_code': 'IL', 'type': 'facility', 'lineage': ['https://openalex.org/I104146711']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'A. Bromberg', 'raw_affiliation_strings': ['Department of Biochemistry, Israel Institute for Biological Research, Ness-Ziona.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Israel Institute for Biological Research, Ness-Ziona.', 'institution_ids': ['https://openalex.org/I104146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001559610', 'display_name': 'Dino Marcus', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I104146711', 'display_name': 'Israel Institute for Biological Research', 'ror': 'https://ror.org/05atez085', 'country_code': 'IL', 'type': 'facility', 'lineage': ['https://openalex.org/I104146711']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'D. Marcus', 'raw_affiliation_strings': ['Department of Biochemistry, Israel Institute for Biological Research, Ness-Ziona.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Israel Institute for Biological Research, Ness-Ziona.', 'institution_ids': ['https://openalex.org/I104146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111855787', 'display_name': 'Arye Lazar', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I104146711', 'display_name': 'Israel Institute for Biological Research', 'ror': 'https://ror.org/05atez085', 'country_code': 'IL', 'type': 'facility', 'lineage': ['https://openalex.org/I104146711']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'A. Lazar', 'raw_affiliation_strings': ['Department of Biochemistry, Israel Institute for Biological Research, Ness-Ziona.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Israel Institute for Biological Research, Ness-Ziona.', 'institution_ids': ['https://openalex.org/I104146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015533648', 'display_name': 'Baruch Velan', 'orcid': 'https://orcid.org/0000-0002-2725-3249'}, 'institutions': [{'id': 'https://openalex.org/I104146711', 'display_name': 'Israel Institute for Biological Research', 'ror': 'https://ror.org/05atez085', 'country_code': 'IL', 'type': 'facility', 'lineage': ['https://openalex.org/I104146711']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'B. Velan', 'raw_affiliation_strings': ['Department of Biochemistry, Israel Institute for Biological Research, Ness-Ziona.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Israel Institute for Biological Research, Ness-Ziona.', 'institution_ids': ['https://openalex.org/I104146711']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5024386954', 'display_name': 'Avigdor Shafferman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I104146711', 'display_name': 'Israel Institute for Biological Research', 'ror': 'https://ror.org/05atez085', 'country_code': 'IL', 'type': 'facility', 'lineage': ['https://openalex.org/I104146711']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'A. Shafferman', 'raw_affiliation_strings': ['Department of Biochemistry, Israel Institute for Biological Research, Ness-Ziona.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Israel Institute for Biological Research, Ness-Ziona.', 'institution_ids': ['https://openalex.org/I104146711']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 11.313, 'has_fulltext': False, 'cited_by_count': 182, 'citation_normalized_percentile': {'value': 0.999745, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '269', 'issue': '9', 'first_page': '6296', 'last_page': '6305'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12023', 'display_name': 'Cholinesterase and Neurodegenerative Diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12023', 'display_name': 'Cholinesterase and Neurodegenerative Diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13124', 'display_name': 'Chemical synthesis and alkaloids', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10211', 'display_name': 'Computational Drug Discovery Methods', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/degeneracy', 'display_name': 'Degeneracy (biology)', 'score': 0.69622785}], 'concepts': [{'id': 'https://openalex.org/C2778816929', 'wikidata': 'https://www.wikidata.org/wiki/Q22676679', 'display_name': 'Acetylcholinesterase', 'level': 3, 'score': 0.73603743}, {'id': 'https://openalex.org/C2777727622', 'wikidata': 'https://www.wikidata.org/wiki/Q5251772', 'display_name': 'Degeneracy (biology)', 'level': 2, 'score': 0.69622785}, {'id': 'https://openalex.org/C2164484', 'wikidata': 'https://www.wikidata.org/wiki/Q5170150', 'display_name': 'Core (optical fiber)', 'level': 2, 'score': 0.6508182}, {'id': 'https://openalex.org/C46762472', 'wikidata': 'https://www.wikidata.org/wiki/Q178648', 'display_name': 'Peripheral', 'level': 2, 'score': 0.63396543}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.53478193}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.42435843}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.37215775}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.33366096}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.24879983}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.22317213}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.2146231}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.19311246}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.1710746}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.12800816}, {'id': 'https://openalex.org/C76155785', 'wikidata': 'https://www.wikidata.org/wiki/Q418', 'display_name': 'Telecommunications', 'level': 1, 'score': 0.08031818}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(17)37371-4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(17)37371-4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.41, 'id': 'https://metadata.un.org/sdg/6', 'display_name': 'Clean water and sanitation'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W1480316552', 'https://openalex.org/W1493227437', 'https://openalex.org/W1528949927', 'https://openalex.org/W1541258411', 'https://openalex.org/W1679034178', 'https://openalex.org/W1854458429', 'https://openalex.org/W1856517456', 'https://openalex.org/W1951881669', 'https://openalex.org/W1969489179', 'https://openalex.org/W1970904315', 'https://openalex.org/W1971048984', 'https://openalex.org/W1971878065', 'https://openalex.org/W1972719099', 'https://openalex.org/W1976506000', 'https://openalex.org/W2009095082', 'https://openalex.org/W2013132270', 'https://openalex.org/W2017528132', 'https://openalex.org/W2022964379', 'https://openalex.org/W2032508084', 'https://openalex.org/W204138135', 'https://openalex.org/W2046863474', 'https://openalex.org/W2057931924', 'https://openalex.org/W2063764057', 'https://openalex.org/W2065110936', 'https://openalex.org/W2065453800', 'https://openalex.org/W2074929682', 'https://openalex.org/W2076917186', 'https://openalex.org/W2080351270', 'https://openalex.org/W2085471069', 'https://openalex.org/W2085958374', 'https://openalex.org/W2164320858', 'https://openalex.org/W2395789495', 'https://openalex.org/W2586438004', 'https://openalex.org/W312293387', 'https://openalex.org/W4235000124', 'https://openalex.org/W658709490'], 'related_works': ['https://openalex.org/W2827052901', 'https://openalex.org/W2464260232', 'https://openalex.org/W2372940580', 'https://openalex.org/W2090275629', 'https://openalex.org/W2085472253', 'https://openalex.org/W2027693063', 'https://openalex.org/W2011722865', 'https://openalex.org/W1965423673', 'https://openalex.org/W1699617639', 'https://openalex.org/W1562398969'], 'abstract_inverted_index': {'Several': [0], 'of': [1, 19, 69, 113, 210, 213, 220, 235, 248, 258, 261, 279, 282], 'the': [2, 5, 33, 115, 119, 150, 160, 174, 183, 192, 207, 218, 221, 242, 245, 259, 262, 277, 280], 'residues': [3, 70, 226, 239], 'constituting': [4], 'peripheral': [6], 'anionic': [7], 'site': [8, 117, 223], '(PAS)': [9], 'in': [10, 78, 83, 107, 154, 284], 'human': [11], 'acetylcholinesterase': [12], '(HuAChE)': [13], 'were': [14, 41, 179, 189], 'identified': [15], 'by': [16, 37, 149, 159, 196], 'a': [17, 211, 231, 256], 'combination': [18], 'kinetic': [20], 'studies': [21, 31], 'with': [22, 32, 43, 59, 198, 202], '19': [23], 'single': [24], 'and': [25, 36, 53, 65, 75, 118, 139, 164, 228, 276], 'multiple': [26, 91], 'HuAChE': [27, 176, 249], 'mutants,': [28], 'fluorescence': [29], 'binding': [30, 214], 'Trp-286': [34, 200, 229, 263], 'mutant,': [35], 'molecular': [38, 171], 'modeling.': [39], 'Mutants': [40], 'analyzed': [42], 'three': [44], 'structurally': [45], 'distinct': [46, 187], 'positively': [47], 'charged': [48], 'PAS': [49, 87, 101, 120, 208], 'ligands,': [50, 88], 'propidium,': [51], 'decamethonium,': [52], 'di(p-allyl-N-dimethylaminophenyl)pentane-3-one': [54], '(BW284C51),': [55], 'as': [56, 58, 147, 230], 'well': [57], 'selective': [60], 'active': [61, 116, 222], 'center': [62], 'inhibitors,': [63], 'hexamethonium': [64], 'edrophonium.': [66], 'Single': [67], 'mutations': [68], 'Tyr-72,': [71], 'Tyr-124,': [72], 'Glu-285,': [73], 'Trp-286,': [74], 'Tyr-341': [76], 'resulted': [77], 'up': [79, 93], 'to': [80, 94, 110, 217, 237, 244, 266], '10-fold': [81], 'increase': [82, 96, 153], 'inhibition': [84, 158], 'constants': [85], 'for': [86, 90, 156, 173, 182], 'whereas': [89], 'mutants': [92], '400-fold': [95], 'was': [97], 'observed.': [98], 'The': [99], '6th': [100], 'element': [102], 'residue': [103], 'Asp-74': [104, 227, 283], 'is': [105, 255], 'unique': [106], 'its': [108], 'ability': [109, 260], 'affect': [111], 'conformation': [112], 'both': [114], '(Shafferman,': [121], 'A.,': [122, 126], 'Velan,': [123], 'B.,': [124], 'Ordentlich,': [125], 'Kronman,': [127], 'C.,': [128], 'Grosfeld,': [129], 'H.,': [130], 'Leitner,': [131], 'M.,': [132], 'Flashner,': [133], 'Y.,': [134], 'Cohen,': [135], 'S.,': [136], 'Barak,': [137], 'D.,': [138], 'Ariel,': [140], 'N.': [141], '(1992)': [142], 'EMBO': [143], 'J.': [144], '11,': [145], '3561-3568)': [146], 'demonstrated': [148], 'several': [151], 'hundred-fold': [152], 'Ki': [155], 'D74N': [157], 'bisquaternary': [161], 'ligands': [162, 236], 'decamethonium': [163, 184], 'BW284C51.': [165], 'Based': [166], 'on': [167], 'these': [168, 238], 'studies,': [169], 'singular': [170], 'models': [172], 'various': [175], 'inhibitor': [177], 'complexes': [178], 'defined.': [180], 'Yet,': [181], 'complex': [185], 'two': [186], 'conformations': [188], 'generated,': [190], 'accommodating': [191], 'quaternary': [193], 'ammonium': [194], 'group': [195], 'interactions': [197], 'either': [199, 268], 'or': [201, 272, 286], 'Tyr-341.': [203], 'We': [204], 'propose': [205], 'that': [206], 'consists': [209], 'number': [212], 'sites,': [215], 'close': [216], 'entrance': [219], 'gorge,': [224], 'sharing': [225], 'common': [232], 'core.': [233], 'Binding': [234], 'may': [240], 'be': [241], 'key': [243], 'allosteric': [246], 'modulation': [247], 'catalytic': [250], 'activity.': [251], 'This': [252], 'functional': [253], 'degeneracy': [254], 'result': [257], 'indole': [264], 'moiety': [265], 'interact': [267], 'via': [269, 273], 'stacking,': [270], 'aromatic-aromatic,': [271], 'pi-cation': [274], 'attractions': [275], 'involvement': [278], 'carboxylate': [281], 'charge-charge': [285], 'H-bond': [287], 'interactions.': [288]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1577601626', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2025-01-07T23:58:02.477824', 'created_date': '2016-06-24'}