Title: Photorefractive Keratectomy With Mitomycin C Versus LASIK in Custom Surgeries for Myopia: A Bilateral Prospective Randomized Clinical Trial
Abstract: <H4>PURPOSE</H4><p> To compare photorefractive keratectomy (PRK) with prophylactic use of mitomycin C (MMC) and LASIK in custom surgeries for myopic astigmatism.</p> <H4>METHODS</H4><p> Eighty-eight eyes of 44 patients with a minimum estimated ablation depth of 50 µm were randomized to receive PRK with MMC 0.002% for 1 minute in one eye and LASIK in the fellow eye. Uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), cycloplegic refraction, slit-lamp microscopy, contrast sensitivity, specular microscopy, aberrometry, and a subjective questionnaire were evaluated. Forty-two patients completed 6-month follow-up.</p> <H4>RESULTS</H4><p> Mean spherical equivalent refraction error before surgery and mean ablation depth were –3.99±1.20 diopters (D) and 73.0±914.55 µm in LASIK eyes, and –3.85±1.12 D and 70.7±14.07 µm in PRK with MMC eyes, respectively. Uncorrected visual acuity was significantly better in PRK with MMC eyes 3 months (<i>P</i>=.04) and 6 months (<i>P</i>=.01) after surgery. Best spectacle-corrected visual acuity and spherical equivalent refraction did not differ significantly in the groups during follow-up (<i>P</i>>.05). Significant haze was not observed in any PRK with MMC eye. Mean higher order aberration was lower in PRK with MMC eyes postoperatively compared with LASIK eyes (<i>P</i>=.01). Better contrast sensitivity was observed in PRK with MMC eyes than LASIK eyes (<i>P</i><.05). The endothelial cell count did not differ significantly between groups (<i>P</i>=.65). In terms of visual satisfaction, PRK with MMC eyes were better rated.</p> <H4>CONCLUSIONS</H4><p> Photorefractive keratectomy with MMC appears to be more effective than LASIK in custom surgery for moderate myopia. During 6-month follow-up, no toxic effects of MMC were evident. Long-term follow-up is necessary to attest its safety. [<cite>J Refract Surg.</cite> 2008;24:326-336.]</p> <h4>ABOUT THE AUTHORS</h4> <p>From Vision Institute, Federal University of São Paulo, Department of Ophthalmology, São Paulo, Brazil.</p> <p>Presented at the International Society of Refractive Surgery of the American Academy of Ophthalmology Subspecialty Day; November 10-11, 2006; Las Vegas, Nev.</p> <p>The authors have no proprietary interest in the materials presented herein.</p> <p>Correspondence: Mauro Campos, MD, Vision Institute, Federal University of São Paulo, R. Monsanto 166, 05412-030, São Paulo, SP, Brazil. Fax: 55 11 50822191; E-mail: <a href="mailto:[email protected]">[email protected]</a></p> <p>Received: November 22, 2006</p> <p>Accepted: September 5, 2007</p>
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 45
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot