Title: Endogenous MPTP-Like Amines in the Brain: Isoquinolines
Abstract:The discovery of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as a parkinsonism-producing neurotoxin (Davis et al., 1979; Langston et al., 1983) has greatly contributed to the pathogenesis of P...The discovery of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as a parkinsonism-producing neurotoxin (Davis et al., 1979; Langston et al., 1983) has greatly contributed to the pathogenesis of Parkinson's disease. Efforts have been made to find MPTP-like neurotoxins in the brain of parkinsonian patients. MPTP is a precursor neurotoxin, and the oxidized form, by monoamine oxidase type B, N-methyl-4-phenylpyridinium ion (MPP+), is the active neurotoxin (Chiba et al., 1984). It is assumed, therefore, that if any hypothetical MPTP-like neurotoxins exist in the parkinsonian brain they might be oxidized by monoamine oxidase to active neurotoxins.Read More
Publication Year: 1994
Publication Date: 1994-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
Access and Citation
Cited By Count: 1
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